Colon cancer hct 116. Medical search. Frequent questions

New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
The cell cycle analysis showed a significant inhibition of the HCT 116 cells proliferation following FBX-EMLs treatment compared to all the other conditions, with a higher number of cells accumulating on G2/M and pre-G1 phases, paralleled by a significant reduction of cells in G0/G1 and S phases. (carusogiuseppe.net)
The proliferation of HCT116 colonies was found to be inhibited by 5-Fu/P85 copolymer micelles. (wikipedia.org)
HCT116 cells are used in a variety of biomedical studies involving colon cancer proliferation and corresponding inhibitors. (wikipedia.org)
The article also underscores the various possible mechanisms by which honey may inhibit growth and proliferation of tumors or cancers. (mdpi.com)
All the compounds produced a significant reduction in HCT-116 cell line proliferation, except compounds 2 and 6. (mendeley.com)
Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
The five tested lines-LS 180, Vaco 432, Colo 205, CX 1, and HCT 116 responded with differentiation and reduced proliferation to Gal-4 binding. (uni-muenchen.de)
Cell proliferation assay showed that compound 4j possessed good antitumor activity against three different types of cancer cells derived from colon (HCT-116), breast (MDA-MB-468) and blood-leukemia (CCRF-CEM) with cell viability of 40.0%, 53.2% and 27.2% respectively at 50 μM. (unboundmedicine.com)
Spanish and Italian researchers have proven that when honey from strawberry trees, a product typical of Mediterranean areas, is added to colon cancer cells grown in the laboratory, cell proliferation is stopped. (agenciasinc.es)
The results, published in the Journal of Functional Foods, show that strawberry tree honey is capable of inhibiting the proliferation of tumour cells cultivated in laboratory plates - more specifically, those of a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo), widely used to investigate this type of tumour. (agenciasinc.es)
It also suppresses the receptor of the epidermal growth factor called EGFR/HER2 and its signalling pathways, which could be an attractive target in cancer therapies because of their important role in the processes of cell survival and proliferation, as well as in those of apoptosis and metastasis. (agenciasinc.es)
Strawberry tree honey is capable of inhibiting the proliferation of tumour cells on a line of human colon adenocarcinoma (HCT-116) and another with metastatic characteristics (LoVo). (agenciasinc.es)
Aspirin suppresses proliferation and induces apoptosis and autophagy in colorectal cancer cells, but the precise mechanism is not clear. (oncotarget.com)

All the compounds exhibited antiproliferative activity against the HCT-116 cell line with IC50 values at 33 ± 1.25, 36 ± 2.25, 34 ± 2.15, 32 ± 2.35, 34 ± 2.65, and 36 ± 1.95 μg/mL for compounds 1 to 6, respectively. (mendeley.com)

Here we provide evidence that there may be a direct link between inhibition of intestinal cancer growth and selective inhibition of the COX-2 pathway. (nih.gov)
The extract also showed a dose dependent growth inhibition of all tested cell lines, IC 50 values against HCT-116, HUVEC, CCD-18CO and HT-29 were 14, 23, 50 and 52 μg mL -1 , respectively. (scialert.net)
As test cases to examine changes in protein presence associated with tumor growth inhibition, we applied SILAC-based proteomics on human colon carcinoma cells treated with galectin-4 (Gal-4). (uni-muenchen.de)
consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)

In the present study, we demonstrated trifluoroselenomethionine, a new non-natural amino acid with enhanced methioninase-induced cytotoxicity toward human colon cancer cells. (usda.gov)
TFSeM shows enhanced methioninase-induced cytotoxicity toward human colon cancer derived HCT- 116 cells compared to selenomethionine (SeM). (usda.gov)
The cytotoxicity and anti-tumour effects of strawberry tree honey in relation to colon cancer lines increased with the amount and time of treatment. (agenciasinc.es)

Regular use of aspirin can reduce cancer incidence, recurrence, metastasis and cancer-related mortality. (oncotarget.com)

however, Lalla et al, while reviewing published trials for the 2014 Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO) guidelines, found that mucositis occurs in approximately 20-40% of patients receiving conventional chemotherapy and in 80% of patients receiving high-dose chemotherapy. (medscape.com)

Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
In the present study, our aim was to determine the time-dependent, ER-mediated apoptotic and autophagy induction of purvalanol in HCT 116 colon cancer cells. (spandidos-publications.com)
HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
Olomoucine, roscovitine and purvalanol are examples of CDK inhibitors (CDKIs) designed and investigated for their apoptotic potential on cancer cells ( 3 ). (spandidos-publications.com)
Increased levels of polyamines in cells are considered to be involved in cancer progression. (spandidos-publications.com)
Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)
In the present study, an optimized formulation in terms of vesicle size and drug release, obtained by encapsulation of FBX into the emulsomes (FBX-EMLs), was evaluated for its cytotoxic potential in human colorectal carcinoma (HCT 116) cells. (carusogiuseppe.net)
In conclusion, the new formulation of FBX into EMLs improved all the parameters related to the anti-proliferative activity and the toxic potential of the drug towards colorectal cancer cells. (carusogiuseppe.net)
HCT116 cells have a mutation in codon 13 of the KRAS proto-oncogene, and are suitable transfection targets for gene therapy research. (wikipedia.org)
When transducted with viral vectors carrying the p53 gene, HCT116 cells remain arrested in the G1 phase. (wikipedia.org)
Furthermore, it was found that the knockout of MARCH2 limited growth of HCT116 cells via stress on the endoplasmic reticulum. (wikipedia.org)
HCT116 cells can also function in xenografts, with docetaxel, 5-FU, and flavopiridol limiting tumor growth in vitro. (wikipedia.org)
We evaluated HCA-7 cells which express high levels of COX-2 protein constitutively and HCT-116 cells which lack COX-2 protein. (nih.gov)
The viability of the HEK-293 normal cells was found to be significantly higher than the viability of the cancerous cells at all of the tested concentrations, thus suggesting that all the compounds have better inhibitory activity on the cancer cell line. (mendeley.com)
The critical challenge in cancer treatment is how to effectively kill cancer cells without affecting healthy cells. (hindawi.com)
By tracing significant alterations of protein expression likely relevant for the observed phenotypic effects, the capacity of a galectin to affect the proteome of human colon cancer cells at multiple sites is revealed. (uni-muenchen.de)
One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
In this study, we demonstrated that aspirin induced autophagosome formation in colorectal cancer cells, but autophagic degradation was blocked through aspirin-mediated Beclin 1 acetylation. (oncotarget.com)
Collectively, our findings indicate the dual roles of aspirin on autophagy, and demonstrate a new mechanism by which Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells. (oncotarget.com)
In this study, we investigated the effect of aspirin on Beclin 1 acetylation and autophagy in CRC cells, providing new insight into aspirin for cancer therapy. (oncotarget.com)
Many ORs are expressed by tumor cells and tissues, suggesting that they may be associated with cancer progression or may be cancer biomarkers. (bmbreports.org)

The expression of caspase-3 and caspase-9 genes increased in HCT-116 cell lines after 48 h of treatment, suggesting cell death by the apoptotic pathways. (mendeley.com)
At 50 μg mL -1 , the extract had potently induced apoptotic cell death of HCT-116 colon cancer cell line by inducing caspases 3 and 7 activity. (scialert.net)
These results showed that n-hexane extract of S. koetjape possess both anti-angiogenic and apoptotic properties on colon cancer cell lines making it a good candidate for further studies. (scialert.net)

The anticancer activity of these compounds was evaluated in colon cancer, HCT-116, and noncancerous, HEK-293, cell lines using the MTT antiproliferative assays. (mendeley.com)

This review article focuses on the role of honey in modulating the development and progression of tumors or cancers. (mdpi.com)
LPA receptors and autotaxin (ATX), a secreted phosphodiesterase that produces this phospholipid, are overexpressed in many cancers and impact several features of the disease, including cancer-related inflammation, development, and progression. (hindawi.com)
In this review, we discuss the evidence linking LPA signaling to cancer-related inflammation and its impact on cancer progression. (hindawi.com)

According to the World Cancer Report, colorectal cancer (CRC) is one of the most dangerous malignant tumors in humans. (hindawi.com)
In addition, OR expression pattern in various cancers were analyzed based on RNA-sequencing data reported in the Cancer Genome Atlas (TCGA), and the associations between patient survival outcomes and OR levels were analyzed to determine the clinical relevance and significances of OR expression in tumors. (bmbreports.org)

Conversely, SC-58125 had no effect on HCT-116 implants in nude mice or colony formation in culture. (nih.gov)

I told her that I was aware of 15 or so supplements that studies have shown potential to fight colon cancer and might be helpful as adjunctive treatment to her oncologist's treatment plan and asked if she wanted to know about them, and she said yes. (earthclinic.com)
Studies show that CS has demonstrated the potential to fight Colon Cancer, and I will list several of these below. (earthclinic.com)
Now, scientists from the universities of Vigo and Granada (Spain) and from the Polytechnic University of Marche (Italy) have analysed for the first time the potential of this Mediterranean product to fight colon cancer. (agenciasinc.es)

HCT116 is a human colon cancer cell line used in therapeutic research and drug screenings. (wikipedia.org)
The immediate application of our findings is to determine trifluoroselenomethionine's anti-(colon cancer) property with animal models and human intervention studies, which may lead to yield the next generation Se compound against human diseases. (usda.gov)
Collectively, the information will be useful for scientists and health-care professionals who are interested in using Se as a nutrient/drug in the prevention/treatment of human cancer/bacterial infection. (usda.gov)
In this study, we selected two transformed human colon cancer cell lines for studies on the role of COX-2 in intestinal tumorigenesis. (nih.gov)
Natural products derived from plant resources have been extensively used in folk medicine for the treatment of different human illnesses including cancer. (scialert.net)
Colorectal cancer (CRC) is a severe threat to human health. (hindawi.com)
MicroRNA expression profiles classify human cancers. (eurekaselect.com)

We observed 20 cancer patients (15 male, 5 female) from September 2020 to January 2022 who insisted on using camel urine for treatment. (who.int)

Many ongoing studies aim to understand ATX-LPA axis signaling in cancer and its potential as a therapeutic target. (hindawi.com)
Understanding Lunasin 's biology and potential as a cancer therapeutic by utilizing Drosophila genetics. (weeksmd.com)
Immunostimulatory cytokines can enhance anti-tumor immunity and are part of the therapeutic armamentarium for cancer treatment. (weeksmd.com)
These analyses of the relationships between patient survival and expression patterns obtained from an open mRNA database in cancer patients indicate that ORs may be cancer biomarkers and therapeutic targets. (bmbreports.org)

Epidemiological evidence indicates that selenium (Se) status is inversely associated with cancer/bacterial infection risk, and results from several intervention studies show that high Se intakes effectively reduce colon cancer risk. (usda.gov)
I am writing this to make an anecdotal report of a friend who had outstanding results in treating her colon cancer effectively. (earthclinic.com)

This review describes OR expression in various types of cancer and the association of these receptors with various types of signaling mechanisms. (bmbreports.org)

With these data it is not yet possible to speak of a cure or safe prevention of colorectal cancer thanks to strawberry tree honey," emphasizes Battino, who adds: "This work constitutes a starting point in the effort to evaluate its possible biological and anti-cancer effects and indicates the main molecular mechanisms through which it exerts its effect, reinforcing the interest in the study and production of this Mediterranean foodstuff. (agenciasinc.es)

Colon Cancer is a severe life-threatening condition, and you should always consult with your oncologist regarding any treatment you are considering using. (earthclinic.com)
Oral mucositis leads to pain and restriction of oral intake, and, in severe cases (eg, patients undergoing myeloablative therapy prior to HCT), necessitates total parenteral nutrition and increased use of narcotic analgesics. (medscape.com)

These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)

Oral mucositis is a common complication of cancer chemotherapy. (medscape.com)

Patients should also be educated about the importance of maintaining good oral hygiene throughout the course of their cancer therapy. (medscape.com)

None of these effects was observed when honey was applied to healthy cell lines," the authors point out, noting the anticarcinogenic potential of this natural product, but insisting on the need for new studies with colon cancer in vivo models to confirm its chemopreventive effects. (agenciasinc.es)

At present, it offers a promising direction for the treatment of cancer patients. (weeksmd.com)
One of the common practices is the use of camel urine alone or mixed with camel milk for the treatment of cancer, which is often supported by religious beliefs. (who.int)

Familial CRC, caused by hereditary mutations, is the type of cancer that neither its molecular mechanism is precisely known nor cannot be classified as a specific hereditary cancer ( Stoffel and Kastrinos, 2014 ). (frontiersin.org)

In addition to its classical anti-inflammatory function, epidemiological studies in several trials have demonstrated that prolonged aspirin use reduces cancer risk, particularly colorectal cancer (CRC) [ 2 - 7 ], indicating a promising role of aspirin for cancer prevention [ 8 - 10 ]. (oncotarget.com)

Chemotherapy, either at conventional levels or in the higher-dosed myeloablative protocols used in conditioning regimens (with or without total body radiation in preparation for hematopoietic cell transplantation [HCT]), often results in erythema, edema, atrophy, and ulceration of the oral mucosa, a condition generally referred to as oral mucositis. (medscape.com)

It reviews available evidence (some of which is very recent) with regards to the antimetastatic, antiproliferative and anticancer effects of honey in various forms of cancer. (mdpi.com)

Several studies have also been directed at its use as anti-cancer drug during the last years, opening a window for its off-label use. (carusogiuseppe.net)
Large epidemiologic studies have shown a 40-50% reduction in mortality from colorectal cancer in persons taking aspirin or other nonsteroidal antiinflammatory drugs on a regular basis. (nih.gov)
I have no way of knowing whether the CS and or vitamin D is the reason for her remission, but she told me she didn't do anything else, and studies clearly show that Colloidal Silver is active against Colon Cancer in testing. (earthclinic.com)
TY - JOUR T1 - Benzimidazoles as new scaffold of sirtuin inhibitors: green synthesis, in vitro studies, molecular docking analysis and evaluation of their anti-cancer properties. (unboundmedicine.com)

A growing body of scientific evidence shows that berry polyphenols' antioxidant capacity powerfully targets numerous degenerative diseases, from cancer and atherosclerosis to impaired glucose control and blood lipid abnormalities. (lifeextension.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

Dr. Weeks' Comment: Lunasin is an anti-cancer peptide derived from soy which has solid science behind it. (weeksmd.com)
While the salicylate group implicates in the anti-inflammatory and anti-cancer properties via targeting cyclin A2/CDK2, HMGB1 and NF-κB pathway [ 11 - 13 ], the acetyl group causes the inactivation of cyclooxygenases (COXs) through acetylation of serine residues [ 14 ]. (oncotarget.com)

Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
however Keefe et al reviewed the reported toxicity data from 99 published clinical trials including patients with non-Hodgkin lymphoma, breast, lung, or colorectal cancer. (medscape.com)

It has been documented that methylseleninic acid (MSeA), a methylselenol precursor, is a superior choice of Se for cancer chemoprevention over other Se compounds. (usda.gov)
It is one more piece of evidence that a healthy, balanced and natural diet can provide bioactive compounds with possible interesting effects on the control and development of diseases as critical as this type of cancer," concludes the researcher. (agenciasinc.es)

Anatomy11

Organisms1

Diseases20

Chemicals and Drugs12

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Phenomena and Processes13

Information Science1

Health Care5

Proliferation14

Antiproliferative Activity1

Inhibition4

Cytotoxicity3

Metastasis1

Oncology1

Cells24

Apoptotic3

Anticancer Activity1

Progression3

Tumors2

Colony formation1

Fight colon cancer3

Human7

20221

Therapeutic4

Effectively2

Types of cancer1

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Therapy1

Vivo1

Treatment of Cancer2

Mutations1

Reduces1

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Honey1

Studies4

Targets2

Anti-cancer2

Data2

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