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  • inhibitors
  • We need other target specific and other types of inhibitors but the addition of epigenetic drugs can increase the efficacy of the therapy, inhibiting formation of new cancer progenitor/stem cells by re-expressing tumor suppressor genes and blocking the expression of growth promoting genes even after remission after standard therapy. (medindia.net)
  • The drug memantine, which received FDA approval in 2003, is the first of a second class of agents that modulate the actions of the amino acid glutamate and is often used in combination with cholinesterase inhibitors (CIs). (eurekalert.org)
  • therapeutic
  • Not only was the combination therapy effective against multiple myeloma cells, it notably did not harm normal bone marrow cells, raising the possibility of therapeutic selectivity," says Grant, the study's lead investigator and Shirley Carter Olsson and Sture Gordon Olsson Chair in Cancer Research, associate director for translational research and program co-leader of Developmental Therapeutics at VCU Massey Cancer Center. (eurekalert.org)
  • If it's a V600 substitution, there's a reasonable chance that the standard therapeutic combination will work. (onclive.com)
  • study
  • Although liver failure after chemoembolization has been a concern, adverse effects on liver function did not offset the advantages of combination therapy in the study. (medpagetoday.com)
  • However, a team of researchers led by Xin-Yan Pei, M.D., Ph.D., and Steven Grant, M.D., recently published the findings of a study in the journal PLoS ONE demonstrating that a novel drug combination both reduces Mcl-1 expression and disrupts its interactions with other proteins to effectively kill multiple myeloma cells. (eurekalert.org)
  • In a new study published in Nature today, Barouch and colleagues demonstrate that administering broadly neutralizing antibodies (bNAb) designed to target HIV in combination with agents that stimulate the innate immune system delayed viral rebound following discontinuation of ART in monkeys. (eurekalert.org)
  • The study, published online in the journal PLoS One on Feb. 29, suggests that two common cancer-fighting strategies may have "tremendous synergy" if used in combination, says Andrei Gartel, UIC associate professor of biochemistry and molecular genetics and medicine and principal investigator on the study. (innovations-report.com)
  • OBJECTIVE: Evaluate the responses to different combined inhaled therapies in adolescent asthmatics and study its impact on exercise induced AHR. (biomedsearch.com)
  • In the 30-week study, BYETTA 10 micrograms or placebo was added to existing insulin glargine therapy (with or without metformin, pioglitazone or both), which was titrated to achieve target fasting glucose levels. (news-medical.net)
  • For their study, the Yale-led team first tested in mice with diminished immune systems four drugs that are currently used in the form of two combinations to treat human babesiosis. (eurekalert.org)
  • The novelty of the study was identifying a combination therapy that will both kill the parasite and also paralyze the target enzyme, making it nearly impossible for the parasite to develop resistance. (eurekalert.org)
  • latent
  • Known as the latent reservoir, these infected cells - where HIV remains hidden despite antiretroviral therapy (ART) - can become active again at any time. (eurekalert.org)
  • effective
  • Given that gonorrhea is a bacterial infection which causes symptoms in approximately 90 percent of infected men and 50 percent of infected women, the most critical aspect of reducing the public health burden of gonorrhea for affected populations is provision of effective antimicrobial therapy. (clinicaltrials.gov)
  • Researchers at University of Colorado have revealed that using a combination of two drugs instead of just one could be an effective way of keeping the blood sugar levels within normal range in children. (medindia.net)
  • treatments
  • Others, whose LDL cholesterol is controlled, will need combination treatments to control other aspects of their dyslipidemia, he told a satellite symposium held in conjunction with the annual meeting of the American College of Cardiology. (medpagetoday.com)
  • treat
  • In contemporary usage, the expression combination therapy most often refers to the simultaneous administration of two or more medications to treat a single disease, but the expression is also used when other types of therapy are used at the same time. (medicalxpress.com)
  • Combination therapy may be considered as the initial therapy to treat blood pressure that is more than 20/10 mm Hg over goal. (aafp.org)
  • evidence
  • The primary endpoints were functional ability, as measured by the Dutch version of the Health Assessment Questionnaire (D-HAQ), and radiographic evidence of joint damage, as measured by the modified Sharp/Van der Heijde score (SHS), with a range of 0-448 assessed on radiographs of the hands and feet at baseline and after one year of therapy. (medpagetoday.com)
  • drugs
  • Combination of Lipid-Lowering Agents with Antihypertensive Drugs: A Joint Fight Against the Two Most Important Risk Factors? (springer.com)
  • We believe that epigenetic drugs alone are not the best choice for cancer therapy. (medindia.net)
  • Many of the posts that I have written discussed the need for evaluating our current advanced prostate cancer drugs in both combinations and their sequencing. (malecare.org)
  • They decided to test the two drugs in combination. (eurekalert.org)
  • Phase
  • And then, for some of the newer agents in the phase I setting, we have 1 trial, as an adaptive design, where we have 3 combinations in the frontline setting. (onclive.com)
  • infection
  • In cases of new infection, prompt and targeted therapy is vital, as it can prevent the disease developing into a chronic condition that can lead to inoperable liver cancer . (medicalxpress.com)
  • optimal
  • The combination of the antibodies and the immune stimulant led to optimal killing of HIV-infected cells," said Barouch, who is also Professor of Medicine at Harvard Medical School. (eurekalert.org)
  • Dyslipidemia
  • Comprising contributions from leading lipidologists from around the world, this book presents the latest and most comprehensive knowledge on the different options for combination therapy of dyslipidemia and includes discussion of future therapies that are currently in late stages of clinical evaluation. (springer.com)