• [ 1 ] Early stage head and neck squamous cell carcinoma (HNSCC) is treated relatively well with single-modality therapy (either surgery or radiation alone). (medscape.com)
  • Go to Imaging of Nasopharyngeal and Laryngeal Squamous Cell Carcinoma and Head and Neck Squamous Cell Carcinoma for complete information on these topics. (medscape.com)
  • Notably, many lncRNAs dysregulation are associated with Oral squamous cell carcinoma (OSCC) and affect various aspects of cellular homeostasis, including proliferation, survival, migration or genomic stability. (biomedcentral.com)
  • Overexpression of LINC00673 promotes invasion and metastasis which associated with a poor prognosis in tongue squamous cell carcinoma [ 6 ] . (jcancer.org)
  • This cancer is divided into two types: (1) squamous cell carcinoma, which appears in the middle or top of the esophagus and (2) adenocarcinoma, seen in the glandular cells of the esophagus [ 1 ]. (hindawi.com)
  • However, its role in the development and metastasis of tongue squamous cell carcinoma (TSCC) remains unclear. (oncotarget.com)
  • This activity can be observed in both populations of conventional NK and NKT cells in vitro and in athymic nude mice in vivo. (houstonmethodist.org)
  • In vivo T-cell depletion in both the primary tumor treatment and the long-term survival rechallenge study reveals that T cells in addition to NK cells are required in the development of the long-term survival and immunity attributed to Adv.mIL-12 gene therapy in this orthotopic tumor model of colon carcinoma. (houstonmethodist.org)
  • We used a prototype of an in vivo BT-MRI apparatus to visualise organs and tumors and to analyse tumor progression in nude mouse xenograft models of human testicular germ cell tumor and colon carcinoma. (biomedcentral.com)
  • The antitumor activity and survival analysis of VALD-3 in vivo was determined by the nude mice xenograft assay. (researchsquare.com)
  • For the in vivo assay, for each cell line, each experimental group consisted of 6 mice injected subcutaneously with control cells on the right flank, and cells treated with cyclopamine or GLI1 siRNA on the left flank. (scholars.direct)
  • To ascertain whether or not OSW-1 is as effective in vivo, a nude mouse model inoculated by LoVo cells is adopted, in which OSW-1 treatment is performed when tumors became palpable. (medchemexpress.com)
  • Finally, the inhibitory effect of the combined chidamide and bortezomib treatment on MGC-803 cells was verified in vivo through tumor formation experiments in nude mice. (dovepress.com)
  • The effects of the low-dose chidamide and bortezomib combination reduced the growth on gastric cancer in vivo were investigated by using a subcutaneous tumor mouse model. (dovepress.com)
  • An in vivo investigation in nude mice was done to assess the anti-tumor activity of L. rhamnosus supernatant and whole-cell culture. (hindawi.com)
  • Scientific Methods: In vitro growth inhibition assays were completed with AHCC alone and in combination with PLD in panel of human cancer cell lines and findings confirmed in vivo in an ovarian cancer xenograft mouse model. (researchgate.net)
  • BT-MRI provides satisfactory image quality to visualize organs and tumors and to monitor tumor progression and structure in mouse models. (biomedcentral.com)
  • Nude mouse xenograft models of different human tumors were used to test the suitability of the new BT-MRI system for visualisation of organs and tumors and for quantification of tumor progression. (biomedcentral.com)
  • The uptake and retention in the tumor of 111 In-/ 125 I-labeled bivalent peptides ( l -a.a. peptide and d -a.a. peptide) were studied in female BALB/c athymic mice with subcutaneous SK-RC-52 RCC tumors. (snmjournals.org)
  • Tumors were pretargeted with the bispecific monoclonal antibody (bs-mAb) G250xDTIn-1 and, 72 h later, mice were injected intravenously with one of both radiolabeled peptides. (snmjournals.org)
  • Although this most common gynecologic cancer carries the best prognosis, it is important to differentiate between the classic endometrioid tumors that tend to be estrogen dependent and well differentiated, from other less common high-risk uterine malignancies, such as uterine papillary serous carcinomas (UPSCs), clear cell carcinomas, mixed mullerian tumors (MMTs), or sarcomas, which appear to have a different biology. (medmuv.com)
  • Mutation of the transforming growth factor (TGF) beta receptor type II gene is common in RER+ colon and gastric cancers, but uncommon in RER+ endometrial cancers even those arising in HNPCC kindreds, suggesting that the genesis of RER+ tumors even within the same familial cancer syndrome is not the same. (medmuv.com)
  • Although inactivation of both alleles of either hMSH2 or MLH1 (DNA mismatch repair genes) appears to underlie microsatellite instability in tumors of HNPCC kindreds, similar to the findings in sporadic colon cancers, sporadic endometrial cancers were not associated with mutations of any of the four known human mismatch repair genes. (medmuv.com)
  • cells were described to induce tumors in athymic mice and to synthesize lecithin. (maayanlab.cloud)
  • The results show that the size of tumors in treated mice is smaller on average than control mice. (medchemexpress.com)
  • Pomegranate extract reduced the number and size of experimentally induced colon tumors in animal subjects. (superfoods-scientific-research.com)
  • Photocarcinogenesis in hairless mice induced tumors harbors more UVA than UVB fingerprint by ultraviolet A tanning devices with or without mutations: A role for UVA in human skin car- subsequent solar-simulated ultraviolet irradia- cinogenesis. (who.int)
  • A human colon carcinoma cell line, designated GEO, is marginally responsive to TGFβ and expresses a low level of RI mRNA relative to colon carcinoma cells, which are highly responsive to TGFβ. (nebraska.edu)
  • Tumorigenicity in athymic nude mice was significantly delayed in RI-transfected cells. (nebraska.edu)
  • Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • We also discovered that the invasiveness of metastatic colon cancer cells was alleviated following drug treatment. (spandidos-publications.com)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • In recent years, we focused on investigating the anti-carcinogenic properties of total Astragalus saponins (AST) in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • Augmented expression of FJX1 in colon cancer cells promotes growth of xenografts in athymic mice and is associated with increased tumor cell proliferation and vascularization. (nih.gov)
  • One of 3 strains of malignant cells isolated from a male with colonic carcinoma. (xlbiotec.com)
  • Cells are tumourigenic in nude mice and form colonies on agarose. (xlbiotec.com)
  • By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
  • While no mutations were found in the exons of the DCC gene in endometrial cancers, chromosome 18 was found to be capable of suppressing tumorigenicity of endometrial cancer cells in nude mice by the procedure of microcell fusion, with DCC expression elevated in most of the suppressed hybrids. (medmuv.com)
  • OSW-1 has a strong inhibitory effect on colon carcinoma cells with low cytotoxicity on normal cells. (medchemexpress.com)
  • The anti-proliferative effects of OSW-1 on SW480 and LoVo colon carcinoma cells are characterized by measuring cell viability using the CCK8 assay, and compared the results with other clinical anticancer agents. (medchemexpress.com)
  • Elvira GM, Chandra S, Marco Vinicio RM, Wenyi W (2006) Catalytic inhibition of human DNA topoisomerase by phenolic compounds in Ardisia compressa extracts and their effect on human colon cancer cells. (springer.com)
  • Nude mice were subcutaneously or intramuscularly implanted with luciferase-expressing murine 1029H or human KRIB osteosarcoma cells. (biomedcentral.com)
  • Mice that had been inoculated with human prostate cancer cells received a four week therapy of pomegranate extract. (superfoods-scientific-research.com)
  • In the lab, pomegranate juice inhibited the proliferation and increased programmed cell death of human colon cancer cells. (superfoods-scientific-research.com)
  • Methods: We have not only analyzed the database using GEO, but have examined the effect of KIF18A on the development of CRC by subcutaneous tumorigenesis in nude mice. (aging-us.com)
  • The results of subcutaneous tumorigenesis and HE staining in nude mice explained that KIF18A promoted the progression of CRC. (aging-us.com)
  • LINC00673 overexpression inhibited caner progression in nude mice. (jcancer.org)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • SW480 and LoVo cell lines are derived from a Dukes' stage B colon carcinoma and a colon carcinoma metastatic nodule, which represent non-metastatic and metastatic carcinomas, respectively. (medchemexpress.com)
  • Aberrant (upregulated) expression of the MUC1 mucin has been seen in breast carcinomas and other neoplasms, such as colon and pancreatic cancers. (bmj.com)
  • Suppressive effects of vascular endothelial growth factor-B on tumor growth in a mouse model of pancreatic neuroendocrine tumorigenesis. (emanresearch.org)
  • The replication error (RER+) phenotype is characteristic of cancers arising in HNPCC kindreds (a familial cancer syndrome with a high incidence of colon, endometrial, gastric, and a lower incidence of ovarian and pancreatic cancers), and is also found in approximately 20% of sporadic endometrial cancers. (medmuv.com)
  • MMPs have been implicated in these processes and a previous study has suggested that the plasma level of MMP-2 and MMP-9 may be viewed as a non-invasive indicator of invasiveness and metastasis in colon cancer ( 3 ). (spandidos-publications.com)
  • Previous studies have reported that LINC00673 can promote epithelial-mesenchymal transition (EMT), proliferation and metastasis in thyroid carcinoma [ 5 ] . (jcancer.org)
  • Furthermore, FJX1 null mice develop significantly fewer colonic polyps than wild-type littermates after combined dextran sodium sulfate (DSS) and azoxymethane (AOM) treatment. (nih.gov)
  • METHODS: An Atp8a1 knockout mouse model was employed, from which the HSC (long-term HSCs and short-term HSCs) population was analyzed to assess their abundance and function. (bvsalud.org)
  • We have used stroma-rich models in immunodeficient mice, which recapitulate the histotypic arrangement found in human epithelial cancers. (aacrjournals.org)
  • Several studies have reported conflicting and inconclusive results concerning the clinical relevance of mucin expression in gastric carcinoma. (bmj.com)
  • This study investigated the correlations between aberrant expression of mucins in gastric carcinoma and patient clinicopathological features. (bmj.com)
  • The expression of MUC1, MUC2, MUC3, MUC5AC, and MUC6 was investigated immunohistochemically in gastric carcinoma (n = 46) in relation to patient clinicopathological features. (bmj.com)
  • Membrane bound mucins MUC1 and MUC3 appear to be associated with the development of gastric carcinoma. (bmj.com)
  • In our previous study, intratumoral transfer of Adv.mIL-12 (5 x 10 8 pfu) to the MCA26 colon carcinoma liver tumor induced an effective anti-tumor response, extending the median survival time from 29 to over 54 days, while 25% of the animals became tumor-free after a single treatment. (houstonmethodist.org)
  • Chromosome 17p is frequently involved, which contains the p53 gene known to confer a poor prognosis in endometrial cancers when mutated or deleted, and which plays an important role in the transition to carcinoma from atypical hyperplasia. (medmuv.com)
  • Kirsten (Ki)-ras activating point mutations in codons 12 and 13 have been implicated in the development of atypical endometrial hyperplasias and endometrioid carcinomas in Japanese women, as well as in colon cancers. (medmuv.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • A novel antibody-maytansinoid conjugate, monoclonal antibody (mAb) FAP5-DM1, was developed to target a shared epitope of human, mouse, and cynomolgus monkey fibroblast activation protein-α, enabling preclinical efficacy and tolerability assessments. (aacrjournals.org)
  • Chromosome 18q contains the DCC gene, a putative tumor suppressor gene frequently mutated in colon cancers. (medmuv.com)
  • It was noted that in clinical samples of breast cancer, ALDH + accounted for 39.4% in samples of BLBC, and similar results were obtained in studies on breast cancer cell lines [ 7 ] , while lower expression was observed in intraductal carcinoma and luminal type with better prognosis [ 8 ] . (ijbs.com)
  • 1, 2 Most studies of MUC1 expression in breast carcinomas have shown that increased membrane MUC1 mucin expression on the apical cell surface is associated with a better prognosis (reviewed in Rahn and colleagues 2 ), whereas circumferential staining in tumour cell cytoplasm is associated with a worse prognosis. (bmj.com)
  • We treated carcinoma-bearing mice with Vehicle, CTX, IL-2 and CTX + IL-2 to investigate the effects of low-dose CTX combined with IL-2 in antitumor treatment. (bvsalud.org)
  • derived from a human prostate carcinoma xenograft (CWR22R) that was serially propagated in nude mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft. (maayanlab.cloud)
  • The effect of bs-mAb-diDTPA-bs-mAb (DTPA is diethylenetriaminepentaacetic acid) bridging at the tumor cell surface on the internalization of the bs-mAb-diDTPA complex was investigated in SK-RC-52 tumor-bearing mice. (snmjournals.org)
  • In cancer conditions, the increase of RAGE ligands levels leads to hyperstimulation of the receptor translating into systemic inflammation and muscle wasting, and reducing mouse survival (4). (unipg.it)
  • Diet-induced irritation and flaws in blood sugar metabolism had been attenuated in IL-6 knockout mice implicating the function of IL-6 in obesity-associated cardiac irritation. (cancer-ecosystem.com)
  • Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. (oncotarget.com)
  • Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. (uky.edu)
  • In previous studies we have shown that with this strategy relatively high uptake of the 111 In label in various RCC mouse models can be achieved (maximum uptake from 54.1 to 287 %ID/g) (%ID/g is percentage injected dose per gram) ( 11 ). (snmjournals.org)
  • Our latest study (7) discovered that chronic high-fat nourishing impairs myocardial blood sugar metabolism which was connected with ventricular hypertrophy and cardiac dysfunction in obese mice. (cancer-ecosystem.com)
  • IL-6 reduces blood sugar fat burning capacity by suppressing AMPK and insulin PTK787 2HCl receptor substrate (IRS)-linked insulin signaling in center whereas IL-6-deficient mice are covered from diet-induced modifications in blood sugar metabolism. (cancer-ecosystem.com)
  • The reduction in tumor volume as well as pro-apoptotic and anti-proliferative effects in HT-29 nude mice xenograft are comparable to those produced by 5-FU. (spandidos-publications.com)
  • These data indicate that AST may be an effective chemotherapeutic agent in colon cancer treatment, and may also be used as an adjuvant in combination with other orthodox chemotherapeutic drugs to reduce the side-effects of the latter compounds. (spandidos-publications.com)
  • It was the aim of the current study to explore the potential of BT-MRI on tumor models in mice. (biomedcentral.com)