Combination therapy drug targets. Medical search. Frequent questions

Yerly S , Vora S , Rizzardi P , Chave JP , Vernazza PL , Flepp M , Acute HIV infection: impact on the spread of HIV and transmission of drug resistance. (cdc.gov)
de Mendoza C , del Romero J , Rodríguez C , Corral A , Soriano V . Decline in the rate of genotypic resistance to antiretroviral drugs in recent HIV seroconverters in Madrid. (cdc.gov)
Routy JP , Machouf N , Edwardes MD , Brenner BG , Thomas R , Trottier B , Factors associated with a decrease in the prevalence of drug resistance in newly HIV-1 infected individuals in Montreal. (cdc.gov)
Boden D , Hurley A , Zhang L , Cao Y , Guo Y , Jones E , HIV-1 drug resistance in newly infected individuals. (cdc.gov)
Harzic M , Pellegrin I , Deveau C , Chaix ML , Dubeaux B , Garrigue I , Genotypic drug resistance during HIV-1 primary infection in France (1996-1999): Frequency and response to treatment. (cdc.gov)
Little SJ , Holte S , Routy JP , Daar ES , Markowitz M , Collier AC , Antiretroviral-drug resistance among patients recently infected with HIV. (cdc.gov)
Grant RM , Hecht FM , Warmerdam M , Liu L , Liegler T , Petropoulos CJ , Time trends in primary HIV-1 drug resistance among recently infected persons. (cdc.gov)
Combination therapies to overcome intrinsic or acquired resistance. (nih.gov)
We consider the following two optimization criteria (a) generating drug combinations with high sensitivity and minimal toxicity and (b) generating drug combinations targeting multiple parallel pathways for avoiding resistance. (ttu.edu)
Reference: Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy. (neb.com)
A variety of these mutations cause cross-resistance to several other NRTIs or NNRTIs and consequently may hamper the effectiveness of the other drugs. (neb.com)
Other RT mutations are quite specific and selective in their drug-resistance spectrum and do not influence the potency of the majority of other available drugs. (neb.com)
Combination therapy has proven to be able to markedly suppress virus replication (and subsequent appearance of drug resistance) for a relatively long time period. (neb.com)
Also, it has been shown that drugs that alter cellular deoxynucleotide pools not only are able to potentiate the antiviral efficacy of some RT inhibitors, but also may influence the resistance spectrum of certain anti-HIV drugs. (neb.com)
All available information argues for the use of a rational combination of different anti-HIV inhibitors with different resistance spectra to suppress virus replication efficiently and to delay the emergence of drug-resistant virus as long as possible, but it also indicates that there is a strong need for additional drugs to further optimize and improve the efficacy of long-term HIV treatment. (neb.com)
Amaria and other researchers are continuing to follow patient outcomes and will be conducting further translational studies to discern the mechanisms of response and resistance to this combination. (mdanderson.org)
By discovering clever new combinations that aim to treat cancer in different ways, we hope we can stop cancer from developing resistance early on. (icr.ac.uk)
Drug resistance - where cancer adapts, evolves, and becomes resistant to treatment - is one of the biggest challenges we face in cancer research. (icr.ac.uk)
These potential drugs are being designed to stop the action of a molecule called APOBEC to reduce the rate of mutation in cancer cells, slow down evolution and delay resistance. (icr.ac.uk)
In recent years, AXL has emerged as a key facilitator of immune escape and drug-resistance by cancer cells, leading to aggressive and metastatic cancers. (wikipedia.org)
AXL has been shown to be a key driver of drug-resistance to targeted therapies, immuno therapies and chemotherapy in various animal models. (wikipedia.org)
Based on current knowledge of AXL's role in therapy resistance, future studies will help to determine whether AXL has a translational application as a biomarker for predicting therapeutic response to established drugs. (wikipedia.org)
HIV/STI surveillance including drug resistance surveillance will be strengthened. (who.int)
Analysis of ATP-Binding Cassette Transporter Expression in Drug-Selected Cell Lines by a Microarray Dedicated to Multidrug Resistance. (nih.gov)
The newer approaches to cancer treatment not only supplement the conventional chemotherapy and radiotherapy but also prevent damage to normal tissues and prevent drug resistance. (researchandmarkets.com)
In this study, St. Jude investigators identified a role for NEU1-regulated lysosomal exocytosis in cancer-drug resistance and tumor invasiveness, specifically in sarcomas that have spread. (stjude.org)
This is the first report that lysosomal exocytosis may play a role in drug resistance. (stjude.org)
However, most patients eventually relapse due to drug resistance. (uu.nl)
I have previously studied the role of extracellular vesicles in drug resistance and the influence of extracellular vesicles from cancer cells exposed to cisplatin on naïve cancer cells. (brookes.ac.uk)
Since cancer cells often become resistant to these targeted therapies by activating alternative signaling pathways, we focus on identifying these key resistance signals in cancer cells. (massgeneral.org)
We utilize this information to devise effective combinations of targeted therapies that anticipate and ultimately overcome these mechanisms of drug resistance. (massgeneral.org)
However, while targeted therapy strategies can lead to dramatic tumor responses, clinical benefit is often limited by the ability of tumor cells to evolve and develop resistance to therapy. (massgeneral.org)
By identifying and understanding the key signals driving resistance, our laboratory aims to devise combinations of targeted agents that can overcome or even prevent resistance. (massgeneral.org)

The STRIPE program seeks to support pre-clinical research projects utilizing state-of-the-art cancer biology methods and model systems that study how radiopharmaceutical therapy (RPT) agents affect the biology of normal tissue, tumor cells and the tumor microenvironment. (nih.gov)
The drug targets member 10b of the tumor necrosis factor receptor superfamily (TNFRSF10B, better known as death receptor 5 or trail receptor 2), a protein with limited expression in normal tissues but overexpressed in many kinds of tumours, including colon, gastric, pancreatic, lung, and cervical. (wikipedia.org)
Wilms tumor and other childhood kidney tumors treatment usually includes surgery and may be followed by radiation therapy or chemotherapy. (nih.gov)
In this article, we consider the design of combination therapy based on tumor sensitivity measurements over a panel of targeted drugs. (ttu.edu)
15. Highly effective treatment of acquired immunodeficiency syndrome-related lymphoma with dose-adjusted EPOCH: impact of antiretroviral therapy suspension and tumor biology. (nih.gov)
Gemcitabine has been the standard chemotherapy drug for patients with pancreatic cancer for over 20 years, but its anti-tumor effect is limited. (wjgnet.com)
Recently, some studies have reported that combinations of gemcitabine and targeted drugs have had significant anti-tumor effects on pancreatic cancer cells. (wjgnet.com)
This randomized, double-blind trial evaluated the efficacy and safety of 16 weeks of treatment with infliximab monotherapy, azathioprine monotherapy, or the 2 drugs combined in tumor necrosis factor-a antagonist-naive adults with moderate to severe UC. (nih.gov)
These may be injected into the arterial circulation and guided to the tumor by a magnetic field for targeted drug delivery. (researchandmarkets.com)
Encapsulating anticancer drugs in liposomes enables targeted drug delivery to tumor tissues and prevents damage to the normal surrounding tissues. (researchandmarkets.com)
This study helps to answer a central question of cancer biology, which is how tumor cells become invasive and drug resistant," said corresponding author Alessandra d'Azzo, Ph.D ., who holds the Jewelers For Children Endowed Chair in Genetics and Gene Therapy and is a member of the St. Jude Department of Genetics . (stjude.org)
Researchers also demonstrated that blocking lysosomal exocytosis helped to restore tumor cell sensitivity to chemotherapy, specifically to the drug doxorubicin. (stjude.org)
In most cases, patients must have had previous treatment with certain treatments or have specific tumor markers in order to be eligible for these therapies. (mdanderson.org)
Recently, compounds have been developed that target tumor-associated macrophages. (nki.nl)
As an alternative approach, by identifying the key gene mutations present in an individual patient's tumor, we can "personalize" therapy by matching each patient with specific therapies that target those mutations essential for tumor growth. (massgeneral.org)
When the tumor samples were analyzed after surgery there was evidence that the virus had targeted and killed some of the bladder cancer cells in all 15 of the patients, with no significant side effects. (physiciansnews.com)
These are drugs used to shrink your tumor before surgery or kill cancer cells after surgery. (webmd.com)
Radiation therapy for NSCLC uses high-energy X-rays or radioactive particles to shrink or kill your tumor or wipe out cancer cells after surgery. (webmd.com)
RFA is a therapy that uses high-energy radio waves delivered through a small needle to heat and kill your tumor. (webmd.com)

The pathogenic cause of AD remains incompletely understood and FDA approved drugs are partial inhibitors rather than curative. (nih.gov)
Mice with fungal infections didn't tolerate the Hsp90 inhibitors well, so the researchers had to devise another way to confirm that inhibiting Hsp90 could boost the effectiveness of an antifungal drug. (nih.gov)
BCR inhibitors are a type of targeted therapy used to treat CLL. (macmillan.org.uk)
BCR inhibitors target the B-cell receptors to stop the cancer growing and dividing. (macmillan.org.uk)
We hope that a new class of APOBEC inhibitors could be given alongside a targeted cancer treatment to ensure it can keep cancer at bay for much longer. (icr.ac.uk)
Efficacy of first-line atezolizumab combination therapy in patients with non-small cell lung cancer receiving proton pump inhibitors: post hoc analysis of IMpower150. (nih.gov)
In this study, we describe a novel class of dual c-Kit/Aur inhibitors, characterized by a 1,2,4-triazole core and developed by a structure-based optimization of a previously developed hit, and report the evidence of their significance as drug candidates for the treatment of melanoma. (nature.com)
There have been some recent advances in immunotherapy drugs known as checkpoint inhibitors (used in some other cancers as well) to treat bladder cancer. (physiciansnews.com)

[7] However, in the years since its discovery, research into AXL's expression profile and mechanism has made it an increasingly attractive target, especially for cancer therapeutics. (wikipedia.org)
Cancer therapeutics that target metabolism. (researchandmarkets.com)
The results, published in Nature , could accelerate the development of targeted cancer therapeutics. (embl.org)
Results from the VeriStrat analysis of a phase II trial of first line erlotinib in combination with sorafenib in patients with advanced non-small cell lung cancer (NSCLC) were presented today at the 22nd EORTC-NCI-AACR Symposium on Molecular Targets in Cancer Therapeutics being held in Berlin, Germany by Egbert Smit, MD, PhD of the VU Medical Center, Amsterdam, The Netherlands. (biodesix.com)

If the only problem is an enlarged spleen or swollen lymph nodes in one part of the body, localized treatment with low-dose radiation therapy may be used. (cancer.org)
Unlike traditional treatments like chemotherapy and radiation therapy, immunotherapies do not target the cancer itself. (mdanderson.org)
Melanoma is the most serious form of skin cancer, as it quickly metastasizes and poorly responds to conventional oncology treatments such as chemotherapy and radiation therapy 1 . (nature.com)
surgeries, laser and light-based treatments and radiation therapy. (skincancer.org)
Treatment may include a combination of surgery, chemotherapy and/or radiation therapy. (akronchildrens.org)
Chemotherapy is a systemic treatment, which means it travels throughout the body rather than treating one specific area as with surgery or radiation therapy. (scripps.org)
Stage II cancer is treated with surgery followed by chemo and/or radiation therapy, or targeted therapy if you have an EGFR gene mutation. (webmd.com)
External beam radiation therapy (EBRT) aims a burst of radiation to the spot of your cancer. (webmd.com)

Researchers from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could also have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other forms of dementia. (nih.gov)
Moreover, few studies are conducted to examine the effects of the specific types of radiation used in RPT in combination with other therapeutic agents. (nih.gov)
These data suggest that the multi-target mechanism of low-dose prednisolone and dipyridamole creates a dissociated activity profile with an increased therapeutic window through cellular network selective amplification of glucocorticoid-mediated anti-inflammatory signaling. (biomedcentral.com)
Therapeutic drug monitoring is recommended for all patients ( 2.5 , 5.17 ). (nih.gov)
The investigators thought to evaluate the combination of the aforementioned individually successfully therapeutic options in athletes to shorten the recovery period and return to play interval. (druglib.com)
Like most drugs that target the immune system, ATG treatment has side effects of administration, and its therapeutic effects wane over time after treatment. (nih.gov)
However, the mechanisms underlying therapeutic benefit are still poorly understood and it is unknown which chemotherapeutic drugs can be best combined with these macrophage-targeting compounds. (nki.nl)
Interestingly, the targeting of macrophages enhanced the therapeutic benefit of platinum-based chemotherapeutics, but not taxane-based chemotherapeutics, illustrating that the use of macrophage-targeting compounds requires careful matching with chemotherapeutic drugs. (nki.nl)
Protein kinases represent therefore a sound target for the molecular therapy of people affected by melanomas and their inhibition is now pursued as an effective and viable therapeutic strategy 14 . (nature.com)
Working in a mouse model and tissue from patients with triple-negative breast cancer, the research team screened 133 FDA-approved drugs that have a therapeutic effect against androgen receptor cells. (ecancer.org)
For the first time, in a data-driven way, we provide guidance at a genome-scale on which new therapeutic targets should be put forward for the development of new anti-cancer drugs. (embl.org)
The research published in Nature today is the first fruition of a key strategy for Open Targets, using high throughput gene editing by the CRISPR-Cas9 system to identify new drug targets, not only in cancer but in future in our other key therapeutic areas of neurodegeneration and immunity," says Ian Dunham, Director of Open Targets. (embl.org)
2019). Prioritisation of oncology therapeutic targets using CRISPR-Cas9 screening. (embl.org)
How can we improve the therapeutic effectiveness of an existing drug through combination therapy? (slideshare.net)

How-ever, the numerous aberrations in molecular pathways that can produce cancer necessitate the use of drug combinations as compared to single drugs for treatment of individual cancers. (ttu.edu)
We have discovered a new drug that could reinvigorate the response to chemotherapy in cancers that had become resistant. (icr.ac.uk)
We have shown that combining two innovative targeted medicines - the PARP inhibitor olaparib and a promising new drug, capivasertib - could treat a variety of advanced, drug-resistant cancers. (icr.ac.uk)
Cancers can be resistant to radiotherapy, just as they can be to drugs. (icr.ac.uk)
Not all cancers have the same targets. (lls.org)
Role of drug delivery in the management of cancers of the brain, the bladder, the breast, the ovaries and the prostate are used as examples to illustrate different approaches both experimental and clinical. (researchandmarkets.com)
The Corcoran laboratory focuses on developing new and effective therapies for gastrointestinal cancers, including colorectal, pancreatic, stomach, and esophageal cancers, by targeting the specific survival signals that are active in a given patient's cancer. (massgeneral.org)
Our laboratory focuses on developing targeted therapy strategies directed against specific mutations commonly found in gastrointestinal cancers, including cancers with BRAF and KRAS mutations. (massgeneral.org)
Research led by Suresh Alahari, PhD, Professor of Biochemistry at LSU Health New Orleans schools of Medicine and Graduate Studies, suggests a combination of drugs already approved by the FDA for other cancers may be effective in treating chemo-resistant triple-negative breast cancer. (ecancer.org)
Since androgen receptors stimulate tumour cell progression in estrogen receptor-negative breast cancers, they have become a target of triple-negative breast cancer therapy. (ecancer.org)
They found that ceritinib, an FDA-approved drug for lung cancers, efficiently inhibited the growth of androgen receptor triple-negative breast cancer cells. (ecancer.org)

The Need for Combination Antihypertensive Therapy to Reach Target Blood Pressures: What Has Been Learned From Clinical Practice and Morbidity-Mortality Trials? (medscape.com)
Mechanistic studies using current "-omic" tools and relevant pre-clinical model systems have strong potential to elucidate new targets (e.g., pathways, phenotypes, microenvironment) for both radiopharmaceutical agents used alone and in combination with conventional targeted therapies. (nih.gov)
The results of these studies, which will be presented at the virtual 2021 American Society of Clinical Oncology (ASCO) Annual Meeting , highlight new advances in drug therapy research to improve patient outcomes. (mdanderson.org)
TrialNet is continuing to follow the study participants, and the data from the 2-year follow-up will help researchers determine whether treatment with ATG alone or in combination with other agents should be pursued for preventing or delaying type 1 diabetes in individuals prior to clinical diagnosis. (nih.gov)
The list is expanding frequently as more immunotherapy drugs complete testing through clinical trials . (mdanderson.org)
The Journal of Allergy and Clinical Immunology , the most prestigious journal in the field of allergology, has recently published an extensive review article on the prospects of drug therapy for allergy. (medindia.net)
New drugs targeting the histamine H4 receptor are also undergoing clinical trials. (medindia.net)
To give a new drug the best chance of succeeding in the very final phases of clinical trials, it is crucial to select the best and most promising drug target at the beginning of the drug development process," said Francesco Iorio, Principal Staff Scientist at the Wellcome Sanger Institute and Open Targets. (embl.org)
In particular, Dr. Azad's laboratory and clinical trials explore epigenetic therapy in combination with chemotherapy and immunotherapy to improve survival for patients, as well as molecularly targeted drugs. (hopkinsmedicine.org)
She is an active clinical trialist, leading numerous multiple clinical trials of molecularly targeted agents for advanced cancer patients. (hopkinsmedicine.org)
Still some way to go: comparison with PBPK FDA submissions using PBPK modelling Ping Zhao 41 Labels with in-silico substitutes for clinical data informed by Simcyp QSP: Dose (regimen) prediction and Target validation? (slideshare.net)
Limited power of bioinformatics approach to predict clinical outcome indicates that other factors than MHC II binding are important (e.g. co-therapy, disease, age). (slideshare.net)
Researchers concluded that the proteomic test, VeriStrat, may identify a subset of patients that derive significant clinical benefit from first- line treatment of advanced NSCLC with dual targeted therapies. (biodesix.com)
Biodesix collaborates with investigators to address key clinical questions, and partners with biotechnology and pharmaceutical companies for development of companion diagnostics and improved targeting of therapies in clinical trials. (biodesix.com)

Several target molecules have also been identified in intracellular signalling pathways and in cell survival proteins. (medindia.net)
Our research utilizes targeted therapies, which are drugs that inhibit signaling pathways activated by the specific mutations that drive individual tumors. (massgeneral.org)

Because these drugs only target the cancer cells, they have less effect on healthy cells than other treatments. (macmillan.org.uk)
We have made huge progress in discovering new targeted treatments for cancer, helping patients live longer and well with cancer. (icr.ac.uk)
With your support today, we can unlock new combinations of treatments to continue outsmarting cancer. (icr.ac.uk)
One way we are doing this is by seeing if different combinations of treatments, either given at the same time, or in a certain sequence, will work better. (icr.ac.uk)
We need your donations to improve our understanding of the biology behind cancer, so we can find more combinations of treatments and help cancer patients have a better chance of surviving their cancer. (icr.ac.uk)
We need to stay one step ahead of cancer by finding new treatments and combination therapies that can keep patients alive and healthy for much longer. (icr.ac.uk)
The drug works especially well in combination with chemotherapy in triple negative breast cancer cells - the deadliest form of breast cancer, for which there are few successful treatments. (icr.ac.uk)
Talk to your doctor about treatments available to target specific genetic mutations. (lls.org)
This form of medicine uses information about a patient's genes and proteins to identify drugs or other treatments that block the growth and spread of cancer. (akronchildrens.org)
It is expected that the collaborations between researchers, at Sanger and EMBL-EBI, and pharmaceutical companies within the Open Targets partnership, will bolster the translation of these research results into new treatments. (embl.org)
These companies provide a comprehensive range of goods and therapies to meet the diverse demands of consumers seeking effective acne treatments. (maximizemarketresearch.com)
The company specializes in dermatological treatments and provides a comprehensive selection of acne treatment products, including prescription and over-the-counter drugs. (maximizemarketresearch.com)
Furthermore, leading companies in the acne treatment market include Johnson & Johnson, Nestlé Skin Health (Galderma), Bayer AG, Sun Pharmaceutical Industries Ltd., and Stiefel Laboratories, Inc. These companies spend in R&D to continuously enhance their products and bring innovative therapies to market, positioning themselves competitively to satisfy the growing demand for effective acne treatments. (maximizemarketresearch.com)
Treatments for bladder cancer typically involve a combination of aggressive therapy and surgery that can many times be debilitating to the patient. (physiciansnews.com)
Some chemo drugs are pills, but often, it's dripped or injected into your vein in a series of IV treatments. (webmd.com)

At time t = 10 years we introduce a 1) increase in high-risk behavior from 2 to 4 contacts/person/year, or 2) decrease in the yearly fraction of acutely infected persons on treatment from 0.4 to 0.1, or 3) increase in treatment efficacy from monotherapy with zidovudine (AZT) to highly active antiretroviral therapy (HAART). (cdc.gov)
The safety and efficacy of sirolimus as immunosuppressive therapy have not been established in liver or lung transplant patients, and therefore, such use is not recommended ( 5.2 , 5.3 ). (nih.gov)
The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for ulcerative colitis (UC) have not been evaluated previously. (nih.gov)
Compound 6a , merging the best inhibitory profile against the target kinases, showed anti-proliferative efficacy against the human melanoma cell lines A2058, expressing the BRAF V600D mutation, and WM266-4, expressing BRAF V600E. (nature.com)
Significantly, it displayed also a highly synergistic profile when tested in combination with vemurafenib, thus proving its efficacy not only per se but even in a combination therapy, which is nowadays acknowledged as the cornerstone approach of the forthcoming tumour management. (nature.com)
This is the first study to demonstrate that a biomarker can identify patients who are likely to benefit from the erlotinib plus sorafenib combination, " stated Egbert Smit, MD, PhD. "This is exciting for lung cancer patients as the all-oral combination may be more tolerable than traditional platinum-based regimens, with similar efficacy. (biodesix.com)
Less than 5% of advanced NSCLC patients survive for 5 years, emphasizing the need for improved patient selection to maximize drug efficacy. (biodesix.com)

Combination targeted therapy with sorafenib and bevacizumab results in enhanced toxicity and antitumor activity. (hopkinsmedicine.org)

We also offer personalized therapies for certain brain tumors through our Shannon E. Wilkes Targeted Therapy Program. (akronchildrens.org)

In the last decade, a number of drugs targeting specific proteins have been developed that are becoming common in cancer research as a basis for personalized therapy. (ttu.edu)
Potential targets include proteins that interact with Hsp90, which vary more than Hsp90 itself. (nih.gov)
Finally, cytokine therapies rely on immune proteins called interferons and interleukins to stimulate immune activity. (mdanderson.org)
Several drugs that are approved target PD-1 and PD-L1 proteins that normally help keep the immune system "in check" from attacking other cells in the body. (physiciansnews.com)

An immunotherapy drug has now been approved by the FDA for stage II NSCLC. (webmd.com)
Radiation may be given alone or combined with other NSCLC therapies like drugs or surgery. (webmd.com)

This is for instance the case for the preparation containing the angiotensin-converting enzyme inhibitor perindopril (2 mg) and the diuretic indapamide (0.625 mg), a fixed low-dose combination that has recently been shown in controlled interventional trials to be more effective than monotherapies in reducing albuminuria, regressing cardiac hypertrophy and improving macrovascular stiffness. (medscape.com)
Association Between Body Mass Index and Overall Survival With Immune Checkpoint Inhibitor Therapy for Advanced Non-Small Cell Lung Cancer. (nih.gov)
NEW YORK-(BUSINESS WIRE)- Pfizer Inc. (NYSE: PFE) today announced positive topline results from the Phase 3 TALAPRO-2 study of TALZENNA ® (talazoparib), an oral poly ADP-ribose polymerase (PARP) inhibitor, in combination with XTANDI ® (enzalutamide) compared to placebo plus XTANDI in men with metastatic castration-resistant prostate cancer (mCRPC), with or without homologous recombination repair (HRR) gene mutations. (zerocancer.org)
The plan moving forward is to use this cocksackie virus in combination with the aforementioned checkpoint inhibitor therapy prior to surgery in a future trial with even more patients. (physiciansnews.com)

Multi-PI applications will be encouraged to maximize the potential of team science efforts and combine capabilities that might be necessary to fulfill the need for specialized multidisciplinary research at the intersection between RPT drug development and cancer biology research. (nih.gov)
Targeted therapies are drugs that target something that is helping the cancer cells grow and survive. (macmillan.org.uk)
Targeted therapy uses drugs to find and attack cancer cells. (macmillan.org.uk)
Each type targets something in or around the cancer cell that is helping it grow and survive. (macmillan.org.uk)
Watch how Karen O'Malley, from Fife in Scotland (pictured centre front with friends) is living well with advanced bowel cancer and pursuing her passion for wild swimming, thanks to a combination of chemotherapy and a targeted treatment. (icr.ac.uk)
What are cancer combination therapies? (icr.ac.uk)
Many cancer patients are treated with combination therapies. (icr.ac.uk)
Over the years, our discovery of new targeted drugs has helped to improve the lives of cancer patients. (icr.ac.uk)
But as cancer can become resistant to these drugs, we need to find ways to make them work harder. (icr.ac.uk)
This can involve treating patients with several drugs that work by different molecular mechanisms, or re-sensitising a cancer to an original treatment by giving the patient another therapy. (icr.ac.uk)
Cancer's ability to evolve and become resistant to treatment is one of the biggest challenges we face in creating effective cancer therapies - and the dream of a single pill to cure cancer looks outdated. (icr.ac.uk)
We used the drug combination to target two fundamental weaknesses in cancer at the same time - a damaged system for repairing DNA, and 'addiction' to the AKT molecule which fuels tumour growth. (icr.ac.uk)
Chemotherapy drugs kill fast-growing cells throughout the body, including both cancer cells and normal, healthy cells. (lls.org)
Targeted therapy is a type of treatment that uses drugs or other substances to identify and attack specific types of cancer cells with less harm to normal cells. (lls.org)
Consolidation therapy," also called "post-remission therapy," is treatment that is given after cancer is in remission following induction therapy. (lls.org)
Conversely, in the past decade, the ocular adaptation of a cancer drug that blocks growth of abnormal blood vessels treats two of the leading causes of blindness: age-related macular degeneration (AMD) and diabetic retinopathy, stopping disease progression, and in many cases, reversing vision loss for medical benefit to thousands of patients. (nih.gov)
Drug delivery remains a challenge in the management of cancer. (researchandmarkets.com)
Approximately 12.5 million new cases of cancer are being diagnosed worldwide each year and considerable research is in progress for drug discovery for cancer. (researchandmarkets.com)
Cancer drug delivery is no longer simply wrapping up cancer drugs in a new formulations for different routes of delivery. (researchandmarkets.com)
The focus is on targeted cancer therapy. (researchandmarkets.com)
Innovative cancer therapies are based on current concepts of the molecular biology of cancer. (researchandmarkets.com)
Important methods of immunotherapy in cancer involve the use of cytokines, monoclonal antibodies, cancer vaccines and immunogene therapy. (researchandmarkets.com)
Several innovative methods of drug delivery are used in cancer. (researchandmarkets.com)
Small interfering RNAs (siRNAs) can be targeted to tumors and one example is the suppression of H-ras gene expression indicating the potential for application in therapy of ovarian cancer. (researchandmarkets.com)
Cancer gene therapy is a sophisticated form of drug delivery for cancer. (researchandmarkets.com)
Drug delivery strategies vary according to the type and location of cancer. (researchandmarkets.com)
Profiles of 238 companies involved in developing innovative cancer therapies and methods of delivery are presented along with their 291 collaborations. (researchandmarkets.com)
The picture gives a graphical rendering of a cancer cell that up-regulates the process of lysosomal exocytosis to transition to a more metastatic/migratory and drug resistant status. (stjude.org)
We are constantly evaluating therapies in new cancer types and testing new therapies that have not been used before," says Naing. (mdanderson.org)
As a member of Children's Oncology Group (COG), we participate in the development of National Cancer Institute-approved treatment protocols and offer the most up-to-date cancer therapies. (akronchildrens.org)
Chemotherapy for cancer attacks cancer cells with drugs taken by mouth or given intravenously (infusion therapy). (scripps.org)
Scripps medical oncologists specialize in chemotherapy and other infusion therapies to treat cancer. (scripps.org)
Depending on the cancer treatment plan, chemotherapy may involve a single drug or combination of drugs. (scripps.org)
Researchers at the Wellcome Sanger Institute, Open Targets, EMBL's European Bioinformatics Institute (EMBL-EBI) and collaborators used CRISPR technology to disrupt every gene in over 300 cancer models. (embl.org)
This paper reveals a rich source of targets for potential intervention in cancer either directly or in combination therapies with existing drugs. (embl.org)
Her research efforts are dedicated to developing new drug combinations for patients with advanced cancer. (hopkinsmedicine.org)
Dr. Azad is a national leader in GI cancer, including serving as a member of the national NCI Colon Cancer Task Force and the NCI MATCH (Molecular Analysis for Therapy Choice) Agents and Genes Working Group, the largest trial of personalized medicine in the country. (hopkinsmedicine.org)
Based on these compelling combination data with XTANDI, we believe TALZENNA in prostate cancer may become the next potential blockbuster opportunity in our leading Pfizer Oncology portfolio, subject to regulatory approval. (zerocancer.org)
However, in addition to the arsenal of therapies to help treat this type of cancer may soon be on the horizon. (physiciansnews.com)
It is a therapy that is currently used also to encourage the immune system to attack and destroy cancer cells. (physiciansnews.com)
Oncologists , also called medical oncologists, are cancer specialists who prescribe drugs. (webmd.com)
Stage III cancer is treated with a combination of chemotherapy, radiation, and surgery. (webmd.com)
Stage IV cancer is treated with a combination of chemotherapy, radiation, surgery, targeted therapy, and/or immunotherapy, depending on how far your cancer has spread and your overall health. (webmd.com)

The intention of the biomarker analysis was to evaluate the ability of the blood-based test, VeriStrat, to predict patient outcomes with the erlotinib plus sorafenib combination regimen. (biodesix.com)

Each QSP Consortium is a tree, where trunk represents biology common to all applications, while branches and leaves represent target specific mechanisms. (slideshare.net)

Therefore, we designed an integrated strategy using (phospho)proteomic and functional genomic platforms to identify drug targets whose inhibition sensitizes melanoma cells to BRAF inhibition. (uu.nl)
By integrating our functional genomic and (phospho)proteomic data, we identified ROCK1 as a potential drug target for BRAF mutant melanoma. (uu.nl)
These data merit exploration of ROCK1 as a target in combination with current BRAF mutant melanoma therapies. (uu.nl)

Many different drugs and drug combinations can be used as the first treatment for CLL. (cancer.org)
After 8 weeks of oral dosing in mice, treatment with the combination did not alter prednisolone-induced reduction in osteocalcin and mid-femur bone density, which are markers of steroid-induced osteoporosis. (biomedcentral.com)
Your doctor, nurse or pharmacist will explain the possible side effects of the specific drugs you are having before you start treatment. (macmillan.org.uk)
Radiotherapy - an established treatment with a connection to triggering the immune response - is a natural next step when looking at combination therapy. (icr.ac.uk)
We are using our understanding of the biology of tumours, alongside cutting-edge laboratory models to develop new treatment options for patients - which can then be tried in different combinations. (icr.ac.uk)
The first phase of your treatment is induction therapy. (lls.org)
This is called the "7 + 3" regimen, because cytarabine is most often given by continuous intravenous (IV) infusion over 7 days, while the anthracycline drug is given by an IV infusion in a single dose for 3 days during the first week of treatment. (lls.org)
If the initial treatment does not induce a remission, induction therapy can be repeated, either with the same drugs or with a new chemotherapy regimen. (lls.org)
Testing for MRD can help doctors identify patients who may benefit from further treatment with intensified therapies, such as allogeneic stem cell transplantation. (lls.org)
What Type of Treatment Is Used for AML Consolidation Therapy? (lls.org)
Trials compared effectiveness of different therapies for AMD, diabetic retinopathy, and an inflammatory eye condition called uveitis, to inform patients and their doctors of options for personalized treatment. (nih.gov)
Antiretroviral treatment programme and HIV targeted interventions including harm reduction, management of STIs have been scaled up in all member countries. (who.int)
For example, a pilot study previously showed that treatment with ATG in combination with a modified protein called GCSF preserved insulin production for 1 year in people with established type 1 diabetes (duration of disease of 4 months to 2 years). (nih.gov)
Researchers in NIDDK's Type 1 Diabetes TrialNet built on the results of the pilot study to determine whether treatment with ATG alone or in combination with GCSF could preserve insulin production when used close to the initial diagnosis of type 1 diabetes. (nih.gov)
It also may be used alone or in combination with other types of treatment. (scripps.org)
Originally designed for the treatment of type 2 diabetes, the GLP-1 receptor agonists Ozempic , Wegovy (both made by Novo Nordisk), and the combination drug, Mounjaro (made by Eli Lilly), have experienced shortages due to increased demand from customers seeking their potential benefits as weight loss medications. (cas.org)
In response to this growing crisis, GLP-1 receptor agonists and their combined potential with GIP analogs and related therapies have emerged as promising treatment options for obesity and its related diseases. (cas.org)
TALZENNA or the combination of TALZENNA plus XTANDI have not been approved by any regulatory agency for the treatment of mCRPC . (zerocancer.org)
For patients with unresectable disease, evolving liver-directed locoregional therapies provide efficacious treatment across the spectrum of disease stages and via a variety of catheter-directed and percutaneous techniques. (wjgnet.com)
Oncolytic virotherapy has been an emerging treatment, with major institutions investing research and time into fine tuning this therapy. (physiciansnews.com)
They are approved after failure of platinum-based therapy which is still the base of first-line treatment or if it can't be tolerated given the serious complications that can arise from this toxic regimen. (physiciansnews.com)
The older age of onset many times can make treatment with aggressive therapy difficult for patients to tolerate. (physiciansnews.com)
Therefore, in addition to early and effective treatment, finding a better therapy is imperative. (physiciansnews.com)
In some cases, your doctor may prescribe either targeted therapy or immunotherapy with pembrolizumab as a first treatment instead. (webmd.com)

The options include monoclonal antibodies , targeted drugs , chemotherapy , and different combinations of these. (cancer.org)
Monoclonal antibodies are usually given with chemotherapy or with other types of targeted therapy. (macmillan.org.uk)

When I had targeted radiation for tumors on the Caudate Lobe of my Liver, I was placed in sort of a body mold with weighted pads over my body. (cancer.org)
Investigators showed that tumors can use the same pathway to resist chemotherapy by sequestering drugs in lysosomes and then purging them. (stjude.org)

Thirty patients were enrolled in the study and received two doses of nivolumab with relatlimab before surgery, followed by up to 10 additional doses of the combination therapy after surgery. (mdanderson.org)

Goudsmit J , Weverling GJ , van der Hoek L , de Ronde A , Miedema F , Coutinho RA , Carrier rate of zidovudine-resistant HIV-1: the impact of failing therapy on transmission of resistant strains. (cdc.gov)
Bezemer D , Jurriaans S , Prins M , van der Hoek L , Prins JM , de Wolf F , Declining trend in transmission of drug-resistant HIV-1 in Amsterdam. (cdc.gov)
de Mendoza C , Rodríguez C , Eiros JM , Colomina J , García F , Leiva P , Antiretroviral recommendations may influence the rate of transmission of drug-resistant HIV type 1. (cdc.gov)
Appearance of drug-resistant virus strains under the selective pressure of anti-HIV chemotherapy rapidly occurs as a consequence of the low fidelity of the RT-catalyzed DNA polymerisation reaction and the massive viral turnover. (neb.com)
Researchers have devised a way to stymie fungi's ability to become resistant to antifungal drugs. (nih.gov)
Few drugs are available, and fungi become resistant to them. (nih.gov)
A team led by Dr. Susan Lindquist and Dr. Luke Whitesell at the Massachusetts Institute of Technology and Dr. Leah E. Cowen at the University of Toronto previously established that a protein called Hsp90 helps a diverse range of fungi become resistant to antifungal drugs. (nih.gov)

Moreover, drug-specific mutations are identified that are able to restore drug sensitivity again when concomitantly present with other drug-specific mutations. (neb.com)

and pioneering the application of gene therapy to correct blinding disease-causing mutations. (nih.gov)

Therefore our team includes members from multiple specialties including neurology, neurosurgery, endocrinology, physiatry, neuro-psychology and school intervention to help address the many potential side effects of therapy. (akronchildrens.org)
In a given biological pathway, what is the best target for pharmacological intervention to treat disease X? (slideshare.net)

The most common induction regimen for AML includes cytarabine and an anthracycline drug, such as daunorubicin or idarubicin . (lls.org)

At week 24, the proportion of patients with 50 percent improvement in disease symptoms according to the ACR criteria, the primary end point, was significantly greater with the rituximab-methotrexate combination (43 percent, P=0.005) and the rituximab-cyclophosphamide combination (41 percent, P=0.005) than with methotrexate alone (13 percent). (nih.gov)

Researchers have identified uric acid as a potential therapy to enhance recovery from acute ischemic stroke using a new method for conducting preclinical animal research. (nih.gov)
Using an experimental drug, researchers were able to suppress a mutated amyotrophic lateral sclerosis (ALS) gene. (nih.gov)
The genetic mutation had earlier been discovered by an NEI scientist in 1993, but researchers had to invent the tools to turn that discovery into a gene therapy. (nih.gov)
Researchers also showed the process may be reversible using medications like the hypertension drug verapamil. (stjude.org)
Several target molecules that are suitable for the development of new allergy drugs have been identified by researchers. (medindia.net)
Over the past years, researchers have identified several mast cell molecules which can be targets of new drugs. (medindia.net)
The researchers also developed a system to prioritise and rank the drug targets identified. (embl.org)

Ongoing research is likely to lead to new therapies with fewer side effects. (nih.gov)

Although estrogen has been shown to antagonize anticancer drugs, the role of BPA in chemoresistance has not been examined. (nih.gov)
We determined the responsiveness of cells to anticancer drugs and BPA using the 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl tetrazolium bromide (MTT) cytotoxicity assay. (nih.gov)
The market value of drug delivery technologies and the anticancer drugs are difficult to separate. (researchandmarkets.com)

The advance paves the way for future therapies to treat fungal infections, a leading cause of death for people with weakened immune systems. (nih.gov)

One landmark occurred in December 2017, when the FDA approved the first ever gene therapy in the U.S. to correct a retinal degeneration, Leber Congenital Amaurosis, which causes blindness in infants and children. (nih.gov)
These include antiangiogenic agents, immunotherapy, bacterial agents, viral oncolysis, targeting of cyclic-dependent kinases and tyrosine kinase receptors, antisense approaches, gene therapy and combination of various methods. (researchandmarkets.com)
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury. (medindia.net)
These data highlight the potential for TALZENNA in combination with XTANDI, if approved, to become a new standard of care for mCRPC, irrespective of HRR gene mutation status. (zerocancer.org)

In July, the government released a list of targets for 2020 to measure progress in the fight against HIV/AIDS. (motherjones.com)

The combination of paclitaxel and ceritinib showed drastic inhibition of tumour growth compared to a single drug alone," Alahari adds. (ecancer.org)

The goal is to accelerate the development of effective, disease-modifying, and palliative therapies for the cognitive as well as neuropsychiatric symptoms of Alzheimer's disease. (nih.gov)

Fixed-dose combinations are becoming more and more popular and are even proposed by current hypertension guidelines as a first-line option to treat hypertensive patients. (medscape.com)
Only physicians experienced in immunosuppressive therapy and management of renal transplant patients should use sirolimus for prophylaxis of organ rejection in patients receiving renal transplants. (nih.gov)
o Patients at high-immunologic risk: Use in combination with CsA and corticosteroids for the first 12 months following transplantation ( 1.1 ). (nih.gov)
Some patients may also receive targeted therapy. (lls.org)
Patients with favorable risk factors are often given intensive chemotherapy with high-dose cytarabine and other drugs for their consolidation therapy. (lls.org)
Patients with high-risk AML, based on their prognostic factors, receive more aggressive therapy, such as allogeneic stem cell transplantation. (lls.org)
Not all patients can tolerate intensive therapies or even want them. (lls.org)
However, even high doses of H1 antihistamine drugs aren't enough to alleviate the symptoms of some patients. (medindia.net)
This presents a bottleneck for treating patients with a rationally designed combination therapy. (nki.nl)
We have a dedicated comprehensive, multi-disciplinary team that follows our patients after therapy to monitor for any potential late effects. (akronchildrens.org)
More research is needed to fully define the role of this biomarker and identify the specific groups of patients that this combination may benefit. (biodesix.com)

One promising preventative therapy involves treating uninfected but at-risk people with a combination of anti-HIV drugs known as Truvada. (motherjones.com)

FDA-approved CAR T cell therapies include brexucabtagene autoleucel, tisagenlecleucel, axicabtagene ciloleucel and lisocabtagene maraleucel. (mdanderson.org)

5. HIV-Related Lymphoproliferative Diseases in the Era of Combination Antiretroviral Therapy. (nih.gov)
7. Human immunodeficiency virus-associated plasmablastic lymphoma: poor prognosis in the era of highly active antiretroviral therapy. (nih.gov)

The common antifungal drugs proved much more effective when the mice were infected with the genetically modified fungi. (nih.gov)

Adoptive cellular therapies are another form of immunotherapy. (mdanderson.org)

Polyethylene glycol (PEG) technology has been used to overcome some of the barriers to anticancer drug delivery. (researchandmarkets.com)

Traditionally, drug therapy for allergy is based on the use of non-sedative antihistamines, i.e. blocking of the histamine H1 receptors, but sometimes additional help is obtained from blockers of the cysteinyl leukotriene receptor-1. (medindia.net)
In the near future, it is possible that drug therapy for allergy is a combination of H1 and H4 receptor blockers. (medindia.net)
Below is a summary of the drugs and GLP-1 receptor agonists being considered for weight loss. (cas.org)

topical therapies and drugs that are injected, infused intravenously or taken orally. (skincancer.org)

With recent dramatic increases in funding and progress, including a drug in the news for possible approval, the promise of Alzheimer's disease research has never been more exciting. (nih.gov)
Ongoing research and development efforts are driving the creation of innovative products and therapies, fostering advancements within the market. (maximizemarketresearch.com)

Anatomy3

Organisms16

Diseases21

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes36

Disciplines and Occupations8

Technology, Industry, Agriculture1

Information Science8

Health Care9

Geographicals3

Resistance33

Tumor19

Inhibitors8

Therapeutics4

Radiation therapy8

Therapeutic14

Cancers11

Clinical14

Pathways2

Treatments15

Efficacy7

Bevacizumab1

Brain tumors1

Proteins4

NSCLC2

Inhibitor4

Cancer43

Outcomes1

Mechanisms1

BRAF3

Treatment24

Monoclonal2

Tumors2

Relatlimab1

Resistant7

Sensitivity1

Mutations1

Intervention2

Regimen1

Rituximab1

Researchers7

Fewer side effects1

Anticancer drugs3

Immune1

Gene4

20201

Tumour growth1

Accelerate the development1

Patients11

Anti-HIV drugs1

Include1

Antiretroviral2

Effective1

Cellular1

Overcome1

Receptor3

Intravenously1

Research2