• Our second objective was to determine whether Nocardia bacteria could form a biofilm on CVCs in a laboratory model and whether biofilm growth could be prevented with the use of antimicrobial lock solutions. (cdc.gov)
  • Bacteria form biofilms by attaching themselves to the host and to each other by sticky hair-like filaments. (dentalreach.today)
  • Adhesive pili are essential for colonization, biofilm formation, virulence and pathogenesis of many environmental and pathogenic bacteria. (dentalreach.today)
  • Pili are vital for both the survival of the bacteria and the creation of the biofilms," said Dr. Satoshi Shibata, first author and staff scientist at the Okinawa Institute of Science and Technology Graduate University. (dentalreach.today)
  • Besides periodontal pathogens, Type V pili are seen in major colon bacteria such as Bacteroides and Prevotella species and their Type V pili may contribute to formation of colon microbiota," said professor Koji Nakayama of Nagasaki university. (dentalreach.today)
  • Bacteria use a chemical communication process known as quorum sensing to control collective behaviors like pathogenesis and biofilm formation. (princeton.edu)
  • Our results specifically suggest that bacterial colonization and biofilm development under flow and complex geometries can lead to heterogeneous quorum sensing activation, which promotes diversity in the genetic programs that bacteria enact. (princeton.edu)
  • HomB protein contributes to the colonization and persistence of H. pylori , and the presence of homB genes affects the number of bacteria adhering to the host cells. (nature.com)
  • This information contributes to our understanding of protein transport in Gram-positive bacteria in general and informs our understanding of S. mutans pathogenesis. (bvsalud.org)
  • Gtfs enhance the biofilm formation and promotes colonization of cariogenic bacteria by generating biofilm extracellular polysaccharides (EPSs), the key virulence property in the cariogenic process. (bvsalud.org)
  • Bacteria biofilms are increasingly recognized as contributing to bacterial persistence and disease pathogenesis in CF. (nih.gov)
  • [13] The biofilm bacteria can share nutrients and are sheltered from harmful factors in the environment, such as desiccation, antibiotics, and a host body's immune system. (wikipedia.org)
  • They can be found very early in Earth's fossil records (about 3.25 billion years ago) as both Archaea and Bacteria, and commonly protect prokaryotic cells by providing them with homeostasis, encouraging the development of complex interactions between the cells in the biofilm. (wikipedia.org)
  • [8] [5] The first colonist bacteria of a biofilm may adhere to the surface initially by the weak van der Waals forces and hydrophobic effects. (wikipedia.org)
  • Previously thought of as a group of rather benign environmental bacteria associated with random colonization and only rarely with genuine infection of the airway [ 1 ], perceptions have now changed. (springer.com)
  • The study intends to explore the therapeutic potential of naturally produced compounds by competitive marine bacteria residing in marine biofilms against C. albicans biofilm. (solamonrenewableenergy.com)
  • Several independent studies have shown that surface-associated bacteria produce bioactive compounds with clinical importance, including antibiotics and anti-biofilm agents8,9,10. (solamonrenewableenergy.com)
  • The bacteria elaborate a lipopolysaccharide endotoxin, coagulase, and a fibrinolysin, which are the principal factors in the pathogenesis of plague. (medscape.com)
  • Early onset colonization of an implant is often caused by introduction of bacteria into the surgical site during placement of the implant, however, another source of bacteria is the blood. (biomedcentral.com)
  • We used whole-transcriptome shotgun sequencing (RNA-seq) to compare the S. pneumoniae transcriptome in biofilms, bacteria dispersed from biofilms after exposure to IAV, febrile-range temperature, or ATP, and planktonic cells grown at 37°C. Compared with biofilm. (lu.se)
  • We used whole-transcriptome shotgun sequencing (RNA-seq) to compare the S. pneumoniae transcriptome in biofilms, bacteria dispersed from biofilms after exposure to IAV, febrile-range temperature, or ATP, and planktonic cells grown at 37°C. Compared with biofilm bacteria, actively dispersed S. pneumoniae, which were more virulent in invasive disease, upregulated genes involved in carbohydrate metabolism. (lu.se)
  • Outer membrane proteins (OMPs) of H. pylori play a crucial role in the host-pathogen interaction, virulence and pathogenesis. (nature.com)
  • For example, if an irrigation solution becomes colonized with this organism, irrigating an open wound can cause colonization or infection of the wound. (medscape.com)
  • S maltophilia has few pathogenic mechanisms and, for this reason, predominantly results in colonization rather than infection. (medscape.com)
  • Spore germination is an important part of the pathogenesis of Clostridium difficile infection (CDI). (exeter.ac.uk)
  • To elucidate the molecular details of UPEC pathogenesis, several murine models of infection have been established which recapitulate many of the clinical manifestations often seen in humans. (justia.com)
  • Using a combination of bioluminescent B. burgdorferi and mouse model of infection, we will further analyze the contribution of each bacterial ligand-host receptor interaction in Lyme pathogenesis. (rutgers.edu)
  • Since making these findings, her work has mainly concentrated on biofilm formation and subsequent infection by the Candida species C. albicans and C. dubliniensis - highly related strains that behave in similar ways, which makes them ideal as model systems of pathogenic yeasts. (sasm.org.za)
  • We compared oral and systemic isolates for the capacity to form biofilm in an in vitro biofilm model and pathogenicity in the Galleria mellonella infection model. (biomedcentral.com)
  • Importantly, for C. albicans the pathogenicity of oral Candida isolates was similar to systemic Candida isolates, suggesting that Candida isolates have similar biofilm-forming ability and virulence regardless of the infection site from which it was isolated. (biomedcentral.com)
  • Filamentous forms may contribute to colonization and infection, although species that do not form filaments, such as Candida glabrata, colonize and cause invasive disease in VLBW infants. (medscape.com)
  • Implanted medical devices, such as intramedullary nails or total joint prostheses, encourage bacterial colonization at the site of implantation and are therefore highly susceptible to infection [ 7 ]. (biomedcentral.com)
  • Nasopharyngeal colonization occurs in biofilms and precedes infection. (lu.se)
  • However, influenza A virus (IAV) infection releases virulent pneumococci from biofilms in vitro and in vivo. (lu.se)
  • These data help explain pneumococcal virulence after IAV infection and have important implications for studies of S. pneumoniae pathogenesis. (lu.se)
  • Pathogenic characteristics such as germ tube and biofilm formation and production of tissue damaging enzymes are possible targets of new drugs. (hindawi.com)
  • New measures being investigated involve reducing oropharyngeal and gastric colonization by pathogenic microorganisms. (cdc.gov)
  • Nocardia promoted heavy biofilm formation on the surface of central venous catheter segments tested in an in vitro biofilm model. (cdc.gov)
  • Trimethoprim- and minocycline-based lock solutions had potent in vitro activity against biofilm growth. (cdc.gov)
  • To evaluate the feasibility of this micro-pattern for this application, the microbial range of performance was investigated in addition to biofilm studies with and without a mucin-rich medium to simulate the tracheal environment in vitro . (springeropen.com)
  • This engineered micro-pattern reduces the colonization and biofilm formation of key VAP-associated pathogens in vitro . (springeropen.com)
  • This study investigated ability of NTHi to form biofilms and its impact on airway epithelia using in vivo and in vitro analyses. (nih.gov)
  • To further investigate the pathogenesis of NTHi in respiratory infections, we developed a novel in vitro coculture model of NTHi biofilm formation on polarized human airway epithelial cells grown at the air-liquid interface. (nih.gov)
  • Addressing whether in vivo biofilm growth takes place in the CF lung could prove pivotal in explaining the notorious unreliability of in vitro susceptibility testing. (springer.com)
  • Genetic analysis was used to identify signaling pathways impacting the white-opaque transition both in vitro and in a murine model of commensal colonization, and three sugar sensing pathways are revealed as regulators of the switch. (pasteur.fr)
  • HomB and HomA are the most studied OMPs from H. pylori as they play a crucial role in adherence, hyper biofilm formation, antibiotic resistance and are also associated with severe gastric malignancies. (nature.com)
  • DescriptionAn NIH-funded postdoctoral position is available immediately to conduct structural and biophysical studies of staphylococcal cell-surface proteins involved in host adherence and biofilm formation. (asbh.org)
  • Yeast cells à adherence à surface à development of hyphae cells à in the upper part of biofilm à leads to a more resistant mature biofilm à dispersion of yeast cell. (microbenotes.com)
  • The pathogenesis of fungal infections in preterm infants involves adherence, colonization, and dissemination (as is shown in the image below). (medscape.com)
  • The researchers speculated that the yeast forms are critically important for adherence and tissue dissemination and that hyphal formation in the tissues contributes to parenchymal destruction. (medscape.com)
  • The top five pathogens associated with ETT-related pneumonia, Methicillin-Resistant Staphylococcus aureus (MRSA) , Pseudomonas aeruginosa , Klebsiella pneumonia, Acinetobacter baumannii, and Escherichia coli, were evaluated for attachment to micro-patterned and un-patterned silicone surfaces in a short-term colonization assay. (springeropen.com)
  • Two key pathogens, MRSA and Pseudomonas aeruginosa, were evaluated for biofilm formation in a nutrient rich broth for four days and minimal media for 24 hours, respectively, on each surface type. (springeropen.com)
  • P. aeruginosa was further evaluated for biofilm formation on each surface type in a mucin-modified medium mimicking tracheal mucosal secretions. (springeropen.com)
  • Biofilm formation was also reduced, with 67% ( p = 0.12) and 52% ( p = 0.05) reductions in MRSA and P. aeruginosa biofilm formation, respectively. (springeropen.com)
  • 0.01) reduction was demonstrated on micro-patterned surfaces for P. aeruginosa biofilms under clinically-simulated conditions when compared to un-patterned controls. (springeropen.com)
  • Phenotypic characteristics of P.aeruginosa might be responsible for increased colonization and antibiotic resistance observed in vivo and understanding these differences may lead to development of clinical guidelines for the management of MDR infections. (springeropen.com)
  • The aim of our present study was to screen P. aeruginosa strains isolated from ocular infections, for their potential to produce various phenotypic virulence factors and correlating them with biofilm formation and their antibiotic susceptibility profile. (springeropen.com)
  • My laboratory is studying the molecular basis of pathogenesis of bacterial species, Borrelia burgdorferi , Treponema pallidum and Pseudomonas aeruginosa . (rutgers.edu)
  • We will assess the role of selected virulence factors in biofilm formation while P. aeruginosa is present in communities along with the other organisms. (rutgers.edu)
  • Salmonella can also form complex surface-associated communities (also known as biofilms), which contribute to its persistence in host and non-host environments and is especially important in food processing environments. (news-medical.net)
  • A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface. (wikipedia.org)
  • Biofilms can attach to a surface such as a tooth or rock, and may include a single species or a diverse group of microorganisms. (wikipedia.org)
  • The formation of a biofilm begins with the attachment of free-floating microorganisms to a surface. (wikipedia.org)
  • Biofilms are diverse communities of microorganisms embedded within a self-produced matrix of extracellular polymeric substance which are firmly attached to biotic or abiotic surfaces. (skintherapyletter.com)
  • The main virulence factors that lend to disease pathogenesis include production of a variety of extracellular enzymes, evasion of host immune response, and triggering intense tissue inflammation. (medscape.com)
  • The data presented here have implications both for understanding early CF lung disease pathogenesis and for the treatment of early, asymptomatic colonization of patients with CF with H. influenzae. (nih.gov)
  • The isolates were identified by Vitek-2 and characterized based on growth kinetics, biofilm formation, motility, pyoverdine and pyocyanin production, phospholipase and catalase activity, urease production along with expression of exotoxins (exo-A, exo-U and exo-S) and correlated to its antibiotic profiles. (springeropen.com)
  • When dexamethasone was added to the antibiotic regimen (presumably amplifying the inherent immunoincompetence), both colonization and dissemination increased in these animal models. (medscape.com)
  • Biofilm formation is the prime cause of antibiotic resistance during C. albicans infections and treating biofilm-forming cells is challenging due to their intractable and persistent nature. (solamonrenewableenergy.com)
  • Bacterial factors that contribute toward colonization of respiratory tract or prosthetic devices such as intravascular, surgical catheters and endotracheal tubes include cationic surface charge, flagella and fimbriae, which assist adhesion, and biofilm formation. (medscape.com)
  • We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
  • Intriguingly, quantitative PCR analysis of 3HC-treated C. albicans biofilm revealed significant downregulation of virulence genes (hst7, ume6, efg1, cph1, ras1, als1) associated with adhesion and morphogenesis. (solamonrenewableenergy.com)
  • Further, virulence traits, including adhesion, hyphal, and biofilm formation enable C. albicans to access deep tissues for systemic infections. (solamonrenewableenergy.com)
  • These include enzyme secretion, cellular adhesion, host defence evasion, and biofilm formation [ 7 ]. (encyclopedia.pub)
  • Pathogenesis varies based on the strain, but it can include toxin production, invasion of the mucosal surface, and adhesion with alteration of enterocyte structure. (lecturio.com)
  • [2] [3] The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides , proteins , lipids and DNA . (wikipedia.org)
  • Pathogenesis and invasive fungal infections in very low birth weight infants. (medscape.com)
  • angustifolia extract on the germ tube and biofilm formation of C. albicans . (hindawi.com)
  • DVA extract has ability to reduce virulence of C. albicans by inhibiting germ tube and biofilm formation through damage to the cell wall. (hindawi.com)
  • The present study investigated the effect of subinhibitory concentration of crude extract of DVA on the germ tube and biofilm formation by C. albicans . (hindawi.com)
  • On silicone pads, C. albicans and C. dubliniensis produced more biofilm (1.12 to 6.61 mg) than the other species (0.25 to 3.66 mg). (biomedcentral.com)
  • To this end, 3-hydroxy coumarin (3HC), a compound identified from the cell-free culture supernatant of the marine bacterium Brevundimonas abyssalis, was found to exhibit anti-biofilm and anti-hyphal activity against both reference and clinical isolates of C. albicans. (solamonrenewableenergy.com)
  • In conclusion, this study showed that marine biofilms are a hidden source of diverse therapeutic drugs, and 3HC could be a potent drug to treat C. albicans infections. (solamonrenewableenergy.com)
  • The prime factor that is conducive to the pathogenesis of C. albicans is its ability to form biofilm on both biotic and abiotic surfaces, followed by other major virulence traits, such as yeast-to-hyphal transitions, filamentous morphology, wrinkle morphology, and secretion of proteolytic and lipolytic enzymes5. (solamonrenewableenergy.com)
  • However, biofilm formation by C. albicans has been found to gain genetic resistance against most of the currently used antifungal drugs. (solamonrenewableenergy.com)
  • In addition, 10 clinical NTHi isolates from patients with CF formed biofilms on plastic surfaces. (nih.gov)
  • The biofilm formation and pathogenicity in Galleria was similar between oral and systemic isolates. (biomedcentral.com)
  • In this investigation, we obtained potent biofilm-forming bacterial isolates from the early-stage biofilm formed on three different artificial surfaces (stainless steel, high-density polyethylene, and titanium) immersed in the intake area of a coastal located power plant22. (solamonrenewableenergy.com)
  • The microbial cells growing in a biofilm are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single cells that may float or swim in a liquid medium. (wikipedia.org)
  • Microbes form a biofilm in response to a number of different factors, [9] which may include cellular recognition of specific or non-specific attachment sites on a surface, nutritional cues, or in some cases, by exposure of planktonic cells to sub-inhibitory concentrations of antibiotics . (wikipedia.org)
  • Therefore, Gtfs have become an appealing target for effective therapeutic interventions that inhibit cariogenic biofilms. (bvsalud.org)
  • These findings are in stark contrast with the reported heterogeneity of the species as a whole, as wells as to other bacterial pathogens mediating OM and COPD, providing important insight into M. catarrhalis pathogenesis that will aid in the development of novel therapeutic regimens. (biomedcentral.com)
  • In all of these models the adhesin FimH has been shown to play an integral role in pathogenesis, highlighting it as an excellent therapeutic target. (justia.com)
  • SARS-CoV-2 E protein: Pathogenesis and potential therapeutic development. (environmed.pl)
  • Therefore, there is a critical need for alternative therapeutic agents to fight against biofilm-mediated infections and to conquer the limitations of current antifungal therapies. (solamonrenewableenergy.com)
  • Below is a list of common coagulase-negative staphylococcal species and their preferred sites of colonisation. (dermnetnz.org)
  • Animal models of UTI have revealed that the mannose-binding FimH adhesin of type 1 pili is critical for the colonization of and invasion into the bladder epithelium by UPEC, as well as other uropathogenic members of the Enterobacteriaceae family, such as Klebsiella, Enterobacter , and Citrobacter species. (justia.com)
  • In this study, the long-chain stearidonic fatty acid stopped biofilm formation by increasing reactive oxygen species production and the rate of apoptosis. (sasm.org.za)
  • The quantity of biofilm formed and the virulence in G. mellonella were different for each of the species studied. (biomedcentral.com)
  • investigated pathogenesis and immunological response caused by HomB protein in clinical patients and 190 H. pylori strain isolated from patients with peptic ulcer disease (PUD) or gastritis were evaluated for the clinical importance of homB . (nature.com)
  • En mayo de 2007 obtuve el Certificate of Training in Molecular Biological Techniques en el Department of Molecular Biology y desde Junio de 2008 a Junio de 2009 completé el Certificate in Clinical Research en el Center for Translational Science Activities en Mayo Clinic College of Medicine, Rochester Minnesota. (unav.edu)
  • Un 40% de esos trabajos han sido publicados en revistas del primer cuartil entre las que destacan New England Journal of Medicine, Lancet, Lancet Infectious Diseases, Clinical Infectious Diseases, Clinical Microbiology Reviews, Antimicrobial Agents and Chemotherapy, Journal Clinical Microbiology, Journal Antimicrobial Chemotherapy, Mayo Clinic Proceedings y Malaria Journal. (unav.edu)
  • Previous studies have evaluated the relationship between supragingival plaque control and clinical and microbiological effects on subgingival areas, reporting a positive effect in systemically healthy subjects with periodontitis, i.e., a reduction in probing depth and some periodontal pathogens and preventing re-colonization 9-11 . (bvsalud.org)
  • However, conflicting results of the impact of supragingival dental biofilm control on clinical features in untreated periodontal sites are found in the literature 12-14 . (bvsalud.org)
  • Comparison of Oligon catheters and chlorhexidine-impregnated sponges with standard multilumen central venous catheters for prevention of associated colonization and infections in intensive care unit patients: a multicenter, randomized, controlled study. (cdc.gov)
  • Now, with the increasing use of implanted medical equipment, they have become leading pathogens for nosocomial infections owing to their ability to form biofilms on foreign material [1,2]. (dermnetnz.org)
  • Approximately 80% of all human infections are associated with biofilms. (skintherapyletter.com)
  • Traditional preventive measures for nosocomial pneumonia include decreasing aspiration by the patient, preventing cross-contamination or colonization via hands of personnel, appropriate disinfection or sterilization of respiratory-therapy devices, use of available vaccines to protect against particular infections, and education of hospital staff and patients. (cdc.gov)
  • Despite many insights gained on the structure and functions played by flagellum and pili in motility, biofilm formation, surface attachment and interactions with bacteriophages, we know little about how these appendages are regulated in Xcc . (biomedcentral.com)
  • Subpopulations of cells within the biofilm differentiate to perform various activities for motility, matrix production, and sporulation, supporting the overall success of the biofilm. (wikipedia.org)
  • By taking a close look at these pili, our research has provided insights into how we can prevent biofilms from forming. (dentalreach.today)
  • . campestris ( Xcc ) involves the coordinate expression of many virulence factors, including surface appendages flagellum and type IV pili, which are required for pathogenesis and the colonization of host tissues. (biomedcentral.com)
  • Currently several key areas are being revised: The first outbreak of human NTM transmission has been proven and new evidence of biofilm growth in vivo has been demonstrated. (springer.com)
  • New evidence that rapidly growing NTM can grow in vivo as biofilms on intravascular catheters [ 3 ] could be an indication that biofilm growth in pulmonary NTM disease might also be a concern. (springer.com)
  • Tissue colonization by the spirochetes will be monitored non-invasively by employing in vivo imaging system. (rutgers.edu)
  • Thus, the primary goal of periodontal therapy is to target the subgingival biofilm present in periodontally diseased sites that are associated with the progressive destruction of the supportive periodontal tissues. (bvsalud.org)
  • Proteases is said to contribute to pathogenesis through destruction of connective tissue and degradation of host immunological factors [ 20 ] in patients with keratitis. (springeropen.com)
  • The ETT provides a conduit for bacterial access to the lower respiratory tract and a substratum for biofilm formation, both of which lead to VAP. (springeropen.com)
  • NTHi formed adherent biofilms on the apical surface airway epithelia with decreased susceptibility to antibiotics, and respiratory cells exhibited inflammatory and host defense responses-evidence of a dynamic host-pathogen interaction. (nih.gov)
  • These biofilms exhibited decreased susceptibility to antibiotics and were adherent to epithelial surfaces. (nih.gov)
  • Biofilms may form on living (biotic) or non-living (abiotic) surfaces and can be prevalent in natural, industrial, and hospital settings. (wikipedia.org)
  • The Herr Laboratory at Cincinnati Children's Hospital uses a wide range of biophysical and structural approaches to understand the structure, higher-order assembly, and ligand interactions of proteins implicated in staphylococcal pathogenesis. (asbh.org)
  • For example, resident bacterial communities establish either cooperative (beneficial) or competitive (harmful) interactions, which affect biofilm succession, biomass, and resistance to stress. (solamonrenewableenergy.com)
  • Our study provides essential structural information of unexplored proteins of the Hom family that can help in a better understanding of H. pylori pathogenesis. (nature.com)
  • Dozens of bacterial factors are involved in H. pylori molecular pathogenesis (i.e. flagella, urease, catalase, neutrophil-activating protein Nap-A, vacA and cagA). (nimml.org)
  • Periodontitis is followed by the accumulation of biofilm. (dentalreach.today)
  • Hyperglycemia and resultant advanced glycation end product formation, which is one of several pathways thought to lead to the vascular complications with diabetes, are also involved in the pathophysiology of periodontitis in diabetic subjects 3 , leading to an imbalanced release of pro- and anti-inflammatory cytokines 4-6 and osteoclastogenesis-related factors 7 . (bvsalud.org)
  • In this context, there is an interest in the possible effect of supragingival biofilm control on the subgingival environment in untreated periodontitis sites in diabetic patients, since, in previous studies, these patients presented with some altered biofilm compositions, with a higher prevalence of periodontal pathogens. (bvsalud.org)
  • The inhibition of quorum sensing, called quorum quenching, may disrupt oral biofilm formation, which is the main etiological factor of oral diseases, including periodontitis. (mdpi.com)
  • The primary focus is to characterize the host ligand(s) for staphylococcal lectins responsible for skin colonization. (asbh.org)
  • It is the interaction of FimH with mannosylated host proteins that is believed to mediate colonization of the lower urinary tract by UPEC and other Enterobacteriaceae during UTI. (justia.com)
  • Analysis of virulence related gene expression and computational simulations of pivotal proteins involved in pathogenesis demonstrate that myricetin downregulates the saeR global regulator and interacts with sortase A and α-hemolysin. (nature.com)
  • SEM results showed concentration dependent reduction in biofilm and hyphae formation. (hindawi.com)
  • Its pathogenesis is multifactorial - the interplay of hormonal, bacterial, and immunological (inflammatory) factors results in the formation of acne lesions. (skintherapyletter.com)
  • Glucosyltransferases (Gtfs) play critical roles in the etiology and pathogenesis of Streptococcus mutans (S. mutans)- mediated dental caries including early childhood caries. (bvsalud.org)
  • They can also bring about structural changes in the yeast that then assist its colonisation activities or help it to evade host defences. (sasm.org.za)
  • The compound demonstrated significant inhibitory effects on biofilms and impaired the yeast-to-hyphal transition, wrinkle, and filament morphology at the minimal biofilm inhibitory concentration (MBIC) of 250 µg mL−1. (solamonrenewableenergy.com)
  • In natural environmental conditions, marine biofilms consist of multispecies bacterial communities in close proximity, with large metabolite and protein exchange, as well as coordinated lifestyles. (solamonrenewableenergy.com)
  • [10] [11] A cell that switches to the biofilm mode of growth undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated . (wikipedia.org)
  • Dispersed pneumococci also upregulated genes associated with production of bacteriocins and downregulated colonization-associated genes related to competence, fratricide, and the transparent colony phenotype. (lu.se)
  • Coagulase-negative staphylococci are gram-positive, aerobic organisms distinguished from the closely related Staphylococcus aureus by the group's inability to form coagulase, an enzyme that promotes thrombus formation via the conversion of fibrinogen into fibrin [2]. (dermnetnz.org)
  • [8] Biofilms can form on the teeth of most animals as dental plaque , where they may cause tooth decay and gum disease . (wikipedia.org)
  • A biofilm usually begins to form when a free-swimming bacterium attaches to a surface. (wikipedia.org)
  • With both, the formation of biofilms, and subsequent increase in ability to form PGE 2 , is an important disease-causing mechanism through the stimulation of inflammation. (sasm.org.za)
  • Recently, we have initiated studies to understand molecular basis of T. pallidum pathogenesis using this as a surrogate system. (rutgers.edu)
  • After successful intestinal colonization, this organism enters enterocytes, M cells and dendritic cells in the intestinal epithelium, subsequently reaching the submucosa and disseminating through the bloodstream. (news-medical.net)
  • Despite the differences in pathogeneses, biofilm still remains the primary etiologic factor for the development of a destructive periodontal disease 2 . (bvsalud.org)
  • We evaluated bronchoalveolar lavage fluid from young patients with CF for evidence of NTHi biofilms. (nih.gov)
  • In bronchoalveolar lavage fluid samples from young, asymptomatic patients with CF, we found morphologic evidence suggestive of NTHi biofilm formation. (nih.gov)
  • Previous reports have also suggested that pyocyanin and pyoverdine not only contribute to the increased colonization in the lungs of patients with cystic fibrosis, it also interferes with cell respiration, calcium homeostasis and prostacyclin release from lung endothelial cells as well [ 21 ]. (springeropen.com)
  • in some instances they aid organisms to defend themselves, propagate or prompt symbiotic relationships, whereas in other situations they can induce pathogenesis. (sasm.org.za)
  • NTHi formed biofilms on the apical surface of cultured airway epithelia. (nih.gov)