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  • deficiency
  • Ullrich congenital muscular dystrophy (UCMD) is caused by mutations in either COL6A1 , COL6A2 or COL6A3 gene, thereby leading to collagen VI deficiency in the ECM. (bmj.com)
  • Collagen XVIII/endostatin deficiency altered matrix redesigning enhanced the inflammatory response and advertised capillary rarefaction and vascular endothelial cell damage but did not impact endothelial proliferation. (world-of-links.com)
  • Procollagen
  • Serum Markers for Hepatic Fibrosis in Alcoholic Liver Disease: Which is the Best Marker, Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase? (wikipedia.org)
  • occurs
  • Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury. (wikipedia.org)
  • Collagen occurs in many places throughout the body. (wikipedia.org)
  • Gradual calcium deposition within collagen occurs as a natural function of aging. (wikipedia.org)
  • Receptor activation happens when collagen binds into preformed DDR dimers on cell membrane, when collagen is bound, a conformational change probably occurs, which causes cytosolic kinases to rotate to face each other, and their autophospohorylation. (wikipedia.org)
  • Unlike other tyrosine-kinase receptors, maximal activation of receptors occurs 18 hours after collagen stimulation. (wikipedia.org)
  • When damage occurs, endotelial collagen is uncovered and is bound by GPVI receptor on platelets. (wikipedia.org)
  • bone
  • Bone Grafts can now be preformed using collagen and the patients bone marrow as opposed to bone (painfully) harvested from the patient. (everything2.com)
  • In bone for example, entire collagen triple helices lie in a parallel, staggered array. (news-medical.net)
  • Type I collagen gives bone its tensile strength. (news-medical.net)
  • Collagen has been widely used in cosmetic surgery, as a healing aid for burn patients for reconstruction of bone and a wide variety of dental, orthopedic, and surgical purposes. (wikipedia.org)
  • Collagen is used in bone grafting as it has a triple helical structure, making it a very strong molecule. (wikipedia.org)
  • Several studies have shown that a daily intake of hydrolyzed collagen increases bone mass density in rats. (wikipedia.org)
  • It seems that hydrolyzed collagen peptides stimulated differentiation and osteoblasts activity- the cells that build bone- over that of osteoclasts (cells that destroy bone). (wikipedia.org)
  • proteoglycans
  • Different collagen types form larger fibrillar bundles with the help of several different classes of proteins like glycoproteins and proteoglycans. (news-medical.net)
  • Collagen, and to a lesser extent, elastin, were among the earliest of this group to be studied in more detail than the proteoglycans and adhesive glycoproteins. (springer.com)
  • vitro
  • It has been suggested, based on mouse and in vitro studies, that hydrolyzed collagen peptides have chemotactic properties on fibroblasts or an influence on growth of fibroblasts. (wikipedia.org)
  • Corneal
  • Corneal collagen cross-linking with riboflavin (vitamin B2) and UV-A light is a surgical treatment for corneal ectasia such as keratoconus, PMD, and post-LASIK ectasia. (wikipedia.org)
  • A 2015 Cochrane review that looked at all high quality evidence on corneal collagen cross-linking found that it was insufficient to determine if it is useful in keratoconus. (wikipedia.org)
  • The standard protocol of Corneal Collagen Cross-linking, with epithelium removal, is approved for use throughout Europe. (wikipedia.org)
  • The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. (wikipedia.org)
  • strands
  • The process of hydrolysis involves breaking down the molecular bonds between individual collagen strands and peptides using combinations of physical, chemical or biological means. (wikipedia.org)
  • The riboflavin causes new bonds to form across adjacent collagen strands in the stromal layer of the cornea, which recovers and preserves some of the cornea's mechanical strength. (wikipedia.org)
  • tensile
  • The ratio and the proportion of collagen play an important role in the tensile and compressive strength, as well as the elasticity of the tissue. (wikipedia.org)
  • induces
  • This makes one wonder if the collagen used in cosmetic treatments induces, increases or hastens the development of arthritis of humans , even in some small way. (everything2.com)
  • subunit
  • The alpha-3 subunit (COL4A3) of collagen IV is thought to be the antigen implicated in Goodpasture syndrome , wherein the immune system attacks the basement membranes of the glomeruli and the alveoli upon the antigenic site on the alpha-3 subunit becomes unsequestered due to environmental exposures. (wikipedia.org)
  • These an receptors comprise an α and β transmembrane subunit, which are noncovalently bound.Collagen binding is primarily provided by integrins α1β1, α2β1, α10β1 a α11β1. (wikipedia.org)
  • Integrin α1β1 binds to collagen via the MIDAS motif in the α subunit I domain. (wikipedia.org)
  • Therapy
  • Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease and hepatitis C and fall following successful therapy. (wikipedia.org)
  • Serum Collagen Type IV for the Assessment of Fibrosis and Resistance to Interferon Therapy in Chronic Hepatitis C". Scandinavian Journal of Gastroenterology . (wikipedia.org)
  • Anti- Cancer therapy utilizes collagen as a mode of transport to get the anti-cancer agent to the tumor . (everything2.com)
  • Collagen induction therapy (CIT) also known as microneedling RF or skin needling is a cosmetic procedure that involves repeatedly puncturing the skin with tiny, sterile needles (microneedling the skin). (wikipedia.org)
  • peptides
  • Alpha collagen is specifically designed to deliver specific ratios of α- chain peptides as building blocks. (wikipedia.org)
  • Scientists believe that Alpha collagen can help to deliver specific ratios of peptides to benefit the targeted cells. (wikipedia.org)
  • A 2005 study in humans found hydrolyzed collagen absorbed as small peptides in the blood. (wikipedia.org)
  • Creams
  • Eye Creams - Cucumber Eye Firming Cream, Firming Eye Gels, Cucumber Collagen Creams, Eye Wrinkle Cream and Serum. (dermasoft.com)
  • In cosmetics, hydrolyzed collagen may be found in topical creams, acting as a product texture conditioner, and moisturizer. (wikipedia.org)
  • Urinary
  • Urinary Incontinence is treated by injecting collagen into the urethra , where it forms a small bulk , decreasing the diameter of the urethra. (everything2.com)
  • Adhesion
  • Functions include: Platelet adhesion and activation - the most important platelet collagen receptor in terms of signaling. (wikipedia.org)