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CollagenCollagen Type ICollagen Type IIICollagen Type IVCollagen Type IICollagen Type VFibrillar CollagensCollagen Type VICollagen Type XIReceptors, CollagenExtracellular MatrixExtracellular Matrix ProteinsCollagen Type XVIIIProcollagenCollagen Type XCartilageCollagen Type XIIFibronectinsHydroxyprolineFibroblastsBasement MembraneCells, CulturedLamininCollagen DiseasesDecorinCollagen Type IXFibrosisProteoglycansCartilage, ArticularChondrocytesRNA, MessengerCollagen Type VIIITendonsSkinMicrobial CollagenaseCollagen Type VIICattlePepsin AGelsCollagenasesCell AdhesionHydroxylysineTransforming Growth Factor beta1Transforming Growth Factor betaConnective TissueImmunohistochemistryTissue EngineeringIntegrinsIntegrin alpha2HSP47 Heat-Shock ProteinsChondrogenesisAggrecansIntegrin alpha1beta1ElastinOsteogenesis ImperfectaGlycosaminoglycansMicroscopy, ElectronMatrix Metalloproteinase 1Fibril-Associated CollagensPlatelet AdhesivenessMolecular Sequence DataChick EmbryoDescemet MembranePeptide FragmentsWound HealingCorneaFluorescent Antibody TechniqueMicroscopy, Electron, ScanningAmino Acid SequenceTissue ScaffoldsProcollagen-Lysine, 2-Oxoglutarate 5-DioxygenaseGene ExpressionNon-Fibrillar CollagensBiglycanCell DifferentiationBone and BonesMatrix Metalloproteinase 2Corneal StromaArthritis, ExperimentalAntigens, CD29Electrophoresis, Polyacrylamide GelProlineCollagen Type XIIICyanogen BromideTissue Inhibitor of Metalloproteinase-1QuinazolinonesOsteogenesisDisease Models, AnimalReverse Transcriptase Polymerase Chain ReactionGene Expression RegulationPeptidesCell Culture TechniquesCell MovementMatrix MetalloproteinasesGelatinTime FactorsDermisTensile StrengthProtein BindingStress, Mechanical
PeptidesCartilageHyaluronic acidSupplementsSupplementMarine CollagenDifferent types of collaTendonsJointsChain of type I collagElasticityOsteoarthritisBasement membraneWays of boostingProtein in the humaPowderConnective tissuesCOL1a2Body'sAmino acidsProteinsGrass-fed collagenChanges in collagenProduction of collagenMutationsBiosynthesisBovineMRNAFibroblastsWrinklesFibersHomologyGeneELISA KitBonesScaffoldBone MineralAntibodyJoint painSymptomsDigestionNaturallyStructuresDietaryBiolGlycineBlood vesselsIngredientsProcollagenDisordersBiomarkersCellsBoostCOL4A1
Peptides13
Cartilage20
Hyaluronic acid4
Supplements16
Supplement8
  • If you're looking for a supplement to help you fight type 2 diabetes, you've probably wondered if Glucofort is FDA-approved. (virginrecords.net)
  • In a 2019 blinded placebo-controlled study, subjects were given a collagen supplement. (sundt.de)
  • Hydrolyzed Collagen Type 2 is a safe and well-tolerated supplement, with no known side effects. (optiwizehealth.com)
  • In conclusion, Hydrolyzed Collagen Type 2 is a safe and effective supplement that can provide numerous health benefits, including improved joint health, skin health, gut health, and muscle mass. (optiwizehealth.com)
  • Meet complete: this all-encompassing collagen supplement makes beauty, gut health, and joint support easy as 1, 2, 3. (bodyenergyclub.com)
  • Made with powerful hair skin and nails vitamins such as Biotin, Vitamin C, and Hyaluronic complex, this collagen supplement is perfectly formulated to strengthen your hair follicles, increase keratin proteins, and increase skin elasticity from the inside out. (livezeal.com)
  • This type of collagen supplement is not broken down and is not as well absorbed as hydrolyzed collagen. (healthnews.com)
  • This is the most basic form of collagen supplement as your body can quickly absorb it. (practicethis.com)
Marine Collagen6
Different types of colla2
  • The molecules of the 28 different types of collagen are arranged according to how the body uses them. (healthnews.com)
  • Mutations can exist in the genes that encode different types of collagen (eg, type I, III, or V) or collagen-modifying enzymes (eg, lysyl hydroxylase, a collagen-cleaving protease). (msdmanuals.com)
Tendons5
Joints11
Chain of type I collag1
  • USA 85: 5254 (1988)] found that the previously demonstrated shortened pro-alpha-2 chain of type I collagen resulted from deletion of exon 28 which in turn resulted from substitution of G for A at the 3-prime end of intron 27. (coriell.org)
Elasticity6
  • This study was able to show that a collagen preparation can improve skin moisture and the elasticity, roughness and density of the skin (4). (sundt.de)
  • As age and other factors reduce collagen levels, the skin loses its elasticity, and lines can form. (medicalnewstoday.com)
  • Skin Health: Collagen is an important component of the skin, and Hydrolyzed Collagen Type 2 has been shown to improve skin hydration, elasticity, and firmness. (optiwizehealth.com)
  • Collagen is the most abundant form of protein in our body, providing it with strength, elasticity, and tone. (bodyenergyclub.com)
  • Healthy Skin, Hair & Nails: Collagen is the main protein that gives our skin elasticity. (nowketo.com)
  • Collagen is the protein that gives our skin elasticity, makes hair and nails strong and maintains bone and joint strength. (nowketo.com)
Osteoarthritis3
Basement membrane4
Ways of boosting1
Protein in the huma2
  • Collagen is the most abundant protein in the human body. (sundt.de)
  • Type 2 collagen is the body's most important structural protein and makes up about a third of all protein in the human body. (sundt.de)
Powder4
Connective tissues1
COL1a22
  • Description: A sandwich quantitative ELISA assay kit for detection of Rat Collagen Type I Alpha 2 (COL1a2) in samples from serum, plasma, tissue homogenates or other biological fluids. (2sars.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Collagen Type I Alpha 2 (COL1a2) in serum, plasma, tissue homogenates and other biological fluids. (2sars.com)
Body's7
  • The body's own production of collagen can be stimulated with the help of a balanced diet with a focus on vitamin C and the amino acids proline and lysine. (sundt.de)
  • In people with diabetes, the body's ability to use or produce insulin, a hormone that assists to regulate blood sugar level levels, is impaired collagen for type 2 diabetes. (caningest.com)
  • Type 1 diabetes is an autoimmune condition in which the body's immune system attacks and damages the insulin-producing cells in the pancreas. (caningest.com)
  • Type 2 diabetes is a metabolic disorder that takes place when the body becomes resistant to the effects of insulin and/or the pancreas is not able to produce enough insulin to keep up with the body's needs. (caningest.com)
  • This type of hair loss is an unexplained response to the body's production of androgens or male sex hormones but other causes can include fungal infections, thyroid problems, severe illness and the use of certain prescription medicines. (victoriahealth.com)
  • The main purpose of taking collagen is to resupply our body's collagen supply, which has been lowered for various reasons. (healthnews.com)
  • There are many food items you can eat to increase your body's collagen amount, such as pork skin and bone broth. (practicethis.com)
Amino acids2
Proteins4
Grass-fed collagen1
Changes in collagen2
  • As people get older, changes in collagen structure occur that weaken the bond between the different layers of the skin. (medicalnewstoday.com)
  • These values, normalized to a color scale displaying the ultrasound image, will allow for a comparative analysis of changes in collagen and elastin fiber content in the dermis. (who.int)
Production of collagen1
Mutations3
  • de Wett W, Sippola M, Tromp G, Prockop D, Chu ML, Ramirez F , Use of R-loop mapping for the assessment of human collagen mutations. (coriell.org)
  • Mutations of the Janus kinase 2 ( JAK2 ) gene are present in a high proportion of cases of primary myelofibrosis. (msdmanuals.com)
  • Different gene mutations affect the amount, structure, or assembly of different collagens. (msdmanuals.com)
Biosynthesis2
Bovine2
MRNA3
  • d - i Type IV collagen protein and mRNA expression in the lung. (biomedcentral.com)
  • the expression of type 1 and type 4 collagens and SVCT2 mRNA was enhanced, and type 1 procollagen synthesis increased. (nih.gov)
  • Thus, these results indicate that human skin fibroblasts exposed to AA over time had rising levels of type 1/type 4 collagens and SVCT2 mRNA expression and type 1 procollagen synthesis. (nih.gov)
Fibroblasts3
  • de Wet WJ, Chu ML, Prockop DJ , The mRNAs for the pro-alpha 1(I) and pro-alpha 2(I) chains of type I procollagen are translated at the same rate in normal human fibroblasts and in fibroblasts from two variants of osteogenesis imperfecta with altered steady state ratios of the two mRNAs. (coriell.org)
  • In fact, several studies have shown that T2D induces senescence in multiple types of cells, including fibroblasts and endothelial cells ( 11 , 12 ). (frontiersin.org)
  • These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)
Wrinkles3
  • Collagen gives skin a smoother fuller appearance, reducing the look of lines and wrinkles. (nowketo.com)
  • Collagen supplementation has been shown to support skin health to improve signs of aging, such as wrinkles and decreased puffiness. (prohealth.com)
  • Collagen is a vital component of your skin and plays a crucial role in strengthening it-lack of collagen results in the formation of wrinkles and dry skin. (practicethis.com)
Fibers3
  • Collagen is fiber-forming (fibrillar): The individual collagen fibers form a collagen framework. (sundt.de)
  • This includes the collagen fibers. (sundt.de)
  • It has a special configuration that gives particular elastic properties to protein: collagen fibers are located in the extracellular matrix and have the capacity to increase or reduce their volume according to the degree of compression to which they are subjected. (springer.com)
Homology1
  • They are classified into 5 groups according to substrate specificity and internal homology: collagenases, gelatinases, stromelysins, membrane-type MMPs, and others, including matrilysins 8 . (bvsalud.org)
Gene4
  • Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene. (wikipedia.org)
  • This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. (wikipedia.org)
  • Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. (wikipedia.org)
  • Moreover, we determined the effects on type 1 and type 4 collagen and sodium-dependent vitamin C transporter (SVCT) gene expression when medium containing 100 μM AA was replaced every 24h for 5 days to avoid depletion of AA. (nih.gov)
ELISA Kit1
  • Description: A sandwich ELISA kit for detection of Collagen Type XI Alpha 2 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (unicoupi.com)
Bones5
  • Collagen has the ability to provide skin with structure and strengthens bones. (practicethis.com)
  • Collagen is a significant part of your tissues and bones, and your body requires a proper amount of collagen on a daily basis. (practicethis.com)
  • The bones contain a certain amount of collagen, which gives them structure and helps keep them strong. (practicethis.com)
  • Bones vary widely in size, ranging from the tiny inner ear bones that are responsible for transmitting mechanical sound waves to the sensory organs to the large (nearly 2 ft long) femur bone that is strong enough to withstand 30 times one's body weight. (medscape.com)
  • 1, 2, 4] Short bones arise from the same precursors but are not necessarily structurally similar to long bones, often taking on unique shapes (eg, carpal bones). (medscape.com)
Scaffold6
  • In this study, we compared the osteoinductive potential of BMP-2 homodimer with a heterodimer of BMP-2/7, both delivered via a collagen-hydroxyapatite (CHA) scaffold delivery system, with the aim to reduce the overall therapeutic BMP doses and the associated side-effects. (lu.se)
  • Using fluorescently labelled BMP-2/7 and BMP-2, we demonstrated that the CHA scaffold provided a long-term delivery of both molecules for at least 20 days. (lu.se)
  • Our results indicate that the sustained delivery of BMP-2/7 via a CHA scaffold could bring us a step closer in the quest for the use of physiological growth factor doses in fracture healing. (lu.se)
  • Incorporation of hydroxyapatite (HA) in a collagen scaffold dramatically improves bone morphogenic protein (BMP) sequestration via biophysical interactions with BMP, thereby providing more controlled BMP release compared with pristine collagen. (lu.se)
  • An ultra-low dose of BMP-2/7 delivered via a collagen-HA (CHA) scaffold leads to accelerated healing of a critical femoral defect in rats while a 20-times higher BMP-2 dose was required to achieve comparable results. (lu.se)
  • In order to control biofilm formation, sequester proteolytic enzymes, and provide a biocompatible scaffold to support healing, the investigators utilize a purified collagen matrix containing polyhexamethylene biguanide (PCMP) in a case series of 9 wounds on 8 patients with multiple comorbidities who did not respond to previous conventional or adjuvant therapy. (medscape.com)
Bone Mineral1
Antibody2
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Collagen Type XI Alpha 1 (COL11a1) in samples from serum, plasma and other biological fluids with no significant corss-reactivity with analogues from other species. (unicoupi.com)
  • We have generated a monoclonal antibody against a synthetic peptide whose sequence was derived from the nucleotide sequence of a cDNA encoding alpha 1(XII) collagen. (rupress.org)
Joint pain2
  • Improved Joint Health: Hydrolyzed Collagen Type 2 has been shown to improve joint health by reducing joint pain, increasing joint mobility, and improving joint function. (optiwizehealth.com)
  • Can Collagen Relieve Joint Pain? (healthnews.com)
Symptoms2
  • Treatment is often supportive, but Janus kinase 2 (JAK2) inhibitors, such as ruxolitinib , fedratinib , or pacritnib, may decrease symptoms and stem cell transplantation may be curative. (msdmanuals.com)
  • Symptoms and signs of Ehlers-Danlos syndromes vary widely, but certain manifestations are considered characteristic of different types. (msdmanuals.com)
Digestion1
  • Metabolic labeling of primary cultures of Schwann cells plus neurons and analysis by SDS PAGE revealed the presence of a closely spaced pair of polypeptides in the medium of these cultures that (a) were susceptible to digestion by purified bacterial collagenase, (b) co-migrated with type IV procollagen secreted by rat parietal endoderm cells, and (c) were specifically immunoprecipitated by antibodies against mouse type IV collagen. (rupress.org)
Naturally2
Structures2
  • Collagen is the protein that structures your arteries, the blood vessels that carry blood from your heart to the rest of the body. (practicethis.com)
  • Lastly, we revealed that addition of type IV collagen protein induced myofibroblast proliferation and migration in monolayer culture and increased the formation of mesenchymal-epithelial septal-like structures in co-culture. (biomedcentral.com)
Dietary1
  • The 2 main sources of vitamin D in humans are vitamin D 3 ( cholecalciferol ), produced by the skin after ultraviolet (UV) radiation (290-320nm)-dependent conversion of 7-dehydrocholesterol, and dietary intake of either vitamin D 2 (ergocalciferol) or vitamin D 3 . (medscape.com)
Biol2
Glycine1
  • Gut Health: Hydrolyzed Collagen Type 2 contains high levels of glycine, which has been shown to improve gut health by promoting the growth of beneficial bacteria in the gut. (optiwizehealth.com)
Blood vessels1
Ingredients2
  • OptiWize blend contains perfectly balanced amounts of high-quality hydrolized collagen type II that works in synergy with other ingredients to provide the most optimized results. (optiwizehealth.com)
  • For a detailed breakdown of this product's collagen profile, click " Ingredients " below! (bodyenergyclub.com)
Procollagen5
  • We have obtained evidence that rat Schwann cells synthesize and secrete type IV procollagen. (rupress.org)
  • Removal of neuronal cell bodies from the cultures immediately before labeling did not reduce the amount of type IV procollagen detected in the medium. (rupress.org)
  • This indicated that Schwann cells, not neurons, were responsible for synthesis of type IV procollagen. (rupress.org)
  • We believe type IV procollagen is a major constituent of the Schwann-cell extracellular matrix based upon (a) its presence in a detergent-insoluble matrix preparation, (b) its presence in the cell layer of the cultures in a state in which it can be removed by brief treatment with bacterial collagenase or trypsin, and (c) positive immunofluorescence of Schwann cell-neuron cultures with anti-type-IV collagen antibodies. (rupress.org)
  • Secretion of type IV procollagen was substantially reduced when Schwann cells were maintained in the absence of neurons. (rupress.org)
Disorders1
  • Ehlers-Danlos syndromes are hereditary collagen disorders characterized by joint hypermobility, dermal hyperelasticity, and widespread tissue fragility. (msdmanuals.com)
Biomarkers1
  • The fibrogenic response to short and long SWCNTs was assessed via oxidative stress generation, collagen expression and transforming growth factor-beta (TGF-beta) production as potential fibrosis biomarkers. (cdc.gov)
Cells6
  • Insulin resistance, an illness in which cells do not respond to insulin as it should, is the precursor to type 2 diabetes . (caningest.com)
  • Collagen helps the skin cells renew and repair themselves. (medicalnewstoday.com)
  • Blue cells = expressed in wild-type. (jax.org)
  • In the developing lung, the specific temporal-spatial interactions between mesenchymal and epithelial cells are carefully orchestrated to permit the gradual establishment of an effective blood-gas barrier (BGB) [ 1 , 2 ]. (biomedcentral.com)
  • Many studies have evaluated the relationship between AA and collagen expression in short- and long-term effects on cells after a single administration of AA into the culture medium. (nih.gov)
  • Because age-related cellular senescence and type 2 diabetes (T2D) have been recognised as risk factors for CRC development, the recent finding that type 2 diabetic patients present an elevated circulating volume of senescent cells raises the question whether type 2 diabetes facilitates the process of CRC tumorigenesis by inducing premature cell senescence. (frontiersin.org)
Boost4
COL4A11
  • Mutated COL4A1 disrupts the basic structure of cerebral small vessels via a dominant-negative effect or haploinsufficiency, which results in autosomal-dominant cerebral small-vessel disease 1 , 2 . (nature.com)