In 2009, results from a pivotal clinical trial sponsored by DNDi and Médecins Sans Frontières (MSF) showed that NECT, a combined treatment of Bayer's nifurtimox and Sanofi's eflornithine, was a safe and effective treatment for sleeping sickness. (dndi.org)
NECT has significant practical benefits in comparison to eflornithine: there are fewer intravenous infusions (14 instead of 56), treatment length is shorter, and it is more cost effective than using eflornithine alone. (dndi.org)
Nifurtimox-eflornithine combination treatment (NECT) is an effective regimen for the treatment of second stage gambiense African trypanosomiasis. (wikipedia.org)
The NECT combination regimen appears to be more effective and less toxic than eflornithine monotherapy. (cdc.gov)
Nifurtimox-eflornithine combination therapy, or NECT, is now the WHOs recommended course. (msf-me.org)
Melarsoprol monotherapy gave fewer relapses than pentamidine or nifurtimox, but resulted in more adverse events.Later trials evaluate nifurtimox combined with eflornithine (NECT), showing this gives few relapses and is well tolerated. (unl.pt)
Choice of therapy for second stage Gambiense HAT will continue to be determined by what is locally available, but eflornithine and NECT are likely to replace melarsoprol, with careful parasite resistance monitoring. (unl.pt)
Efficacy and Safety of Fexinidazole Compared to Nifurtimox-Eflornithine Combination Therapy (NECT) in Patients With Late-stage Human African Trypanosomiasis (HAT) Due to T.b. (who.int)
Any contraindication to imidazole products (known hypersensitivity to imidazoles) and NECT (known hypersensitivity to eflornithine). (who.int)
Nifurtimox5
Efornithine is commonly given in combination with nifurtimox, which reduces the treatment time to 7 days of eflornithine infusions plus 10 days of oral nifurtimox tablets. (wikipedia.org)
Another randomized control trial in Uganda compared the efficacy of various combinations of these drugs and found that the nifurtimox-eflornithine combination was the most promising first-line theory regimen. (wikipedia.org)
Nitroaromatic compounds, such as nifurtimox (in combination with eflornithine) and fexinidazole (in clinical trials), have been recently introduced for the treatment of the second stage of sleeping sickness. (bl.uk)
When administering nifurtimox-eflornithine combined therapy, the dosage of nifurtimox in children and adults is 5 mg/kg every 8 hours for 10 days. (msf.org)
DFMO6
Eflornithine is also called difluoromethylornithine or DFMO. (msf.org)
Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma. (ucbraid.org)
To determine whether administration of eflornithine (DFMO) in combination with dinutuximab, irinotecan hydrochloride (irinotecan) and temozolomide results in an improved response rate compared to dinutuximab, irinotecan and temozolomide in patients with relapsed or refractory neuroblastoma and therefore is a therapeutic regimen worthy of further testing in patients with newly-diagnosed high-risk neuroblastoma. (arnoldpalmerhospital.com)
MINNEAPOLIS, April 06, 2023 (GLOBE NEWSWIRE) -- Panbela Therapeutics, Inc . (Nasdaq: PBLA), a clinical stage biopharmaceutical company developing disruptive therapeutics for the treatment of patients with cancer today announced that an abstract about CPP-1X (also known as DFMO or Eflornithine) research, has been accepted for poster presentation at the Endocrine Society meeting, which will be held June 15-18, 2023. (mammothtimes.com)
So, we can envision giving DFMO in addition to something that targets the immune system, as a combination therapy," said Sims, who also worked on the pivotal study of teplizumab. (medscape.com)
Neuroblastoma Emerging therapies such as - P LK4 Inhibitor Program, AUM302, BG-P-TAT, KUR-501, 9-ING-41, TAA06, DFMO (Eflornithine HCl), Iobenguane (131I) , and others are expected to have a significant impact on the Neuroblastoma market in the coming years. (giridihjournal.in)
Human African trypano2
After its introduction to the market in the 1980s, eflornithine has replaced melarsoprol as the first line medication against Human African trypanosomiasis (HAT) due to its reduced toxicity to the host. (wikipedia.org)
If eflornithine is prescribed to a patient with Human African trypanosomiasis caused by a trypanosome that contains a mutated or ineffective TbAAT6 gene, then the medication will be ineffective against the disease. (wikipedia.org)
Therapy7
Typically, drugs that inhibit cell growth are considered candidates for cancer therapy, so eflornithine was naturally believed to have potential utility as an anti-cancer agent. (wikipedia.org)
The efficacy and safety of combination therapy with eflornithine and sulindac , as compared with either drug alone, in delaying disease progression in patients with familial adenomatous polyposis are unknown. (bvsalud.org)
A study concluded that the combination therapy increased mortality by about 50% when compared to Parkinson's disease patients treated with l-dopa medications alone. (digitalnaturopath.com)
This phase I/II trial tests the safety, side effects, and best dose of selinexor given in combination with standard radiation therapy in treating children and young adults with newly diagnosed diffuse intrinsic pontine glioma (DIPG) or high-grade glioma (HGG) with a genetic change called H3 K27M mutation. (ucbraid.org)
It also tests whether combination of selinexor and standard radiation therapy works to shrink tumors in this patient population. (ucbraid.org)
The combination of selinexor and radiation therapy may be effective in treating patients with newly-diagnosed DIPG and H3 K27M-Mutant HGG. (ucbraid.org)
I think long-term combination therapy is going to be the answer," study author Emily K. Sims, MD, a pediatric endocrinologist at Indiana University School of Medicine, Indianapolis, told Medscape Medical News . (medscape.com)
Melarsoprol3
Sleeping sickness, or trypanosomiasis, is treated with pentamidine or suramin (depending on subspecies of parasite) delivered by intramuscular injection in the first phase of the disease, and with melarsoprol and eflornithine intravenous injection in the second phase of the disease. (wikipedia.org)
Resistance to eflornithine has increased the use of melarsoprol despite its toxicity, which has been linked to the deaths of 5% of recipient HAT patients. (wikipedia.org)
Sulindac6
Flynpovi is a combination of CPP-1X (eflornithine) and sulindac with a dual mechanism inhibiting polyamine synthesis and increase polyamine export and catabolism. (wkrn.com)
Focusing on FAP patients with lower gastrointestinal tract anatomy in the recent Phase 3 trial comparing Flynpovi to single agent eflornithine and single agent sulindac, FAP patients with lower GI anatomy (patients with an intact colon, retained rectum or surgical pouch), Flynpovi showed statistically significant benefit compared to both single agents (p≤0.02) in delaying surgical events in the lower GI for up to four years. (wkrn.com)
Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis. (bvsalud.org)
We evaluated the efficacy and safety of the combination of eflornithine and sulindac , as compared with either drug alone, in adults with familial adenomatous polyposis . (bvsalud.org)
The patients were then randomly assigned in a 111 ratio to receive 750 mg of eflornithine , 150 mg of sulindac , or both once daily for up to 48 months. (bvsalud.org)
In this trial involving patients with familial adenomatous polyposis , the incidence of disease progression was not significantly lower with the combination of eflornithine and sulindac than with either drug alone. (bvsalud.org)
Intravenous1
It's sold under the name eflornithine as an intravenous treatment for African sleeping sickness (trypanosomiasis) and as a cream for unwanted hair growth in women. (medscape.com)
Vaniqa7
Eflornithine, sold under the brand name Vaniqa among others, is a medication used to treat African trypanosomiasis (sleeping sickness) and excessive hair growth on the face in women. (wikipedia.org)
This new H1N1 virus contained a unique combination of influenza A (H1N1) viruses, and low levels of influenza Cost of vaniqa prescription. (columbusafricanamerican.com)
If your order is approved by one of our doctors before 3pm on a weekday, our pharmacy can dispatch your item the same day Vaniqa (Eflornithine) belongs to the class of medications called hair growth inhibitors. (columbusafricanamerican.com)
Excessive hair growth can be reduced with spironolactone (Aldactone) or eflornithine (Vaniqa). (mostwomen.org)
Monotherapy1
It also has practical advantages in reducing the burden on health personnel and patients, when compared to eflornithine monotherapy. (unl.pt)
Sleeping sickness3
Before 2009, the best treatment for sleeping sickness, eflornithine, was very complex to distribute and administer in regions affected by the disease. (dndi.org)
Should these findings translate to the field, emerging nitrodrug resistance could reverse all recent advances in the treatment of sleeping sickness, made since the introduction of eflornithine 20 years ago. (bl.uk)
Therefore, all efforts should be made to ensure nitroaromatic drugs are used only in drug combination therapies against sleeping sickness, in order to protect them from emerging resistance. (bl.uk)
Efficacy3
The purpose of this study is to compare the efficacy and safety of eflornithine in combination with lomustine, compared to lomustine taken alone, in treating patients whose anaplastic astrocytoma has recurred/progressed after radiation and temozolomide chemotherapy. (mycancergenome.org)
The poster highlights the efficacy of SBP-101 in combination with standard of care chemotherapy agents used to treat platinum-resistant ovarian cancer. (thepilotnews.com)
Utilizing the VDID8 + murine ovarian cancer model (ID8 + C57Bl/6 ovarian cells overexpressing both VEGF and Defensin), the efficacy of SBP-101 in combination with either gemcitabine, topotecan, or doxorubicin was evaluated. (thepilotnews.com)
Spironolactone1
Spironolactone or eflornithine may be recommended to decrease hair growth, but these drugs should not be taken and handled by women who are pregnant as they can become toxic to fetus. (fruitofspirit.com)
Lomustine1
A total of approximately 340 patients will be randomized in a 1:1 ratio to receive either eflornithine + lomustine or lomustine alone. (mycancergenome.org)
Temozolomide1
This phase II trial studies how well irinotecan hydrochloride, temozolomide, and dinutuximab work with or without eflornithine in treating patients with neuroblastoma that has come back (relapsed) or that isn't responding to treatment (refractory). (ucbraid.org)
Therapeutics1
These studies are the basis for moving into a clinical trial program in ovarian cancer with a goal of developing effective novel therapeutics in combination with standard of care for patients with unmet medical needs. (thepilotnews.com)
Patients1
Combinations of l-dopa medications and selegiline have also been tried in early stage Parkinson's disease patients, but were found to have no advantage. (digitalnaturopath.com)
Chemotherapy1
The treatment of C57Bl/6 mice injected with VDID8+ ovarian cancer with SBP-101 in combination with chemotherapy was observed to significantly prolong survival and decrease overall tumor burden," said Jennifer K. Simpson, PhD, MSN, CRNP, President & Chief Executive Officer of Panbela. (thepilotnews.com)
Drug3
Eflornithine is not effective in the treatment of Trypanosoma brucei rhodesiense due to the parasite's low sensitivity to the drug. (wikipedia.org)
I don't think we've seen any drug that won't need to be used in combination. (medscape.com)
If the female desires pregnancy despite having PCOS, a drug by the name of Clomid, a combination of clomiphene and metformin, can be used. (fruitofspirit.com)
Evaluate1
Future studies will be designed to evaluate the effects of SBP-101 in combination with other polyamine metabolism modulators as well as with immune modulators. (thepilotnews.com)
Injectable1
If pregnancy is the goal, the use of clomiphene (Clomid), a combination of clomiphene and metformin, or injectable gonadotropins, such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH) medications. (mostwomen.org)
Treatment1
The poster concludes that the treatment of C57Bl/6 mice containing VDID8 + ovarian cancer with SBP-101 in combination with doxorubicin significantly prolonged survival and decreased overall tumor burden. (thepilotnews.com)
Compounds1
rsv infection bowel inflammation In the 1960s the structure of compounds, especially in combination with chromatographic methods. (auxerretv.com)
Valacyclovir1
The purpose of this study was to assess the safety and feasibility of delivering an experimental approach called GliAtak which uses AdV-tk, an adenoviral vector containing the Herpes Simplex thymidine kinase gene, plus an oral anti-herpetic prodrug, valacyclovir, in combination with standard of care radiation. (mountaintoday.in)
PCOS1
If you are diagnosed with polycystic ovary syndrome PCOS can be diagnosed by any combination of The scan can detect the typical appearance of PCOS (PCOS) it means that your hormones are not in bal- blood test results, an ultrasound scan or from a with the many follicles (small cysts) in slightly ance. (pdfdrugs.com)
Dose1
CPP-1X (eflornithine) is being developed as a single agent tablet or high dose power sachet for several indications including prevention of gastric cancer and recent onset Type 1 diabetes. (wkrn.com)
Gene2
The gene TbAAT6, conserved in the genome of Trypanosomes, is believed to be responsible for the transmembrane transporter that brings eflornithine into the cell. (wikipedia.org)
The loss of this gene due to specific mutations causes resistance to eflornithine in several trypanosomes. (wikipedia.org)
Time1
The SBP-101 and doxorubicin combination mice had the greatest survival time with a 265% increase in median survival compared to untreated animals. (thepilotnews.com)
Cream1
9% Cream Eflornithine Hydrochloride Manufactured by Almirall Ltd Product of United Kingdom Dispensed by a licensed pharmacy in the United Kingdom * UK label strength is 11. (columbusafricanamerican.com)
Cancer2
Eflornithine blocks the production of chemicals called polyamines that are important in the growth of cancer cells. (ucbraid.org)
The results suggest that SBP-101 in combination with doxorubicin may have a role in the clinical management of ovarian cancer, in particular the platinum-resistant population where few options exist," said Dr. Simpson. (thepilotnews.com)
Disease1
In regions of the world where the disease is common eflornithine is provided for free by the World Health Organization. (wikipedia.org)
Medical1
Eflornithine was developed in the 1970s and came into medical use in 1990. (wikipedia.org)
Determine1
The choices may be coupled to analytical methods pyridium being used to simultaneously determine combination products. (auxerretv.com)