• Glycoprotein VI belongs to collagen receptors that are primarily expressed on platelets surface. (wikipedia.org)
  • When damage occurs, endothelial collagen is uncovered and is bound by GPVI receptor on platelets. (wikipedia.org)
  • In the present study, we have tested the hypothesis that thrombin-induced endostatin release from rat platelets is mediated via proteinase-activated receptor-4 (PAR4). (nih.gov)
  • Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. (ox.ac.uk)
  • niche categories to GPVI-FcCfree sections of collagen materials and recruited additional platelets onto aggregates via ADP and TxA2 launch. (cancerhugs.com)
  • Because dimeric GPVI on relaxing platelets is vital for collagen binding and platelet activation? (cancerhugs.com)
  • The binding of GPVI to collagen also signals additional platelets to come together to increase the size of the clot. (medlineplus.gov)
  • Without GPVI binding to collagen, platelets cannot come together efficiently to form a clot, leading to the bleeding problems associated with glycoprotein VI deficiency. (medlineplus.gov)
  • Proteogenomics was applied here to investigate this phenomeon in platelets activated in vitro with Collagen or Thrombin Receptor Activating Peptide. (nature.com)
  • CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. (thermofisher.com)
  • The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. (thermofisher.com)
  • 1) Immune mediated damage near infected endothelial cells leads to collagen exposure, fibrin deposition, platelet activation, endothelial activation, and release of ultra-high molecular weight vWF from endothelial cells and platelets. (cdc.gov)
  • The released ADP acts on the P2Y12 receptor on other platelets, thereby activating them and recruiting them to the site of injury. (msdmanuals.com)
  • Platelet aggregation tests assess the ability of platelets to clump in response to the addition of various activators (eg, collagen, epinephrine , ADP, ristocetin). (msdmanuals.com)
  • DR=EC 50 with the addition of various concentrations of receptor antagonist)/EC 50 without the addition of a receptor antagonist. (avma.org)
  • We investigated, whether GPVI-Fc added in vitro on top of acetylsalicylic acid (ASA), the P2Y 12 antagonist ticagrelor, and the fibrinogen receptor antagonist abciximab alone or in combination would increase inhibition of platelet activation by atherosclerotic plaque. (thieme-connect.com)
  • the effect was inhibited by the H1 receptor antagonist diphenhyramine, suggesting that BEAS cells retain functioning histamine receptors. (epa.gov)
  • The antiCGPVI antibodies BLO8-1 (10 g/ml, 833 nM) and 5C4 (1.25 g/ml, 25 nM) almost completely inhibited plaque- and collagen-induced platelet aggregation within a concentration-dependent way (Online Numbers?2A and 2B, rather than shown). (cancerhugs.com)
  • GPVI-Fc added on top of abciximab, a clinically used anti-fibrinogen receptor antibody which blocks platelet aggregation, strongly inhibited total (81%) and stable (89%) platelet adhesion. (thieme-connect.com)
  • The collagen-induced platelet aggregation of platelet-rich plasma samples from 14 healthy rabbits was measured turbidometrically using a platelet aggregometer, before and 1 hour after intravenous injection of alum. (who.int)
  • Collagen-induced platelet aggregation was significantly reduced after alum injection. (who.int)
  • Unlike other tyrosine-kinase receptors, maximal activation of receptors occurs 18 hours after collagen stimulation. (wikipedia.org)
  • This work identifies DDR2, a unique receptor tyrosine kinase, as a potential therapeutic target active in both tumor cells and tumor stromal cells of the tumor environment. (wustl.edu)
  • Collagen-related peptide (CRP), a collagen homologue, induces platelet activation through a tyrosine kinase-dependent pathway, leading to sequential tyrosine phosphorylation of Fc receptor (FcR) gamma-chain, Syk, and phospholipase C-gamma2. (ox.ac.uk)
  • i.e., activin receptor-like kinase 5 (ALK5) receptor] and TGF-Beta/Smad signaling pathway in CNT-induced collagen production in human lung fibroblasts. (cdc.gov)
  • Beneficial effects of collagen type III on β-cell function via activation of the cAMP/protein kinase A pathway, suppression of RhoA and caspase-3 activity, increased β-cell viability, and proliferation were abolished when ADGRG1 was downregulated in β-cells. (lu.se)
  • We observed that direct stimulation with LT D4, induced intestinal epithelial cell migration, through activation of the CysLT1 receptor, phosphotidylinositol-3 kinase, Vav2 and Rac localisation to membrane ruffles. (lu.se)
  • There are at least eight human collagen receptors. (wikipedia.org)
  • The binding of different collagen receptor integrins to citrullinated collagen was studied by CHO cell lines, each overexpressing 1 of the 4 human collagen receptors on the cell surface, and with solid-phase binding assays, using the recombinant human integrin α1I, α2I, α10I, and α11I domains. (abo.fi)
  • We recently identified the collagen I receptor discoidin domain receptor 2 (DDR2) as a novel upstream regulator of Snail1 protein stability. (wustl.edu)
  • Platelet membrane glycoproteins, mainly GPIa/IIa, GPVI and probably GPIV as well, function as receptors engaged in platelet adhesion to collagen. (wikipedia.org)
  • Glycoprotein VI Receptor GPVI belongs to immunoglobulin family of glycoproteins. (wikipedia.org)
  • Background Discussion between immunoglobulin-like receptor glycoprotein VI (GPVI) and collagen plays a central role in platelet activation and sequent firm adhesion. (ap26113.com)
  • Background Glycoprotein VI (GPVI) may be the necessary platelet collagen receptor in atherothrombosis, but its inhibition causes just a mild blood loss tendency. (cancerhugs.com)
  • The?compound-specific differences have relevance for medical trials targeting GPVI-collagen interaction coupled with founded antiplatelet therapies in individuals with spontaneous plaque rupture or AMG 073 intervention-associated plaque injury. (cancerhugs.com)
  • In response to an injury that causes bleeding, the GPVI protein begins clot formation by attaching (binding) to another protein called collagen that is found on blood vessel walls . (medlineplus.gov)
  • GPVI-Fc, a recombinant dimeric fusion protein binding to plaque collagen and concealing binding sites for platelet GPVI, acts as a lesion-focused antiplatelet drug, and does not increase bleeding in vivo. (thieme-connect.com)
  • High levels of fibrillar collagen in mammary tissue are correlated with increased incidence of breast tumor development in both mice and humans, and tumors that develop in this setting are more invasive and metastatic. (wustl.edu)
  • Synovial cells isolated from the knee joints of naive or sham-immunized mice, or from mice immunized with collagen but without arthritis, released little or no detectable VEGF. (ox.ac.uk)
  • In DBA1/J mice, collagen type II was injected intradermally at the tail base to prepare the CIA model. (ac.ir)
  • This study was undertaken to investigate the effects of PDRN in collagen-induced arthritis (CIA) in mice. (unime.it)
  • METHODS: Arthritis was induced in DBA/1 mice by an intradermal injection of 100 μl of bovine type II collagen in Freund's complete adjuvant. (unime.it)
  • IL-10-knockout (IL-10 −/− ) mice and wild-type (WT) mice were immunized with chicken type II collagen (CII) to induce arthritis. (biomedcentral.com)
  • The expression levels of IL-17 and retinoid-related orphan receptor γt (RORγt) in macrophages and joint tissues of IL-10 −/− and WT mice were analyzed by enzyme-linked immunosorbent assay, quantitative RT-PCR (qRT-PCR) and Western blotting. (biomedcentral.com)
  • Ing chicken-wire pattern of collagen deposition tissue sections revealed a perivenular th3/+ bridging chicken-wire pattern of collagen deposiin the livers of Hbb mice (Figure 6C,C',D,D'). tion within the livers of Hbbth3/+ mice (Figure 6C,C',D,D').Figure 6. (5htreceptor.com)
  • In this study, we sought to elucidate the function of epithelial TGF-β signaling via TGF-β receptor II (TβRII) and its contribution to fibrosis by generating mice in which TβRII was specifically inactivated in mouse lung epithelium. (jci.org)
  • Integrin α11β1 is expressed by mesenchymal cells in some parts of embryo during its development and also in muscles in adults: it preferably binds fibrillar collagen. (wikipedia.org)
  • In tumor stromal cells, the action of DDR2, likely in cancer-associated fibroblasts (CAFs), is critical for fibrillar collagen and extracellular matrix (ECM) production and the organization and architecture of collagen fibers. (wustl.edu)
  • thrombin receptor-activating peptide. (cancerhugs.com)
  • Synthetic peptide within Human Scavenging Receptor SR-BI aa 50-150 (N terminal). (abcam.com)
  • OBJECTIVE: Broad antiinflammatory effects following adenosine A(₂A) receptor stimulation have been demonstrated in acute inflammatory diseases, including arthritis. (unime.it)
  • Many invasive human breast cancers are associated with increased local collagen deposition (desmoplasia) and display increased perpendicular alignment of collagen fibers, both of which have been shown to be negative prognostic factors. (wustl.edu)
  • Black arrow represents the inflammatory foci and collagen deposition. (5htreceptor.com)
  • Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (rcsb.org)
  • Introduction and Objective: Because L-PRP constitutes an important source of growth factor that is associated with osteogenesis and fibrogenesis, the aim of this study was to evaluate the effect of L-PRP on the presence of collagen III and MMP-2 and MMP-9, while comparing these results by means of a histomorphometric analysis of bone matrix and fibrous deposition on bone repair. (bvsalud.org)
  • These results coincided with the larger occurrence of diffuse collagen III deposition and the scarce presence of MMP- 2 and -9 spread among the fibrous tissue. (bvsalud.org)
  • Collagen receptors are membrane proteins that bind the extracellular matrix protein collagen, the most abundant protein in mammals. (wikipedia.org)
  • Human lung fibroblasts and epithelial cells were exposed to low, physiologically relevant concentrations (0.02-0.6 microg/cm2) of single-walled CNTs (SWCNT) and multiwalled CNTs (MWCNT) in culture and analyzed for collagen, TGF-Beta1, TGF-Beta R1, and SMAD proteins by Western blotting and immunofluorescence. (cdc.gov)
  • or a protein that is less able to bind to collagen. (medlineplus.gov)
  • Mutations in GPR56 , an orphan G-protein-coupled receptor (GPCR), cause bilateral frontoparietal polymicrogyria (BFPP), a disorder characterized by mental retardation, seizures, motor developmental delay, and ataxia. (jneurosci.org)
  • Context: Adhesion G protein-coupled receptor (GPCR)-G1 (ADGRG1) is the most abundant GPCR in human pancreatic islets, but its role in islet function is unclear. (lu.se)
  • Previous studies indicated that the ability of CNTs to penetrate lung epithelium, enter interstitial tissue, and stimulate fibroblasts to produce collagen matrix is important to lung fibrosis. (cdc.gov)
  • Yang D, Yuan J, Liu G, Ling Z, Zeng H, Chen Y, Zhang Y, She Q, Zhou X. Angiotensin Receptor Blockers and Statins Could Alleviate Atrial Fibrosis via Regulating Platelet-Derived Growth Factor/Rac1 /Nuclear Factor-Kappa B Axis. (medsci.org)
  • Conclusion: Thus, the results suggest that L-PRP not only induces an intense fibrosis rich in collagen III, which is not degraded, but also suppresses MMP-2 and -9 expressions, mimicking a similar pathological event as that of a cleft-palate or cranial suture. (bvsalud.org)
  • Integrin α1β1 binds to collagen via the MIDAS motif in the α subunit I domain. (wikipedia.org)
  • It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. (thermofisher.com)
  • Our results indicate the critical role of TGF-Beta R1/Smad2/3 signaling in CNT-induced fibrogenesis by upregulating collagen production in lung fibroblasts. (cdc.gov)
  • With use of molecular modeling suite of programs, a (Gly-Pro-Pro) n triple-helical structure was built on the basis of high-resolution X-ray crystallographic coordinates and then replaced with the actual bovine collagen residues 924-938, the triple-helical α1(I)-N-telopeptide-receptor sequences. (northwestern.edu)
  • Since its approval in 1981, bovine collagen had been the only US Food and Drug Administration (FDA)-approved dermal filler more than a decade. (medscape.com)
  • Inhibition of LPS-induced neutrophil ROS production by various adenosine receptor agonists. (avma.org)
  • Improving Combination Therapies: Targeting A2B Adenosine Receptor to Modulate Metabolic Tumor Microenvironment and Immunosuppression. (vicc.org)
  • Signal transduction Nuclear and membrane receptors. (unibo.it)
  • It preferentially binds collagens IV, VI and type XIII collagen, but also fibril-forming collagens. (wikipedia.org)
  • 2000), include integrin α10β2, which is situated on monocytes and binds type I collagen. (wikipedia.org)
  • It binds fibril-forming collagens and primarily type IV collagen, but also collagen of types I, VI, VIII. (wikipedia.org)
  • The in vitro rate and specificity of fibrillogenesis in type I collagen depends on the integrity of the amino (N)-telopeptide domain. (northwestern.edu)
  • Objective: Investigate how ADGRG1 expression and activation by its ligand, collagen III, impacts β-cell function in normal and type 2 diabetic (T2D) islets. (lu.se)
  • Nevertheless, the native conformation of collagen is a requirement for receptor binding, denatured collagen is not bound. (wikipedia.org)
  • This study was undertaken to determine if the docking of the N-telopeptide to its helix receptor domain could induce the telopeptides to take up a specific conformation. (northwestern.edu)
  • Overexpression of the IGF-II/M6P receptor in mouse fibroblast cell lines differentially alters expression profiles of genes involved in Alzheimer's disease-related pathology. (nih.gov)
  • Concentration of cAMP in equine neutrophils induced by 5 adenosine A 2A receptor agonists (A) and effects of ZM241385 and MRS1706 on ATL313-induced accumulation of cAMP (B). Each point represents the mean ± SEM of 3 replicates. (avma.org)
  • Receptor activation happens when collagen binds into preformed DDR dimers on cell membrane, when collagen is bound, a conformational change probably occurs, which causes cytosolic kinases to rotate to face each other, and their autophosphorylation. (wikipedia.org)
  • The exact way of receptor activation is unknown so far. (wikipedia.org)
  • Together with integrin receptor α2β1 they provide coagulation cascade activation when a blood-vessel is damaged. (wikipedia.org)
  • 1401). 'Activation of β2-adrenergic Receptor Alleviates Collagen-induced Arthritis by Ameliorating Th17/Treg Imbalance', سامانه مدیریت نشریات علمی , 20(1), pp. 16-25. (ac.ir)
  • This suggests that SLP-76 has a specific role downstream of receptors that signal via an immunoreceptor tyrosine-based activation motif. (ox.ac.uk)
  • Acts as a ligand for the LILRB4 receptor, inhibiting FCGR1A/CD64-mediated monocyte activation (PubMed:34089617). (rcsb.org)
  • Pharmacological agents that promote expression or activation of the ADGRG1 receptor may represent a novel approach for the treatment of T2D. (lu.se)
  • Here in our study, we found that autophagy deficiency in CAFs impedes CAF activation by inhibiting proline biosynthesis and collagen production. (bvsalud.org)
  • 1 One of the most important molecular mechanisms that cause the physical signs of aging is enzymatic degradation of collagen and elastin. (dovepress.com)
  • As a woman evolves through the period of the menopause, anatomic changes, such as diminished collagen and elastin, reduced vascular supply, and thinned and retrenched tissue, frequently create symptoms common to GSM (Rahn et al. (medscape.com)
  • Its ectodomain consists of a collagen-binding discoidin domain followed by ~200 residues of unknown structure. (wikipedia.org)
  • Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis. (ox.ac.uk)
  • Our data demonstrate that, in collagen-induced arthritis, expression of the potent angiogenic cytokine VEGF correlates with disease severity. (ox.ac.uk)
  • This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). (nih.gov)
  • Our objective in this study was to measure the kinetics of VEGF production in a murine model of collagen-induced arthritis and to determine whether VEGF blockade reduces disease progression. (ox.ac.uk)
  • To block VEGF activity, animals were treated after arthritis onset with a soluble form of the Flt-1 VEGF receptor (sFlt), which was polyethylene glycol (PEG)-linked to increase its in vivo half-life. (ox.ac.uk)
  • To explore the effects of β2-AR in collagen-induced arthritis (CIA) on the imbalance of T helper (Th) 17/ regulatory T (Treg) cells. (ac.ir)
  • Citrullinated collagen II (CII) is a well-known autoantigen in rheumatoid arthritis (RA). (abo.fi)
  • abstract = "Citrullinated collagen II (CII) is a well-known autoantigen in rheumatoid arthritis (RA). (abo.fi)
  • Our objective in the present study was to determine the signaling pathway of interleukin 10 (IL-10) for modulating IL-17 expression in macrophages and the importance of this mediation in collagen-induced arthritis (CIA). (biomedcentral.com)
  • Collagen-induced arthritis (CIA) is a well-established animal model that has been studied extensively because of its similarities to human RA. (biomedcentral.com)
  • In this study, GLI1 expression in the synovial tissue of RA patients was positively correlated with RA-related scores and was highly expressed in collagen-induced arthritis (CIA) mouse articular macrophage-like cells. (elifesciences.org)
  • Identification of TGF-beta receptor-1 as a key regulator of carbon nanotube -induced fibrogenesis. (cdc.gov)
  • These receptors comprise an α and β transmembrane subunit, which are noncovalently bound. (wikipedia.org)
  • Another part of the receptor consists of transmembrane helix with a short cytosolic domain. (wikipedia.org)
  • Each N-telopeptide domain can form linkages with two adjacent, aligned helix receptor domains. (northwestern.edu)
  • SWCNT- and MWCNT-induced collagen production was blocked by ALK5 inhibitor or shRNA knockdown of TGF-Beta R1 and Smad2. (cdc.gov)
  • I'm partial to vitamin C because vitamin C also helps promote collagen production. (upstate.edu)
  • an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. (lu.se)
  • The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)