• The interferon-α/β receptor (IFNAR) is a virtually ubiquitous membrane receptor which binds endogenous type I interferon (IFN) cytokines. (wikidoc.org)
  • We demonstrate that deletion of the macrophage vitamin D receptor (VDR) in mice (KODMAC) is sufficient to induce insulin resistance by promoting M2 macrophage accumulation in the liver as well as increasing cytokine secretion and hepatic glucose production. (regenerativemedicine.net)
  • A soluble TNF receptor (etanercept) clogged enzalutamide-induced CCL2 protein secretion and mRNA implying dependence on secreted TNF. (acancerjourney.info)
  • RT-PCR and Southern analyses revealed that all six RCC cell lines expressed ET(A) receptor mRNA, while 3/6 cell lines also expressed ET(B) mRNA. (jsce-ip.com)
  • receptors may be manifested in an animal model that expresses both depressive-like characteristics and high alcohol intake. (alkpathway.com)
  • Thus, Fawn-Hooded (FH) rats along with their control ACI rats were used to measure the density of the high affinity nicotinic receptor in discrete brain regions. (alkpathway.com)
  • IFNAR is a heteromeric cell surface receptor composed of two subunits, referred to as the low affinity subunit, IFNAR1 , and the high affinity subunit, IFNAR2 . (wikidoc.org)
  • [7] Each type I IFN ligand contains a "hotspot", or a sequence of conserved amino acids that are involved in binding to the receptor, specifically the high affinity receptor IFNAR2, which determines the affinity of each ligand for the receptor. (wikidoc.org)
  • In recent years, engineering T cell therapy has made great progress in tumor immunotherapy, which mainly includes T-cell receptor-engineered T cell (TCR-T) therapy and chimeric antigen receptor T cell (CAR-T) therapy. (cip.com.cn)
  • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia[J]. The New England Journal of Medicine , 2013 , 368 (16): 1509-1518. (cip.com.cn)
  • Gamma delta T cells (γδ T cells) are T cells that have a γδ T-cell receptor (TCR) on their surface. (wikipedia.org)
  • DETCs arise during fetal development and express an invariant and canonical Vγ3 Vδ1 T-cell receptor (using Garman nomenclature). (wikipedia.org)
  • A skewed preference for BV7 genes and sequential "G" amino acids motif is observed in complementarity-determining region-3 of T cell receptor-β. (nature.com)
  • Increased binding scores are observed in T-cell clones with complementarity-determining region-3 of T cell receptor-β with a "(G)GG" motif. (nature.com)
  • An individual T-cell has a specific complementarity-determining region 3 (CDR3) of T cell receptor (TCR)-α and -β, which is a result of the recombination of somatic TCR V-(D)-J genes and junction diversity. (nature.com)
  • Endothelin-1 (ET-1) is a potent vasoconstrictor that has been shown to significantly impact many benign and malignant tissues by signaling through its two cognate receptors: ET(A) and ET(B). As ET-1 has a role in both normal and diseased kidney, we initiated studies to investigate endothelin axis expression and function in renal cell carcinoma (RCC). (jsce-ip.com)
  • Increased foam cell formation results from lack of VDR-SERCA2b interaction, causing SERCA dysfunction, activation of ER stress-CaMKII-JNKp-PPARγ signaling, and induction of the scavenger receptors CD36 and SR-A1. (regenerativemedicine.net)
  • Chemokine receptor 5 (CCR5) has gained attention as therapeutic target in various malignancies. (cancerindex.org)
  • NMR structure of the interferon-binding ectodomain of the human interferon receptor. (wikidoc.org)
  • The purpose of this study was to study the expression of endothelin-1 (ET-1) and its receptors ETA and ETB in normal human gingiva and cyclosporin-induced gingival fibroblasts. (jsce-ip.com)
  • The expression of ET-1 and its receptors was also examined in gingival fibroblast cells treated with CsA. (jsce-ip.com)
  • Measurements of [(3)H]cytisine binding (selective for alpha 4 buy Nutlin-3a beta 2 nicotinic receptor subtype) revealed a reduction in these receptors only in the striatum of FH rats, a result very similar to that observed in selectively-bred alcohol-preferring (P) rats. (alkpathway.com)
  • This oxidative stress mediated change was detected both at the transcriptional and translational level and functionally resulted in increased Ca2+ release into the nucleoplasm from Elacridar the membranes of the nuclear envelope at a given receptor-specific stimulus. (alkpathway.com)
  • Macrophages are plastic and will change in response to environmental cues through pattern-recognition receptors and other sensors. (musculoskeletalkey.com)
  • Using an experimental approach that included quantitative polymerase chain reaction, quantitative immunoblotting, microfluorimetry and the optical imaging of intracellular Ca2+ release, we show that sub-lethal tert-butyl hydroperoxide-mediated oxidative stress result in a selective up-regulation of type-2 inositol-1,4,5,-trisphophate receptors. (alkpathway.com)
  • However, the various subsets may also be considered part of the innate immunity in which a specific TCR can function as a pattern recognition receptor. (wikipedia.org)
  • We examined the role of HO-1 in regulating monocyte chemoattractant protein-1 (MCP-1) and chemokine receptor 2 (CCR2), two molecules involved in monocyte-macrophage cell trafficking after infection. (nih.gov)
  • Ovarian tumors overexpressed three known cognate receptors of CCL11, CC chemokine receptors (CCR) 2, 3, and 5. (nih.gov)
  • CC-motif chemokine ligand 2/monocyte-chemoattractant protein-1 (CCL2/MCP-1) orchestrates inflammatory monocyte trafficking between the bone marrow, circulation, and atherosclerotic plaques by binding to its cognate receptor CCR2. (bvsalud.org)
  • Many chemokine receptors belonging to the rhodopsin family of G protein-coupled receptors (GPCRs) are translated from a single exon. (molcells.org)
  • Some of these gene transcripts proceed through alternative splicing pathways to produce chemokine receptors containing different amino acids at the N-terminal region. (molcells.org)
  • In this review, we focus on expression of chemokine receptors and chemokine ligands by MSCs isolated from different tissues. (biomedcentral.com)
  • CXCR3 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. (guidetopharmacology.org)
  • They act as sentinels that monitor the brain via surface receptors that recognize complement fragments, immunoglobulins, adhesion molecules, chemokine receptors (CCR), toll-like receptors (TLR), purinoreceptors, and scavenger and Fc receptors (Jurga et al. (sysy-histosure.com)
  • To determine the specific contributions of VEGFs and their receptors (VEGFRs) to joint pathology and pain transmission during OA progression, we studied intra-articular (IA) injections of VEGF ligands into murine knee joints. (ijbs.com)
  • VEGF ligands interact with their corresponding receptor tyrosine kinases VEGFR1, VEGFR2 or VEGFR3 to trigger their biological functions [ 7 ]. (ijbs.com)
  • CXCR3 (GPR9/CD183) is a receptor for four CXC chemokines: monokine induced by gamma interferon (MIG), interferon gamma-induced protein 10 (IP-10), interferon-inducible T-cell alpha chemoattractant (I-TAC), and platelet factor 4 (PF-4). (molcells.org)
  • CXCR3 is the receptor for CXCL9, -10 and -11, three CXC chemokines that are preferentially expressed on Th1 lymphocytes. (guidetopharmacology.org)
  • Adding to a strong body of data from experimental atherosclerosis models, a coherent series of recent large-scale genetic and observational epidemiological studies along with data from human atherosclerotic plaques highlight the relevance and therapeutic potential of the CCL2-CCR2 axis in human atherosclerosis. (bvsalud.org)
  • NanoBiT technology are useful to integrative studies of CXCR3-mediated cell signaling, and expand our knowledge of the cellular responses mediated by molecular interactions among the splicing variants, including cell surface expression, ligand-dependent receptor activation, and chemotaxis. (molcells.org)
  • It has been reported that CCL11, despite binding with high affinity, may be neither an agonist or an antagonist of the CXCR3 receptor, but sequesters available CCL11 resulting in a lowered response at other receptors [ 31 ]. (guidetopharmacology.org)
  • HN - 2008 (1993) MH - Agouti-Related Protein UI - D054369 MN - D12.644.276.74 MN - D12.776.467.74 MN - D23.529.74 MS - A secreted protein of approximately 131 amino acids that is related to AGOUTI SIGNALING PROTEIN and is also an antagonist of MELANOCORTIN RECEPTOR activity. (nih.gov)
  • DETCs arise during fetal development and express an invariant and canonical Vγ3 Vδ1 T-cell receptor (using Garman nomenclature). (wikipedia.org)
  • CCL11 potently stimulated proliferation and migration/invasion of ovarian carcinoma cell lines, and these effects were inhibited by neutralizing antibodies against CCR2, CCR3, and CCR5. (nih.gov)
  • In this study, we investigate how focal adhesion kinase (FAK) and the related kinase Pyk2 integrate adhesion signaling and growth factor receptor signaling to regulate diverse macrophage functions. (silverchair.com)
  • Therefore, further investigations are required to understand how these sensome receptors and their dysfunctioning regulate microglial functions and contribute to disease pathogenesis in AD. (nature.com)
  • It remains largely unknown how sensome receptors are regulated and interact with DAMPs to control specific functions during microglial DAMP clearance, including chemotaxis and phagocytosis. (nature.com)
  • Inhibition of HO by zinc protoporphyrin-IX led to inhibition of MCP-1 and increased expression of CCR2, its cognate receptor. (nih.gov)
  • During DAMP clearance, microglia modify their sensome receptor expression profile while transitioning between functional states. (nature.com)
  • This panel includes 780 genes covering T-cell biology and the pathways and processes important to T-Cell research and development, especially signaling pathways influencing T-cell differentiation and activity, phenotypic and metabolic switches, T-cell subsets associated with differentiation and activation state, T-Cell Receptor diversity and immune cell profiling. (canopybiosciences.com)
  • AIRE is also known to transcriptionally activate or repress non-TRA, such as cytokine and cytokine receptors 47 and thus could influence immune responses. (micrornasynthesis.com)
  • Curated panel content includes: Signaling pathways influencing T-cell differentiation and activity, phenotypic and metabolic switches, T-cell subsets associated with differentiation and activation, T-Cell Receptor diversity and immune cell profiling. (canopybiosciences.com)
  • Deficiency of cannabinoid receptor of type 2 worsens renal functional and structural abnormalities in streptozotocin-induced diabetic mice. (unito.it)
  • uPAR, urokinase type plasminogen-activator receptor. (rupress.org)
  • In Alzheimer's disease (AD), sensome receptor dysfunction impairs microglial danger-associated molecular pattern (DAMP) clearance and exacerbates disease pathology. (nature.com)
  • Lipopolysaccharide (LPS) or lipoteichoic acid (LTA) from bacteria) or damage-associated molecular patterns (DAMPs, e.g., nuclear or cytosolic proteins or nucleic acids from damaged neurons, extracellular ATP or parasite hemozoin) via pattern-recognition receptors (PRRs). (sysy-histosure.com)