Combination with dexamethasone. Medical search. Frequent questions

Combination of bortezomib, thalidomide, and dexamethasone (VTD) as a consolidation therapy after autologous stem cell transplantation for symptomatic multiple myeloma in Japanese patients. (stembook.org)
Does the VenDd +/- bortezomib combination represent a new treatment option for patients with RRMM? (multiplemyelomahub.com)
For patients with newly diagnosed multiple myeloma, combination induction therapy with bortezomib, pomalidomide, and dexamethasone (VPd) may be a safe and efficacious option, according to the results of the phase II POMACE trial published in the Blood Cancer Journal . (jnccn360.org)
Therapy with bortezomib (a proteasome inhibitor (PI)), thalidomide and dexamethasone (VTD) has been shown to be highly effective in relapsed/refractory MM (RRMM). (edu.au)
Daratumumab, a CD38 human monoclonal antibody, demonstrated significant clinical activity in combination with bortezomib and dexamethasone versus bortezomib and dexamethasone alone in the primary analysis of CASTOR, a phase 3 study in relapsed and/or refractory multiple myeloma. (haematologica.org)
0.0001) compared with bortezomib and dexamethasone alone. (haematologica.org)
The safety profile of daratumumab plus bortezomib and dexamethasone remained consistent with longer follow up. (haematologica.org)
Daratumumab plus bortezomib and dexamethasone demonstrated significant clinical activity across clinically relevant subgroups and provided the greatest benefit to patients treated at first relapse. (haematologica.org)
Additionally, studies of melflufen plus dexamethasone in combination with bortezomib (Velcade) or daratumumab (Darzalex) are also ongoing, with promising results reported to date. (cancernetwork.com)
Jan. 15, 2021 /PRNewswire/ -- The Janssen Pharmaceutical Inc. Companies of Johnson & Johnson announced today the U.S. Food and Drug Administration (FDA) approval of DARZALEX FASPRO ® (daratumumab and hyaluronidase-fihj), a subcutaneous formulation of daratumumab, in combination with bortezomib, cyclophosphamide and dexamethasone (D-VCd) for the treatment of adult patients with newly diagnosed light chain (AL) amyloidosis. (biospace.com)
A year later, the combination of daratumumab plus bortezomib-and indeed daratumumab plus lenalidomide-is now FDA approved. (medscape.com)
Although preliminary, encouraging studies indicate that it can be added to standard induction regimens prior to transplant, such as bortezomib-lenalidomide-dexamethasone or carfilzomib-lenalidomide-dexamethasone. (medscape.com)

This trial will evaluate the efficacy and safety of combination of pomalidomide (POM) and low-dose dexamethasone (LD-Dex) (Cohort A) or the combination of pomalidomide (POM) , daratumumab (DARA) and low-dose dexamethasone (LD-Dex) (Cohort B) in subjects with relapsed or refractory multiple myeloma who have received a first or second line treatment of lenalidomide-based therapy. (clinicaltrials.gov)
A phase 2, multicenter, multi-cohort, open-label study of pomalidomide in combination with low-dose dexamethasone or pomalidomide in combination with low-dose dexamethasone and daratumumab in subjects with relapsed or refractory multiple myeloma following lenalidomide based therapy in the first or second line setting. (clinicaltrials.gov)
Kyprolis and Dexamethasone (Kd) or Kyprolis, Daratumumab, and Dexamethasone (DKd), or Kyprolis, Daratumumab and Hyaluronidase-fihj and Dexamethasone (DKd): 20/70 mg/m 2 once weekly. (aetna.com)
Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment. (vchri.ca)
Multiple myeloma in patients whose disease has relapsed or is refractory despite receiving 1-3 previous drug therapies (in combination with dexamethasone, or lenalidomide + dexamethasone, or daratumumab + dexamethasone, or daratumumab/hyaluronidase + dexamethasone, or isatuximab + dexamethasone). (unboundmedicine.com)
Continue carfilzomib, daratumumab (or daratumumab/hyaluronidase), and dexamethasone until unacceptable toxicity or disease progression. (unboundmedicine.com)

On March 31, 2021, the FDA approved isatuximab-irfc (brand name Sarclisa) in combination with carfilzomib and dexamethasone, for the treatment of adult patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy. (fda.gov)
The efficacy and safety of isatuximab in combination with carfilzomib and dexamethasone was evaluated in IKEMA, a multicenter, multinational, randomized, open-label, two-arm, phase 3 trial in patients with relapsed and/or refractory multiple myeloma who had received one to three prior lines of therapy. (fda.gov)
The new approval was based on improved progression-free survival in a phase III open-label trial in which 792 patients with relapsed or refractory multiple myeloma after one to three lines of prior therapy were randomly assigned to receive lenalidomide plus low-dose dexamethasone with (n = 396) or without carfilzomib (n = 396) for 18 cycles. (ascopost.com)
This is a phase 1a/1b, multicenter, single-arm, open-label, dose escalation study to determine the maximum tolerated dose (MTD) and evaluate the safety and preliminary antitumor activity of ACY-241 for oral administration as monotherapy and in combination therapy with orally administered pomalidomide and low-dose dexamethasone in eligible patients with relapse d or relapsed-and-refractory multiple myeloma (MM). (survivornet.com)
In this video, Jonathan L. Kaufman, Emory University, Atlanta, US, answers the question: Is venetoclax, in combination with dexamethasone, efficacious for patients with t(11;14) relapsed/refractory multiple myeloma? (multiplemyelomahub.com)
A phase II study of venetoclax with carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma seems to be. (multiplemyelomahub.com)
This is an open-label, multi-center, international, Phase 1/2 study to assess the safety, PK and efficacy of CC-92480 monotherapy and in combination with dexamethasone in subjects with relapsed and refractory multiple myeloma (RRMM). (themmrf.org)
The phase 2 HORIZON study indicated that melflufen plus dexamethasone (Ozurdex) demonstrated clinically meaningful efficacy as well as a manageable safety profile in patients with heavily pretreated relapsed/refractory multiple myeloma. (cancernetwork.com)
Results from the phase 2 HORIZON study published in the Journal of Clinical Oncology indicated that melflufen plus dexamethasone (Ozurdex) demonstrated clinically meaningful efficacy as well as a manageable safety profile in patients with heavily pretreated relapsed or refractory multiple myeloma, including those with triple-class refractory and extramedullary disease. (cancernetwork.com)
Importantly, the phase 2 data are the basis for the ongoing priority review of the new drug application to the FDA for accelerated approval of melflufen in combination with dexamethasone in patients with triple-class refractory multiple myeloma who are refractory to at least 1 proteasome inhibitor, 1 immunomodulatory drug, and 1 anti-CD38 monoclonal antibody. (cancernetwork.com)
The pivotal, single-arm, multicenter study enrolled patients with relapsed or refractory multiple myeloma who were refractory to pomalidomide (Pomalyst) and/or an anti-CD38 monoclonal antibody to receive melflufen at a 40 mg dose intravenously on day 1 of each 28-day cycle plus once weekly oral dexamethasone at a dose of 40 mg or 20 mg for patients older than 75 years. (cancernetwork.com)
Melflufen and Dexamethasone in Heavily Pretreated Relapsed and Refractory Multiple Myeloma. (cancernetwork.com)
It is indicated as monotherapy, in combination with dexamethasone, or in combination with lenalidomide plus dexamethasone for relapsed or refractory multiple myeloma in patients who have received at least 1 prior line of therapy. (medscape.com)

Currently there are limited data on the efficacy/tolerability of the combination of ixazomib, thalidomide and dexamethasone (ITD). (edu.au)
Aim: To evaluate the efficacy and safety of the combination of ixazomib, thalidomide and dexamethasone (ITD) in RRMM. (edu.au)
ITD (Ixazomib: 4mg orally D1, 8, 15, Thalidomide 100mg orally nocte D1-28, Dexamethasone 40mg orally D1, 8, 15, 22 of a 28-day cycle) was continued until disease progression or unacceptable toxicity. (edu.au)
Safety/tolerability: Fourteen patients (42.4%) tolerated ITD dosing as per protocol with thalidomide dose reduced/ceased in 15 patients (reduced: 8, ceased: 7) and dexamethasone dose reduced in 6 patients. (edu.au)

lenalidomide coupons 2020 plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial remedy for newly recognized a number of myeloma: an open-label randomised managed trial. (postheaven.net)

A total of 302 patients were randomized in a 3:2 ratio to receive isatuximab with carfilzomib and dexamethasone or carfilzomib and dexamethasone alone. (fda.gov)
Median progression-free survival was not reached in the isatuximab with carfilzomib and dexamethasone arm and was 20.27 months in the carfilzomib and dexamethasone arm. (fda.gov)
This represented a 45% reduction in the risk of disease progression or death in patients treated with isatuximab with carfilzomib and dexamethasone compared to those treated with carfilzomib and dexamethasone alone. (fda.gov)
Kd, DKd, or Kyprolis, Isatuximab and Dexamethasone (Isa-Kd), or Kyprolis Monotherapy: 20/56 mg/m 2 twice weekly. (aetna.com)

Continuous lenalidomide-dexamethasone (Rd)-based regimens are among the standards of care in transplant-ineligible newly diagnosed multiple myeloma (NDMM) patients. (nih.gov)
Long-term health-related quality of life in transplant-ineligible patients with newly diagnosed multiple myeloma receiving lenalidomide and dexamethasone. (vchri.ca)

People with cancer undergoing chemotherapy are often given dexamethasone to counteract certain side effects of their antitumor treatments. (wikipedia.org)
Fosnetupitant and palonosetron is a combination medicine used to help prevent nausea and vomiting caused by chemotherapy. (everydayhealth.com)
You will also take dexamethasone 30 minutes before chemotherapy, and you may need to keep taking dexamethasone for 3 days afterward. (everydayhealth.com)
Chemotherapy is usually given as a combination of drugs (combination chemotherapy). (leukaemia.org.nz)
The safety profile of KEYTRUDA in combination with chemotherapy in this study was consistent with previously reported studies. (merck.com)
Patients are in need of new treatments that can improve survival outcomes, and these positive results support the potential of KEYTRUDA in combination with chemotherapy as a first-line treatment for patients with the most common form of malignant mesothelioma. (merck.com)
The trial evaluated KEYTRUDA in combination with chemotherapy for the treatment of patients with unresected advanced malignant pleural mesothelioma. (merck.com)

in group 2 (GT2), oral dose of dexamethasone 12 mg one hour beforesurgery, and oral dose of 15 mg of meloxicamimmediatelypostoperative oral, at 24, 48 e 72h following surgery. (bvsalud.org)
The usual initial dose of dexamethasone phosphate varies between 0.4 and 9 mg a day, depending on the disease being treated. (who.int)

This might decrease the effects of dexamethasone. (webmd.com)
The effects of dexamethasone are frequently seen within a day and last for about three days. (wikipedia.org)

A phase II study of venetoclax with carfilzomib and dexamethasone in patients with. (multiplemyelomahub.com)

Ixazomib (an oral PI) in combination with lenalidomide and dexamethasone (IRD) has been shown to increase progression-free survival (PFS) in RRMM. (edu.au)
In the double-blind, placebo-controlled TOURMALINE-MM2 trial, transplant-ineligible NDMM patients were randomized to ixazomib 4 mg (n = 351) or placebo (n = 354) plus Rd. After 18 cycles, dexamethasone was discontinued and treatment was continued using reduced-dose ixazomib (3 mg) and lenalidomide (10 mg) until progression/toxicity. (nih.gov)
Ixazomib-Rd is a feasible option for certain patients who can benefit from an all-oral triplet combination. (nih.gov)
Ixazomib is the third generation proteasome inhibitor used in the treatment of refractory or relapsing multiple myeloma in combination with dexamethasone and lenalidomide. (hindawi.com)

On July 24, 2015, carfilzomib (Kyprolis) was approved for use in combination with lenalidomide (Revlimid) and dexamethasone in the treatment of patients with relapsed multiple myeloma who have received one to three prior lines of therapy. (ascopost.com)
01:55 was with REVLIMID and dexamethasone Rd. (yalecancercenter.org)
02:06 REVLIMID and dexamethasone there Rd. (yalecancercenter.org)

However, the firm has lately submitted to combine the antiviral drug, Favipiravir along with steroid Dexamethasone. (medicaldialogues.in)
Favipiravir is presently the subject of several trials around the world as a potential treatment for Covid-19, while Dexamethasone is a steroid used to suppress skin allergies and treat rheumatic disorders and is part of India's approved clinical management protocol for Covid-19. (medicaldialogues.in)
Dexamethasone intravitreal steroid implants have been approved by the US Food and Drug Administration (FDA) to treat ocular conditions such as diabetic macular edema, central retinal vein occlusion, and uveitis. (wikipedia.org)
This medicine is given together with a steroid called dexamethasone. (everydayhealth.com)
Dexamethasone is a steroid. (cigna.com)

Patients who complete the ACY-241 monotherapy cycle without a dose limiting toxicity (DLT) and are clinically stable may continue to phase 1b combination therapy, beginning with Cycle 2. (survivornet.com)
Patients who experience a DLT or other unacceptable toxicity in Cycle 1 of phase 1a monotherapy or Cycle 2, the first cycle of phase 1b combination therapy, will be removed from study treatment . (survivornet.com)
Kyprolis, Lenalidomide, and Dexamethasone (KRd) or Kyprolis Monotherapy: 20/27 mg/m 2 twice weekly. (aetna.com)

Decadron DSC, Dexamethasone Intensol, more. (medscape.com)

Patients were administered four cycles of combination induction therapy with VPd. (jnccn360.org)
Methods: This is a planned preliminary analysis of a multi-centre, single arm, open label, phase 2 study of the combination of ITD in RRMM patients with 1-3 prior lines of therapy. (edu.au)
There are varying dose recommendations for Kyprolis for multiple myeloma, depending on line of therapy and combination with other agents. (aetna.com)
There are varying dose recommendations for Kyprolis for Waldenstrom's macroglobulinemia, depending on line of therapy and combination with other agents. (aetna.com)
When the FDA approved selinexor for patients with MM in 2019, 4 the patient was able to receive the therapy again in combination with other MM agents. (onclive.com)
In patients with renal failure or highly aggressive disease, therapy with vincristine, Adriamycin (doxorubicin), and dexamethasone (VAD) may be preferred. (medscape.com)
Antibiotic treatment should consist of broad-spectrum antibiotic or combination therapy with CNS penetration until culture results are available. (medscape.com)
A large Italian study demonstrated the feasibility of using carfilzomib in frontline therapy combined with either cyclophosphamide - dexamethasone (KCD) or lenalidomide -dexamethasone (KRD). (medscape.com)

Cycles 19 and subsequent cycles- Continue lenalidomide and dexamethasone (without carfilzomib) until unacceptable toxicity or disease progression. (unboundmedicine.com)

Is venetoclax, in combination with dexamethasone, efficacious for patients with t(11;14) RRMM? (multiplemyelomahub.com)
Conclusion: The combination of ITD is efficacious and tolerable in RRMM and would represent an attractive all oral therapeutic option for RRMM particularly in jurisdictions with limited access to other therapeutics such as lenalidomide. (edu.au)

Oral lenalidomide is given at 25 mg on days 1 to 21, and oral or intravenous dexamethasone at 40 mg on days 1, 8, 15, and 22 of each cycle. (ascopost.com)
This double-blind clinical trial assessed the incidence of nausea and vomiting after cataract surgery with intravenous anaesthesia in 100 patients randomly assigned to preinduction placebo (saline), metoclopramide (10 mg), dexamethasone (8 mg) or the 2 drugs combined. (who.int)
Findings from the RECOVERY Trial showed that low doses of dexamethasone (6 mg of oral or intravenous preparation once daily for 10 days) si. (bvsalud.org)

Epinephrine and corticosteroids such as dexamethasone are commonly used for this purpose. (petmd.com)

These findings build substantially on previously reported results but in a population that is more aligned with current treatment practice in the relapsed and refractory as well as highly resistant disease setting (ie, patients refractory to an anti-CD38 monoclonal antibody and/or pomalidomide, as well as exposed and refractory to prior lenalidomide, dexamethasone, and proteasome inhibitors)," the study authors wrote. (cancernetwork.com)

tell your doctor and pharmacist if you are allergic to dexamethasone, sulfites, or any other drugs. (medlineplus.gov)
New Delhi: In a major setback to Glenmark, the Subject Expert Committee of the apex the drug regulator, Central Drugs Standard Control Organisation (CDSCO) has declined to clear the drugmaker's proposal to conduct of phase III Clinical Trial of Favipiravir along with Dexamethasone for Covid-19 treatment.The Mumbai-based drugmaker had earlier introduced a stronger version of Favipiravir in. (medicaldialogues.in)
The drugs used to treat WM can be given in a variety of combinations and schedules depending on the situation. (cancer.org)
They are often given in combination with other drugs. (leukaemia.org.nz)
This combination of drugs treats bacterial infection and decreases the inflammation associated with bacterial infections. (medscape.com)

Chari's patient joined the phase 2 STORM trial (NCT02336815), which evaluated the combination of oral selinexor (Xpovio) plus low-dose dexamethasone in patients with refractory heavily pretreated MM. The patient saw significant clinical improvements, including in his renal function, enabling him to join other clinical trials. (onclive.com)

Dexamethasone is a glucocorticoid medication used to treat rheumatic problems, a number of skin diseases, severe allergies, asthma, chronic obstructive lung disease, croup, brain swelling, eye pain following eye surgery, superior vena cava syndrome (a complication of some forms of cancer), and along with antibiotics in tuberculosis. (wikipedia.org)
In adrenocortical insufficiency, it may be used in combination with a mineralocorticoid medication such as fludrocortisone. (wikipedia.org)
Ciprofloxacin and dexamethasone may also be used for purposes not listed in this medication guide. (cigna.com)

Mezigdomide plus dexamethasone showed promising preliminary efficacy in this heavily pretreated population, with myelosuppression and infection as the main toxic effects. (medpagetoday.com)

Dexamethasone reduced nausea, vomiting and use of ondansetron. (druglib.com)
The incidence of nausea in the recovery room was 44% with placebo, 20% with metoclopramide, 16% with dexamethasone and 8% with the combination. (who.int)

The results from the HORIZON study demonstrate that melflufen in combination with dexamethasone, has a potential to provide a therapeutic option for patients who are difficult to treat and have a poor prognosis, including patients with triple class refractory myeloma and patients with extramedullary disease," Klaas Bakker, MD, PhD, chief medical officer at Oncopeptides AB, said in a press release. (cancernetwork.com)
More than 200 therapeutic options or their combinations are being investigated in more than 1,700 clinical trials. (bvsalud.org)

medical citation needed] Dexamethasone is commonly given as a treatment for croup in children, as a single dose can reduce the swelling of the airway to improve breathing and reduce discomfort. (wikipedia.org)
Dexamethasone or similar steroids are recommended for certain severely ill patients under federal treatment guidelines. (ajc.com)
The study evaluated DARZALEX FASPRO ® in combination with VCd, compared with VCd alone, a common treatment regimen used in adult patients with newly diagnosed AL amyloidosis. (biospace.com)

Patients should be premedicated with dexamethasone at the recommended dose prior to all cycle 1 doses and if infusion reactions occur or recur. (ascopost.com)
Premedicate Kyprolis infusions with dexamethasone prior to all Cycle 1 doses and if infusion reaction symptoms develop or reappear. (aetna.com)

Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy. (druglib.com)

Dexamethasone can increase the antiemetic effect of 5-HT3 receptor antagonists, such as ondansetron. (wikipedia.org)

What is the most important information I should know about ciprofloxacin and dexamethasone otic? (cigna.com)
Ciprofloxacin and dexamethasone otic (for the ear) is a combination medicine used to treat infections inside the ear (also called otitis media), and infections of the ear canal (also called otitis externa). (cigna.com)
What should I discuss with my healthcare provider before using ciprofloxacin and dexamethasone otic? (cigna.com)
Ciprofloxacin and dexamethasone should not be used on a child younger than 6 months old. (cigna.com)
How should I use ciprofloxacin and dexamethasone otic? (cigna.com)
What should I avoid while using ciprofloxacin and dexamethasone otic? (cigna.com)

[ 2 ] Single-agent cisplatin and the combination of an anthracycline and cyclophosphamide are rated at high risk by all three organizations. (medscape.com)

Doses of [CV004 trade name] are calculated in terms of dexamethasone phosphate. (who.int)

Serious adverse reactions occurred in 43 percent of patients who received DARZALEX FASPRO ® in combination with VCd. (biospace.com)

Some participants with multiple myeloma will receive CFT7455 in combination with dexamethasone. (mskcc.org)
Merck has an extensive clinical development program in lung cancer and is advancing multiple registration-enabling studies, with research directed at earlier stages of disease and novel combinations. (merck.com)

METHODS: One hundred and sixteen patients were randomly assigned to either group A (paracetamol+placebo x 2), group B (paracetamol+pregabalin+placebo) or group C (paracetamol+pregabalin+dexamethasone). (druglib.com)
According to randomization and preoperatively, patients received paracetamol 1000 mg, pregabalin 300 mg, dexamethasone 8 mg or placebo. (druglib.com)
Cette étude clinique en double aveugle évaluait l'incidence des nausées et des vomissements après une chirurgie de la cataracte avec anesthésie par voie intraveineuse chez 100 patients auxquels un placebo (eau saline), du métoclopramide (10 mg), de la dexaméthasone (8 mg) ou les deux médicaments associés avaient été administrés de manière randomisée avant l'opération. (who.int)
L'incidence des nausées en salle de réveil était de 44 % avec le placebo, 20 % avec le métoclopramide, 16 % avec la dexaméthasone et 8 % avec l'association des deux médicaments. (who.int)

CONCLUSION: Combinations of paracetamol and pregabalin, or paracetamol, pregabalin and dexamethasone did not reduce morphine consumption and pain score compared with paracetamol alone for patients undergoing abdominal hysterectomy. (druglib.com)
In conclusion, both the rapieswerevalids in controlling edema andtrismus, and combination the rapeutic more effective in regardingpaincontrol. (bvsalud.org)

Dexamethasone eye drops may be used to reduce redness, burning, and swelling or inflammation in the ear. (medlineplus.gov)

In brain tumors (primary or metastatic), dexamethasone is used to counteract the development of edema, which could eventually compress other brain structures. (wikipedia.org)
Your vet will use a combination of medications to reduce the immune response and counteract the symptoms. (petmd.com)

Each ampoule contains 3.3 mg dexamethasone (as sodium phosphate) which is equivalent to 4 mg dexamethasone phosphate or 4.3 mg dexamethasone sodium phosphate. (who.int)

3 Lenalidomide and dexamethasone were continued thereafter until disease progression. (ascopost.com)
Dose and duration of Dexamethasone in COVID patients vary with the severity of the disease and other conditions. (medicaldialogues.in)
Therefore a combination may be more effective than a single drug in controlling your disease and the side effects are kept to a minimum. (leukaemia.org.nz)

The government continues to sponsor many studies testing other treatments alone and in combination with remdesivir. (ajc.com)

Anatomy3

Organisms3

Diseases6

Chemicals and Drugs24

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes7

Health Care2

Bortezomib12

Daratumumab6

Refractory multiple13

Thalidomide4

Lenalidomide plus low-dose dexamethasone1

Isatuximab4

Newly diagnosed multiple myeloma2

Chemotherapy7

Dose of dexamethasone2

Effects of dexamethasone2

Carfilzomib and dexamethasone1

Ixazomib4

Revlimid3

Steroid5

Monotherapy3

Decadron1

Therapy8

Cycles1

Efficacious2

Intravenous3

Corticosteroids1

Relapsed-and-refractory1

Drugs5

Oral1

Medication3

Heavily pretreated1

Nausea2

Therapeutic2

Treatment3

Infusion2

Postoperative1

Antiemetic1

Ciprofloxacin6

Cisplatin1

Doses1

Adverse1

Multiple2

Placebo4

CONCLUSION2

Inflammation1

Counteract2

Sodium1

Disease3

Treatments1