• In 2020, there were an estimated 1.93 million new cases of colorectal cancer and 935,173 deaths. (cancer.gov)
  • OBJECTIVES: To evaluate the expression of COX-2 and HER2 and determine their correlation with clinicopathologic parameters in surgically resected histologically diagnosed cases of colorectal cancer. (bvsalud.org)
  • These include polyps, sporadic colorectal carcinoma (CRC) and familial colon cancer (familial adenomatous polyposis [FAP]), and hereditary nonpolyposis colorectal cancer (HNPCC). (medscape.com)
  • This study evaluated the diagnostic potential of plasma NTS for colorectal polyps and cancers. (springer.com)
  • Plasma NTS had an optimal sensitivity of 60.4% and specificity of 71.6% for the diagnosis of colorectal polyps and cancers. (springer.com)
  • Non-small cell lung cancer (NSCLC) accounts for 70%-80% in lung cancer, and among them, lung adenocarcinoma (LAD) accounting for almost half of lung cancers, was one of the most common histologic subtype. (biomedcentral.com)
  • Gastric adenocarcinoma is one of the most lethal cancers worldwide due to inherent treatment resistance, but the cellular and molecular mechanisms involved in the progression from early pre-cancer to tumor formation and metastasis are not well understood. (news-medical.net)
  • Paraffin wax sections of 70 surgically resected colorectal adenocarcinomas were examined for the overexpression of HER2/c-erbB-2 oncoprotein using three different specific antibodies and the avidin-biotin immunoperoxidase technique. (ox.ac.uk)
  • Among all racial groups in the United States, Black individuals have the highest sporadic colorectal cancer incidence and mortality rates. (cancer.gov)
  • [ 4 , 8 ] whereas sessile serrated adenomas made up 9% of all colorectal polyps and 22% of serrated polyps. (medscape.com)
  • Gastric adenocarcinoma exhibits a high degree of heterogeneity with respect to both its phenotypes and molecular characteristics, but research around it has lagged behind other cancer types. (news-medical.net)
  • This study represents the largest single-cell RNA sequencing cohort of gastric adenocarcinoma to date and brings important new insights into how these cell populations impact disease progression. (news-medical.net)
  • A notable discovery is that two ecotypes (EC3 and EC6) correlated with different histological, genomic and clinical features of primary gastric adenocarcinomas. (news-medical.net)
  • While stromal components within the tumor microenvironment play crucial roles in tumor initiation, progression and metastases, cancer treatment strategies have thus far rarely focused on modulating stromal components, especially in patients with gastric adenocarcinoma. (news-medical.net)
  • There are unmet needs for patients with gastric adenocarcinoma every step of the way in their clinical journey,' Ajani said. (news-medical.net)
  • Gastric adenocarcinomas can be further categorized into an intestinal type and a diffuse type. (oncolink.org)
  • In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)
  • The aim of this study is to detect the expression of Notch-1 and analyze its clinicopathological or prognostic significance in different histological subtypes of Lung Adenocarcinomas (LADs). (biomedcentral.com)
  • Notch-1 could be used as a predictable biomarker to be detected in different pathological and histological subtypes in LAD for diagnosis or prognosis. (biomedcentral.com)
  • 1 ] MOC treatment is the same as other histological subtypes, i.e., upfront debulking surgery where possible, followed by platinum-based chemotherapy when indicted. (thieme-connect.de)
  • We included 151 patients with invasive adenocarcinoma on adenomas endoscopically resected between 1999 and 2009. (isciii.es)
  • El 84% de las colonoscopias fueron completas y en el 60,3% se detectaron adenomas sincrónicos. (isciii.es)
  • Patients were drawn from a hospital registry of colorectal cancer resections. (biomedcentral.com)
  • METHODS: Fifty-three paraffin-embedded tissue blocks of colorectal resections and corresponding patient information were retrieved from the archives of the Anatomic and Molecular Pathology Department of Lagos University Teaching Hospital.A 4-micron slide section was obtained from each specimen and immunohistochemistry for COX-2 and HER-2 expression was performed. (bvsalud.org)
  • Distinguishing the common adenocarcinoma from the uncommon lymphoma may sometimes be difficult, but it is important because of major differences in staging, treatment, and prognosis. (oncolink.org)
  • That study and many others in colorectal cancer have been prognostic rather than predictive in that they have examined GST Pi in consecutive patients who have received the same treatment or mix of treatments, without random allocation to different treatment groups. (biomedcentral.com)
  • In colorectal cancer, the prognostic or predictive value of GST Pi expression or genomic polymorphisms for outcomes after chemotherapy has been examined in several studies. (biomedcentral.com)
  • Adenocarcinoma ex-goblet cell carcinoid (AdexGCC) was considered a neuroendocrine adenocarcinoma, despite majority of tumor cells being negative for conventional neuroendocrine markers such as chromogranin and synaptophysin. (gastrores.org)
  • Appendiceal goblet cell carcinoid (GCC) and adenocarcinoma ex-goblet cell carcinoid (AdexGCC) have previously been described as two entities in a spectrum of neoplasms showing both glandular/mucinous and neuroendocrine differentiation [ 1 ]. (gastrores.org)
  • Figure 32.1 Histological appearance of a carcinoid tumor of the lung. (osmosis.org)
  • HER2 (c-erbB-2) oncoprotein expression in colorectal adenocarcinoma: an immunohistological study using three different antibodies. (ox.ac.uk)
  • CONCLUSION: This study detects a high COX-2 and low HER2 expression in colorectal cancer using immunohistochemistry,suggesting a possible role for COX-2 in CRC pathogenesis.This report should trigger further investigations of both markers vis-à-vis the management of CRC in our environment. (bvsalud.org)
  • Plasma NTS has the potential to be a non-invasive biomarker for colorectal neoplasia. (springer.com)
  • In addition, SDC2 expression was consistently elevated in stromal cells across various other cancer types, including pancreatic cancer, colorectal cancer, bladder cancer, breast cancer and clear cell renal cell carcinoma. (news-medical.net)
  • It is difficult to separate epidemiological considerations of rectal cancer from those of colon cancer because studies often consider colon and rectal cancer together (i.e., colorectal cancer). (cancer.gov)
  • Worldwide, colorectal cancer is the third most common form of cancer. (cancer.gov)
  • Colorectal cancer affects men and women almost equally. (cancer.gov)
  • Family history of colorectal cancer in a first-degree relative. (cancer.gov)
  • Evidence supports screening for rectal cancer as a part of routine care for all adults aged 50 years and older, especially for those with first-degree relatives with colorectal cancer. (cancer.gov)
  • For more information, see Colorectal Cancer Screening . (cancer.gov)
  • Earlier detection of colorectal cancer (CRC) results in improved survival. (springer.com)
  • Colorectal cancer (CRC) is a worldwide health problem that ranks third in incidence and fourth in mortality with an estimated 1.2 million cases and 0.6 million deaths annually. (springer.com)
  • In this context, we assess the reliability of the neurotensinergic system to cancer progression as well as the regulation and mechanism of the system in order to determine its potential in colorectal cancer diagnosis, surveillance and screening. (springer.com)
  • According to the International Multidisciplinary Classification of Lung Adenocarcinoma (LAD) by International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) in 2011, the diagnosis of LAD is changing from simple morphology into a comprehensive multidisciplinary classification. (biomedcentral.com)
  • Colorectal cancer. (isciii.es)
  • Colorectal adenoma is the primary precursor lesion of colorectal cancer (CRC). (isciii.es)
  • BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer in Nigeria, and it affects mostly persons in their middle age. (bvsalud.org)
  • In adults, colorectal cancer is the second leading cancer that causes death worldwide. (medscape.com)
  • When discovered in children, they suggest one of several types of inherited colorectal cancer. (medscape.com)
  • Mismatch repair deficiency occurs in 5% to 10% of patients with rectal adenocarcinomas. (cancer.gov)
  • In this retrospective study, we examined 103 patients with KRAS-mutant lung adenocarcinoma who were treated with immunotherapy-based regimens and we evaluated the clinical outcomes according to PD-L1 expression and the type of KRAS mutation. (bvsalud.org)
  • It is suggested that the overexpression of c-erbB-2 gene product is unlikely to be as common and as pronounced in colorectal adenocarcinoma as it is in ductal carcinoma of the breast. (ox.ac.uk)
  • The tumours were derived from various parts of the large intestinal tract, and represented all three stages of Dukes' classification and the three histological grades of differentiation. (ox.ac.uk)
  • At least 50% of the Western population will develop a colorectal tumor by age 70 years. (medscape.com)
  • Our goal is was to determine the factors associated with complete endoscopic resection of invasive adenocarcinoma. (isciii.es)