• Immunohistochemical analysis of paraffin-embedded human squamous cell lung carcinoma using Btk (D3H5) Rabbit mAb performed on the Leica ® Bond ™ Rx. (cellsignal.com)
  • Cancer Lett, 300:215-224.doi:10.1016/j. squamous cell carcinoma in north-eastern Iran. (who.int)
  • The most common cancers reported in Bloom syndrome include lymphomas, leukemia, oral/esophageal squamous cell carcinoma, and adenocarcinoma of the sigmoid colon. (medscape.com)
  • Zdenka is investigating the role of WNT5A signaling in Oral Squamous cell Carcinoma. (lu.se)
  • E6 and Metabolic syndrome and risks of colon and rectal renal cell carcinoma. (who.int)
  • Sarcomatoid conversion of clear cell renal cell carcinoma in relation to epithelial-to-mesenchymal transition. (lu.se)
  • Approximately 8% of clear cell renal cell carcinoma cases contain regions of radically different morphology, demonstrating a mesenchymal appearance histologically resembling sarcomas. (lu.se)
  • These biphasic neoplasms are called sarcomatoid clear cell renal cell carcinoma. (lu.se)
  • Patients diagnosed with sarcomatoid clear cell renal cell carcinoma face a considerably worse prognosis due to an increased propensity for metastasis. (lu.se)
  • In the present study we investigate whether the sarcomatoid conversion of clear cell renal cell carcinoma could be interpreted as linked to the process of epithelial-mesenchymal transition. (lu.se)
  • Using 6 biphasic clear cell renal cell carcinoma cases we show that sarcomatoid clear cell renal cell carcinoma shares characteristic markers associated with loss of von Hippel-Lindau tumor suppressor with conventional clear cell renal cell carcinoma and also exhibits a markedly higher proliferative index. (lu.se)
  • Furthermore the sarcomatoid elements demonstrate an enhanced expression of epithelial-mesenchymal transition related mesenchymal markers as compared with the clear cell renal cell carcinoma counterparts. (lu.se)
  • We further selected a representative case, clinically demonstrating direct overgrowth of the sarcomatoid component into the liver and colon, for extended immunohistochemical characterization, resulting in a further set of positive and negative epithelial-mesenchymal transition markers as well as pronounced transforming growth factor β positivity, indicating that sarcomatoid clear cell renal cell carcinoma may be associated to epithelial-mesenchymal transition. (lu.se)
  • Transforming growth factor β1 exposure of in vitro cultured primary clear cell renal cell carcinoma cells resulted in cells adopting a mesenchymal morphology similar to sarcomatoid clear cell renal cell carcinoma. (lu.se)
  • We therefore suggest that sarcomatoid clear cell renal cell carcinoma morphologically and immunohistochemically may represent a completed epithelial-mesenchymal transition and that transforming growth factor β1 could be an important driving force during the sarcomatoid transdifferentiation of clear cell renal cell carcinoma. (lu.se)
  • English The short-chain fatty acid butyrate plays an essential role in colonic mucosa homeostasis through the capacity to block the cell cycle, regulate differentiation and to induce apoptosis. (unifr.ch)
  • Recent studies show that the human parathyroid calcium sensing receptor (CaSR) is expressed in human colon epithelium and functions to regulate epithelial proliferation and differentiation. (aacrjournals.org)
  • Both agents concomitantly induced a series of changes in the CBS cells that influence proliferation and differentiation, but cellular responses to the two agents were not identical. (aacrjournals.org)
  • It is concluded that CaSR may function in the colon to regulate epithelial differentiation and that loss of CaSR expression may be associated with abnormal differentiation and/or malignant progression. (aacrjournals.org)
  • GEP-NENs are subdivided according to their differentiation into well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs). (karger.com)
  • Cell Death and Differentiation. (monash.edu)
  • Changes in Telomerase Activity, Expression and Splicing in Response to Differentiation of Normal and Carcinoma Colon Cells. (muni.cz)
  • Beta-catenin helps control the activity (expression) of particular genes and promotes the growth and division (proliferation) of cells and the process by which cells mature to carry out specific functions (differentiation). (medlineplus.gov)
  • In vivo T-cell depletion in both the primary tumor treatment and the long-term survival rechallenge study reveals that T cells in addition to NK cells are required in the development of the long-term survival and immunity attributed to Adv.mIL-12 gene therapy in this orthotopic tumor model of colon carcinoma. (houstonmethodist.org)
  • Olsson PO, Kalamajski S, Maccarana M, Oldberg Å, Rubin K. Fibromodulin deficiency reduces collagen structural network but not glycosaminoglycan content in a syngeneic model of colon carcinoma. (lu.se)
  • In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. (oncotarget.com)
  • For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
  • Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
  • CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
  • Moreover, mitochondria control cell death through apoptosis and supply Ca 2+ and metabolites required for cellular homeodynamics [ 3 ]. (hindawi.com)
  • Hepatocellular Carcinomas from Iran: Evidence study of lung cancer among European asphalt carcinoma among postmenopausal women in the for Lack of Association between HBV Genotype workers. (who.int)
  • Conjugation of glucose with metabolic agents to selectively target cancer cells was inspired by the widespread use of radiolabeled glucose analog to visualize tumors and their metastases. (oncotarget.com)
  • CaSR expression was weak in colon carcinomas with a more-differentiated histologic pattern, whereas CaSR expression was undetectable in less-differentiated tumors. (aacrjournals.org)
  • Such tumor-specific T RM cells are recognized as both necessary and sufficient for long-lived protection against tumors in peripheral tissue locations. (frontiersin.org)
  • Cancer can be considered a disease of immune dysfunction, with a failure of immune recognition leading to the outgrowth of malignant cells as tumors ( 1 ). (frontiersin.org)
  • Following effective priming in lymph nodes, T cells traffic to tumors and other peripheral tissues. (frontiersin.org)
  • In a growing number of cases, CD8 T cells have been shown to mediate the regression of large bulky tumors, resulting in durable long-term disease remissions ( 5 ). (frontiersin.org)
  • To investigate the effect of hyperglycemia on anti-tumor function induced by anti-PD-1 antibody treatment, we treated STZ-induced diabetic mice with subcutaneous MC38 colon carcinoma tumors with anti-PD-1 antibody, and examined changes in tumor growth, the number of tumor-infiltrating immune cells, and the expression of chemokines and chemokine receptors. (nature.com)
  • The myofibroblast is the cell considered to be responsible for the development of desmoid tumors (see Procedures). (medscape.com)
  • Although APC -related desmoid tumors are commonly associated with a form of colon cancer called familial adenomatous polyposis (described below), APC gene mutations can cause tumors in individuals without this inherited disease. (medlineplus.gov)
  • Excess beta-catenin promotes uncontrolled growth and division of cells, allowing the formation of desmoid tumors. (medlineplus.gov)
  • Calretinin ( CALB2 ) is a member of the EF-hand family of Ca²⁺-binding proteins and is expressed in a majority of poorly differentiated colon carcinoma and additionally in mesothelioma of the epithelioid and mixed type. (unifr.ch)
  • Cell proliferation studies were performed by MTT assays and cell cycle analyses were performed by flow cytometry. (biomedcentral.com)
  • TGFβ 1 neutralizing antibody stimulated the proliferation of RI-transfected cells but had little effect on GEO control cells, indicating that increased autocrine-negative TGFβ activity also resulted from increased RI expression. (nebraska.edu)
  • Furthermore, we show that the ligands Wnt5a/b are upstream regulators of the non-canonical signature and moreover regulate proliferation of cancer cells in a β-catenin-independent manner. (nature.com)
  • Our experiments indicate that colon cancer cells are dependent on both β-catenin-dependent and -independent Wnt signaling routes for growth and proliferation. (nature.com)
  • CD326 functions as a homotypic calcium-independent cell adhesion molecule and is believed to be involved in carcinogenesis by its ability to induce genes involved in cellular metabolism and proliferation. (biolegend.com)
  • Two retrospective studies from Israel 12 and Japan 13 recently reported that diabetes was negatively correlated to overall survival in patients with non-small cell lung cancer (NSCLC) treated with ICIs. (nature.com)
  • [ 1 ] Pulmonary lymphangitic carcinomatosis (PLC) is the spread of tumor to the lymphatic system of the lungs, and primary lesions commonly associated with pulmonary lymphangitic carcinomatosis include breast, stomach, lung, pancreas, colon, stomach, and prostate. (medscape.com)
  • This cell surface glycosylated 40 kD protein is highly expressed in bone marrow, colon, lung, and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin. (biolegend.com)
  • No significant differences were found in the survival from tumours largely refractive to therapy, e.g., carcinomas of the pancreas, lung and liver. (who.int)
  • To induce hyperglycemia, mice were intraperitoneally injected with STZ, which can damage pancreatic β cells resulting in the development of insulin dependent diabetes, a model of type 1 diabetes mellitus (T1DM). (nature.com)
  • Here we report a severe life-threatening complication of treatment with streptozotocin in a patient with pancreatic island-cell carcinoma. (cancerindex.org)
  • This report describes the results of a study on the antiproliferative activity of the morpholine-based ligand 1,3-bis(1-morpholinothiocarbonyl)benzene (HL) and its nickel(II) complex (NiL) against human breast cancer cells (MCF-7), colon carcinoma cells (C26), and normal fibroblast NIH-3T3 cells. (ac.ir)
  • A human colon carcinoma cell line, designated GEO, is marginally responsive to TGFβ and expresses a low level of RI mRNA relative to colon carcinoma cells, which are highly responsive to TGFβ. (nebraska.edu)
  • Additionally, saikosaponins A and D inhibited mRNA expression of parathyroid hormone-related protein as well as cell viability and invasion in metastatic human breast cancer cells. (hindawi.com)
  • mRNA expression levels of CXCL9, a chemokine recruiting CD8 + T cells, were lower in dLNs of STZ-mice than in normoglycemic mice after PD-1-Ab treatment, and its protein was expressed in DCs. (nature.com)
  • In MC38 cells cultured with 25 mM glucose, mRNA expression of CCL7, a chemokine recruiting DCs, was decreased compared to cells cultured with 5 mM glucose. (nature.com)
  • mRNA microarray analyses of A549, PC14, and PC14CDDP cells that were transiently transfected with either pre-miR-197 or LNA-miR-197 and their controls. (nih.gov)
  • Differential splicing of hTERT mRNA may be involved in faster loss of telomerase activity in normal cells with respect to malignant cells. (muni.cz)
  • Chung TH, Wu SH, Yao M, Lu CW, Lin YS, Hung Y, Mou CY, Chen YC, Huang DM (2007) The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles 3T3-L1 cells and human mesenchymal stem cells. (springer.com)
  • Elvira GM, Chandra S, Marco Vinicio RM, Wenyi W (2006) Catalytic inhibition of human DNA topoisomerase by phenolic compounds in Ardisia compressa extracts and their effect on human colon cancer cells. (springer.com)
  • Since CALB2 is one of the genes negatively regulated by butyrate in colon cancer cells and butyrate decreases calretinin protein expression levels in those cells, we investigated whether expression is regulated via putative butyrate-responsive elements (BRE) in the human CALB2 promoter. (unifr.ch)
  • Synthesis and biological evaluation of new 3(2)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells. (amrita.edu)
  • We found that Ca 2+ and/or 1,25(OH) 2 D 3 stimulated CaSR promoter activity and CaSR protein expression in the human colon carcinoma CBS cells, which possessed a functional CaSR. (aacrjournals.org)
  • We and others have recently found that the CaSR is expressed in human colon epithelium (8, 9) . (aacrjournals.org)
  • Characterized by cell-surface molecules including CD103, CD69, and CD49a, T RM -like tumor-infiltrating lymphocytes (TILs) can be found in a wide range of human cancers, where they portend improved prognosis. (frontiersin.org)
  • WB: HFF-1 and MRC-5 whole cell lysates, Human stomach, skin and adrenal gland tissue lysates. (abcam.com)
  • IHC-P: Human breast carcinoma, colon, placenta and stomach tissues. (abcam.com)
  • Immunoprecipitation of Phospho-Btk (Tyr223) from Ramos cells, serum-starved followed by treatment with anti-human IgM (12 μg/ml, 10 min) using Phospho-Btk (Tyr223) (D1D2Z) Rabbit mAb. (cellsignal.com)
  • Immunohistochemical analysis of paraffin-embedded human colon carcinoma using Btk (D3H5) Rabbit mAb. (cellsignal.com)
  • Chinese hamster ovary (CHO) is one of the most widely used non-human mammalian cell lines. (thermofisher.com)
  • CD326 antigen is an immunotherapeutic target for the treatment of human carcinomas. (biolegend.com)
  • Within the scope of this trial, we investigated the effects of the natural pine bark extract pycnogenol on human fibrosarcoma cells. (spandidos-publications.com)
  • In the past biennium, working groups have concluded that there is sufficient evidence to classify infection with human immunodeficiency virus (HIV-1), human T-cell lymphotropic virus (HTLV-1), Epstein-Barr virus (EBV) and the Kaposi sarcoma-associated herpesvirus 8 as carcinogenic to humans (IARC 0RQRJUDSKV, Vol. 67 and 70). (who.int)
  • How it acts at the molecular level to inhibit or delay carcinogenesis in the colon, however, is not understood. (aacrjournals.org)
  • The in vitro GA release from MSNs-GA exhibited the same antitumor properties as free GA on Caco-2 cells. (springer.com)
  • Immunohistopathological analysis of the tumor and in vitro cytotoxicity study of the mononuclear cells of the liver show that NK cells are the first to infiltrate and mediate tumor cell killing, as early as 48 hr after Adv.mIL-12 treatment. (houstonmethodist.org)
  • In vivo and in vitro depletion of these cells completely abolishes this early anti-tumor response. (houstonmethodist.org)
  • This activity can be observed in both populations of conventional NK and NKT cells in vitro and in athymic nude mice in vivo. (houstonmethodist.org)
  • NiL showed better cytotoxicity on both cancerous cells relative to normal cells in vitro with the highest selective index of 2.22 in MCF-7 cells. (ac.ir)
  • However, hemolysins are often capable of lysing red blood cells in vitro. (wikipedia.org)
  • Hemolysins can be identified by their ability to lyse red blood cells in vitro. (wikipedia.org)
  • There is sufficient evidence in experimental animals for a cancer-preventive effect of limitation of body-weight gain by dietary restriction, for cancers of the mammary gland, colon, liver, pancreas, skin, and pituitary gland. (who.int)
  • Molecular characterization of this cell line revealed low expression levels and activity of Retinoblastoma protein and elevated basal levels of Erk1/2 activity and p70S6K expression and activity, which may be related to chemoresistance mechanisms. (biomedcentral.com)
  • In contrast, although stable transfection of an RII expression vector into the same GEO cells increased TGFβ 1 binding to RII, growth inhibition by exogenous TGFβ 1 was not altered. (nebraska.edu)
  • Tetracycline repressed RI expression in transfected cells and reversed the reduction in plating efficiency of RI-transfected clones, confirming that growth effects were due to increased RI expression in transfected cells. (nebraska.edu)
  • In epithelial cells of the colon, both in normal and colon cancer cells, the expression of several genes is positively or negatively regulated by butyrate likely through modulation of histone acetylation and thereby affecting the transcriptional activity of genes. (unifr.ch)
  • In contrast, in cells of mesothelial origin, MeT-5A and ZL34, the same two elements do not operate as butyrate-sensitive repressors and calretinin expression levels are insensitive to butyrate indicative of cell type-specific regulation of the CALB2 promoter. (unifr.ch)
  • Calretinin expression in colon cancer cells is negatively regulated by butyrate via a bipartite BRE flanking the TATA box and this may be linked to butyrate's chemopreventive activity. (unifr.ch)
  • In this study, we show that the cells of the colon crypt acquire CaSR expression as they differentiate and migrate towards the apex of the crypt. (aacrjournals.org)
  • Extracellular Ca 2+ and 1,25(OH) 2 D 3 are potential candidates involved in regulating CaSR expression in the colon and the chemopreventive actions of Ca 2+ and 1,25(OH) 2 D 3 in colon cancer may be mediated, in part, through the CaSR. (aacrjournals.org)
  • Many osteopenic disorders, including a postmenopausal osteoporosis and lytic bone metastasis in breast and prostate cancers, are linked with a hyperosteoclast activity due to increased receptor activator of nuclear factor kappa-B ligand (RANKL) expression in osteoblastic/stromal cells. (hindawi.com)
  • Furthermore, we assessed the expression of chemokines by polymerase chain reaction (PCR) array in tumor-draining lymph nodes (dLNs) of these mice and MC38 cells cultured in different glucose concentrations. (nature.com)
  • These results suggest that the STZ-induced hyperglycemia impairs the effect of PD-1-Ab treatment on MC38 tumor growth, and is accompanied by reduced infiltration of DCs and CD8 + T cells and decreased expression of CCL7 and CXCL9. (nature.com)
  • Identification of PARD3 signature on PARD3 deficient H157 cell line, reconstituting the expression of PARD3 gene, with a wt and a mutant form. (nih.gov)
  • Cells co-transfected with an estrogen response element (ERE)-driven luciferase (Luc) reporter gene and an ERalpha- or ERbeta-expression vector were exposed to graded concentrations of ellagic acid. (nutrimedical.com)
  • Each reagent was used to transfect HEK 293, HeLa, LNCaP, HepG2, and A549 cell lines in a 96-well format, and GFP expression was analyzed 48 hours post-transfection. (thermofisher.com)
  • Compared with N-803+αPD-L1, N-809 enhanced natural killer (NK) and CD8 + T-cell activation and function in the dLN and TME, relating to increased gene expression associated with interferon and cytokine signaling, lymphoid compartment, costimulation and cytotoxicity. (bmj.com)
  • Foremost, N-809 enhances intratumoral lymphocyte numbers by increasing trafficking via altered chemokine levels in the TME and chemokine receptor expression on CD8 + T cells and NK cells. (bmj.com)
  • Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. (lu.se)
  • Interleukin-6 drives melanoma cell motility through p38α-MAPK-dependent up-regulation of WNT5A expression. (lu.se)
  • Such cells are capable of tumour initiating, self-renewal, invasion and metastasis, resulting in tumour relapse and resistance. (researchgate.net)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. (oncotarget.com)
  • We assessed their cytotoxic effect after sensitizing cancer cells with insulin. (oncotarget.com)
  • Colorectal carcinoma is a common cause of cancer. (biomedcentral.com)
  • Using cell culture techniques, we isolated clonal populations from primary cultures of ascitic effusion derived from a colon cancer patient and after several passages an established cell line, HGUE-C-1, was obtained. (biomedcentral.com)
  • We have established a new cell line from ascitic efussion of a colon cancer patient who did not respond to 5-fluorouracil or irinotecan. (biomedcentral.com)
  • Adjuvant chemotherapy in stage III colon cancer is fully justified. (biomedcentral.com)
  • The novel colon cancer cell line HGUE-C-1 was obtained from ascitic efussion of a 76-year old man with colon cancer. (biomedcentral.com)
  • The beneficial effect of dietary fibers on preventing colon cancer is essentially mediated through butyrate, derived from luminal fermentation of fibers by intestinal bacteria. (unifr.ch)
  • We identified two elements that act as butyrate-sensitive repressors in all colon cancer cell lines tested (CaCo-2, HT-29, Co-115/3). (unifr.ch)
  • Successive assays revealed that some compounds were endowed with a promising anti-proliferative effect against HCT116 cells, alone or stimulated by serotonin as a pro-inflammatory factor in order to mimick an inflamed model of cancer cell microenvironment. (amrita.edu)
  • Ca 2+ is a chemopreventive agent for colon cancer (6, 7) . (aacrjournals.org)
  • Here, we aimed at identifying a β-catenin-independent Wnt target gene signature in order to understand the functional significance of non-canonical signaling in colon cancer cells. (nature.com)
  • Independent experiments confirmed several target genes, including PLOD2 , HADH , LCOR and REEP1 as non-canonical target genes in various colon cancer cells. (nature.com)
  • While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal T RM cells as a vital component of the host immune response to cancer. (frontiersin.org)
  • Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
  • This review will recount the path to discovering the importance of resident memory CD8 T cells as they pertain to cancer immunity. (frontiersin.org)
  • The recent success of T cell immune checkpoint inhibitor (ICI) therapies for cancer has revealed CD8 T cells as potent mediators of immunity against advanced cancers ( 4 , 5 ). (frontiersin.org)
  • As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
  • These early classifications of T cell memory were quickly brought to bear on the question of what T cell subset provides the best immunity against cancer. (frontiersin.org)
  • Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. (nutrimedical.com)
  • New Therapeutic Procedure To Eliminate Cancer Cells Infiltrated In Brain. (usherbrooke.ca)
  • Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and oxygen supply to the tumor cells through the decrease of the vascular network and the avoidance of new blood vessels formation. (mdpi.com)
  • 2021. Cancer Cell. (biolegend.com)
  • 99:209 -215.doi:10.1007/s11060 - 010 - 0129 -5 cell carcinoma-a population-based study in with and without cervical cancer in Tbilisi, Georgia. (who.int)
  • On therapeutic front, we have developed a hexapeptide, Foxy5 (an agonist of WNT5A) which is currently in Phase1 clinical trial for breast cancer, prostate cancer and colon carcinoma (NCT02020291). (lu.se)
  • WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism. (lu.se)
  • This change was initially thought to be harmless, but has been shown to be associated with a 10 percent to 20 percent increased risk of colon cancer. (medlineplus.gov)
  • In addition, the absence of excess body fatness may reduce the risk of fatal cancer of the prostate, diffuse large B-cell lymphoma, and cancer of the breast in men. (who.int)
  • These changes have been predicted by cancer epidemiologists for many years, but even they are surprised by the speed at which these changes are occurring, e.g., the emergence of cancer of the breast, colon and prostate in several countries in which these neoplasms were hardly known only 20 to 30 years ago. (who.int)
  • For MSNs-GA, cell viability was reduced as a function of incubation time and different concentrations of nanoparticles. (springer.com)
  • MSNs can easily internalize into Caco-2 cells without deleterious effects on cell viability. (springer.com)
  • The cell viability of Caco-2 cells was affected during MSNs-GA uptake. (springer.com)
  • Endometrium-derived epithelial cells (Ishikawa) showed no response to the natural compound by using a cell viability assay (MTT). (nutrimedical.com)
  • It delivers exceptional transfection efficiency with improved cell viability for the widest range of hard-to-transfect and common cell types including HEK 293, HeLa, LNCaP, HepG2, and A549 cell lines (Figure 1) . (thermofisher.com)
  • Resident memory (T RM ) cells are a distinct tissue-localized T cell lineage that is crucial for protective immunity in peripheral tissues. (frontiersin.org)
  • whereas T EM cells were shown to recirculate predominantly through blood, and peripheral tissues ( 10 ). (frontiersin.org)
  • In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
  • COX-1 is expressed constitutively and is isolated throughout most cell lines in almost all mammalian tissues. (medscape.com)
  • WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. (lu.se)
  • The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. (medlineplus.gov)
  • Background Anti(α)-programmed cell death-1 (PD-1)/programmed death-ligand 1 (PD-L1) monotherapy fails to provide durable clinical benefit for most patients with carcinoma. (bmj.com)
  • These results provide mechanistic insight and rationale supporting the potential clinical study of N-809 in patients with carcinoma. (bmj.com)
  • While the use of single-agent immunotherapies, in particular immune checkpoint inhibitors, can produce durable and effective responses in some patients, clinical benefit for most patients with carcinoma is minimal. (bmj.com)
  • In FAP syndrome patients, one APC germline gene is already mutated in every cell in the body (barring a rare reverse somatic mutation in some cells), and, therefore, only one new somatic mutation is required in the opposite APC gene for the tumor to develop. (medscape.com)
  • Recent studies suggested that strategies to reduce immunosuppressive cells, promote systemic T-cell responses and lymphocyte trafficking to the tumor microenvironment (TME) may improve efficacy. (bmj.com)
  • In our previous study, intratumoral transfer of Adv.mIL-12 (5 x 10 8 pfu) to the MCA26 colon carcinoma liver tumor induced an effective anti-tumor response, extending the median survival time from 29 to over 54 days, while 25% of the animals became tumor-free after a single treatment. (houstonmethodist.org)
  • In addition to highlighting key studies that directly implicate T RM cells in anti-tumor immunity, we will highlight earlier work that implicitly suggested their importance. (frontiersin.org)
  • however, it remains unknown whether the anti-tumor effects of anti-programmed cell death-1 antibody (PD-1-Ab) treatment are changed in hyperglycemic conditions. (nature.com)
  • Immune checkpoint inhibitors (ICIs), including antibodies against programmed cell death-1 (PD-1) and PD-1 ligand-1 (PD-L1), induce their anti-tumor effects by improving the function of immune cells 11 . (nature.com)
  • Fine reticular opacification with Kerley B lines and a tiny left pleural effusion are demonstrated in a patient with a lymphangitic spread of cervical carcinoma. (medscape.com)
  • Hence, there is still a need for alternative and well-tolerated compounds that exhibit antineoplastic effects in sarcoma cells. (spandidos-publications.com)
  • They also showed reduced growth and clonogenicity in plating efficiency and soft agarose assays, whereas RII-transfected cells did not show any differences from the NEO control cells in these assays. (nebraska.edu)
  • This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications. (abcam.com)
  • Western blotting is an important technique used in cell and molecular biology. (delos.info)
  • Although the lytic activity of some microbe-derived hemolysins on red blood cells may be of great importance for nutrient acquisition, many hemolysins produced by pathogens do not cause significant destruction of red blood cells during infection. (wikipedia.org)
  • A) Cytopathic effects (round cells) observed 6 days after infection of rhesus monkey kidney (LLC-MK2) cells (second passage) with the Can112051-06 Saffold virus-like cardiovirus strain. (cdc.gov)
  • In particular, the interchangeable modes of migration tumour cells utilise during invasion and the factors involved. (lu.se)
  • Mice were intraperitoneally injected with STZ or sodium citrate buffer (CB) 7 days before subcutaneous inoculation with MC38 cells in the right flank on day 0 (Fig. 1 A). Then, the mice were treated with anti-PD-1 antibody or normal rat IgG on days 5, 8, and 11. (nature.com)
  • Confocal immunofluorescent analysis of Ramos cells, untreated (left) or IgM-treated (middle), and Jurkat cells (right) using Phospho-CD79A (Tyr182) Antibody (green). (cellsignal.com)
  • Njainday's research focuses on WNT5A, and its role in tumour cell progression and plasticity. (lu.se)
  • Simple Western™ analysis of lysates (0.1 mg/mL) from Raji cells using Syk (D3Z1E) XP® Rabbit mAb #13198. (cellsignal.com)
  • Simple Western™ analysis of lysates (0.1 mg/mL) from Raji cells using Btk (D3H5) Rabbit mAb #8547. (cellsignal.com)
  • [ 9 ] They may be derived from mesenchymal stem cells. (medscape.com)
  • The HGUE-C-1 cell line was sensitive to erlotinib, gefitinib, NVP-BEZ235, rapamycin and trichostatin, among other drugs, but partially resistant to heat shock protein inhibitors and highly resistant to AZD-6244 and oxaliplatin, even though the patient from which this cell line was derived had not been exposed to these drugs. (biomedcentral.com)
  • We analyzed the effect of PD-1-Ab on tumor growth in streptozotocin-induced diabetic mice (STZ-mice) subcutaneously inoculated with MC38 (a colon carcinoma cell line). (nature.com)
  • Moreover, ellagic acid induced nodule mineralization in an osteoblastic cell line (KS483), an effect that was abolished by the estrogen antagonist. (nutrimedical.com)
  • This superior transfection performance allows you to reduce the reagent dose, thus helping lower toxicity risk when transfecting your cell line. (thermofisher.com)
  • We were very happy and surprised to see Lipofectamine® 3000 reagent provide a more than 10-fold difference in transfection efficiency in our difficult-to-transfect cell line. (thermofisher.com)
  • In line with this notion, mitochondria are highly dynamic organelles that undergo fission and fusion and move into the cell along the microtubules to generate the mitochondrial network [ 6 ]. (hindawi.com)
  • Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
  • In this study, the effects of intracellular delivery of various concentrations of gallic acid (GA) as a semistable antioxidant, gallic acid-loaded mesoporous silica nanoparticles (MSNs-GA), and cellular uptake of nanoparticles into Caco-2 cells were investigated. (springer.com)
  • Cauda V, Engelke H, Sauer A, Arcizet D, Brauchle C, Radler J, Bein T (2010) Colchicine-loaded lipid bilayer-coated 50 nm mesoporous nanoparticles efficiently induce microtubule depolymerization upon cell uptake. (springer.com)
  • Tumor development has been said to occur in three distinct steps: inefficient elimination of early transformed cells, development of a state of equilibrium between tumor cells and immune cells, and tumor escape from immune pressure ( 2 ). (frontiersin.org)
  • Hemolysins or haemolysins are lipids and proteins that cause lysis of red blood cells by disrupting the cell membrane. (wikipedia.org)
  • Cells express a pool of thousands of different proteins that need to be tightly controlled for proper cellular structure, organization, and function. (hindawi.com)
  • The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling. (medlineplus.gov)
  • This was accompanied by fewer tumor-infiltrating CD8 + T cells, and STZ-mice had fewer tumor-infiltrating CD11c + dendritic cells (DCs) than normoglycemic mice. (nature.com)
  • To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERalpha and ERbeta in HeLa cells. (nutrimedical.com)