Combined modality cancer therapy antineoplastic combined chemotherapy protocols. Medical search. Frequent questions

A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the head and neck compared induction chemotherapy with docetaxel plus cisplatin and fluorouracil (TPF) with cisplatin and fluorouracil (PF), followed by chemoradiotherapy. (nih.gov)
Patients with squamous-cell carcinoma of the head and neck who received docetaxel plus cisplatin and fluorouracil induction chemotherapy plus chemoradiotherapy had a significantly longer survival than did patients who received cisplatin and fluorouracil induction chemotherapy plus chemoradiotherapy. (nih.gov)
It is a common site of cancer referred to as stump cancer or carcinoma of the gastric stump. (wakehealth.edu)
Objective: To analyze differences in the presentation of clinicopathological variables according to GRB7 protein expression in HER2-positive tumors in Colombian patients with invasive ductal breast carcinomas diagnosed between 2013 and 2015 at the Instituto Nacional de Cancerología (Bogotá, Colombia).Methods: A total of 158 breast cancer patients were included with a confirmed diagnosis of invasive ductal carcinoma. (bvsalud.org)
Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. (biomedcentral.com)
The treatment of non-muscle-invasive bladder cancer (Ta, T1, carcinoma in situ [CIS]) begins with transurethral resection of bladder tumor (TURBT). (medscape.com)

The majority of the patients had combined cisplatin-based chemoradiation. (bepress.com)
The patients were randomly assigned to receive either surgery alone or three courses of chemotherapy (6 mg of mitomycin per square meter of body-surface area, 3 g of ifosfamide per square meter, and 50 mg of cisplatin per square meter) given intravenously at three-week intervals and followed by surgery. (ox.ac.uk)
Results of Polish medical centres within an international randomized phase III study of docetaksel plus cisplatin and docetaksel plus carboplatin versus winorelbine plus cisplatin for advanced non-small-cell lung cancer. (edu.pl)

The authors conclude that combined radiotherapy and chemotherapy, although significantly more effective in reducing recurrence than no therapy, is significantly more toxic than single-modality therapy in many parameters, although most of the toxicity is transient and therefore not limiting. (emmes.com)
A strong rationale is provided for subsequent clinical trials of concurrent radiotherapy and chemotherapy with antiangiogenic agents or with specific TP inhibitors. (ox.ac.uk)
Compliance was good with 93 and 89% of patients completing radiotherapy and chemotherapy, respectively. (ox.ac.uk)

Effects of adjuvant chemotherapy on specific and non-specific immune mechanisms. (curehunter.com)
Adjuvant chemotherapy is a well accepted concept in the treatment of breast cancer and has resulted in most clinical studies in a significant prolongation of the disease-free interval in certain subgroups of patients. (curehunter.com)
However, very little is known about the late effects of adjuvant chemotherapy and its influence upon the function of a series of physiologic mechanisms. (curehunter.com)
42 Adjuvant chemotherapy is given after a local treatment (radiotherapy or surgery). (wikipedia.org)
These micrometastases can be treated with adjuvant chemotherapy and can reduce relapse rates caused by these disseminated cells. (wikipedia.org)

Balancing the Therapeutic Ratio in DLBCL Requires Appropriate, Individualized Patient Selection Rather Than Broad Elimination of Radiation Therapy. (ucdenver.edu)
Our findings are basis of proposing 2HF as therapeutic or preventative drug for lung cancer. (oncotarget.com)
Because most lung cancers cannot be cured with currently available therapeutic modalities, the appropriate application of skilled palliative care is an important part of the treatment of patients with NSCLC. (medscape.com)

Interferon maintenance therapy improves progression-free and overall survival of patients with multiple myeloma who respond to melphalan and prednisone. (mcmaster.ca)
The results of this study are published elsewhere and show a significantly reduced recurrence rate and prolonged disease-free survival time for the combined modality arm compared with the no therapy arm. (emmes.com)
It is concluded that thymidine phosphorylase is associated with angiogenesis, with resistance to radiotherapy and cytotoxic therapy, and with poorer survival in squamous cell head and neck cancer. (ox.ac.uk)
Disease-free survival versus overall survival as a primary end point for adjuvant colon cancer studies: individual patient data from 20,898 patients on 18 randomized trials. (ox.ac.uk)
BackgroundThe efficacy of surgery for patients with non-small-cell lung cancer is limited, although recent studies suggest that preoperative chemotherapy may improve survival. (ox.ac.uk)
Most of the patients treated with chemotherapy plus surgery had tumors that consisted of diploid cells, whereas the patients treated with surgery alone had tumors with aneuploid cells.ConclusionsPreoperative chemotherapy increases the median survival in patients with non-small-cell lung cancer. (ox.ac.uk)
It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. (lookformedical.com)
From 1980 to 1990, event-free and overall survival progressively improved, following adoption of an American therapy template and use of two post-remission intensification modules. (ox.ac.uk)
Possible reasons for the plateau in event-free survival (including type and dose of induction steroid, dropping of induction anthracycline, type and dose of asparaginase, gaps early in therapy following intensification, and overall lack of compliance in maintenance) are being explored in the latest protocol ALL '97. (ox.ac.uk)
Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall survival. (wikipedia.org)
In patients with localized disease, overall 5-year survival rates have improved to more than 80% with the combined use of surgery, radiation therapy, and chemotherapy. (medscape.com)
At 6 months, event-free survival in these patients, whose prognosis was unfavorable, was 65% with temsirolimus versus 50% with bevacizumab, when these agents were added to a chemotherapy regimen of vinorelbine and cyclophosphamide. (medscape.com)
BCL2 and other components of the intrinsic cell death pathway are critical regulators of cell survival, frequently perturbed by cancer cells resulting in evasion of programmed cell death [ 1 ]. (biomedcentral.com)
Due to the widespread application of intensity-modulated radiation therapy (IMRT), the locoregional disease control and overall survival of patients with NPC have considerably improved [ 2 ]. (biomedcentral.com)
OBJECTIVES: The goals of treating recurrent platinum-resistant ovarian cancer are palliative, aimed at reducing symptoms and improving progression free survival. (omeka.net)

The rate of recurrence was 56 percent in the group treated with chemotherapy plus surgery and 74 percent in the group treated with surgery alone. (ox.ac.uk)
It can be used when there is little evidence of cancer present, but there is risk of recurrence. (wikipedia.org)
Treatment with chemotherapeutic agents, after initial ovarian tumor debulking, and during recurrence, results in extended chemotherapy. (omeka.net)
Bladder cancer is a common urologic cancer that has the highest recurrence rate of any malignancy. (medscape.com)

55-59 : 17-18 Neoadjuvant chemotherapy is given prior to a local treatment such as surgery, and is designed to shrink the primary tumor. (wikipedia.org)
Nevertheless, few tools are available to corroborate prediction of response to neoadjuvant chemotherapy. (bvsalud.org)
We aimed to apply Artificial intelligence models to predict the response to neoadjuvant chemotherapy based solely on clinical and pathological data. (bvsalud.org)
Methods: Medical records of 130 patients treated with neoadjuvant chemotherapy were reviewed and divided into two groups: 90 samples to train the network and 40 samples to perform prospective testingand validate the results obtained by the Artificial intelligence method. (bvsalud.org)
To date, no published research has used clinicopathologic data to predict the response to neoadjuvant chemotherapy in patients with breast cancer, thus highlighting the importance of the present study. (bvsalud.org)
Chemotherapy is currently used in adjuvant or neoadjuvant settings combined with radiotherapy or, in a palliative situation, as a single modality. (biomedcentral.com)

Patients were treated with combined chemotherapy of epirubicin (EPIR), mitomycin C (MMC), 5-fluorouracil (5-FU), by hepatic infusion using a subcutaneously implanted reservoir. (nih.gov)
All patients were treated with conventionally fractionated radiotherapy combined with induction (platinum- and 5-fluorouracil-based) or concurrent platinum chemotherapy. (ox.ac.uk)
These results suggest that DFS after 3 years of median follow-up is an appropriate end point for adjuvant colon cancer clinical trials of fluorouracil-based regimens, although marginally significant DFS improvements may not translate into significant OS benefits. (ox.ac.uk)
A phase I/II study of irinotecan when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group Study. (ox.ac.uk)
The objective of this study was to evaluate the maximum tolerated dose (MTD) and recommended dose of irinotecan administered as a 5-day schedule synchronously with 5-fluorouracil (5FU), leucovorin (LV) and preoperative pelvic radiation (45 Gy) for primary borderline/unresectable, locally advanced rectal cancer. (ox.ac.uk)

PURPOSE: To assess the patterns of practice among Canadian radiation oncologists who treat esophageal cancers, using a trans-Canada survey, completed at the end of 1996. (bepress.com)
METHODS AND MATERIALS: One of 3 case presentations of different stages of cervical esophageal cancer was randomly assigned and sent to participating radiation oncologists by mail. (bepress.com)
Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy. (ox.ac.uk)
Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e., treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (wikipedia.org)
55-59 Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or hyperthermia therapy. (wikipedia.org)
Protocols that use combinations of radiation therapy, chemotherapy, and surgery are currently being studied to determine the best therapy. (medscape.com)
Early-stage, localized disease may be treated with radiation therapy or excision in certain cases. (medscape.com)
Treatment for patients with rhabdomyosarcoma involves a combination of surgery, chemotherapy, and radiation therapy. (medscape.com)
Most patients with rhabdomyosarcoma require radiation therapy to achieve adequate local control, though this treatment is not usually performed until after initial surgical resection and the start of chemotherapy. (medscape.com)
Radiation Therapy Use in Refractory and Relapsed Adolescent and Young Adult Hodgkin Lymphoma: A Report from the Children's Oncology Group. (ucdenver.edu)
Radiation Therapy for Young Children Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant for Primary Brain Tumors. (ucdenver.edu)
Clinical Outcomes Confirm Conjecture: Modern Radiation Therapy Reduces the Risk of Late Toxicity in Survivors of Hodgkin Lymphoma. (ucdenver.edu)
Metastatic lesions are usually multiple and resistant to conventional therapies, jeopardizing successful surgical resection, chemo and radiation treatment [ 4 ] . (oaepublish.com)
A patient with Stage IIB squamous cell cancer of the cervix presented 10 days into her primary radiation therapy with neutropenic fever and diarrhea requiring hospitalization and delay in treatment. (omeka.net)
Surgery, systemic therapy, and radiation are the main treatment options for NSCLC. (medscape.com)
Alternatively, a bladder-sparing approach of TURBT followed by concurrent radiation therapy and systemic chemotherapy (trimodality therapy) may be used. (medscape.com)

Severe toxicity in the combined therapy arm was significantly worse (P less than 0.001) than in either single modality arm. (emmes.com)

We randomly assigned 501 patients (all of whom had stage III or IV disease with no distant metastases and tumors considered to be unresectable or were candidates for organ preservation) to receive either TPF or PF induction chemotherapy, followed by chemoradiotherapy with weekly carboplatin therapy and radiotherapy for 5 days per week. (nih.gov)
Concurrent paclitaxel, carboplatin, and radiotherapy in advanced head and neck cancers: a phase II study--preliminary results. (rush.edu)

The most commonly used chemotherapy regimen was the BFM-95 protocol. (bvsalud.org)
Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. (semanticscholar.org)
Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. (wikipedia.org)

Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs) or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
55-59 Salvage chemotherapy or palliative chemotherapy is given without curative intent, but simply to decrease tumor load and increase life expectancy. (wikipedia.org)
Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)

Toxicity associated with adjuvant postoperative therapy for adenocarcinoma of the rectum. (emmes.com)

Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer, which is called medical oncology. (wikipedia.org)
In a proof-of-concept study, we assessed the feasibility and psychometric performance of the Functional Assessment of Cancer Therapy-Gynecologic Oncology Group-Neurotoxicity (FACT-GOG-Ntx), a unidimensional CIPN symptom scale widely used adults with CIPN, in pediatric HL at risk for CIPN. (bvsalud.org)
METHODS: Youth (11+ years) and parents of all children (5-17.9 years) with newly diagnosed high-risk HL enrolled on Children's Oncology Group AHOD1331 (NCT02166463) were invited to complete the FACT-GOG-Ntx and a health-related quality of life (HRQL) measure at pre-treatment (Time 1), and during cycles 2 (Time 2) and 5 (Time 3) of chemotherapy during the first half of study accrual. (bvsalud.org)
Quality of life, symptoms and care needs in patients with persistent or recurrent platinum-resistant ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study. (omeka.net)
Chemotherapy completion in elderly women with ovarian, primary peritoneal or fallopian tube cancer - An NRG oncology/Gynecologic Oncology Group study. (omeka.net)

BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is an under-recognized complication of several chemotherapy agents used as part of curative-intent therapy for Hodgkin Lymphoma (HL). (bvsalud.org)
To this end, in vitro models with cell lines established from human HNSCC have been used, and several chemotherapy sensitivity and resistance assays (CSRA) are currently available. (biomedcentral.com)

Tumor volume as a potential imaging-based risk-stratification factor in trimodality therapy for locally advanced non-small cell lung cancer. (uchicago.edu)

A low percentage of cancer cells with nuclear TP expression in pretreatment biopsies was associated with a high rate of CR after combined chemoradiotherapy (P = 0.006) and induction chemotherapy (0.01). (ox.ac.uk)
Lower maternal educational level was associated with increased frequency of mucositis, as were induction chemotherapy and maintenance chemotherapy after relapse. (bvsalud.org)
Oral lesions were associated with the induction phase of chemotherapy. (bvsalud.org)
Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
55-59 Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is used. (wikipedia.org)

The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. (lookformedical.com)
Clinical protocols used to inhibit the growth or spread of NEOPLASMS. (bvsalud.org)

Randomized trial of interferon maintenance in multiple myeloma: a study of the National Cancer Institute of Canada Clinical Trials Group. (mcmaster.ca)
METHODS: Individual patient data were pooled from 18 randomized phase III colon cancer adjuvant clinical trials. (ox.ac.uk)
We aim to synthesize and carry out a formulation with these antineoplastic molecules for clinical trials. (nature.com)
comment the results of three large, phase III, randomized clinical trials in early-stage favorable Hodgkin Lymphoma (HL), aimed at exploring the non-inferiority of ABVD chemotherapy alone compared to combined-modality treatment with ABVD and Involved Field/Node Radiotherapy (INRT). (bvsalud.org)
Primary interests include clinical trials design and the design and analysis of biomarker and imaging studies especially in the areas of GI cancer, lymphoma, melanoma, transplant and cancer immunotherapy. (dukecancerinstitute.org)

For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
Among tumors with higher incidence in females, both in developed and developing countries, is breast cancer. (isciii.es)
Once universally fatal, Pancoast tumors are currently treatable with outcomes similar to those of other stage-matched non-small cell lung cancers. (medscape.com)
Pancoast tumors are a subset of lung cancers that invade the apical chest wall. (medscape.com)
In case of chemotherapeutically pretreated recurrent tumors, physicians are especially challenged to determine an appropriate therapy. (biomedcentral.com)

Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. (wikipedia.org)
Symptoms depend on the location of cancer. (medscape.com)

This schedule of combined modality therapy is not only effective but appears to have tolerable toxicity, because of the relative lack of late effects. (emmes.com)

The most frequently used prescription dose was 60 Gy/30 fractions/6 weeks, given with concurrent chemotherapy. (bepress.com)

Both TP expression and tumor vascularization are putative postoperative prognostic markers of cancer. (ox.ac.uk)
We provided a comprehensive analysis of rate, pattern, and severity of early and late postoperative complications in a very large, single-institution series of locally advanced cervical cancer (LACC) patients administered CT/RT plus radical surgery (RS). (unicatt.it)

To evaluate the efficacy of intra-arterial chemotherapy combined with hyperthermia for metastatic liver cancer, our cooperative study group carried out a randomized clinical trial comparing intra-arterial chemotherapy alone and intra-arterial chemotherapy combined with hyperthermia. (nih.gov)
Hyperthermia (8MHz radiofrequency) was usually performed for 40-60 min every week, and intra-arterial chemotherapy was performed immediately before hyperthermia. (nih.gov)
Our results suggest that intra-arterial chemotherapy combined with hyperthermia is a useful modality for the treatment of metastatic liver cancer. (nih.gov)

Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for cancer in that they are introduced into the blood stream and are therefore in principle able to address cancer at any anatomic location in the body. (wikipedia.org)
Approximately 80% of all patients with lung cancer are considered for systemic therapy at some point during the course of their illness. (medscape.com)

Long-term follow-up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980-1997. (ox.ac.uk)

This type of chemotherapy is used for curative intent. (wikipedia.org)

Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)

Conclusions The present study found that levels of BPIFA1 and glycosylated forms of BPIFA2 are affected by radiotherapy, suggesting that these proteins may play a role in the oral microenvironment in irradiated patients with head and neck cancer. (uandes.cl)

Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)

Twenty-six patients were registered by telephone contact and allocated at random to groups treated with either intra-arterial chemotherapy alone (14 patients) or combination therapy (12 patients). (nih.gov)
The response rate was 7% in the chemotherapy alone group (1 PR among 14 evaluable patients), and 40% in the combination therapy group (4 PR among 10 evaluable patients). (nih.gov)
and (4) a combination of both modalities. (emmes.com)
55-59 Combination chemotherapy involves treating a person with a number of different drugs simultaneously. (wikipedia.org)
In addition to cancer diagnosis, the interaction between nutritional status, body composition and factors related to treatment represent a complex combination which can dictate the quality of life of cancer patients. (isciii.es)
Multiagent chemotherapy in combination with rituximab is the most common first-line treatment strategy for follicular lymphoma. (medscape.com)
Over 3000 years ago, since the Ancient, Indian and Chinese civilizations it has been used for the treatment of various diseases [ 5 ] mainly in combination with reactive chemicals, for example to treat conditions like vitiligo, psoriasis and skin cancer [ 6 ] . (oaepublish.com)

Conclusions: Oral abnormalities were common in children receiving chemotherapy and mucositis was the most prevalent manifestation. (bvsalud.org)

In a phase II trial of 87 patients with rhabdomyosarcoma who had experienced a first relapse or disease progression and whose prognosis was unfavorable, temsirolimus (Torisel) proved superior to bevacizumab (Asvastin) as add-on therapy. (medscape.com)
microRNA-183-3p Inhibits Progression of Human Prostate Cancer by Downregulating High-Mobility Group Nucleosome Binding Domain 5. (cancerindex.org)
microRNAs are a class of noncoding RNAs that play important roles in cancer progression. (cancerindex.org)

The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (wikipedia.org)
The development of therapies with specific molecular or genetic targets, which inhibit growth-promoting signals from classic endocrine hormones (primarily estrogens for breast cancer and androgens for prostate cancer) are now called hormonal therapies. (wikipedia.org)

Results of in-vivo nude mouse xenograft studies of SCLC and NSCLC, which showed that orally administered 2HF inhibited growth of both histological types of lung cancer, confirmed in-vitro study results. (oncotarget.com)
Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancers. (medscape.com)

The two enteritis fatalities occurred late at 605 and 1000 days after start of combined modality treatment, respectively. (emmes.com)
Materials and Methods Unstimulated whole-mouth saliva was collected from 45 cancer patients (1 week before treatment, during the treatment, and 1 week after completion of radiotherapy) and from 20 controls. (uandes.cl)
The systemic treatment of non-small-cell lung cancer. (ox.ac.uk)
We conducted a randomized trial to examine the possible benefit of preoperative chemotherapy and surgery for the treatment of patients with non-small-cell lung cancer.MethodsWe studied 60 patients (59 men and 1 woman) with stage IIIA non-small-cell lung cancer. (ox.ac.uk)
Anthracycline-based chemotherapy as primary treatment for intravascular lymphoma. (semanticscholar.org)
MACOP-B chemotherapy for the treatment of diffuse large-cell lymphoma. (semanticscholar.org)
Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. (wikipedia.org)
Aetna considers percutaneous ethanol injection (PEI) medically necessary for the treatment of hepatocellular cancers (HCC) without extra-hepatic spread. (aetna.com)
Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
Combined radiofrequency ablation and PEI for the treatment of HCC. (aetna.com)
From the patient's perspective, the measurement of quality of life in women with breast cancer presents itself as an important resource to evaluate the treatment results. (isciii.es)
As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
In this trial patients are stratified, before treatment onset, according to the risk of therapy failure in a single patient basis, taking into account non only the results of interim and End-of-Therapy PET, but also the value of new metrics extracted from the baseline PET/CT such as the Large Nodal Mass (LNM) and Total Metabolic Tumor Volume (TMTV). (bvsalud.org)
Treatment intensity, consisting in ABVD chemotherapy, INRT and Nivolumab maintenance, is modulated on the presence/absence of the above factors, in a personalized-medicine approach. (bvsalud.org)
The JSH Practical Guidelines for Hematological Malignancies, 2018 expanded edition, newly adopted brentuximab vedotin, doxorubicin, vinblastine, dacarbazine(A+AVD)protocol as a standard treatment for advanced-stage classical Hodgkin lymphoma(CHL). (bvsalud.org)
Since photodynamic therapy (PDT) does not compromise other treatment options and presents reduced long-term morbidity when compared with chemotherapy or radiotherapy, it appears as a promising alternative treatment for controlling malignant diseases. (oaepublish.com)
In this review, we set out to perform a broad up-date on PDT in cancer research and treatment, discussing how this approach has been applied and what it could add to breast cancer therapy. (oaepublish.com)
Photodynamic therapy (PDT) is currently being used as an alternative treatment for the control of malignant diseases [ 8 - 10 ] . (oaepublish.com)
In this review, we set out to perform a broad up-date on PDT and it implication in cancer research and treatment. (oaepublish.com)
Consistent with increased drug accumulation, combined treatment with 1-chloro-2, 4-dinitrobenzene, reduced the GI 50 of 2HF by an order of magnitude. (oncotarget.com)

Transarterially administered gene therapy for primary and secondary liver malignancies. (aetna.com)

But the efficacy of chemotherapy in HNSCC remains unsatisfactory due to the frequent development of non-responsiveness or chemoresistance [ 3 ]. (biomedcentral.com)

A randomized trial comparing preoperative chemotherapy plus surgery with surgery alone in patients with non-small-cell lung cancer. (ox.ac.uk)
The prevalence of mutated K-ras oncogenes was 15 percent among the patients receiving preoperative chemotherapy and 42 percent among those treated with surgery alone (P = 0.05). (ox.ac.uk)
That portion of the stomach remaining after gastric surgery, usually gastrectomy or gastroenterostomy for cancer of the stomach or peptic ulcer. (wakehealth.edu)

A cost-effectiveness analysis of sentinel lymph node detection in vulvar cancer by preoperative lymphoscintigraphy versus intraoperative detection alone. (omeka.net)

chemotherapy was more frequently delayed because of hematologic adverse events in the PF group. (nih.gov)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Equivocal end-of-therapy imaging findings do not predict a higher risk of local relapse after definitive radiotherapy in pediatric Ewing sarcoma and rhabdomyosarcoma. (ucdenver.edu)

The connotation of the word chemotherapy excludes more selective agents that block extracellular signals (signal transduction). (wikipedia.org)
Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (wikipedia.org)

EGF61 polymorphism predicts complete pathologic response to cetuximab-based chemoradiation independent of KRAS status in locally advanced rectal cancer patients. (unil.ch)

Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (wikipedia.org)
Since in classic chemotherapies it is observed a decrease in immune response, methotrexate (MTX) was used only to compare the PnV effects on innate immune cells with a highly immunosuppressive antineoplastic drug. (nature.com)

High-dose chemotherapy and autologous bone marrow transplantation compared with MACOP-B in aggressive B-cell lymphoma. (semanticscholar.org)

Aetna considers intra-hepatic chemotherapy (infusion) medically necessary for members with liver metastases from colorectal cancer. (aetna.com)
One-shot" arterial chemotherapy for members with liver metastases from colorectal cancer. (aetna.com)
Liver and renal function, as well as blood electrolytes and chemistry, must be assessed before chemotherapy. (medscape.com)
Metastasis are characterized by a sequential and complex process during which cancer cells invade specific organs including lung, liver, brain, and bone [ 3 ] . (oaepublish.com)

Additionally, hearing loss may not manifest until several weeks or months after completion of antibiotic or antineoplastic therapy. (medscape.com)

Anatomy6

Organisms4

Diseases57

Chemicals and Drugs68

Analytical, Diagnostic and Therapeutic Techniques and Equipment83

Phenomena and Processes31

Disciplines and Occupations6

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture2

Humanities1

Information Science6

Named Groups1

Health Care33

Geographicals1

Carcinoma6

Cisplatin3

Radiotherapy and chemotherapy3

Adjuvant chemotherapy5

Therapeutic3

Survival15

Recurrence4

Neoadjuvant6

Fluorouracil5

Radiation16

Single-modality1

Carboplatin2

Regimen3

Palliative3

Associated with adjuvant1

Oncology5

Several chemotherapy2

Trimodality therapy1

Induction5

Neoplasms2

Clinical trials5

Tumors5

Symptoms2

Toxicity1

Concurrent1

Postoperative2

Hyperthermia3

Systemic therapy2

19971

Curative intent1

Adenocarcinoma1

Head and neck1

Metastatic disease1

Combination7

Conclusions1

Progression3

Inhibit2

NSCLC2

Treatment20

Primary1

Efficacy1

Surgery3

Preoperative1

Adverse1

Targets1

Relapse1

Agents2

Locally advanced rectal cancer1

Immune cells2

Dose1

Liver4

Completion1