OrganismsDiseasesChemicals and Drugs
Clostridium histolyticumDupuytren ContractureMicrobial CollagenaseClostridiumCollagenasesCollagenClostridium difficile
XiaflexEnzymeInjectionInjectionsDupuytren'sXiapexCollagenTreatmentClinicalAlfaEfficacySantylDrugsSurgeryTrialsAdverseTypeDataReduceSolutionCombination of bacterial collagenasesApproved collagenase clostridium histolyticum-aaesIslet isolationInjectable CollagenaseDupuytrenNeutral ProteaseBacterialPeyronie's DiseaseFasciectomyDupuytren's ContractureRecombinantTreatmentsCelluliteBacteriumClostridialProteasesPlantarPowderEnzymesIsletsPurificationSingle doseSubstanceTropocollagenYieldsSecondaryWomenRatioMixtureTissueClassSimilar
Xiaflex3
  • are allergic to collagenase clostridium histolyticum , or any of the ingredients in Xiaflex, or to any other collagenase product. (hdkino.org)
  • Ask your healthcare professional (HCP) about XIAFLEX ® (collagenase clostridium histolyticum) , the only FDA-approved nonsurgical treatment for adult men who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees at the start of therapy. (almoghtribon.net)
  • What is XIAFLEX ® (collagenase clostridium histolyticum) and how can it help? (almoghtribon.net)
Enzyme6
Injection5
  • To determine the safety and efficacy of collagenase clostridium histolyticum (CCH) injection for the treatment of palmar Dupuytren disease nodules. (qxmd.com)
  • Collagenase clostridium histolyticum (CCH) is a novel nonsurgical injection being studied for the treatment of PD. (neaua.org)
  • AAV2 containing cDNA encoding enhanced green fluorescent protein (GFP), under the control of a chicken β-actin promoter, was delivered by intravitreal injection to adult mice in conjunction with enzymes including collagenase, hyaluronan lyase, heparinase III, or chondroitin ABC lyase. (molvis.org)
  • In this narrative review we explore additional indications for which intralesional collagenase Clostridium histolyticum (CCH) injection therapy may be used, in addition to those utilized in the IMPRESS trials. (urotoday.com)
  • Nearly all participants, 97%, treated with collagenase experienced an adverse event compared with around a quarter receiving placebo, most of which were mild or moderate (e.g. swelling, pain, injection site bleeding and itching). (nihr.ac.uk)
Injections3
  • If collagenase injections reduce stiffness, the need for surgical intervention to achieve the same outcome may be reduced. (pedalwithpete.org)
  • Can injections of collagenase reduce the amount of muscle stiffness? (pedalwithpete.org)
  • This review aimed to compare injections of collagenase clostridium histolyticum with standard surgical treatments for Dupuytren's contracture. (nihr.ac.uk)
Dupuytren's3
  • Xiapex (Collagenase Clostridium Histolyticum) Authorised In The European Union For Dupuytren's Contracture, Medical News Today, Bexhill-on-Sea, East Sussex, 3 March 2011.Accessed: 19 March 2011. (wikipedia.org)
  • Draft guidance from NICE recommends against the use of collagenase clostridium histolyticum for Dupuytren's, except in the context of research. (nihr.ac.uk)
  • The aim of this review was to assess the effectiveness of collagenase for adults with Dupuytren's contracture compared with surgery. (nihr.ac.uk)
Xiapex1
  • Xiapex: collagenase clostridium histolyticum, European Medicines Agency, Undated.Accessed: 20 March 2011. (wikipedia.org)
Collagen3
Treatment5
  • Endo International plc (NASDAQ:ENDP) announced today initial results from a Phase I study (EN3835-105) evaluating collagenase clostridium histolyticum (CCH) for the treatment of plantar fibromatosis. (endo.com)
  • DUBLIN , May 5, 2022 /PRNewswire/ -- Endo International plc (NASDAQ: ENDP) today announced the upcoming launch of a new clinical study relevant to the use of Qwo ® (collagenase clostridium histolyticum-aaes) for the treatment of moderate to severe cellulite in the buttocks of adult women. (endo.com)
  • The poster presentation, titled "APHRODITE-1: A Phase 2 Study of Different Interventions to Reduce Bruising Following Collagenase Clostridium Histolyticum-aaes Treatment for Cellulite of the Buttocks in Women," will share the objectives and unique design of this multi-cohort study which will test different interventions to assess their potential impact on reduction of bruising. (endo.com)
  • are allergic to collagenase or to any of the ingredients in QWO, or have an active infection at the treatment area. (endo.com)
  • Herman and Demidova-Rice discovered several peptides from a Clostridium histolyticum collagenase treatment of bio-synthesized extracellular matrix in December 2010 and subsequently singled out key peptides from which they created the peptide, comb1, which has several strategic features, such as the ability to stimulate angiogenesis by increasing blood vessel growth by 200% in vitro. (medicalnewstoday.com)
Clinical3
  • Collagenase is no longer available on the National Health System except as part of a small clinical trial. (wikipedia.org)
  • It is theorised that drugs interfering with matrix metalloproteinases, such as tetracyclines, anthracyclines, quinolones and anthraquinone derivatives, could reduce the efficacy of the collagenases, but no clinical evidence for such an interaction has been observed. (wikipedia.org)
  • Joints treated with collagenase were ten times more likely to achieve clinical success compared to those treated with placebo - 63% versus 6% (relative risk 10.21, 95% confidence interval 5.29 to 19.69). (nihr.ac.uk)
Alfa1
Efficacy1
  • Efficacy and safety of collagenase clostridium histolyticum for Dupuytren disease nodules: a randomized controlled trial. (qxmd.com)
Santyl1
  • A similar ointment preparation called Santyl contains one or many collagenases from the same bacterium, but it is unclear which. (wikipedia.org)
Drugs1
  • Our drug repurposing analysis predicted new candidates for repurposed drugs including ocriplasmin and collagenase. (fortunepublish.com)
Surgery5
  • Unfortunately existing trials are small and there are no head to head trials of surgery vs collagenase, so it is not possible to determine which therapy is more effective in the short or longer term - nor which is likely to be the more cost-effective. (nihr.ac.uk)
  • Two non-randomised trials compared collagenase with surgery, but no higher quality evidence was found. (nihr.ac.uk)
  • However, few studies have directly compared collagenase with surgery, and so there was considerable uncertainty about many of the assumptions used in the model. (nihr.ac.uk)
  • There were no randomised controlled trials comparing collagenase with surgery, and included trials were small and sponsored by companies involved in the development of collagenase. (nihr.ac.uk)
  • The two non-randomised controlled trials comparing collagenase with surgery gave mixed results and had a high risk of bias. (nihr.ac.uk)
Trials1
  • Five randomised controlled trials compared collagenase with placebo. (nihr.ac.uk)
Adverse1
  • Four serious adverse events were observed in the collagenase group: three tendon ruptures and one case of severe, persistent pain. (nihr.ac.uk)
Type1
  • Collagenase, Type 1 (Code: CLS-1), which is filtered through a 0.22 micron membrane and lyophilized in vials. (cellsystems.eu)
Data1
Reduce1
  • Corticosteroids, verapamil , or collagenase clostridium histolyticum ( collagenase ) can be injected into the scar tissue to break it up and, thereby, decrease inflammation and reduce scarring. (merckmanuals.com)
Solution2
Combination of bacterial collagenases1
Approved collagenase clostridium histolyticum-aaes1
  • The Food and Drug Administration has approved collagenase clostridium histolyticum-aaes (Qwo, Endo International) for the treatment of moderate to severe cellulite in the buttocks of adult women. (medscape.com)
Islet isolation3
  • A simple in vitro method for evaluating the efficacy of different batches of crude Clostridium histolyticum collagenase for islet isolation. (ox.ac.uk)
  • Bala achieved respectful human islet yields when using VitaCyte's Thermolysin with purified Collagenase HA for human islet isolation. (vitacyte.com)
  • [3] However, Bala believed that Clostridium histolyticum neutral protease (CHNP) was superior to Thermolysin for human islet isolation based on his earlier work with Rita Bottino at the University of Pittsburgh where they showed the best quality islets were those isolated using Roche's Collagenase P product. (vitacyte.com)
Injectable Collagenase5
  • Injectable collagenase clostridium histolyticum for Dupuytren's contracture. (medscape.com)
  • Injectable Collagenase Versus Percutaneous Needle Fasciotomy for Dupuytren Contracture in Proximal Interphalangeal Joints: A Randomized Controlled Trial. (nih.gov)
  • 4. A Phase I Clinical Trial to Assess Safety and Tolerability of Injectable Collagenase in Women with Symptomatic Uterine Fibroids. (nih.gov)
  • Our initiation of this Phase 2 placebo-controlled clinical trial of CCH in patients with lipoma represents another important development milestone for BioSpecifics as we further advance our pipeline and continue to uncover the vast potential of injectable collagenase," commented Thomas L. Wegman , President of BioSpecifics. (prnewswire.com)
  • BioSpecifics Technologies Corp. is a biopharmaceutical company that has developed injectable collagenase for twelve clinical indications to date. (prnewswire.com)
Dupuytren2
  • collagenase lyses collagen, leading to enzymatic disruption of contracted Dupuytren cord or Peyronie plaque (both comprised primarily of collagen). (geisinger.org)
  • This article presents a comprehensive review of the surgical and nonsurgical treatments of Dupuytren disease, with a focus on collagenase. (stanford.edu)
Neutral Protease1
  • STZ1 & STZ2 , 0.22μ filtered STEMxyme ® AF Collagenase/Neutral Protease (Dispase ® ) blends for primary and stem cell isolation. (worthington-biochem.com)
Bacterial2
Peyronie's Disease2
  • Conclusions: Although intralesional therapy with collagenase Clostridium histolyticum is not yet indicated for the acute phase of Peyronie's disease, these preliminary results suggest the effectiveness of this minimally invasive option by improving penile curvature and IIEF-5 and PDQ scores. (units.it)
  • Bajic P, Wiggins AB, Ziegelmann MJ, Levine LA. Characteristics of Men With Peyronie's Disease and Collagenase Clostridium Histolyticum Treatment Failure: Predictors of Surgical Intervention and Outcomes. (rush.edu)
Fasciectomy1
  • A retrospective cohort analysis was conducted to compare disease-specific healthcare resource utilization and the costs of collagenase clostridium histolyticum and fasciectomy among adult Dupuytren’s contracture patients. (pharmacytimes.com)
Dupuytren's Contracture1
  • Treatment of Dupuytren's Contracture With Collagenase: A Systematic Review. (medscape.com)
Recombinant3
  • The initial studies used a fixed amount of BP Protease with one of four different doses of recombinant C. histolyticum class I and class II. (vitacyte.com)
  • [5] Further studies by Bala and colleagues at the University of Louisville using intact pancreas showed that this dose of BP Protease was very effective in recovering islets when excess purified recombinant or natural collagenase was used in the isolation procedure. (vitacyte.com)
  • [6] The mean islet yield per g tissue from all the studies above was 5,309 IEQ when either excess purified recombinant or natural collagenase with a fixed dose of 23,400 NP U of BP Protease. (vitacyte.com)
Treatments2
  • Currently, minimally invasive treatments for DD include percutaneous needle fasciotomy (PNF) and collagenase clostridium histolyticum (CCH). (nih.gov)
  • 6. Using rheology to quantify the effects of localized collagenase treatments on uterine fibroid digestion. (nih.gov)
Cellulite5
  • Cite this: FDA Approves Collagenase Clostridium Histolyticum-aaes for Cellulite - Medscape - Jul 09, 2020. (medscape.com)
  • If you are receiving collagenase Clostridium histolyticum (QWO) to treat cellulite, your doctor will inject it subcutaneously (just under the skin) into the buttock(s). (medlineplus.gov)
  • Driven by world-class research and development, the company is advancing solutions to address unmet needs beginning with the launch of QwoTM (collagenase clostridium histolyticum-aaes), the first and only FDA-approved injectable for the treatment of moderate to severe cellulite in the buttocks of adult women. (theaestheticguide.com)
  • They are naturally occurring enzymes called collagenases that break down the collagen bands that cause the rippling associated with cellulite. (renaissanceplasticsurgery.net)
  • Qwo (Collagenase Clostridium Histolyticum-aaes) is a prescription injectable used in office to treat moderate to severe cellulite. (charlotteskinandlaser.com)
Bacterium1
  • A similar ointment preparation called Santyl contains one or many collagenases from the same bacterium, but it is unclear which. (wikipedia.org)
Clostridial1
Proteases2
  • Levels of secondary proteases are similar to Types 1 and 2 collagenase. (worthington-biochem.com)
  • CLSAFA is the original AF grade designed to have collagenase and secondary proteases similar to Types 1 and 2 collagenase. (worthington-biochem.com)
Plantar1
  • DUBLIN , July 13, 2023 /PRNewswire/ -- Endo International plc (OTC: ENDPQ) announced today that new data from a Phase 1 study of collagenase clostridium histolyticum (CCH) in patients with plantar fibromatosis will be presented during the American Podiatric Medical Association's (APMA) annual scientific meeting. (businessinsider.com)
Powder1
  • Single-use glass vials containing 0.9 mg of collagenase clostridium histolyticum as a sterile, lyophilized powder for reconstitution. (nih.gov)
Enzymes1
  • Collagenases belong to the family of matrix metalloproteinases (MMPs), the transmembrane zinc endopeptidase enzymes. (ijpsonline.com)
Islets2
  • Further experiments compared the effectiveness of CHNP or thermolysin mixed with a fixed dose of VitaCyte's Collagenase HA to recover islets from a split human pancreas. (vitacyte.com)
  • These results showed that collagenase was in excess, the dose did not affect the recovery of functional islets from the body-tail of human pancreas. (vitacyte.com)
Purification1
  • The inhibitor can be coupled to aminohexyl-agarose by reaction with EDC to yield an affinity gel (28) suitable for purification of collagenase (27). (elastin.com)
Single dose1
  • Each QWO 0.92-mg single-dose vial contains 0.92 mg of collagenase clostridium histolyticumaaes and mannitol (37.7 mg), sucrose (18.9 mg), tromethamine (1.1 mg), and hydrochloric acid as needed to adjust pH. (globalrph.com)
Substance1
  • The substance is a constant mixture of two collagenases (AUX-I and AUX-II) with known amino acid sequences and a length of about 1000 amino acids each. (wikipedia.org)
Tropocollagen1
  • The two collagenases act synergistically by cleaving tropocollagen (the 'collagen molecule') at different points. (wikipedia.org)
Yields1
  • Reconstitution with 4 mL of supplied Diluent for QWO yields a solution containing 0.23 mg/mL collagenase clostridium histolyticum-aaes at a pH of approximately 8.0. (globalrph.com)
Secondary1
  • Purified collagenase, Codes: CLSPA/CLSPANK, contain minimal secondary proteolytic activities along with high collagenase activity. (worthington-biochem.com)
Women2
  • Also, Qwo is not recommended for women who have an allergy to collagenase or any of the other ingredients in this product. (renaissanceplasticsurgery.net)
  • Dr. Matarasso discusses Collagenase clostridium histolyticum (CCH) and how it affects women of all ages and ethnicities. (dermsf.com)
Ratio1
Mixture1
Tissue1
  • In that year, Gross and Lapiere obtained evidence for a collagenase in bullfrog tadpole tissue culture media (Gross 1962, Harper 1980), which was the discovery of the first vertebrate collagenase. (worthington-biochem.com)
Class2
Similar1