• To study the role of cochlear muscarinic receptors, we studied receptor localization with immunohistochemistry and reverse transcription-PCR and measured olivocochlear function, cochlear responses, and histopathology in mice with targeted deletion of each of the five receptor subtypes. (nih.gov)
  • M 3 receptors were present only in whole-cochlear digests ( C ), and M 1 receptors were never amplified from wild types ( A-C ). All five mAChRs are expressed in adult brain ( B , positive control). (nih.gov)
  • The sense of hearing is provided by receptors within the cochlear duct. (medscape.com)
  • Inhibition of FGF receptors using SU5402 on cochlear explants also showed a similar impact on hair cell and support cell formation. (jneurosci.org)
  • These results identify the first molecule, myosin II, which directly regulates cellular patterning and alignment within the cochlear sensory epithelium. (biologists.org)
  • In mammals sounds are perceived by the organ of Corti (OC), a sensory epithelium that extends along the basal-to-apical axis of the cochlear spiral. (biologists.org)
  • We further demonstrate that Fgf receptor ( Fgfr ) 1 signaling within the developing sensory epithelium is required for the differentiation of outer hair cells and SCs, while mesenchymal FGFRs regulate the size of the sensory progenitor population and the overall cochlear length. (elifesciences.org)
  • In 1933 researchers found that cochlear duct length (CDL) in otherwise normal anatomy varied by as much as 10 mm, from 25-35 mm in overall length. (audiologyonline.com)
  • P. Dallos, Response characteristics of mammalian cochlear hair cells, J. Neuroscience , 5:1591 (1985). (springer.com)
  • The endolymph-filled cochlear duct now appears as the central triangular section. (blausen.com)
  • The elegantly coiled, mechanically tuned cochlear duct and functional differentiation between inner hair cells (IHCs) and outer hair cells (OHCs), afferent and efferent neuronal connections are among the features that enable the widest acoustic frequency range and most complex vocalizations among vertebrate species. (pnas.org)
  • A botulinum toxin can be administered to myoclonic middle ear muscles and to inner ear efferent and/or afferent nerves to alleviate otic disorders such as tinnitus, cochlear nerve dysfunction and Meniere's disease. (google.es)
  • The orphan nuclear receptor COUP-TFI (Nr2f1) regulates many aspects of mammalian development, but little is known about its role in cochlear hair cell and Deiter's support cell development. (biologists.org)
  • The total number of hair cells is not increased over wild type, perhaps because of displaced hair cells and a shortened cochlear duct. (biologists.org)
  • This finding, together with previous evidence that type II afferents respond weakly to synaptic transmission from cochlear hair cells, and normally are insensitive to sound, supports the identification of type II afferents as cochlear nociceptors, mediating the sensation of painfully loud sound. (pnas.org)
  • The remaining thin, unmyelinated type II afferents extend hundreds of microns along the cochlear duct to contact many outer hair cells. (pnas.org)
  • EP), both indispensable conditions for cochlear hair cells to transduce acoustic stimuli to electrical signals. (biologists.org)
  • The cochlear duct contains the hair cells that detect sound. (biologyreference.com)
  • It is unclear whether cochlear amplification arises uniquely from a voltage-dependent mechanism (electromotility) associated with outer hair cells (OHCs) or whether other mechanisms are necessary, for the voltage response of OHCs is apparently attenuated excessively by the membrane electrical filter. (royalsocietypublishing.org)
  • We have included experimentally determined parameters of cochlear macromechanics, which govern sound transduction, and data on hair cells' electrical parameters including tonotopical variation in the membrane conductance of OHCs. (royalsocietypublishing.org)
  • b )(i) Equivalent electrical circuit of a single hair cell and (ii) a cochlear cross section from ( a ). (royalsocietypublishing.org)
  • Cochlear duct section stained with antibodies directed against MYO7A (green) and CD44 (red) reveals sensory hair cells and supporting cells in the mouse inner ear. (utah.edu)
  • Portions of the cochlear duct can be dissected free from the otic capsule, placed flat on microscope slides in a liquid medium and cover-slipped (e.g. (cdc.gov)