Colorectal cancer cell. Medical search. Frequent questions

Objective To examine the association between consumption of ultra-processed foods and risk of colorectal cancer among men and women from three large prospective cohorts. (bmj.com)
Main outcome measure Association between ultra-processed food consumption and risk of colorectal cancer, estimated using time varying Cox proportional hazards regression models adjusted for potential confounding factors. (bmj.com)
No association was observed between overall ultra-processed food consumption and risk of colorectal cancer among women. (bmj.com)
Conclusions In the three large prospective cohorts, high consumption of total ultra-processed foods in men and certain subgroups of ultra-processed foods in men and women was associated with an increased risk of colorectal cancer. (bmj.com)
While statin intake has been proven to reduce the risk of colorectal cancer (CRC), the mechanism of antitumor effects and clinical significance in survival benefits remain unclear. (nih.gov)
Before molecular genetic diagnostics became available in the 1990s, a comprehensive family history was the only basis from which to estimate the familial risk of colorectal cancer. (medscape.com)

SW620-V- or SW620-B-transfected (pooled) cells were injected into the splenic capsule ( B ) PET imaging (GB = Gallbladder, arrows indicate metastatic foci). (jci.org)
About 35% of all cancer patients are defined as having metastatic disease [ 2 ], of which less than 20% patients can survive more than 5 years from the date of diagnosis [ 3 ]. (aging-us.com)
Perivascular heterogeneity in clinical samples, and associations with other tumor features and outcome, remain largely unknown.Here we report a novel method for digital quantitative analyses of vessel characteristics and PC, which was applied to two collections of human metastatic colorectal cancer (mCRC).Initial analyses identified marker-defined subsets of PC, including cells expressing PDGFR-β or α-SMA or both markers. (lu.se)
A combination of encorafenib , cetuximab, and binimetinib has been shown to increase overall survival compared to standard therapy in patients with metastatic colorectal cancer with the BRAF V600E mutation. (medscape.com)
Pembrolizumab gained accelerated approval from the FDA in May 2017 for unresectable or metastatic colon cancer that has tested positive for microsatellite instability-high (MSI-H) or deficient mismatch repair (dMMR) and has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan. (medscape.com)
A total of 207 patients (Study Group n=54, Historical Group n=153) with metastatic colorectal cancer were enrolled. (medscimonit.com)
Colorectal cancer (CRC), especially metastatic CRC, is one of the most common causes of cancer-related death and has therefore attracted much attention from researchers for many years ( 1 - 2 ). (ijbs.com)
MRNA-4359 is under clinical development by Moderna and currently in Phase II for Metastatic Colorectal Cancer. (pharmaceutical-technology.com)
According to GlobalData, Phase II drugs for Metastatic Colorectal Cancer have a 34% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. (pharmaceutical-technology.com)
mRNA-4359 is under development for the treatment of advanced or metastatic solid tumors including cutaneous melanoma, non-muscle invasive bladder cancer, head and neck squamous cell carcinoma, microsatellite stable colorectal cancer (MSS CRC), basal cell carcinoma, triple negative breast cancer and non-small cell lung carcinoma (NSCLC). (pharmaceutical-technology.com)
Koukourakis GV, Zacharias G, Tsalafoutas J, Theodoridis D, Kouloulias V. Capecitabine for locally advanced and metastatic colorectal cancer: A review. (wjgnet.com)
Special attention has been paid to trials that compared Capecitabine with standard folinic acid (leucovorin, LV)-modulated intravenous 5-fluorouracil (5-FU) bolus regimens in patients with metastatic colorectal cancer. (wjgnet.com)
Moreover the efficacy of Capecitabine on metastatic colorectal cancer, either alone or in various combinations with other active drugs such as Irinotecan and Oxaliplatin was also assessed. (wjgnet.com)
The combination of Oxaliplatin with Capecitabine represents a new standard of care for metastatic colorectal cancer. (wjgnet.com)
Cetuximab, marketed as Erbitux, is one of the key therapies for metastatic colorectal cancer. (sciencedaily.com)
June 12, 2019 Identifying a metastatic colorectal cancer patient's Consensus Molecular Subtype could help oncologists determine the most effective course of treatment. (sciencedaily.com)
Systemic Chemotherapy for Metastatic Colorectal Cancer. (epnet.com)
Differences between the features of primary cancer and matched metastatic cancer have recently drawn attention in research. (jnccn.org)
This study investigated the concordance in microsatellite instability (MSI) and mismatch repair (MMR) status between primary and corresponding metastatic colorectal cancer (CRC). (jnccn.org)
Along with the change of MSI-high in primary cancer to MSS in metastatic cancer, lymphocyte infiltration decreased significantly ( P =.008). (jnccn.org)

In addition to genetic syndromes and IBD, established risk factors include age, personal history of adenomas, family history of colorectal cancer, diets high in fat and low in fruit/vegetables, obesity, sedentary lifestyle, smoking, and excessive alcohol intake. (naturalmedicinejournal.com)

Cite this: Model Helps Optimize Who Should Be Screened for Cancer - Medscape - Nov 08, 2023. (medscape.com)
Cancer Prev Res (Phila) (2023) 16 (8): 421-427. (aacrjournals.org)
In 2023, an estimated 19,550 people under 50 will be diagnosed with colon cancer. (healthline.com)
In 2023, an estimated 19,550 people under 50 will be diagnosed with colorectal cancer, and 3,750 will die from the disease. (healthline.com)

We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4 + and CD4 + CD8 + double positive T cells were higher, while CD8 + T cells and CD4 − CD8 − double negative T cells were significantly lower in CRC tumors. (mdpi.com)
Further, when the researchers exposed the tumors to anti-cancer drugs, they observed that even closely related cells in the same tumor had markedly different responses, indicating that colorectal cancer cells experience substantial increases in the rates of their somatic mutations as compared to normal colorectal cells. (genomeweb.com)
The team's methylation array experiments, meanwhile, showed that the methylation states of normal colorectal stem cells from the different individuals were relatively similar, but tumors from different individuals had developed divergent epigenetic states. (genomeweb.com)
Approximately 30-50% of colorectal tumors are known to have a mutated (abnormal) KRAS gene, indicating that up to 50% of patients with colorectal cancer (CRC) might respond to anti-epidermal growth factor receptor (EGFR) antibody therapy. (medscape.com)
Using human colon cancer cells and primary human fibroblasts isolated from tumors and adjacent normal tissues, Alexandros Glentis and colleagues at the Institut Curie addressed the question of whether the cancer cells or the CAF cells were responsible for the breakdown of the basement membrane that leads to cancer progression. (medindia.net)
Through imaging the tumors and fibroblasts, the researchers then found the smoking gun of cancer-CAF cooperation--long protrusions like puppet-strings that the tumor cells used to communicate with the fibroblasts well before the cancer cells moved to breach the basement membrane. (medindia.net)
However, the radiation response is limited because of the presence of radio-resistant hypoxic cells within solid tumors [ 7 ]. (biomedcentral.com)
PDT is considered as a complementary therapy aimed at preventing tumor recurrence after surgical resection of colorectal cancer ( 3 ), making it a suitable approach for continuous removal of small fractions of tumors ( 4 ). (researchpad.co)
Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (researchpad.co)
In 1966, Dr. Lynch and colleagues described familial aggregation of colorectal cancer with stomach and endometrial tumors in 2 extended kindreds and named it cancer family syndrome. (medscape.com)
My work on liquid biopsies has involved blood based protein signatures for pancreatic cancer, and single-cell morphometric, proteomic and genomic characterization of circulating tumor cells, in comparison to solid tumors. (lu.se)

Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer. (nature.com)
Currently, colorectal cancer patients can receive treatment through surgery, endoscopic procedures, radiotherapy, chemotherapy, and immunotherapy [ 3 ], but the overall survival rate of colorectal cancer patients has not dramatically enhanced [ 4 ]. (hindawi.com)
Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
Khan K, Wale A, Brown G, Chau I. Colorectal cancer with liver metastases: Neoadjuvant chemotherapy, surgical resection first or palliation alone? (wjgnet.com)
Chemotherapy involves taking medicines that kill cancer cells. (medlineplus.gov)
Most people with stage III colon cancer receive chemotherapy after surgery for 3 to 6 months. (medlineplus.gov)
Even though the tumor was removed, chemotherapy is given to treat any cancer cells that may remain. (medlineplus.gov)
Chemotherapy is also used to improve symptoms and prolong survival in people with stage IV colon cancer. (medlineplus.gov)
The impact of therapeutic drug management (TDM) on reducing toxicity and improving efficacy in colorectal cancer (CRC) patients receiving fluorouracil-based chemotherapy is still unclear. (medscimonit.com)
TDM in colorectal cancer can reduce toxicity, improve efficacy and clinical outcome, and can be routinely used in 5-FU-based chemotherapy. (medscimonit.com)
Treatment for Colorectal Cancers may involve surgery,chemotherapy, radiation therapy or biological therapy. (medindia.net)
PURPOSE: This nationwide study evaluated results of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) for peritoneal metastasis of colorectal origin in the Netherlands following a national protocol. (lu.se)
24, 2019 Some colorectal cancer patients with a certain gene mutation benefit from a chemotherapy drug called cetuximab, although the mechanism of how this drug worked was unknown. (sciencedaily.com)
Chemotherapy uses drugs to destroy cancer cells. (epnet.com)
Chemotherapy for colorectal cancer is usually given through an IV. (epnet.com)

BVES was found to be underexpressed in all stages of human colorectal carcinoma (CRC) and in adenomatous polyps, indicating its suppression occurs early in transformation. (jci.org)
Nearly all colorectal cancers begin as noncancerous (benign) lumps (polyps) in the lining of the colon and rectum. (medlineplus.gov)
This study evaluated the diagnostic potential of plasma NTS for colorectal polyps and cancers. (springer.com)
Plasma NTS had an optimal sensitivity of 60.4% and specificity of 71.6% for the diagnosis of colorectal polyps and cancers. (springer.com)
Personal history of colorectal polyps. (mindmeister.com)
Although a colonoscopy is more invasive and requires significant preparation to empty the colon the day before the procedure, it also prevents colon cancer by removing the potentially cancerous polyps before they become cancerous. (healthline.com)
Over time, some polyps may turn into cancer. (cdc.gov)
Screening tests can find polyps so they can be removed before turning into cancer. (cdc.gov)

Colorectal cancer (CRC) is one of the most prevalent neoplasms in the world, being the second type of cancer more frequent in women and the third type more frequent in men. (biorxiv.org)

The consumption of probiotics has attracted attention for the maintenance of health and the prevention of diseases, such as colorectal cancer or hepatocellular carcinoma ( 1 - 3 ). (iiarjournals.org)
Herein, DNA microarray analysis was conducted to investigate the common mechanisms responsible for the antitumor effects of butyric acid, isobutyric acid and acetic acid on human colorectal carcinoma cells and identified candidate signal transduction pathways using the Ingenuity Pathway Analysis (IPA) software. (iiarjournals.org)
Cell culture and in vitro assessment of the inhibitory effects of butyric acid, isobutyric acid and acetic acid on the proliferation of a human colorectal carcinoma cell line. (iiarjournals.org)
The human colorectal carcinoma cell line (DLD-1 cells) was purchased from the Riken BRC Cell Bank, Japan. (iiarjournals.org)
Though a carcinoma "in situ" means a cancer in place, it often does not keep its place. (medindia.net)
PGM1 inhibits hepatocellular carcinoma cell (HCC) proliferation and growth by utilizing sufficient extracellular glucose to convert glycogen, while deletion of the PGM1 gene inhibits glycogen synthesis and leads to glycolysis of additional glucose, thus promoting tumor cell proliferation and growth [ 15 ]. (biomedcentral.com)

These genes encode proteins involved in DNA replication and cell cycle/proliferation that contribute to major pathways responsible for suppression of colorectal carcinogenesis pathways. (iiarjournals.org)
Conclusion: SCFAs inhibited the expression of genes encoding proteins involved in DNA replication and cell cycle/proliferation of human colorectal cancer cells and exerted antiproliferative activity via different pathways. (iiarjournals.org)
They then sequenced the coding regions of 360 known cancer genes in all normal and cancer-derived clonal organoids for likely driver mutations, and a subset were whole-genome sequenced. (genomeweb.com)
There are genes modifying the cancer susceptibility of these mouse models. (wikipedia.org)
The most frequent mutations in Hereditary nonpolyposis colorectal cancer (HNPCC) are mutations in the MSH2 and MLH1 genes. (wikipedia.org)
Genes encoding DAN mismatch repair enzymes are implicated in hereditary nonpolyposis colon cancer. (mindmeister.com)
Differentially expressed genes were investigated using TCGA COAD (colorectal adenocarcinoma) and READ (rectal adenocarcinoma) data sets. (biomedcentral.com)
Over 90% of all colorectal cancers in HNPCC patients demonstrate a high microsatellite instability (MSI-H), which means at least 2 or more genes have been mutated in HNPCC families or atypical HNPCC families. (medscape.com)
In hereditary nonpolyposis colorectal cancer (HNPCC), an inherited mutation in one of the DNA mismatch repair (MMR) genes appears to be a critical factor. (medscape.com)
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. (bvsalud.org)

Mouse models of colorectal cancer and intestinal cancer are experimental systems in which mice are genetically manipulated, fed a modified diet, or challenged with chemicals to develop malignancies in the gastrointestinal tract. (wikipedia.org)
With combination of Min and Mom1 mutations the lifespan of FAP mouse models of colorectal cancer is increased. (wikipedia.org)
The role of CysLT1R in mouse models of colorectal cancer. (lu.se)

The epidermal growth factor receptor (EGFR)/RAS/RAF/MEK/MAPK pathway plays a crucial role in the carcinogenesis, invasion and metastasis of colorectal cancer (CRC). (oncotarget.com)
Today we know that the beta-catenin protein (part of the Wnt signaling pathway) is implicated in colorectal carcinogenesis and its stability in the cell is regulated by APC. (wikipedia.org)
Hereditary gastrointestinal cancer is associated with molecular and neoplastic precursors which have revealed much about sporadic carcinogenesis. (aacrjournals.org)

A rectal exam may reveal a mass in people with rectal cancer, but not colon cancer. (medlineplus.gov)
Radiation therapy is often used in the treatment of rectal cancer. (medlineplus.gov)
Colorectal cancer, also known as bowel cancer, colon cancer, or rectal cancer, is any cancer that affects the colon and rectum. (medicalnewstoday.com)
The American Cancer Society (ACS) estimates that there will be 106,180 new cases of colon cancer and 44,850 new cases of rectal cancer in the United States in 2022. (medicalnewstoday.com)
and 50,310 deaths from colon and rectal cancer combined. (mindmeister.com)
Surgery for rectal cancer may include local transanal, low anterior, or abdominoperianal resection or pelvic exenteration. (mindmeister.com)
Finally, neoadjuvant therapy consisting of Capecitabine plus radiation therapy, for locally advanced rectal cancer was analysed. (wjgnet.com)
Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. (epnet.com)
Rectal cancer is very similar. (msdmanuals.com)
For patient education resources, see Cancer Center , as well as Colon Cancer and Rectal Cancer . (medscape.com)
Determinants of Pre-Surgical Treatment in Primary Rectal Cancer: A Population-Based Study. (cancercentrum.se)
Adverse impact of tumor deposits in lymph node negative rectal cancer - a national cohort study. (cancercentrum.se)
Defunctioning loop ileostomy in anterior resection for rectal cancer and subsequent renal failure: nationwide population-based study. (cancercentrum.se)
Defunctioning stoma before neoadjuvant treatment or resection of endoscopically obstructing rectal cancer. (cancercentrum.se)

Further, sodium butyrate has been shown to influence the adhesion and growth-regulating galectin network that controls the proliferation of human colon cancer cells in vitro ( 10 ). (iiarjournals.org)
The inhibition of cell proliferation was quantified using the WST-8 assay kit (Dojindo Molecular Technologies, Inc., Kumamoto, Japan) by spectrophotometrically measuring the absorbance (450 nm) of the water-soluble formazan formed via reduction by intracellular dehydrogenases. (iiarjournals.org)
Because colorectal cancer's migration and invasion are one of main factors to the severity of the disease, exploring the molecular mechanisms of proliferation, migration and invasion of CRC cells will contribute to the development of targeted therapy [ 5 ]. (aging-us.com)
By conducting an in vitro CRC cell line study through the knockdown of EGFR expression, we analyzed cell proliferation, colony formation and migration. (oncotarget.com)
Oncogenic K-rasG12D allele activated in colon epithelium induces expression of procarcinogenic protein kinase C-βII (PKCβII) and increases cell proliferation of epithelial cells, while in the distal colon the mutant form of K-ras has the opposite effects on PKCβII expression and cell proliferation. (wikipedia.org)
The oxidative stress factor plays a significant role in numerous stages of tumor advancement, including the transformation of normal cells into tumor cells, proliferation, tumor angiogenesis, and metastasis [ 5 - 8 ]. (hindawi.com)
ROS can also promote the metastasis and proliferation of tumor cells [ 15 ]. (hindawi.com)
We previously found that exosomes released from hypoxic CRC cells enhanced tumour growth and angiogenesis by enhancing the proliferation and migration of endothelial cells ( 13 ). (ijbs.com)
Wnt4 promotes the proliferation of cancer stem cells in response to progesterone in breast cancer ( 20 ). (ijbs.com)
PGM1 knockdown stimulated both cell proliferation and colony formation, and inhibited cell cycle arrest and apoptosis, while overexpression of PGM1 produced the opposite effects in CRC cells both in vivo and in vitro. (biomedcentral.com)
Cell proliferation evaluated by clonogenic survival curves was significantly inhibited by 5 mmol/L doranidazole, particularly at doses ranging from 10 to 30 Gy of irradiation. (biomedcentral.com)
EGFR methylation sustained signaling activity and cell proliferation even in the presence of cetuximab," said Hung. (sciencedaily.com)

Liu Y , Sun M , Zhang B , Zhao W , . KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling. (aging-us.com)

Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli (APC), has a major role in colorectal cancer (CRC). (umn.edu)
However, its biological role in colorectal cancer (CRC) has remained unknown. (biomedcentral.com)

For stages I, II, and III cancer, more extensive surgery is needed to remove all or part of the colon and rectum that is cancerous. (medlineplus.gov)
Interval cancers are associated with a better prognosis than cancers arising in a non-screened population, and GFOBT appears to preferentially detect cancers in men and the left side of the colon at the expense of cancers in women and in the right colon and rectum. (bmj.com)

Using three-dimensional live-cell imaging of patient-derived tumor organoids (tumor PDOs), we show that CIN is widespread in colorectal carcinomas regardless of background genetic alterations, including microsatellite instability. (nature.com)
Both the Msh6 and Msh2 mutant mice develop gastrointestinal cancer but the tumours differ in their microsatellite instability (MI) status. (wikipedia.org)

In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)
FAP is a rare dominantly inherited syndrome, the hallmark of which is the development of up to hundreds or thousands of colorectal adenomas and almost inevitable development of colorectal cancer without intervention. (aacrjournals.org)

Conversely, interfering with BVES function by expressing a dominant-negative mutant in human corneal epithelial cells induced mesenchymal features. (jci.org)
Wang et al ( 9 ) reported that miR-30a-5p upregulation can inhibit ovarian cancer epithelial-mesenchymal transition (EMT) and invasion. (spandidos-publications.com)
There was a mean of one genome rearrangement in clonal organoids derived from normal colorectal epithelial cells compared with means in cancer-derived clonal organoids of 71 rearrangements from patient one, 176 from patient two, and 67 from patient three. (genomeweb.com)
Sigalling and trafficking of the cysteinyl leukotriene receptors in intestinal epithelial cells. (lu.se)
Anti-Tumor Effects of CysLT2R in Epithelial Cancer. (lu.se)
Involvement of eicosanoid signalling in epithelial cell migration. (lu.se)
Regulation of survival and proliferationof human intestinal epithelial cells by leukotriene D4. (lu.se)

The intricate molecular mechanisms involved in the regenerative process of the normal intestine and the identity of putative somatic intestinal stem cells have become clear. (mdpi.com)
In a paper published today in Nature , researchers from the UK, the Netherlands, and the US described their efforts to characterize organoids derived from multiple single cells from three colorectal cancers as well as from adjacent normal intestinal crypts. (genomeweb.com)
1 Centre for Familial Intestinal Cancer, St. Marks Hospital & Imperial College, London, United Kingdom. (aacrjournals.org)
To treat patients with colorectal cancer, an approach that selectively targets cancer cells without damaging normal cells and which minimizes the risk of perforating the intestinal barrier is needed ( 2 ). (researchpad.co)

Immune checkpoint inhibition is an effective anti-cancer therapeutic approach but has shown limited efficacy in treating colorectal cancer (CRC) patients. (mdpi.com)
We investigated the expression of immune checkpoints (ICs) on lymphoid populations within the CRC TME and compared with cells from normal colon tissues using samples from 50 patients with varying disease stages. (mdpi.com)
Introduction: Over 50% of patients with colorectal cancer (CRC) will progress and/or develop metastases. (jcancer.org)
Therefore, we hypothesized that CRC cancer stem cell markers (CRCSC) will identify a group of patients at high risk for progression. (jcancer.org)
This study aims to evaluate the prognostic relevance of preoperative CTCs using the Cellsearch® system (CS)in patients, who underwent resection with curative intent of different stages of colorectal cancer (UICC I-IV). (researchsquare.com)
Using machine learning, the team highlighted more than 30 biomarkers and 2 clinical risk factors among patients with cardiovascular disease who smoked and 13 biomarkers and 8 clinical risk factors among patients with Li-Fraumeni syndrome that could effectively identify those at risk for cancer. (medscape.com)
In the study, Fidelle and colleagues first analyzed data in approximately 500 patients from the PREVALUNG trial , which included current or former smokers with cardiovascular disease who were part of a lung cancer screening program. (medscape.com)
To validate the model, the team performed the same assessment of blood and feces samples on more than 100 patients in the LIFSCREEN trial who have Li-Fraumeni syndrome, a rare genetic disorder that increases a person's risk for cancer. (medscape.com)
Using machine learning, the researchers found 33 biomarkers and 2 clinical risk factors among patients with cardiovascular disease that led to a cancer risk estimate with an area under the curve (AUC) of 0.78. (medscape.com)
In the cohort of patients with Li-Fraumeni syndrome, 13 soluble markers and 8 clinical risk factors predicted cancer risk with an AUC of 0.82. (medscape.com)
In the PREVALUNG cohort, 7% of patients were diagnosed with cancer and 3.2% with lung cancer. (medscape.com)
Compared with previous studies that delineated screening eligibility based on tobacco screening scores, "what is striking," Fidelle said, is that about 20%-50% of patients diagnosed with cancer in the PREVALUNG cohort would not have been included in those screening programs. (medscape.com)
This study, combining biomarkers with clinical risk factors, may prove to be a safe and effective way to identify patients at risk for developing malignancy," said Manley, director, of interventional pulmonology at Fox Chase Cancer Center, Philadelphia. (medscape.com)
Colorectal liver metastasises were once considered as incurable disease but with better treatment options and valuable input from multi-disciplinary teams, this disease can be cured in a proportion of patients. (wjgnet.com)
There are clinical challenges related to adjuvant treatment in colorectal cancer (CRC) and novel molecular markers are needed for better risk stratification of patients. (frontiersin.org)
Your gift will help support our mission to end cancer and make a difference in the lives of our patients. (mdanderson.org)
With our critical mass and global reach, we are poised to make an enormous impact on the lives of cancer patients and their families. (mdanderson.org)
The studies investigated the expression of 102 different miRs associated with prognostic aspects in colorectal cancer patients. (biorxiv.org)
Previous studies have shown that uninsured patients and patients with Medicaid present with more advanced stages of cancer. (ajmc.com)
Patients in our tumor registry with a diagnosis of breast or colorectal cancer between 2001 and 2010 were included. (ajmc.com)
2-5 Patients lacking medical insurance have been shown to have lower rates of screening for both these cancers, as well as others. (ajmc.com)
Indeed, many large studies have demonstrated, in a variety of different types of cancer, that patients without insurance consistently present in the later stages of disease. (ajmc.com)
9-15 Many of these studies have used the National Cancer Data Base (NCDB), which, although comprehensive, includes a relatively minor percentage of patients who are uninsured. (ajmc.com)
While IBD-related colorectal cancers account for only 1-2% of all CRC cases, CRC accounts for 10-15% of deaths in patients with IBD. (naturalmedicinejournal.com)
8 The National Cancer Institute (NCI) has created an online risk assessment tool to calculate the risk of colon cancer in patients over 50 years old. (naturalmedicinejournal.com)
Common symptoms of colorectal cancer include alterations in bowel habit, rectal bleeding, weight loss, abdominal pain, obstructive symptoms, and changes in the caliber/shape of stool (See Table I). The general nature and prevalence of benign abdominal complaints make recognizing which patients may have a malignancy very challenging. (naturalmedicinejournal.com)
11 The presence of severe anemia in those patients presenting with rectal bleeding also increases the PPV for colorectal cancer in a primary care setting. (naturalmedicinejournal.com)
METHODS: In a multi-institutional study prospective databases of patients with peritoneal carcinomatosis (PC) from colorectal cancer and pseudomyxoma peritonei (PMP) treated according to the Dutch HIPEC protocol, a uniform approach for the CRS and HIPEC treatment, were reviewed. (lu.se)
Syndromic constitutional pathogenic variants (PV) predispose individuals to a high risk of developing cancer, providing an opportunity to identify and explore precancerous lesions in these patients. (aacrjournals.org)
Donor gut microbiota from patients with colorectal cancer (CRC) has been shown to induce tumourigenesis in germ-deficient mice models. (bmj.com)
Yet the cancer still returns in some patients, shortening overall survival. (sciencedaily.com)
This correlated with poorer clinical outcomes observed in colorectal cancer patients and higher recurrence rates following cetuximab treatment. (sciencedaily.com)
Dec. 14, 2021 Patients with colorectal cancer were among the first to receive targeted therapies. (sciencedaily.com)
Our data have provided evidence for a comparable prediction of clinical outcome in CMF-treated breast cancer patients using conventional clinical variables and gene expression based markers. (lu.se)
Possible mechanisms for gram for breast cancer in southern Sweden issued 1991, pre- recurrence after treatment are low initial drug sensitivity or menopausal lymph node positive (N+) breast cancer patients an acquired drug resistance. (lu.se)
Radiotherapy was delivered to ipsilateral axil- cancer patients in the future, it is essential to increase our lary and supraclavicular lymph nodes and the remaining knowledge in mechanisms responsible for drug resistance, breast parenchyma after breast conservation surgery or tho- and to define reliable indicators for response to therapy. (lu.se)
Who should operate patients presenting with emergent colon cancer? (cancercentrum.se)

Researchers from France are developing a model to find biomarkers and clinical risk factors that can better identify individuals at risk for cancer who should be screened. (medscape.com)
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
Chemoprevention in LS with aspirin and nonsteroidal anti-inflammatory drugs has also translated into clinical cancer, however the efficacy of such agents in FAP remains elusive when cancer is applied as an endpoint in trials rather than the use of 'indirect' endpoints such as polyp burden, and requires further elucidation of biological mechanisms in FAP. (aacrjournals.org)
We have searched the Pubmed and Cochrane databases from 1980 to 2009 with the purpose of reviewing all available information on Capecitabine, focusing on its clinical effectiveness against colorectal cancer. (wjgnet.com)
In: National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology (NCCN Guidelines). (epnet.com)
Significant clinical benefits have been obtained with Ce6-mediated PDT (Ce6-PDT) in the treatment of various cancers including melanoma, bladder, and colorectal cancer ( 12 ). (researchpad.co)
Breast cancer is a heterogeneous disease with a large variabil- survival after adjuvant polychemotherapy was 10% (from ity in clinical outcome. (lu.se)
Clinical Colorectal Cancer. (lu.se)
Transmission of cancer screening data from the facility to Kenya Health Information System can also be improved through continuous mentorship of both clinical as well as health records teams on utility of surveillance data right from the facility level. (who.int)

Aberrant activation of the Wnt signaling pathway is an important step in the initiation and progression of tumor development in diverse cancers. (nih.gov)
The results demonstrated that miR‑30a‑5p downregulation was accompanied by the inactivation of the Hippo signaling pathway, which was demonstrated to promote CRC cell viability, invasion and migration. (spandidos-publications.com)
Curcumol treatment was identified to increase miR‑30a‑5p expression and to activate the Hippo signaling pathway, which in turn inhibited the invasion and migration of CRC cells. (spandidos-publications.com)
Overexpression of miR‑30a‑5p enhanced the effects of curcumol on cell invasion and migration, and the Hippo signaling pathway in CRC cells. (spandidos-publications.com)
Furthermore, it has been demonstrated that dysregulation of the Hippo-YAP signaling pathway is associated with EMT and cancer progression mainly driven by YAP ( 12 , 13 ). (spandidos-publications.com)
The results of Western blot illustrated that KIF18A could forward the migration and invasion of CRC cells, and inhibit PTEN , which promoted the activation of PI3K/Akt signaling pathway, thus bringing about the expression of MMP2 and MMP9 . (aging-us.com)
Promoting PTEN expression in CRC cell lines will stop the activation of the phosphatidylinositol-3-kinase ( PI3K )/sinkserine/threonine kinase ( Akt ) signaling pathway, which affects CRC cell growth, promotes apoptosis, and improves sensitivity to targeted therapy, immunotherapy, and conventional therapy. (aging-us.com)
Therefore, targeting drugs molecules in the PTEN signaling pathway may be another strategy to suppress tumor cells by inhibiting tumor activity [ 7 , 8 ]. (aging-us.com)

Liquid biopsy for identification of CTC preoperatively is of proven utility in predicting prognosis in breast, colon, and prostate cancer. (researchsquare.com)
Screening and early diagnosis have profound effects on the prognosis of individuals with colorectal cancer, and recognizing those at high risk may save lives through early detection. (naturalmedicinejournal.com)
Interval cancers have a relatively good prognosis compared with cancers arising in a similar population that has not been offered screening. (bmj.com)
Therefore, there remains a need to identify reliable biomarkers and cancer-related molecular mechanisms that can assist with making decisions regarding a patient's prognosis and developing suitable therapeutic strategies. (biomedcentral.com)

n=92 482) with valid dietary intake measurement and no cancer diagnosis at baseline. (bmj.com)
In this context, we assess the reliability of the neurotensinergic system to cancer progression as well as the regulation and mechanism of the system in order to determine its potential in colorectal cancer diagnosis, surveillance and screening. (springer.com)
Around 40% of people with this type of cancer receive the diagnosis when the disease is in an early stage. (medicalnewstoday.com)
12 One study from the United Kingdom showed that concomitant signs and symptoms with rectal bleeding doubles the likelihood of a colorectal cancer diagnosis. (naturalmedicinejournal.com)
we can prevent many colorectal cancers through regular screening…screening can identify cancers that are more easily treated, and even pre-cancers that can be removed to avoid a cancer diagnosis entirely," said Limburg. (healthline.com)
Scientists have now come up with a new technology that involves cancer diagnosis through a simple urine test using a strip of paper, making diagnosis simple and affordable for people. (medicaldaily.com)

Importantly, immune constituents of the tumor microenvironment (TME) can influence therapy response and cancer progression. (mdpi.com)
The study is designed to investigate the effect and molecular mechanism of KIF18A on the progression of colorectal cancer. (aging-us.com)
PTEN can inhibit cell cycle progression and induce cell death to stimulate angiogenesis [ 6 ]. (aging-us.com)
These models enable researchers to study the onset, progression of the disease, and understand in depth the molecular events that contribute to the development and spread of colorectal cancer. (wikipedia.org)
Progression from 1st abnormal cell to CRC happens over a 10-15 year period. (mindmeister.com)
Cancer cells release exosomes with various functions into the tumour microenvironment during cancer progression. (ijbs.com)
As previously reported, colorectal cancer cell-derived exosomes have important roles in tumour progression including invasion, angiogenesis, immune modulation and distal metastasis through effectively delivering microRNAs, mRNAs and proteins ( 10 - 12 ). (ijbs.com)
Role of β-catenin and leukotriene in colon cancer progression. (lu.se)

Stage 0 colon cancer may be treated by removing the tumor using endoscopic surgery (colonoscopy). (medlineplus.gov)
In an attempt to improve local control and survival after conventional surgery, radiotherapy is one of the major adjuvant therapies for colorectal cancer. (biomedcentral.com)
The impact of a patient's social network on emergency surgery for colon cancer. (cancercentrum.se)
Long-term oncological outcomes for minimally invasive surgery versus open surgery for colon cancer - a population-based nationwide study with a non-inferiority design. (cancercentrum.se)
cancer surgery versus open. (cancercentrum.se)

the resulting effect is often seen as a double-edged sword, with great controversy over the tumor-promoting and tumor-suppressing effects [ 6 , 10 ], the specific effect of ROS levels on tumor cells themselves, [ 11 ] sensitivity and lack of oxygen, and the tumor microenvironment of regulatory factors. (hindawi.com)
However, when a large amount of ROS causes the amassing of DNA damage in tumor cells to the extent that it cannot be repaired, conventional base excision repair [ 16 ] and nucleotide excision repair cannot remove the damaged DNA. (hindawi.com)
Autophagy contributes to the prolonged survival of tumor cells, whereas defects in autophagy play a critical role in tumorigenesis ( 15 , 16 ). (researchpad.co)
A recent study showed that the hypoxic environment produced by PDT can induce autophagy in tumor cells ( 17 ). (researchpad.co)
This suggests that autophagy is a form of adaptation of the nutritional environment of rapidly growing tumor cells in response to hypoxia. (researchpad.co)

Colorectal cancer is cancer that starts in the large intestine (colon) or the rectum (end of the colon). (medlineplus.gov)
When compared with screen-detected cancers, interval cancers are more likely to arise in women and in the right colon or rectum. (bmj.com)
Colorectal cancer is a disease in which cells in the colon or rectum grow out of control. (cdc.gov)
It is often used to treat cancers of the breast, stomach, pancreas, colon, rectum, head and neck and is given through an IV or infusion. (ccalliance.org)
Colorectal cancer is caused by the out-of-control growth of cells in the lining of your colon or rectum. (msdmanuals.com)

It is the second most lethal malignancy in China, after lung cancer, with an incidence of roughly 40,800 persons. (hindawi.com)

Somatic mutations were identified by comparison with the sequences of DNA extracted from pieces of normal colorectal tissue. (genomeweb.com)
A hypoxic tumour microenvironment, which is defined as a condition in which the oxygen pressure in the tumour tissue is less than 5 to 10 mm Hg, is extremely important for cancer metastasis ( 5 , 6 ). (ijbs.com)
Standing between a cancer cell in situ and the surrounding tissue of fibroblasts and extra-cellular matrix is the basement membrane, a thin sheet of fibers that normally cradles the cells above it. (medindia.net)
Chemo regimen will be adjusted to have the most impact on the cancer cells and fewest effects on healthy tissue. (epnet.com)
Glial cell line-derived neurotrophic factor family receptor alpha (GFRα) members have been widely connected to the mechanisms contributing to cell growth, differentiation, cell migration and tissue maturation. (medsci.org)
Based on whether it cooperates with the second receptor RET, GFRα has also been widely linked to the mechanisms that contribute to cell growth, differentiation and migration and tissue maturation. (medsci.org)
The resulting damage cannot be overcome by the antioxidant system to protect the cell from oxidative damage, leading to necrosis, apoptosis, or autophagy of the target cell and tissue ( 10 , 11 ). (researchpad.co)

Yet these adenocarcinomas do not metastasize and their histopathology is similar to that of the right side colon cancer in human with frequent mutation of the type II receptor for TGF-β. (wikipedia.org)
A heterozygous SOX17 mutation (L194P) was also found in a cell line. (umn.edu)
APC gene mutations were identified in 64% (30/47) of cancers and 7% of these (2/30) had an additional mutation in another Wnt gene. (umn.edu)
In HNPCC, a mutation that inactivates an MMR gene leads to the accumulation of cell mutations and greatly increases the likelihood of malignant transformation and cancer. (medscape.com)

Cancer stem cells are thought to be responsible for tumor initiation, dissemination and treatment failure. (jcancer.org)

Those at greatest risk for colon cancer are carriers of 1 of 2 familial genetic disorders, familial adenomatous polyposis (FAP) or hereditary non-polyposis colon cancer (HNPCC), also known as Lynch syndrome. (naturalmedicinejournal.com)
Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common form of hereditary colorectal cancer. (medscape.com)
HNPCC, accounts for 2-5% of all colorectal carcinomas. (medscape.com)
HNPCC is divided into Lynch syndrome I (familial colon cancer) and Lynch syndrome II (HNPCC associated with other cancers of the gastrointestinal [GI] or reproductive system). (medscape.com)
The widespread implementation of colorectal tumor testing helps to identify families with HNPCC or Lynch syndrome. (medscape.com)

A new study adds to mounting evidence that following a Western-style diet dramatically increases the risk of developing colorectal cancer. (medicaldaily.com)

Familial CRC, caused by hereditary mutations, is the type of cancer that neither its molecular mechanism is precisely known nor cannot be classified as a specific hereditary cancer ( Stoffel and Kastrinos, 2014 ). (frontiersin.org)
primarily based on better understanding of the molecular complexity of colorectal cancer coupled with aggressive approach in management of colorectal liver metastases. (wjgnet.com)
However, the functions and underlying molecular mechanisms of hypoxic CRC cell-derived exosomes are still largely unknown. (ijbs.com)
Our study investigated the role of extracellular methylation in EGFR signaling, and unexpectedly discovered new information about how EGFR renders cancer cells resistant to cetuximab antibody therapy," said Mien Chie Hung, Ph.D., chair of Molecular and Cellular Oncology. (sciencedaily.com)

Local recurrence is a challenge in the treatment of colorectal cancer, since it disables the transference and it is difficult to treat [ 2 ]. (biomedcentral.com)
Colorectal cancer is associated with a high risk of metastasis and recurrence despite an increased availability of diagnostic and therapeutic strategies. (researchpad.co)

5-Fluorouracil (5-FU) is widely applied in the treatment of various cancers, including colorectal cancer (CRC) [1,2]. (medscimonit.com)
The role of iron in various cancers, such as colorectal cancer and liver cancer was presented. (cdc.gov)

Materials and Methods: The DLD-1 cell line was cultured with different SCFAs. (iiarjournals.org)
Methods Interval cancers were defined as cancers diagnosed within 2 years (ie, a complete screening round) of a negative GFOBT. (bmj.com)
Using the MTT test methods the cytotoxic activity of each extract against colorectal HT-29 and breast MCF-7 cancer cells was assessed. (journalcra.com)

Green synthesized silver nanoparticles using the plant-based reducing agent Matricaria chamomilla induce cell death in colorectal cancer cells. (bvsalud.org)

Colorectal cancer (CRC) is a common gastrointestinal tumor in China ( 1 ). (spandidos-publications.com)
Colorectal cancer (CRC) is a common malignant tumor of the gastrointestinal tract [ 1 ]. (hindawi.com)
Finally, we review controversies in gastrointestinal surveillance for LS and FAP, including limitations and opportunities of upper and lower gastrointestinal endoscopy in the prevention and early detection of cancer. (aacrjournals.org)
Of the cancer susceptibility syndromes affecting the gastrointestinal tract, the two best defined syndromes are Lynch syndrome (LS) and familial adenomatous polyposis (FAP). (aacrjournals.org)
The increasing longevity of adults with CF puts them at risk for other diseases, such as gastrointestinal cancer," write the authors. (medscape.com)

Treatment with a DNA-demethylating agent restored BVES expression in CRC cell lines, indicating that methylation represses BVES expression. (jci.org)
In this review we will discuss various treatment options available in management of colorectal liver metastases with potential guidance on how and when to choose these options along with consideration on future directions in management of this disease. (wjgnet.com)
Treatment depends on many things, including the stage of the cancer. (medlineplus.gov)
Targeted treatment zeroes in on specific targets (molecules) in cancer cells. (medlineplus.gov)
We're tackling cancer with a new plan - one that aims to improve cancer prevention, early detection and treatment. (mdanderson.org)
The activation of β-catenin signalling was important for the migration and invasion of normoxic CRC cells, which was eliminated by treatment with the β-catenin inhibitor ICG-001. (ijbs.com)
Taken together, the results of our study indicate that hypoxia may stimulate tumour cells to release Wnt4-rich exosomes that are delivered to normoxic cells to enhance prometastatic behaviours, which might provide new targets for CRC treatment. (ijbs.com)
3 Unfortunately, 20% of those diagnosed with colon cancer are diagnosed in late, less treatment-responsive stages. (naturalmedicinejournal.com)
Early colon cancer detection is crucial for successful treatment, but many people avoid screening for common reasons. (healthline.com)
Screening also helps find colorectal cancer at an early stage, when treatment works best. (cdc.gov)
Colon cancer treatment option overview. (epnet.com)
Available at: https://www.cancer.gov/types/colorectal/patient/colon-treatment-pdq#section/_135. (epnet.com)
Approved in 1950, it has been the primary treatment for colorectal cancer for more than 60 years. (ccalliance.org)
In December 2015, the Food and Drug Administration approved Vistogard (uridine triacetate) for the emergency treatment of adults and children who receive an overdose of the cancer treatment 5-FU or capecitabine, or who develop certain severe or life-threatening toxicities within four days of receiving these cancer treatments. (ccalliance.org)
Photodynamic therapy (PDT) is a treatment that involves photosensitizing agents and light to kill cancer cells. (researchpad.co)
It has also been reported that PDT is an effective alternative treatment for drug-resistant colorectal cancer ( 6 ). (researchpad.co)
However, the exact function of autophagy in PDT for colorectal cancer treatment is unclear. (researchpad.co)

Xiao-Jun Xia Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, P. R. China. (jnccn.org)

Colorectal cancer cells showed extensive mutational diversification and carried several times more somatic mutations than normal colorectal cells. (genomeweb.com)
Most mutations were acquired during the final dominant clonal expansion of the cancer and resulted from mutational processes that are absent from normal colorectal cells," the authors wrote. (genomeweb.com)
The numbers of mutations of several signatures differed markedly between individual branches [of the phylogenetic tree], indicating varying contributions of mutational processes in different parts of the cancer. (genomeweb.com)
To our knowledge, this is the first systematic and integrated analysis at genetic, epigenetic, transcriptomic, and functional levels of multiple single-cell-derived clones from human cancers to incorporate high-quality and comprehensive description of essentially all somatic mutations present in multiple single cells," the authors concluded. (genomeweb.com)
Further analysis of the APC gene revealed the existence of various mutations in cancer sufferers that also play a role in the onset of the sporadic form of colorectal cancer. (wikipedia.org)
Association studies implied specific oncogenic mutations in malignant cells as determinants of PC status. (lu.se)
The increased cancer risk is due to inherited mutations that degrade the self-repair capability of DNA. (medscape.com)

It has been reported that miR-30a-5p expression is decreased in primary gallbladder cancer (GBC) lesions, and inhibition of its expression in GBC cells promoted migration and invasion ( 8 ). (spandidos-publications.com)
50% compared to untreated cells and the signalling pathways responsible for DLD-1 cell growth inhibition were identified and analyzed. (iiarjournals.org)
Inhibition of exosome secretion by GW4869 reduced hypoxic exosome-mediated migration and invasion of normoxic CRC cells. (ijbs.com)
Synergetic Inhibition of Human Colorectal Cancer Cells by Combining Polyyne-Enriched Fraction from Oplopanax elatus and Irinotecan. (uchicago.edu)
The radiosensitizing effect of doranidazole was determined using colony formation and propidium iodide (PI) assays to measure cell growth inhibition and the cell killing effect of human colorectal cancer cell lines exposed to high doses of γ-ray irradiation under hypoxic conditions in vitro . (biomedcentral.com)
Doranidazole can enhance the killing effect and the cell growth inhibition of colorectal cancer after high-dose irradiation in a time and dose-dependent manner. (biomedcentral.com)

Colorectal cancer is the third-leading cause of cancer related mortality in the United States. (mdpi.com)
CRC was the third most widely diagnosed cancer and had the second highest mortality among cancer types worldwide in 2018 ( 2 ). (spandidos-publications.com)
Colorectal cancer (CRC) is a worldwide health problem that ranks third in incidence and fourth in mortality with an estimated 1.2 million cases and 0.6 million deaths annually. (springer.com)
Colorectal cancer (CRC) is a multifactorial disease commonly diagnosed worldwide, with high mortality rates. (biorxiv.org)
1 Early detection through screening has been shown to reduce mortality in many cancers, including breast and colorectal cancers. (ajmc.com)
Population screening using guaiac faecal occult blood testing (GFOBT) reduces colorectal cancer-specific mortality. (bmj.com)

In the UK, the National Bowel Cancer Screening Programmes uses faecal occult blood (FOBT) test, flexible sigmoidoscopy and colonoscopy and virtual colonoscopy. (springer.com)

Nairobi - Kenya piloted a community-based cervical cancer screening in 2021 using the human papillomavirus (HPV) DNA testing to explore ways of effectively scaling up this type of testing across the country. (who.int)

PDT has been reported to be effective for treating aggressive colon cancer showing a high level of the vascular endothelial growth factor, which promotes tumor growth through angiogenesis ( 5 ). (researchpad.co)

CTCs were detected in all stages of the Union of International Cancer Control (UICC), in stage I (1/4, 25%), in stage II (4/12, 33.3%), in stage III (5/19, 26.3%) in stage IV (21/33, 63.6%).The detection of CTCs was associated to the UICC stage (p = 0.035) and to the presence of distant overt metastases (p = 0.014). (researchsquare.com)

We conclude that ongoing CIN is common in colorectal cancer organoids, and propose that CIN levels and the tolerance for mitotic errors shape aneuploidy landscapes and karyotype heterogeneity. (nature.com)
The researchers also analyzed the clonal organoids for DNA methylation at 470,000 CpG sites, performed RNA sequencing, and assessed them for response to several anti-cancer therapeutics. (genomeweb.com)
Further, their RNA-seq analysis found that diversification of methylation and transcriptome state occurred within each cancer and this was apparently heritable, stable, and independent of the tumor microenvironment, as it persisted after the organoids were cultured in vitro . (genomeweb.com)

Meredith Huetter had just turned 46 years old when she was diagnosed with stage 3 colorectal cancer (CRC) in December 2020. (healthline.com)

Colorectal cancer is the fourth most common malignant tumor worldwide [ 1 ]. (biomedcentral.com)

Many cases of colon cancer have no symptoms. (medlineplus.gov)
Through screening tests, colon cancer can be detected before symptoms develop. (medlineplus.gov)
Below, learn about the symptoms and treatments of colorectal cancer. (medicalnewstoday.com)
Colorectal cancer may not cause symptoms in the early stages. (medicalnewstoday.com)
Some people only notice symptoms in the later stages, when the cancer has spread to the lungs, liver, or other areas. (medicalnewstoday.com)
Interestingly, a recent review of 248 published papers found that the only symptoms with positive predictive value (PPV) for colorectal cancers were bleeding and weight loss. (naturalmedicinejournal.com)
11 However, there is greater PPV for colorectal cancer when rectal bleeding is accompanied by changes in bowel habits, or when unaccompanied by perianal symptoms. (naturalmedicinejournal.com)
What are the symptoms of colon cancer? (msdmanuals.com)
Colon cancer grows slowly and doesn't cause symptoms for a long time. (msdmanuals.com)
Because colon cancer is so common, doctors recommend screening tests to look for cancer before it causes symptoms. (msdmanuals.com)
Quality of life and patient reported symptoms after colorectal cancer in a Swedish population. (cancercentrum.se)

Conclusions Although GFOBT screening is associated with substantial interval cancer rates that increase with screening round, the absolute numbers do not. (bmj.com)

Anatomy12

Organisms6

Diseases35

Chemicals and Drugs81

Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes61

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science6

Health Care24

Geographicals1

Risk of colorectal cancer6

Metastatic20

Family history of colorectal cancer1

20234

Tumors11

Chemotherapy15

Polyps8

Neoplasms1

Carcinoma6

Genes10

Mouse models of colorectal cancer3

Carcinogenesis3

Rectal cancer14

Proliferation12

Invasion of colorectal cancer1

Role in colorectal cancer2

Colon and rectum2

Microsatellite instability2

Adenomas2

Epithelial7

Intestinal4

Patients37

Clinical9

Signaling pathway8

Prognosis4

Diagnosis6

Progression8

Surgery5

Tumor cells5

Rectum5

Lung cancer1

Tissue7

Mutation4

Stem cells1

HNPCC5

Increases1

Molecular4

Recurrence2

Various cancers2

Methods3

Induce cell death1

Gastrointestinal5

Treatment17

Oncology1

Mutations7

Inhibition6

Mortality6

Faecal occul1

20211

Angiogenesis1

Metastases1

Organoids3

20201

Malignant1

Symptoms11

CONCLUSIONS1