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  • domain of type IV colla
  • For example, in Goodpasture's syndrome, a disease characterized by hemoptysis and hematuria due to alveolitis and nephritis, respectively, an antibody to the major non-collagenous NC1 domain of type IV collagen is found in the serum of all Goodpasture's patients. (google.com)
  • In a specific embodiment of the invention, the isolated domain of type IV collagen comprises the NC1 (α1), (α2), (α3), or (α6) chain monomer, or protein constructs having substantially the same structure as the NC1 (α1), (α2), (α3), or (α6) chain monomer. (google.com)
  • renal
  • Background: Collagen IV-related nephropathies can lead to End Stage Renal Disease. (clinicaltrials.gov)
  • Methods: This is a retrospective study of patients with Collagen IV-related nephropathies and proteinuria treated with enalapril analyzing the evolution of proteinuria and renal function, as well as predictive variables of progression to end stage renal disease. (clinicaltrials.gov)
  • Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury. (wikipedia.org)
  • Loss of DDR1-expression in the kidney delayed renal fibrosis and inflammation in hereditary type IV collagen disease. (uzh.ch)
  • encodes
  • The COL4A3BP gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. (moldiag.com)
  • amnion
  • The present report documents that type IV collagen is lost from the rat amnion before the onset of labor. (levelofhealth.com)
  • The simplest interpretation of our in vitro studies is that increased expression of the MMP-9 proenzyme leads to the formation of active enzyme, which, in turn, degrades type IV collagen, leading to amnion cell apoptosis. (levelofhealth.com)
  • tissue
  • 35 mm - Culture Dishes - BD BioCoat Cellware, Collagen Type IV, BD Biosciences : These BD BioCoat Collagen IV Cellware products consist of BD Falcon Multiwell Tissue Culture inserts, plates, dishes, and flasks treated with a uniform application of Collagen IV to promote cell adhesion and differentiation of a variety of cell types. (egeneralmedical.com)
  • In degenerated fibrocartilage, including intervertebral disc, as in degenerated hyaline cartilage only collagen type IV was found pericellularly around chondrocytes but with less intense staining than in non-degenerated tissue. (harvard.edu)
  • Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease and hepatitis C and fall following successful therapy. (wikipedia.org)
  • We studied expression of type IV collagen and the MMP-2 and MMP-9 in human fetal teeth (from the 13th to the 20th gestational weeks, covering cap stage through early hard tissue formation). (nih.gov)
  • The expression of type IV collagen and its integrin receptors were examined in vivo in human pancreatic cancer tissue. (diva-portal.org)
  • The instant invention provides methods and kits for inhibiting angiogenesis, tumor growth and metastasis, and endothelial cell interactions with the extracellular matrix, involving contacting the tumor or animal tissue with at least one isolated type IV collagen NC1 α chain monomer. (google.com)
  • alpha2
  • Their GBM instead retain a fetal distribution of alpha1(IV) and alpha2(IV) isoforms because they fail to developmentally switch their alpha-chain use. (jci.org)
  • In these patients, alpha1 (IV) and alpha2 (IV) were normal, whereas alpha3 (IV), alpha4 (IV), alpha5 (IV) and alpha6 (IV) were absent from the BMs of the kidney. (nii.ac.jp)
  • chains
  • FN1 has been reported to bind isolated collagen alpha-1(I), alpha-2(I) and alpha-1(II) chains as well as several CNBr fragments (Ingham et al. (reactome.org)
  • Herein the alpha chains 3, 4 and 5 plays an special role. (moldiag.com)
  • Collagen chains undergo several posttranslational modifications that are indispensable for proper collagen function. (pnas.org)
  • chain
  • 1988, 2002) indicating that there are multiple FN1 binding sites within each collagen chain (Dessau et al. (reactome.org)
  • embryonic
  • Thus, 3-hydroxylation of type IV collagen is indispensable for embryonic development in mice. (pnas.org)
  • The mechanism of the unexpectedly early lethality involves the interaction of non-3-hydroxylated embryonic type IV collagen with the maternal platelet-specific glycoprotein VI (GPVI). (pnas.org)
  • tissues
  • In skin tissues of male patients, neither alpha5 (IV) nor alpha6 (IV) were detected. (nii.ac.jp)
  • apoptosis
  • Furthermore, the interaction between type IV collagen produced by the cancer cell, and integrins on the surface of the cancer cells, are important for continuous cancer cell growth, maintenance of a migratory phenotype, and for avoiding apoptosis. (diva-portal.org)
  • glycoprotein
  • Prolyl 3-hydroxylation of type IV collagen is required to avoid an aberrant interaction with the platelet-specific glycoprotein VI (GPVI), resulting in platelet aggregation, thrombosis of the maternal blood, and death of the embryo. (pnas.org)
  • The variety of functions of type IV collagen suggests that this glycoprotein is important in many diverse and clinically relevant processes such as cell attachment and migration, wound healing, tumor cell metastasis and invasion, diabetic microangiopathy, vascular hypertrophy due to hypertension and several kidney diseases such as diabetic nephropathy and nephrotic syndromes of variable etiology. (google.com)
  • fetal
  • The anomalous persistence of these fetal isoforms of type IV collagen in the GBM in XAS also confers an unexpected increase in susceptibility to proteolytic attack by collagenases and cathepsins. (jci.org)
  • parallel
  • The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. (wikipedia.org)