Combines with complement factor. Medical search. Frequent questions

Preclinical studies suggested that the epidermal growth factor receptor (EGFR) monoclonal antibody was a radiation-sensitizing agent because it increased the rate of apoptosis, regulated the cell cycle, reduced radiation resistance, and increased radiation injuries. (dovepress.com)
To study the effect of MAC on HMEC expression of DAF, EC monolayers were opsonised with IgG2a anti-endoglin monoclonal antibody, thus optimising complement fixation ability. (biomedcentral.com)

In vitro studies have suggested that the p.Lys155Gln substitution reduces C3b binding to complement factor H, potentially creating resistance to inhibition by this factor. (nih.gov)
This resistance to inhibition in turn is predicted to result in enhanced complement activation. (nih.gov)
Inhibition of complement dependent cytotoxicity regulatory proteins may improve responses to rituximab among some patients with chronic lymphocytic leukemia. (cancertherapyadvisor.com)
We have studied the effect of combined radio-immunotherapy, and seen that this can lead to increased survival, for example when combined with IDO inhibition. (lu.se)

lactamases, AMR genes, and virulence factors. (cdc.gov)
Resistance to the lytic effects of serum complement confers virulence. (msdmanuals.com)

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A number of studies of radiotherapy combined with targeted therapy in non-small-cell lung carcinoma have been completed or are ongoing. (dovepress.com)
Radiotherapy combined with targeted therapy has considerably furthered the study of non-small-cell lung carcinoma (NSCLC) under the joint efforts of the two disciplines, yielding both exciting results and worrisome reports. (dovepress.com)
Differences in the experimental results prompted this summary for a more comprehensive and rational understanding of radiotherapy combined with targeted therapy. (dovepress.com)
This retrospective review of the literature indicates that numerous drugs have been used for targeted therapy and that the studies of radiotherapy combined with targeted therapy are diverse and complicated by their variable quality. (dovepress.com)

One mechanism associated with lack of CDC induction is the presence of complement factor H (CFH), a soluble protective protein. (cancertherapyadvisor.com)
Cell surface proteins have evolved which prevent EC damage by the cytotoxic defence system, decay-accelerating factor (DAF), protectin (CD59) and membrane cofactor protein (MCP). (biomedcentral.com)
Factor B is a Major Histocompatibility Complex Class-III protein. (lu.se)

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Three factors contribute to its outstanding capabilities, and they complement each other perfectly. (seapower.it)

Serum interleukin (IL)-1, IL-6, tumour necrosis factor (TNF) and quantitative urinary -2-microglobulin (-2-m) excretion were estimated. (who.int)

Immunological methods utilize antibodies, either alone, in conjunction with homologous, heterologous, or rabbit complement factors which are directed against the T cells. (wikipedia.org)
We investigate this in other human cell lines and rat glioma cell lines, and run animal experiments where the complement inactivation is targeted with antibodies. (lu.se)

We aimed to test combined genomic and microenvironmental indices in prostate cancer to improve risk stratification and complement clinical prognostic factors. (ox.ac.uk)

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We show that combining these two agents to promote anti-inflammatory and remyelinating mechanisms alleviates symptoms in EAE and lessens pathological hallmarks in both MS models. (shengsci.com)
Combined Expression of IFN-γ, IL-17, and IL-4 mRNA by Recall PBMCs Moderately Discriminates Active Tuberculosis from Latent Mycobacterium tuberculosis Infection in Patients with Miscellaneous Inflammatory Underlying Conditions. (shengsci.com)
To test the hypothesis that inflammatory cytokines and complement(C) MACs play a role in the expression of DAF, CD59 and MCP, and to investigate the intracellular signalling pathway involved in DAF expression. (biomedcentral.com)
Recruited and inflammatory macrophages/monocytes and neutrophils expressing interferon-, autoimmune-, and complement-related genes might contribute towards pro-fibrotic inflammatory lung responses following airborne biohazard exposures in setting of autoimmune arthritis and could be predictive and/ or targeted to reduce disease burden. (cdc.gov)

As the main body of scientific and technological innovation, enterprises must proceed from their own perspective and demand resource allocation that meets their own conditions, and the ultimate goal of the enterprise is to make profits and maximize the effectiveness of production factors in order to improve performance more effectively. (hindawi.com)
To evaluate the effectiveness of this program, we will use a mixed method evaluation combining secondary data analysis of Medicare claims with a community provider survey. (justia.com)
Strengthened efforts in the prevention and control of emerging infectious diseases will complement and improve the effectiveness of current efforts in HIV/AIDS, TB, STDs, and immunizations as well as other important infectious diseases. (cdc.gov)

A majority of studies in the clinic have focused on epidermalgrowth factor receptor (EGFR) antagonists, but future studies will likelybuild upon or complement this strategy with agents that target angiogenicor cell-cycle pathways. (cancernetwork.com)
The challenge now is to understand whenthe application of these EGFR inhibitors is relevant to an individualpatient and how or when these drugs should be combined with radiationor chemotherapy. (cancernetwork.com)

Central to the system is digital-certificate-based consumer device ID, seamlessly transforming mobile apps and desktop browsers into regulatory compliant second factors of authentication. (darkreading.com)
NuDetect complements Entersekt's strong device ID with an inherent factor to seamlessly tie the human to the device and brings a new dimension to our regulatory compliant strong authentication suite," said Dewald Nolte , chief strategy officer at Entersekt. (darkreading.com)

Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS). (lu.se)
Complement activation in malignant gliomas. (lu.se)
Our co-operation partner Kurt Osther has seen that human glioma cells express factors suppressing the complement activation. (lu.se)

The first step in making smart platform strategies work is to develop a modular, competitive portfolio, which requires an integrated approach combining modularization, standardization, and design to value. (mckinsey.com)
was created in 2006 and was recently modified to provide for a combined Virtual and Human Factor Approach and to complement Autonomous Personalized Investing. (portfolioresourcecenter.com)
An additional goal is to develop accurate aims to understand how lifestyle factors randomization approach risk prediction models that take into influence cancer onset. (who.int)
The approach aimed to illustrate the local TB burden in the context of the geography of this remote region of PNG, using mapping to illustrate the results as a complement to the underlying quantitative spatial analysis. (who.int)

All possible combinations of nine factors were fed to a generalized linear mixed model for PAI and PBI prediction and quantification of their prediction accuracies. (techscience.com)
A systematic analysis was carried out to complement previous qualitative research, and to clarify which factor combinations produce increased smallholder commercial tree growing in developing country contexts. (helsinki.fi)

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Whether it's a traditional, contemporary, or rustic style, the staircase can be crafted to complement and enhance the overall aesthetic, creating a cohesive and visually pleasing environment. (dabstairs.com)
When it comes to creating a quiet and peaceful environment, soundproof panels offer a practical solution that combines both aesthetic design and effective soundproofing. (fairhome-property.com)
When choosing soundproof panels with aesthetic appeal, consider factors such as colour, texture, and pattern that complement the existing interior design. (fairhome-property.com)

Quantitative and mixed methods are employed in other aspects related to use and interaction which complement this major study. (sigaccess.org)

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This study aims to describe the spatial distribution of TB in the Balimo District Hospital (BDH) catchment area to identify TB patient clusters and factors associated with high rates of TB. (who.int)
This study used spatial epidemiology techniques to (1) define the catchment area of BDH, (2) identify clustering of TB in the BDH catchment area and (3) investigate factors associated with high rates of TB. (who.int)

As purchasing power increases in "middle-income" countries, multiple risk factors affect lower social population groups. (who.int)

Through combining these two essential components the Sapphire screens are designed to maximise any projected image. (projectorpoint.co.uk)

Combining innovative design and on-trend styles, the molded panel Masonite Heritage Series Lincoln Park Primed 1-Panel Hollow Core Composite Interior Door Slab is a minimalistic, classic style design made of solid material all the way through. (homedepot.com)
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In this article, we will explore the importance of custom wooden staircases in home design and uncover the key factors that Hertfordshire homeowners should consider when installing one. (dabstairs.com)
Combination Stairs: Combination stairs offer the flexibility to combine different staircase types, creating a customized design that suits the homeowner's preferences and architectural requirements. (dabstairs.com)
Puig sport bar ends combine a modern, customisable design with a minimalist racing form factor that is an ideal complement for the handlebars of your Kawasaki Ninja 300. (moto-planet.com)

Autoimmune rheumatic diseases are considered to be influenced by both genetic and environmental factors. (nature.com)
Tobacco smoking has been linked to the development of rheumatic diseases, namely systemic lupus erythematosus and rheumatoid arthritis, and has been shown to interact with genetic factors to create a significant combined risk of disease. (nature.com)
Broader public health action is emphasized, including integration of preventive measures against major risk factors for chronic diseases within health services and, particularly in primary health care which has proven to be effective. (who.int)
Numerous studies over the last 40 years, have revealed certain risk factors for noncommunicable diseases and thus the health benefit of programmes to reduce such risks. (who.int)
Goals and Objectives Goal I Detect, promptly investigate, and monitor emerging pathogens, the diseases they cause, and the factors influencing their emergence. (cdc.gov)

Here we studied 11 rare missense variants, with FI secretion levels comparable to wildtype, but a predicted damaging effects based on the Combined Annotation Dependent Depletion (CADD) score. (lu.se)

Monocytic myeloid-derived suppressor cells were reduced, while complement genes (e.g. (cdc.gov)

Thus, the research programme of how they exert their effect along with of the importance of non-genetic factors GCS complements that of GEP, and also environmental factors. (who.int)
Whether an exposure could lead to an adverse health outcome depends on the characteristics of exposure and the exposed population (e.g., developmental stage, existing disease state, genetic factors) that could make them more susceptible to site-related exposures. (cdc.gov)

Factor B which is part of the alternate pathway of the complement system is cleaved by Factor D into 2 fragments: Ba and Bb. (lu.se)
This system with the two main parts and their groups makes it possible to combine two (or more) distinct searches into one search result, while being flexible in removing results from the final list. (diva-portal.org)

Analysis of these large elucidatinG the etioloGical role sites, and also patterns of genetic genome-wide studies also includes a of obeSity and related riSk factorS mutations that are observed in tumours. (who.int)

To date no predictive factor of response has been described. (hindawi.com)

BACKGROUND: Elevated blood pressure and proteinuria are well-established risk factors for chronic kidney disease (CKD) progression in children. (bvsalud.org)
Using an established murine model of RA-associated lung disease combining collagen-induced arthritis (CIA) with organic dust extract (ODE)-induced airway inflammation, differences among lung immune cell populations were analyzed by single cell RNA-sequencing. (cdc.gov)

Inclusive analysis of factors that drive, restrict or challenge the COVID19 Test Kits market growth is provided. (pressnews.biz)
The group regression method is used to test the impact of production factors on R&D. Whether input and corporate performance have a moderating effect, and the specific moderating and lagging effects of production factors are investigated. (hindawi.com)
Are these factors alone enough to enable lenders to make sound decisions, or do you recommend they use your test scores to complement more traditional assessments of creditworthiness? (nextbillion.net)

This study aimed to analyze risk factors for CKD progress, emphasizing detailed ambulatory blood pressure (ABPM) data. (bvsalud.org)
Combining morphological and mechanical risk factors may lead to more accurate progression prediction, compared to the predictions using single factor. (techscience.com)
OBJECTIVE: To determine the prevalence, progression, and modifiable risk factors associated with the development of diabetic retinopathy (DR) in a population-based cohort of youth-onset diabetes. (cdc.gov)
Prevalence estimates were standardized to estimate the burden of DR, and inverse probability weighting for censoring was applied for estimating risk factors for DR at two points of follow-up. (cdc.gov)

In humans the first TCD was performed in severe combined immunodeficiency patients. (wikipedia.org)
By combining this knowledge with the latest advances in medical technology, they offer patients the most comprehensive care available in healthcare today. (osteopathic.org)

Atherosclerotic plaque progression is generally considered to be closely associated with morphological and mechanical factors. (techscience.com)
PWSn is better than WSS for plaque progression using single factor. (techscience.com)

Today's companies must combine their existing credit with alternative credit sources, ones that are easy-to-use and ones that improve a company's cash position. (1stcommercialcredit.com)
Overall, tuftsin effectively combined with benztropine to significantly improve MS-like pathologies in both models. (shengsci.com)

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Here we report that hepatocyte nuclear factor 4α (HNF4α) dictates the sensitivity of liver cancer to methionine restriction. (biomed.news)

This form of diabetes is often associated with lifestyle factors and typically occurs in adulthood, although it's becoming more prevalent in younger individuals. (diahub.org)

The research, first introduced in 2020 and now available as information-based strategy on Bloomberg, shows how reversion and fundamental valuations can be combined into one strategy that complements other traditional style factors. (dbresearch.de)
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Shifts in microbial community composition were influenced by fluctuations in environmental factors within the mangrove forests of the Red Sea influenced by seasonal changes in sea level. (frontiersin.org)
From their first days of medical school, DOs are trained to look beyond your symptoms to understand how lifestyle and environmental factors impact your well-being. (osteopathic.org)

Altered wound inflammation and contraction: Tobacco inhibits endothelial cell and fibroblast function, nitric oxide synthase activity, vascular endothelial growth factor production, and collagen synthesis. (medscape.com)

In 1 patient's sample that remained refractory, combining the CFH-targeted antibody with the negative control was sufficient for inducing CDC, thereby overcoming rituximab resistance. (cancertherapyadvisor.com)

This section provides an overview of how to examine factors that influence whether an exposure to a contaminant could produce harmful health effects and how these factors weigh into your public health conclusions. (cdc.gov)

How expression of these factors is controlled is not clear. (biomedcentral.com)
Flow cytometry determined expression of the three factors, by resting HUVECs and DMECs. (biomedcentral.com)

ComQum-U or quantum neutron refinement is a method to combine neutron crystallographic refinement with QM/MM calculations to obtain an optimum compromise between neutron crystallography and quantum chemistry. (lu.se)

The research study has combined analysis of varied factors that complement market's growth. (pressnews.biz)
Fluid-structure interaction (FSI) models combining IVUS and OCT were constructed to obtain accurate plaque stress/strain and flow shear stress data for analysis. (techscience.com)
We applied two-step Qualitative Comparative Analysis (QCA) to identify necessary and sufficient factors related to tree growing between 1990 and 2015 in Indonesian Java, Kalimantan & Sumatra, Lao PDR, Tanzania, Uganda, and Vietnam. (helsinki.fi)
High-throughput analysis of lung immune cells in a combined murine model of agricultur e dust-triggered airway inflammation with rheumatoid arthritis. (cdc.gov)
Genetic bioinformatic techniques to complement combines large population-based studies analysis comprises either candidate more traditional approaches for the study with laboratory and bioinformatics gene or genome-wide genotyping of rare genetic variants. (who.int)

Attempts to encourage smallholder tree growing with policies and incentives have had variable outcomes, and earlier research and theories have identified various important factors in the enabling environment and in promotional policies. (helsinki.fi)

2006) Smoking, drinking, sleeping habits, and other lifestyle factors and the risk of systemic lupus erythematosus in Japanese females: findings from the KYSS study. (nature.com)

These factors have to complement each other rarely even contrasting when combined will result in excellent food presentation scenario. (finediningindian.com)
As depicted in the figure below, multiple factors influence whether an exposure could result in harmful health effects, as well as the type and severity of those health effects. (cdc.gov)

Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody. (cancertherapyadvisor.com)
How do endothelial cells (ECs) protect themselves against damage by complement, particularly when they are present at the interface between blood and inflamed tissue? (biomedcentral.com)

Select designs offer whole-home solutions in coordinating bi-fold and factor prehung single or double units. (homedepot.com)

This dissertation proposes a different paradigm: from factors towards interaction based on older people as social actors. (sigaccess.org)

The problem is to optimize the rational allocation of future factors of production and provide assistance in achieving a combination of existing and new factors of production. (hindawi.com)

The association of p.Lys155Gln was replicated in AMD case-control samples of European ancestry with OR = 4.22 and P = 1.6 × 10(-10), resulting in OR = 3.65 and P = 8.8 × 10(-16) for all studies combined. (nih.gov)

Simply put, receivables factoring is an asset-based financing solution that allows companies to use their receivables in order to set up a working credit line with a financing company. (1stcommercialcredit.com)

In contrast to existing tablets, its unprecedented dual screen presentation and usability allows its displays to be combined and used as a large screen or for different functions such as playing video on one screen while showing control buttons on the other. (prnewswire.com)

With its off-center of gravity form factor, the 9.4-inch S1 offers stability and a sense of lightness, offering comfortable use for hours. (prnewswire.com)

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