• The World Health Organization (WHO) 2010 has classified GI neuroendocrine neoplasms into neuroendocrine tumor (NET) and high-grade neuroendocrine carcinoma (NEC). (nih.gov)
  • Genetic susceptibility ranges from a well-defined inherited syndrome e.g. familial adenomatous polyposis and some of the benign neoplasms like adenoma carry a high risk of the malignancy and act as precursor lesion for colorectal carcinoma and tubular adenoma was the most common benign tumour of our study. (ispub.com)
  • In contrast, MUC2 is rarely detectable in aggressive pancreatic tumours, but is commonly expressed in intraductal papillary mucinous neoplasms (IPMNs), which are rare, indolent tumours, in intestinal IPMNs, and in indolent colloid carcinomas. (bmj.com)
  • Along with colorectal carcinoma there is seen an increase in the incidence of squamous cell carcinoma in last 50 years due to increase in HIV infection. (ispub.com)
  • are enriched in human colonic adenomas relative to surrounding tissues and in stool samples from colorectal adenoma and carcinoma patients compared to healthy subjects. (bigthink.com)
  • The most common metastatic site is the small bowel, whereas, colonic metastases are very rare. (gastrores.org)
  • Colonoscopy showed many ulcerated tumors along the colon and histology proved that these lesions were metastases of primitive lung carcinoma. (gastrores.org)
  • We report a case of colon metastases from lung carcinoma presenting with rectorrhagia as the first manifestation of gut metastasis. (gastrores.org)
  • Our patient had locally metastatic tonsillar cancer, treated with partial pharyngectomy and selective neck dissection but later developed several bone and colonic metastases concurrently, likely secondary to hematogeneous dissemination after a few months of therapy. (wjon.org)
  • However, gastrointestinal and particularly colonic metastases to the thyroid are extremely rare and usually associated with lung and liver metastasis [ 3 ]. (hindawi.com)
  • Colonic metastases from carcinoma of the lung, an unusual presentation. (bvsalud.org)
  • Metastatic colon carcinoma to the thyroid gland has been reported, and it is not as rare as one might think. (hindawi.com)
  • for example, metastatic medullary thyroid carcinoma typically presents with diarrhoea. (researchgate.net)
  • SOX2 and SOX9 are markers of clinically aggressive disease in metastatic high-grade serous carcinoma. (cancerindex.org)
  • [1] We present the radiological and pathological findings in a patient with metastatic invasive lobular breast carcinoma (ILC) and initial presentation as an obstructing colonic tumour. (hkjr.org)
  • However, because colonic polyps are highly prevalent in the general population (especially with increasing age), they confer an important predisposition to colon cancer and are therefore removed when detected. (medscape.com)
  • Most patients with colonic polyps are asymptomatic. (medscape.com)
  • chronic bleeding from colonic polyps may cause iron deficiency anemia. (medscape.com)
  • Occult blood in stools (detected by guaiac and antibody-based tests) may be found in a minority of patients with colonic polyps. (medscape.com)
  • A stool occult blood test can detect a proportion (20%-40%) of colonic polyps that are larger than 10 mm in diameter, but this test also suggests the presence of other causes of gastrointestinal blood loss. (medscape.com)
  • Flexible sigmoidoscopy is a good screening test for colonic polyps and is the only procedure or imaging modality to be validated by studies that document a decrease in colorectal cancer mortality. (medscape.com)
  • Colonoscopy is the preferred test to detect colonic polyps, obtain biopsies, and/or perform endoscopic resection. (medscape.com)
  • [ 2 ] Sensitivities for large colonic polyps in the 80%-90% range have been reported. (medscape.com)
  • Surgical resection may be advocated for large, sessile polyps that are difficult to remove endoscopically or for advanced colonic polyps that recur despite adequate initial endoscopic treatment. (medscape.com)
  • The colonic mucosa is studded with innumerable sessile and small pedunculated polyps, which involve the entire length of the specimen. (medscape.com)
  • Patients with isolated colonic polyps are usually asymptomatic but can experience overt or occult colonic bleeding. (medscape.com)
  • Colonic polyps can occur as part of inherited polyposis syndromes in which their number is greater and the risk for malignant progression is much higher compared to the risk associated with isolated colonic polyps. (medscape.com)
  • Colon cancer specific nuclear matrix protein alterations in human colonic adenomatous polyps. (nih.gov)
  • Familial adenomatous polyposis is a hereditary disorder causing numerous colonic polyps and frequently results in colon carcinoma, often by age 40. (msdmanuals.com)
  • Expression levels of CCTβ in tumor tissues was significantly higher than in nontumor tissues in all patients with hepatocellular carcinoma (n = 15) and 83% of patients with colonic carcinoma (n = 17). (bioone.org)
  • Hepatoblastoma Primary liver cancer is usually hepatocellular carcinoma (HCC). (msdmanuals.com)
  • Sequences on chromosome 5 that are linked to the gene for familial adenomatous polyposis were not lost in adenomas from the patients with polyposis but were lost in 29 to 35 percent of adenomas and carcinomas, respectively, from other patients. (nih.gov)
  • 3, 11- 14 This Ob-Rb expression is preserved in human colonic adenomas and carcinomas as well as in human colon cancer cell lines. (bmj.com)
  • The association between streptococcal endocarditis and gastrointestinal disease, particularly colonic neoplasia, has been well-documented in the literature ( 4 ). (iiarjournals.org)
  • Is the Routine Abdominal Ultrasound a Sufficiently Sensitive Method for the Detection of Colonic Malignancy? (go.jp)
  • Objective This study examined the sensitivity of routine abdominal ultrasound scanning in the detection of colonic malignancy. (go.jp)
  • Since the complaints pointed to colonic malignancy, the patients underwent routine golden standard diagnostic procedures. (go.jp)
  • These patients were referred to an experienced abdominal ultrasound operator who searched for some characteristic signs of colonic malignancy. (go.jp)
  • In series of 99 cases of endocrine tumours of the duodenum , males were more frequently affected with male to female ratio is 1.5: 1 with mean age of presentation of 59 years [range 33-90 years] [6] .Where as median age of manifestation is approximately 67 years for non mucinious Adenocarcinoma, Mucinous carcinoma and carcinoid. (ispub.com)
  • Specifically when in the adenoma-carcinoma sequence four specific colon cancer NMPs, previously described, appear. (nih.gov)
  • The precursor lesion appears as a discrete proximal colonic adenoma, which occasionally appears flat rather than polypoid. (vesalius.com)
  • Here we examine the levels of CCT subunits and other molecular chaperones in tumor tissues of patients with hepatocelluar and colonic carcinoma, and compare them with nontumor tissues in the same patients. (bioone.org)
  • Colonic resection is also advocated for patients with long-standing ulcerative colitis who have developed high-grade dysplasia or a dysplasia-associated lesion or mass (DALM). (medscape.com)
  • The histologic phenotype of the dysplastic lesion juxtaposing colorectal carcinomas was assessed in 100 consecutive colectomy specimens: in 50 patients with inflammatory bowel disease (IBD) and in 50 controls (non-IBD patients). (nih.gov)
  • He also popularized the colonic j-pouch for patients with rectal cancer. (wikipedia.org)
  • This is now the standard of care for patients with rectal carcinoma across the country and world. (wikipedia.org)
  • The specimens consisted of 40 predominantly early-stage adenomas from 7 patients with familial adenomatous polyposis, 40 adenomas (19 without associated foci of carcinoma and 21 with such foci) from 33 patients without familial polyposis, and 92 carcinomas resected from 89 patients. (nih.gov)
  • Under traditional perioperative treatment, lapararoscopic colonic resections show clinically relevant advantages in selected patients. (cochrane.org)
  • If the long-term oncological results of laparoscopic and conventional resection of colonic carcinoma show equivalent results, the laparoscopic approach should be preferred in patients suitable for this approach to colectomy. (cochrane.org)
  • Although their lesions are more commonly right-sided, clinically they present identically to patients with sporadic colon carcinomas. (vesalius.com)
  • Secondary carcinomas of the small bowel are as common as the primary carcinomas [5] . (ispub.com)
  • Final histological summation reported colonic metastasis to the left lobe of the thyroid. (hindawi.com)
  • Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. (biomedcentral.com)
  • In total, 133 cases of breast carcinoma treated with neo-adjuvant therapy were collected. (biomedcentral.com)
  • There was a significant correlation between the expression of TFF3 in breast carcinoma cells and response to neoadjuvant chemotherapy ( p = 0.0165). (biomedcentral.com)
  • There was significant co-expression of TFF3 with AKT1 ( p = 0.0365), BCl2 ( p = 0.0152), and NF Kappa-B ( p = 0.0243) in breast carcinoma cases with residual carcinoma following neoadjuvant therapy which support the role of TFF3 in chemoresistance. (biomedcentral.com)
  • The expression of TFF3 is significantly associated with residual breast carcinoma following neoadjuvant chemotherapy suggesting its expression is associated with increased resistance to chemotherapy. (biomedcentral.com)
  • BCl2, AKT1 and NF Kappa-B in residual breast carcinoma cells and very low proliferating index and apoptotic bodies in residual tumors. (biomedcentral.com)
  • Archival paraffin blocks of invasive breast carcinoma cases before and after neoadjuvant chemotherapy were obtained from the surgical pathology files in the anatomic pathology division at Tawam hospital in Al Ain city, which is the main oncology center in the UAE. (biomedcentral.com)
  • In total 133 paraffin blocks of core needle biopsies of invasive breast carcinoma before neoadjuvant chemotherapy and 133 paraffin blocks from mastectomy and lumpectomy specimens of similar cases after neoadjuvant chemotherapy were included in this study. (biomedcentral.com)
  • We present a very unique case of colon carcinoma metastasis to the right thyroid lobe and lung five years after colon resection, with reoccurrence two years later in the contralateral thyroid lobe. (hindawi.com)
  • Colorectal resection was most often required for colorectal carcinoma. (cochrane.org)
  • A literature search identified 34 reported cases of colon carcinoma metastasis to the thyroid. (hindawi.com)
  • The final pathological report suggested metastasis of colon carcinoma. (hindawi.com)
  • Urgent computed tomography of the abdomen and pelvis revealed a circumferential colonic tumour at the splenic flexure causing upstream bowel dilatation ( Figure 1 ) and a solid peritoneal nodule suspicious of metastasis ( Figure 2 ). (hkjr.org)
  • The full-thickness circumferential involvement of the colonic wall from the mucosa to serosa and the absence of adjacent peritoneal nodule were consistent with haematogenous metastasis to the colon. (hkjr.org)
  • The majority or 81.2% (31 out of 38) of the dysplastic lesions juxtaposing IBD carcinomas were villous or serrated AGs, but only 55.1% (16 out of 29) in control cases. (nih.gov)
  • Serrated AGs in particular accounted for nearly 29% of the non-invasive dysplastic lesions abutting IBD carcinomas but only for 3% in control specimens. (nih.gov)
  • It would appear that villous and serrated AGs are the most common non-invasive neoplastic lesions from which IBD carcinomas originate. (nih.gov)
  • Because most colorectal carcinomas appear to arise from adenomas, studies of different stages of colorectal neoplasia may shed light on the genetic alterations involved in tumor progression. (nih.gov)
  • In fact, dense cytoplasmic immunostaining for MUC1 can be used as a diagnostic tool, because such staining is not usually seen in normal or preinvasive neoplasia or other carcinoma types in this region. (bmj.com)
  • This report presents a clinical case of a 68-year-old male with a previous diagnosis of non-microcytic lung carcinoma (T4, N2, M1), stage IV, who presented rectorrhagia at the emergency. (gastrores.org)
  • He was diagnosed with non-microcytic cell carcinoma of the lung (TNM: T4, N2, M1), stage IV since February 2012. (gastrores.org)
  • The squamous cell carcinomas (SCCs) of the head and neck commonly metastasize to the lung, bone and liver in descending order. (wjon.org)
  • Molecular alterations of cellular proteins were assessed in three previously described subpopulations of human colon carcinoma cells that were originally isolated from a single human primary colon carcinoma. (nebraska.edu)
  • We found that ras-gene mutations occurred in 58 percent of adenomas larger than 1 cm and in 47 percent of carcinomas. (nih.gov)
  • Tumors from ApcMin/+ mice exposed to F. nucleatum exhibit a proinflammatory expression signature that is shared with human fusobacteria-positive colorectal carcinomas. (bigthink.com)
  • 19. Upper urinary tract urothelial cell carcinomas and other urological malignancies involved in the hereditary nonpolyposis colorectal cancer (lynch syndrome) tumor spectrum. (nih.gov)
  • The aim of this study was to analyze the expression, biological role and clinical relevance of cancer stem cell markers in high-grade serous carcinoma (HGSC). (cancerindex.org)
  • Human COLORECTAL CARCINOMA cell line. (bvsalud.org)
  • Carcinoma, Signet Ring Cell. (rmmg.org)
  • This unique case is presented and the published literature of colonic carcinoma metastasized to the thyroid is reviewed. (hindawi.com)
  • IL cisapride produced a dose-dependent response in the dose range 1 × 10 -9 M to 3 × 10 -1 & l-3 × 10 -7 M in the ileum, and 3 × 10 -11 to 3 × 10 -9 M in the colonic segments, IL cisapride was significantly more effective than IA delivery of equivalent doses. (annals.edu.sg)
  • IL instilled mebeverine (1 × 10 -6 M) inhibited the carbachol dose response of the ileal and colonic segments more than an equivalent dose of mebeverine infused IA. (annals.edu.sg)
  • MUC1 appears to be a marker of aggressive phenotype and may facilitate the vascular spread of carcinoma cells. (bmj.com)
  • Adjuvant chemoradiotherapy was administrated postoperatively and included FOLFIRI (5-FU, leucovorin and irinotecan) as well as pelvic radiation due to positive colonic margins. (hindawi.com)