The colonic mucosa is studded with innumerable sessile and small pedunculated polyps, which involve the entire length of the specimen. (medscape.com)
Risk stratification of colon carcinogenesis through enhanced backscattering spectroscopy analysis of the uninvolved colonic mucosa. (nih.gov)
Goblet cell hyperplasia is the little-recognized initial pathologic lesion of sporadic colorectal cancer, referred to as transitional mucosa, aberrant crypt foci, goblet cell hyperplastic polyps or transitional polyps. (biomedcentral.com)
Resistant starch supplementation increases crypt cell proliferative state in the rectal mucosa of older healthy participants. (quadram.ac.uk)
Calcium butyrate directly applied to the mucosa of the rat colon was able to ameliorate colonic inflammation, suggesting a possible beneficial role in the treatment of inflammatory colon diseases. (unict.it)
In normal patients' colonic mucosa, phagocytic cells do not respond to the resident bacteria. (medscape.com)
Lesions6
Further metabolism by colonic bacteria that produce β-glucuronidase generates methyldiazonium, which can initiate cancer by inducing mutagenic lesions in target cells by the alkylation of DNA at the O6 position of guanine 17 . (scialert.net)
E171 or NM-105 for one week did not initiate intestinal inflammation, while a 100-day E171 treatment promoted colon microinflammation and initiated preneoplastic lesions while also fostering the growth of aberrant crypt foci in a chemically induced carcinogenesis model. (nature.com)
The results suggest that PPE can partially inhibit the development of colonic premalignant lesions in an AOM-induced colorectal carcinogenesis model, by abrogating oxidative stress and improving the redox status of colonic cells. (elsevierpure.com)
In conclusion, findings indicate that AP feeding reduced acute colonic damage after DMH, resulting in fewer preneoplastic lesions. (ugr.es)
Based on our recent silibinin efficacy studies in human colorectal cancer cells, we investigated the effects of its dietary feeding on azoxymethane (AOM)-induced aberrant crypt foci (ACF) formation and associated biomarkers in male Fisher 344 rats. (nih.gov)
This study was conducted to investigate the chemopreventive potential of camel ( Camelus dromedarius ) and bovine milk as well as the impact of fermenting these milks with Lactobacillus acidophilus and Streptococcus thermophilus against early colon carcinogenesis as measured by the reduction of aberrant crypt foci (ACF) in azoxymethane (AOM)-treated Fischer 344 rats. (scialert.net)
In the azoxymethane-treated rat, when compared with saline-treated controls, significant changes in the enhanced backscattering markers were observed as early as 2 weeks after azoxymethane treatment (before the development of aberrant crypt foci and adenomas). (nih.gov)
Epidermal growth factor receptor is required for colonic tumor promotion by dietary fat in the azoxymethane/dextran sulfate sodium model: roles of transforming growth factor-{alpha} and PTGS2. (uchicago.edu)
Epidermal growth factor receptor signaling is required for microadenoma formation in the mouse azoxymethane model of colonic carcinogenesis. (uchicago.edu)
Ursodeoxycholic acid and F(6)-D(3) inhibit aberrant crypt proliferation in the rat azoxymethane model of colon cancer: roles of cyclin D1 and E-cadherin. (uchicago.edu)
The anti-inflammatory activity of calcium butyrate was evaluated in dinitrobenzene sulfonic acid-induced colitis in rats, following intracolonic instillation for 6 consecutive days and its in vivo antitumor activity was evaluated in F344 rats with the azoxymethane (AOM)-induced aberrant crypt foci (AFC) test, following intracolonic instillation for 4 weeks. (unict.it)
Polyps11
However, because colonic polyps are highly prevalent in the general population (especially with increasing age), they confer an important predisposition to colon cancer and are therefore removed when detected. (medscape.com)
Occult blood in stools (detected by guaiac and antibody-based tests) may be found in a minority of patients with colonic polyps. (medscape.com)
A stool occult blood test can detect a proportion (20%-40%) of colonic polyps that are larger than 10 mm in diameter, but this test also suggests the presence of other causes of gastrointestinal blood loss. (medscape.com)
Flexible sigmoidoscopy is a good screening test for colonic polyps and is the only procedure or imaging modality to be validated by studies that document a decrease in colorectal cancer mortality. (medscape.com)
Colonoscopy is the preferred test to detect colonic polyps, obtain biopsies, and/or perform endoscopic resection. (medscape.com)
Surgical resection may be advocated for large, sessile polyps that are difficult to remove endoscopically or for advanced colonic polyps that recur despite adequate initial endoscopic treatment. (medscape.com)
Patients with isolated colonic polyps are usually asymptomatic but can experience overt or occult colonic bleeding. (medscape.com)
Colonic polyps can occur as part of inherited polyposis syndromes in which their number is greater and the risk for malignant progression is much higher compared to the risk associated with isolated colonic polyps. (medscape.com)
Ulcerative colitis4
Colonic resection is also advocated for patients with long-standing ulcerative colitis who have developed high-grade dysplasia or a dysplasia-associated lesion or mass (DALM). (medscape.com)
In this context, overproduction of nitric oxide (NO) attributable to inflammatory stimuli in diseases such as ulcerative colitis and Crohn's disease may contribute to colonic carcinogenesis. (aacrjournals.org)
Colorectal cancer is a complication of ulcerative colitis and colonic Crohn's disease, the two main forms of idiopathic inflammatory bowel disease (IIBD). (biomedcentral.com)
One theory proposes that ulcerative colitis occurs as a direct result of an aberrant immune response to "gut luminal antigen" in a genetically susceptible host. (medscape.com)
Colon cancer2
SUMMARY: Consumption of sambar significantly reduced aberrant crypt foci in DMH-induced colon cancer modelSambar treatment prevented DMH-induced oxidative changes in the colonic tissue, indicating its antioxidant roleSambar comprises a variety of spices that exhibited both pro- and antioxidant properties in different tissues, leading to its overall beneficial effect in this model. (manipal.edu)
The actual goblet cell hyperplasia, simply an increase in the number of goblet cells lining the colonic crypts. (biomedcentral.com)
Biopsies1
Design We performed whole-genome transcriptional analysis of colonic biopsies from patients with histologically active and inactive UC, and non-inflammatory bowel disease (non-IBD) controls. (bmj.com)
Proliferation3
Silibinin dose-dependently decreased AOM-induced colonic cell proliferation, evidenced by proliferative cell nuclear antigen and cyclin D1 immunohistochemical staining, and induced apoptosis in these colon tissues, evidenced by terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling staining and cleaved poly(ADP-ribose) polymerase. (nih.gov)
2012: p53 gene mutation increases hPG80-dependent colonic proliferation and cancer formation. (wikipedia.org)
Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
Inhibition1
1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
Significantly2
Oral doses of 80 and 160 mg/kg body weight of propolis or 10mg/kg of artepillin C (equi-amounts to 160 mg propolis) reduced significantly the frequency of colonic aberrant crypt foci (ACF) by 39.2, 43.7 and 43.4%, respectively. (propolisscience.org)
Both AP treatments (G2-G3) significantly decreased the DMH-induced increase in γ-H2AX (DNA damage) and caspase 3 (DNA damage-induced cell death) in colonic crypts at week 4. (ugr.es)
Intestinal1
Furthermore, DBZ treatment induces a heterogeneous reorganization of the crypt structural-proliferative units along the intestinal tract and of the stem cell niche in the colon, without disturbing the apoptotic compartment. (biologists.com)
Inflammation1
Intraperitoneal or intrarectal treatment of mice with CBD led to improvement of colonic inflammation induced by trinitrobenzene sulfonic acid. (lavvan.com)
Oxidative1
In addition, PPE blocked the AOM-induced impairment of biochemical indicators of oxidative stress in the examined colonic tissue homogenates. (elsevierpure.com)
Neoplastic1
Most epidemiological and experimental studies conducted to determine the effects of milk and dairy product consumption on neoplastic development have focused on bovine milk 5 - 8 , whereas information on camel milk and other types of milk are scarce. (scialert.net)
Induction2
Artepillin C is considered to suppress the formation of colonic ACF through the activation of ARE and induction of phase II enzymes in liver. (propolisscience.org)
Smith T, Mithen R, Johnson IT (2003) Effects of Brassica vegetable juice on the induction of apoptosis and aberrant crypt foci in rat colonic mucosal crypts in vivo . (quadram.ac.uk)
Treatment1
RESULTS: All the treatment groups exhibited a significant change in the number of aberrant crypt foci (ACF). (manipal.edu)
Model1
A vitamin D analogue inhibits colonic carcinogenesis in the AOM/DSS model. (uchicago.edu)
Analysis1
Some animals were euthanised after the last DMH injection (week 4) for histological, immunohistochemical (Ki-67, γ-H2AX and caspase-3) and molecular analyses (real time-PCR for 91 genes), while other animals were euthanised at week 12 for preneoplastic aberrant crypt foci (ACF) analysis. (ugr.es)
Growth1
Epidermal growth factor receptor signaling is up-regulated in human colonic aberrant crypt foci. (uchicago.edu)
Normal2
The crypts lined by hyperplastic goblet cells are either longer and wider or shorter and wider than normal. (biomedcentral.com)
Sambar group showed a significant change in the colonic GSH when compared to both normal and DMH groups. (manipal.edu)
Group1
The results revealed a lower incidence of aberrant crypt foci in the PPE plus AOM administered group as compared to the AOM group. (elsevierpure.com)
Cells2
1991. Control of 1,2-dimethylhydrazine-induced crypt hyperplasia by naturalkiller cells and its relevance to carcinogenics. (cdc.gov)
One can see crypt branching and irregularity of size and shape, with an increase in chronic inflammatory cells in the lamina propria. (medscape.com)
Suggest1
These findings suggest that gut microbiota play a critical role in mediating colitis disease activity and anxiety-like behaviors via aberrant neural processing within the gut-brain axis. (biomedcentral.com)
Application1
However, little is known regarding its effects following direct application on the colonic surface. (unict.it)
Main1
As a clinical researcher, my main focus is on finding improved therapies for autoimmune and cholestatic liver diseases, since an ideal therapy currently does not exist. (stanfordchildrens.org)
Groups1
We conducted four focus groups and 30 telephone interviews with 63 people. (edu.au)