Collagens and elastin extracellular matrix and basement membrane associated proteins collagen and laminin. Medical search. Frequent questions

IMs are found in the space between the tissue stroma cells and contain, among other components, fibrillar collagens and fibronectin. (nature.com)
Because adipose ECM contains many primordial matrix proteins important for embryonic development and regeneration (such as laminin, type IV collagen, and fibronectin), adipose ECM may prove to be an autologous tissue engineering matrix and stem cell culture substrate. (vcu.edu)
It constitutes fibrous proteins such as collagen and elastin, elongated glycoproteins such as fibronectin and laminin, which provide cell matrix adhesion. (biomedcentral.com)
Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)
Furthermore, altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-κB activation, suggesting a novel therapeutic strategy for treating atherosclerosis. (rupress.org)
This growth factor also stimulates production of collagens, proteoglycans, elastin, fibronectin, tenascin and thrombospondin, diminishes production of extracellularly active neutral endoproteinases belonging to the matrix metalloproteinase (MMP) and serine proteinase families, and stimulates production of endogenous MMP inhibitors (tissue inhibitor of metallo-proteinase [TIMP]) and serpins (plasminogen activator inhibitor-1). (biomedcentral.com)

We show here that adipose tissue ECM can, in fact, be electrospun into a nanofiberous mesh, histologically shown to contain connective tissue, collagens, elastic fibers/elastin, proteoglycans, and glycoproteins in the newly synthesized matrix. (vcu.edu)
Agrin-like glycoproteins and proteins with sugar-binding domains are also predominant. (biomedcentral.com)

BMs are specialized structures that underlie epithelia and surround organs and mainly comprise collagen IV, laminins, and heparan sulfate proteoglycans (HSPG). (nature.com)

Collagenases degrade triple-helical fibrillar collagens, which are the main components of bone and cartilage. (periobasics.com)
Stromelysins [MMP-3, MMP-10, MMP-11, and MMP-7 (also known as matrilysins)] are small proteases that degrade components of the ECM, although not the triple-helical fibrillar collagens. (periobasics.com)

A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE. (lookformedical.com)
A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (lookformedical.com)
This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (lookformedical.com)
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules. (lookformedical.com)
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. (lookformedical.com)
Connective tissue consists of cells, mainly fibroblasts , and an extracellular matrix ( ECM ). (amboss.com)
Connective tissue consists of specialized cells that are embedded in the extracellular matrix ( ECM ). (amboss.com)
Her lab is currently interested in unraveling the function of collagens in development, tissue regeneration and rare connective tissue disease as the classic Elhers-Danlos syndrome and neuromuscular disorders associated to collagen deficiency. (sfbmec.fr)
Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals , [1] making up about 25% of the total protein content. (wikidoc.org)
ALLATONIN Allantoin is a natural soothing, anti-irritant, and skin protectant that increases the water content of the extracellular matrix which provides structural support to cells and is an important part of connective tissue. (remi-d.com)

TGFβ is a pleiotropic cytokine that regulates cell proliferation, contributes to epithelial-to-mesenchymal transition (EMT), suppresses the function of immune cells compromising immune response, contributes to the conversion of fibroblasts to myofibroblasts and causes overproduction of extracellular matrix (ECM) in tissues undergoing fibrosis. (researchsquare.com)
A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics. (lookformedical.com)
A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. (lookformedical.com)
ECM consists of proteins and polysaccharides distributed in many different tissues of the body. (biomedcentral.com)
Elastic fibers are composed of elastin molecules and can be found together with collagen fibers in tissues that require elasticity in addition to tensile strength, e.g., the lung . (amboss.com)
Because collagens form intricate network in tissues, predicting their function is difficult. (sfbmec.fr)
tough bundles of collagen called collagen fibers are a major component of the extracellular matrix that supports most tissues and gives cells structure from the outside, but collagen is also found inside certain cells. (wikidoc.org)

Using fibroblasts recovered from wild-type or gene-deleted mice, invasion of three-dimensional fibrin gels proceeded in a matrix metalloproteinase (MMP)-dependent fashion. (silverchair.com)
Consistent with earlier studies supporting a singular role for the membrane-anchored MMP, MT1-MMP, in fibrin-invasive events, fibroblasts from MT1-MMP-null mice displayed an early defect in invasion. (silverchair.com)
Examples of a novel series of phenanthrolinones are shown to be potent competitive inhibitors of avian prolyl 4-hydroxylase, and of collagen hydroxylation, in embryonic chick tendon cells and human foreskin fibroblasts in vitro and in the oestradiol-stimulated rat uterus in vivo. (embl.de)

Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. (lookformedical.com)
Collagen molecules are the basis of collagen fibers and reticular fibers . (amboss.com)
Her main objective was to understand the diversity of collagen functions from molecules to integrative systems using cell and animal models. (sfbmec.fr)
The cuticle of parasitic nematodes consists primarily of a network of collagen molecules. (embl.de)

and ( 3 ) ineffective repair of elastic fibers and perhaps other extracellular matrix components. (atsjournals.org)

Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity and function, and its regulation of cell phenotype is a major aspect of cell biology. (atsjournals.org)
These cells, which can be derived from liposuction fat and lipoaspirate saline, are sources for patient-derivable extracellular matrix (ECM), fibrinogen (Fg) and adipose tissue extracellular matrix, and may prove useful for synthesizing new bone tissue analogues in vitro. (vcu.edu)
In addition to establishing Fg as a source of scaffolding, we developed and characterized a novel method for isolating and subsequently electrospinning adipose tissue matrix. (vcu.edu)
Tissue inhibitors of matrix metallo-proteinases (TIMPs) are known to have the ability to inhibit the catalytic activity of MMPs. (biomedcentral.com)
Turpeenniemi-Hujanen et al suggested that the expressions of matrix expression of MMPs as well as their tissue inhibitors the TIMPs are associated with the clinical behaviour in head and neck malignancy [ 12 ]. (biomedcentral.com)
Although the catalytic domain of MMPs is structurally highly similar, there are many differences with respect to substrate specificity, cellular and tissue localization, membrane binding and regulation that make this a very versatile family of enzymes with a multitude of physiological functions, many of which are still not fully understood. (evelinvahter.com)
porcine (pig) tissue is also widely used for producing collagen sheet for a variety of surgical purposes. (wikidoc.org)
The tissue model thereby mimics structure and function of human soft tissue with endothelial cell-coated larger vessels for perfusion and micro-vessel networks within the hydrogel-matrix. (regenhu.com)

We further found that the pericytic laminin isoforms differentially regulate mouse β-cells. (nature.com)
They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. (lookformedical.com)
The TGF-β family forms an important group of growth factors, consisting of three isoforms in man, and is important for matrix deposition because it modulates fibroblast recruitment and proliferation. (biomedcentral.com)

Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases that are capable of cleaving all extra cellular matrix (ECM) substrates. (biomedcentral.com)
The matrix metalloproteinases (MMPs) are a family of structurally and functionally related endoproteinases that are collectively capable of degrading most of the components of the extracellular matrix (ECM) 1, 2 . (periobasics.com)
The generic structure of matrix metalloproteinases (MMPs). (periobasics.com)
Another type of MMPs are called as the MT-MMPs (Membrane Type Matrix Metalloproteinases) that are localized to the cell surface. (periobasics.com)
For example, neutrophils are short-lived and package active serine proteinases in azurophil (primary) granules and matrix metalloproteinases (MMP-8, MMP-9) in specific (secondary/tertiary) granules. (atsjournals.org)

The structural organization of all MMPs presents a prepeptide sequence that directs their secretion in the extracellular environment and a propeptide domain that maintains them in their zymogenic form. (periobasics.com)
Other MMPs, known as membrane-type MMPs (MT-MMP), are linked to the plasma membrane either by a transmembrane domain or by a glycosyl-phosphatidyl inositol linkage, attached to the hemopexin domain. (periobasics.com)
Matrix metalloproteases (MMPs) comprise a family of enzymes that cleave protein substrates based on a conserved mechanism involving activation of an active site-bound water molecule by a Zn 2+ ion. (evelinvahter.com)
As with most protein families, deciphering the function(s) of MMPs is difficult, as they can modify many proteins. (evelinvahter.com)
MMPs can be grouped into soluble (including matrilysins) and membrane-anchored species. (evelinvahter.com)
Metzincins are a ubiquitously expressed family of multi-domain zinc (II)-dependent endopeptidases (Stocker and Bode 1995 ), the members of which include well-known metalloproteases such as the matrix metalloproteases (MMPs) (Nagase and Woessner 1999 ), a disintegrin and metalloproteases (ADAMs) (White 2003 ), the ADAMs with a thrombospondin motif (ADAMTS) (Tang 2001 ), the bacterial serralysins (Nakahama et al. (evelinvahter.com)

A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. (lookformedical.com)
A fibrillar collagen found primarily in interstitial CARTILAGE. (lookformedical.com)
Collagen has great tensile strength, and is the main component of fascia , cartilage , ligaments , tendons , bone and teeth . (wikidoc.org)

Taken with the present results, this suggests that the potential use of inhibitors of prolyl 4-hydroxylase to control excessive collagen deposition in pathological fibrosis may be limited by the need to maintain continuous inhibition of collagen hydroxylation so as to facilitate intracellular degradation of the accumulated protein. (embl.de)

If collagen is partially hydrolyzed , the three tropocollagen strands separate into globular, random coils , producing gelatin , which is used in many foods , including flavored gelatin desserts. (wikidoc.org)
[2] Nutritionally, collagen and gelatin are poor quality protein since they do not contain all the essential amino acids that the human body requires - they are not complete proteins . (wikidoc.org)
[3] Collagen normally converts to gelatin, but survived due to the dry conditions. (wikidoc.org)
A gelatin-methacrylate/fibrin-based matrix containing multiple cell types mimics the tumor-microenvironment that promotes spontaneous micro-vessel formation by embedded endothelial cells. (regenhu.com)

In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
Of the 42 genes coding for collagen chains, 28 types of collagen triple helices can be assembled. (amboss.com)
During the last years, her group have explored the amazing functional diversity of collagen genes during development and analyzed possible links between defective collagen function and human diseases, using combined approaches including functional genomics, biochemistry, cell biology and integrative biology. (sfbmec.fr)

It is influenced by angiogenesis, cell-cell and cell-extra cellular matrix (ECM) interactions. (biomedcentral.com)
We designed a medium throughput approach to systematically test for interactions between these pneumococcal surface proteins and host proteins (extracellular matrix proteins, circulating proteins or immunity related proteins). (biomedcentral.com)
Interactions were tested in a solid phase assay, which led to the identification of 23 protein-protein interactions among which 20 are new. (biomedcentral.com)
Her primary research interest, as a young investigator at the CNRS, was the analysis of cell-collagen interactions. (sfbmec.fr)

Then, he is investigating biomimetic approaches based on cross-linking enzymes for the improvement of the angiogenic properties of hydrogels of natural polymers, including tropoelastin and collagen. (sfbmec.fr)
Stimulated enzymes to help build new elastin and collagen. (remi-d.com)

Extracellular matrix is important in driving cellular phenotypic responses in fibrotic and other lung disorders. (atsjournals.org)
We define a new method to prepare acellular lung matrix that can be used to study the impact of extracellular matrix on lung cell phenotype. (atsjournals.org)
By using human lungs and cells, this new system provides a novel way to culture cells in vitro to investigate matrix contributions to lung pathology in a disease-specific manner. (atsjournals.org)
Lung development timeline and type IV collagen expression in the chicken and the mouse. (biomedcentral.com)
d - i Type IV collagen protein and mRNA expression in the lung. (biomedcentral.com)
Defining the cells and proteinases responsible for destruction of lung extracellular matrix associated with cigarette smoking will be required for development of appropriate proteinase inhibitors for application in COPD. (atsjournals.org)

most medical collagen is derived from young beef cattle (bovine) from certified BSE (Bovine spongiform encephalopathy) free animals. (wikidoc.org)

Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI. (lookformedical.com)
Flow-induced NF-κB activation is downstream of conformational activation of integrins, resulting in new integrin binding to the subendothelial extracellular matrix and signaling. (rupress.org)

To confirm our gene expression results, osteogenic-induced ASCs on Fg scaffolds were also shown to secrete osteocalcin in the extracellular matrix, a key marker in osteoblastogenesis. (vcu.edu)

They account for the majority of proteins in the ECM , which makes them the most abundant proteins in the human body. (amboss.com)
Collagen is the most ubiquitous and abundant protein in humans. (amboss.com)
We identified a total of 102 OM proteins, 52 are found in the two red coral biominerals with scleritin being the most abundant protein in each fraction. (biomedcentral.com)

Degradation of matrix is a key event in progression, invasion and metastasis of potentially malignant and malignant lesions of the head and neck. (biomedcentral.com)

The extracellular matrix ( ECM ) is composed of various macromolecules arranged in a three-dimensional structure. (amboss.com)

In embryonic avian tendon, cell density regulates collagen production. (embl.de)

Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. (biomedcentral.com)
In addition to its role in the formation of epithelium and vasculature, type IV collagen appears to be key for alveolar myofibroblast development by inducing their proliferation, differentiation and migration throughout the developing septum. (biomedcentral.com)

This nutrient enriched extract contains the amino acid Hydroxyproline, the building block of collagen. (remi-d.com)
8 h following single oral doses of the compounds was associated with significant losses of radiolabelled proline and 4-hydroxyproline from collagen during this period. (embl.de)

Compared to ECs, pancreatic pericytes produce significantly higher levels of α2 and α4 laminin chains, which constitute the peri-islet and vascular BM. (nature.com)
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains. (lookformedical.com)

Here, we show that pericytes produce multiple components of the mouse pancreatic and islet interstitial and BM matrices. (nature.com)

The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer. (lookformedical.com)

Availability of genome sequences facilitated the identification of pneumococcal surface proteins bearing characteristic motifs such as choline-binding proteins (Cbp) and peptidoglycan binding (LPXTG) proteins. (biomedcentral.com)

Robust new collagen synthesis and matrix remodeling were observed on all Fg scaffolds, the levels of which were elevated over time. (vcu.edu)
Other profibrotic, collagen synthesis stimulating cytokines include endothelin, interleukin (IL)-1 and mast cell tryptase. (biomedcentral.com)
Interferons and IL-4 decrease collagen synthesis. (biomedcentral.com)

A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens. (lookformedical.com)

Two compounds, Compound 1 (1,4-dihydrophenanthrolin-4-one-3-carboxylic acid) and Compound 5 [8-(N-butyl-N-ethylcarbamoyl)-1,4-dihydrophenathrolin-4-one-3-carboxylic acid], with comparable potencies in vivo, were chosen to investigate the effect of the inhibition of the hydroxylation of newly synthesized uterine collagen on the turnover of this protein in vivo. (embl.de)

1993 ). Catalysis of protein substrates is (most probably) carried out via a general base mechanism involving activation of a zinc-bound water molecule by the carboxylate group of the conserved glutamate residue in the catalytic pocket followed by attack of water on the polarized carbonyl group in the substrate's scissile bond (Browner et al. (evelinvahter.com)

Collagen has been widely used in cosmetic surgery, as a healing aid for burn patients for reconstruction of bone and a wide variety of dental, orthopedic and surgical purposes. (wikidoc.org)

Matrix metalloproteinase are a family of zinc dependent endopeptidases that are capable of degrading most components of the extra cellular matrix (ECM) [ 7 - 9 ]. (biomedcentral.com)

The enzyme responsible for collagen maturation is prolyl 4-hydroxylase, making this enzyme a central activity in cuticle biosynthesis and a potentially important chemotherapeutic target. (embl.de)

Individuals with problems in these areas are more likely to be suffering from some other underlying condition rather than protein deficiency. (wikidoc.org)

Over the last 15 years, he has shifted his research to the investigation of extracellular matrix remodeling associated with angiogenesis and microvascular integrity. (sfbmec.fr)

Ligation of integrin α2β1 on collagen prevents flow-induced NF-κB activation through a p38-dependent pathway that is activated locally at adhesion sites. (rupress.org)

in this manner we show that fibrotic matrices clearly promote transforming growth factor-β-independent myofibroblast differentiation compared with normal matrices. (atsjournals.org)

A polypeptide substance comprising about one third of the total protein in mammalian organisms. (lookformedical.com)

Derived from rice protein, this unique ingredient prevents collagen breakdown, delaying aging of skin. (remi-d.com)
Soy protein that prevents elastin breakdown. (remi-d.com)

This process results in a more physiologic substrate that retains normal stiffness, architecture, and matrix composition compared with native lungs. (atsjournals.org)

No specific or efficient treatment exists for Alport syndrome, an X-linked hereditary disease caused by mutations in collagen type IV, a crucial component of the glomerular basement membrane. (hindawi.com)
The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers. (lookformedical.com)
Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer. (lookformedical.com)
The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage. (lookformedical.com)
Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits. (lookformedical.com)
Type IV collagen is the main component of the basement membrane that gives strength to the blood-gas barrier (BGB). (biomedcentral.com)
however, the specific role of type IV collagen in regulating alveologenesis remains unknown. (biomedcentral.com)
Our study showed that type IV collagen and, therefore the basement membrane, play fundamental roles in coordinating alveolar morphogenesis. (biomedcentral.com)

Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)

Thus, human endocrine cells are not in direct contact with the vascular BM components but with the invaginated peri-islet membrane. (nature.com)
His interests in this field more specifically target the establishment of the vascular basement membrane during vessel formation and the role of the cross-linking enzyme lysyl oxidase-like 2 (LOXL2) in this context. (sfbmec.fr)

Whereas α2 laminins promoted islet cell clustering, they did not affect gene expression. (nature.com)
The peri-islet membrane, which encapsulates the islets, separates the endocrine cells from the exocrine pancreas and serves as a barrier from immune cell infiltration to the islets. (nature.com)
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. (lookformedical.com)
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. (lookformedical.com)
It now appears clearly that cell-surface proteins participate in many stages of the colonization process and/or the disease transition. (biomedcentral.com)
CARNOSINE there are many great qualities of Carnosine, When is comes to clinical skin care Carnosine stabilizes and protects cell membranes, helping to protect the cells from harmful free radicals. (remi-d.com)
Ceramides are found in high concentrations within the cell membrane of cells.Ceramides greatly improve the skins ability to retain moisture. (remi-d.com)
This control is propagated through the alpha-subunit of prolyl 4-hydroxylase where protein levels were previously shown to rise fivefold with increasing cell density. (embl.de)

Collagens are widely employed in the construction of artificial skin substitutes used in the management of severe burns , as well as for a wide range of dental, orthopedic, and surgical purposes. (wikidoc.org)

2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. (leanfactor.com)
Manufacturers of collagen-based dietary supplements claim that their products can improve skin and fingernail quality as well as joint health. (wikidoc.org)

The inferred regulatory function of these OM proteins suggests that the difference between the two biominerals is due to the modeling of the matrix network, rather than the presence of specific structural components. (biomedcentral.com)

A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. (lookformedical.com)

Since then, the super family of collagens became "her family" and she has now 30 years of experience in matrix biology research. (sfbmec.fr)

Anatomy50

Organisms10

Diseases9

Chemicals and Drugs115

Analytical, Diagnostic and Therapeutic Techniques and Equipment29

Phenomena and Processes39

Disciplines and Occupations2

Technology, Industry, Agriculture3

Information Science3

Fibronectin6

Glycoproteins2

Proteoglycans1

Fibrillar collagens2

Connective tissue10

Tissues7

Fibroblasts3

Molecules4

Elastic fibers1

Tissue8

Isoforms3

Metalloproteinases5

MMPs6

Cartilage3

Deposition1

Gelatin4

Genes3

Interactions4

Enzymes2

Lung6

Bovine1

Integrins2

Secrete1

Abundant3

Degradation1

Macromolecules1

Embryonic1

Proliferation2

Hydroxyproline2

Chains2

Interstitial1

Predominant1

Characteristic1

Synthesis3

Amino acid1

Vivo1

Substrates1

Bone1

Metalloproteinase1

Potentially1

Deficiency1

Angiogenesis1

Adhesion1

Myofibroblast1

Total protein1

Prevents2

Substrate1

Type8

Cellular1

Vascular2

Cell8

Widely1

Dietary2

Components1

Found1

Family1