Thus, these drugs are active against Escherichia coli and Klebsiella and Proteus species (though several strains of these organisms have developed resistance). (britannica.com)
Escherichia coli transferable plasmids, and the gene was transferred to E. strains producing CTX-M-2 -lactamase, one of the CTX- coli CSH2 with a very high frequency (2 x 10-4 to 6 x 10-1 per donor cells) by conjugation. (cdc.gov)
Many labs have adopted CLSI recommendations and only attempted to detect ESBLs in Escherichia coli , Klebsiella pneumoniae , K. oxytoca , and Proteus mirabilis ( 8 ). (asm.org)
A 2006 report of the Infectious Diseases Society of America listed ESBL-producing Klebsiella pneumoniae and Escherichia coli among drug-resistant microbes for which new therapies are urgently needed. (ajlmonline.org)
Klebsiella3
transfer of cefamandole resistance was demonstrated from strains of citrobacter freundii as well as from individual strains of enterobacter cloacae, acinetobacter anitratus and klebsiella pneumoniae isolated from patients in two newborn units. (liverpool.ac.uk)
Undetected, extended-spectrum β-lactamase (ESBL) production by the infecting Klebsiella strain was regarded as responsible for treatment failure. (ajlmonline.org)
Fosfomycin has broad antibacterial activity against both Gram-positive and Gram-negative pathogens, with useful activity against E. faecalis , E. coli , and various Gram-negatives such as Citrobacter and Proteus . (mdwiki.org)
cefuroxime and cefamandole) and third-generation ones (such as ceftazidime) tend to be more effective against gram-negative bacterial species that are resistant to the first-generation cephalosporins. (britannica.com)
Citrobacter1
in citrobacter freundii, cefamandole resistance was transferred always with cephalotin resistance as well as with a tem-like beta lactamase (conferring resistance to ampicillin, carbenicillin and azlocillin). (liverpool.ac.uk)
Cephalosporin1
Cefamandole (also known as cephamandole) is a broad-spectrum cephalosporin antibiotic. (ncats.io)
ESBLs3
ESBLs), such as TEM- or SHV-derived ESBLs, emerged is not easy to explain the predominant isolation of E. coli- in Europe (1), and since then, their variants have been pro- producing CTX-M-2 -lactamase that is usually suscepti- liferating around the world (2,3). (cdc.gov)
RESEARCH about strains in animals producing ESBLs or CMY-type respectively. (cdc.gov)
When the strain produces class A -lacta- cephamycinases, which confer resistance to expanded- mases, including TEM- or SHV-derived ESBLs, or CTX- spectrum cephalosporins (22,23), and no CTX-M-type - M-type enzymes, the color of a disk containing ben- lactamase producer has been isolated from animals. (cdc.gov)
ESBL2
ESBL producers would be rarely isolated and that metallo- strains producing extended-spectrum -lactamases -lactamases would be isolated often in Japan. (cdc.gov)
Activity against extended-spectrum β-lactamase -producing pathogens, notably ESBL-producing E. coli , is good to excellent, because the drug is not affected by cross-resistance issues. (mdwiki.org)
Resistance2
These findings suggest that CTX-M-2 metallo--lactamase, which show resistance to carbapen- producers might have originated from cattle through the ems and cephamycins as well as various expanded-spec- use of cephalosporins such as ceftiofur and that cattle trum cephalosporins, have been identified in Japan (15), could be a reservoir of CTX-M-2-producing E. coli . (cdc.gov)
cefamandole resistance transfer in bacterial strains from two newborn units. (liverpool.ac.uk)
Susceptible1
Cefamandole under brand name mandol is indicated for the treatment of serious infections caused by susceptible strains of the designated microorganisms such as: lower respiratory infections, including pneumonia, caused by S. pneumoniae. (ncats.io)
Broad-spectrum1
Several questions regarding the of strains producing broad-spectrum class A -lactamases origin and mode of proliferation of the CTX-M-type -lac- in Japan. (cdc.gov)
Active1
Avoid coadministration of cholera vaccine with systemic antibiotics since these agents may be active against the vaccine strain. (medscape.com)
From results obtained in this study, it may be concluded that in some strains of nosocomial Enterobacteriaceae, resistance to newer cephalosporins could be transmissible and thus plasmid-located. (nih.gov)
The isolates from the Tennessee patients fermented glycerol and were probably type A strains. (cdc.gov)
Cephalosporins2
These findings suggest that CTX-M-2 metallo--lactamase, which show resistance to carbapen- producers might have originated from cattle through the ems and cephamycins as well as various expanded-spec- use of cephalosporins such as ceftiofur and that cattle trum cephalosporins, have been identified in Japan (15), could be a reservoir of CTX-M-2-producing E. coli . (cdc.gov)
When the strain produces class A -lacta- cephamycinases, which confer resistance to expanded- mases, including TEM- or SHV-derived ESBLs, or CTX- spectrum cephalosporins (22,23), and no CTX-M-type - M-type enzymes, the color of a disk containing ben- lactamase producer has been isolated from animals. (cdc.gov)
Clinical1
Penicillinase was the first β-lactamase to be identified: it was first isolated by Abraham and Chain in 1940 from gram-negative E. coli even before penicillin entered clinical use [1] but penicillinase production quickly spread to bacteria that previously did not produce it or only produced it rarely. (wikidoc.org)
Enzyme2
Type A strains are associated with rabbits and tick vectors and are biochemically characterized by their ability to ferment glycerol and possession of the enzyme citrulline ureidase (5-7). (cdc.gov)
The Phillips mechanism proposed that the enzyme's catalytic power came from both steric strain on the bound substrate and electrostatic stabilization of an oxo-carbenium intermediate. (cloudfront.net)
Streptococci1
The principal bacteria responsible for neonatal meningitis are gram-negative bacilli (usually E. coli strains bearing the K1 capsular antigen) and group B streptococci. (antiinfectivemeds.com)
Similar1
[14] Thus distortion causing the substrate molecule to adopt a strained conformation similar to that of the transition state will lower the energy barrier of the reaction. (cloudfront.net)
Possibly1
In general, tularemia cases tend to be more severe in North America than in other parts of the world, possibly because type A strains of F. tularensis are present in North America but not elsewhere (4). (cdc.gov)