Cochlea in mammals. Medical search. Frequent questions

Orcas are the most cosmopolitan of all marine mammals and inhabit all of the world ' s oceans. (whaleresearch.com)
Killer whales (orca) are the most cosmopolitan of all marine mammals. (whaleresearch.com)
The sea otters' ancestors changed from being land-dwelling mustelids to becoming marine mammals 3 to 5 million years ago . (floofmania.com)
As semi-aquatic marine mammals, sea otters have two unique hearing sensitivity ranges when they're above the water surface and underwater. (floofmania.com)
whale Whales are a widely distributed and diverse group of fully aquatic placental marine mammals. (theinfolist.com)
Sea cows (manatees, dugongs) are the only living marine mammals to feed solely on aquatic plants. (plos.org)
It can comprise up to 50% of the body mass of some marine mammals during some points in their lives. (animalcorner.org)
Blubber serves several different functions, it is the primary area of fat on marine mammals, and essential for storing energy. (animalcorner.org)
Who would've thought that the hearing of some marine mammals such as the toothed whale would lead to the development of "Neptune waterproof MP3 player" with the highest quality sound in the water, but without actual ear buds. (googleusercontent.com)

Further, the auditory innervation of the spiral-shaped cochlea also traces back to the Cretaceous period. (wikipedia.org)
While the basic structure of the inner ear in lepidosaurs (lizards and snakes), archosaurs (birds and crocodilians) and mammals is similar, and the organs are considered to be homologous, each group has a unique type of auditory organ. (wikipedia.org)
The membranous labyrinth spirals around a central bony canal, the modiolus, that contains the auditory division of the vestibulocochlear nerve (i.e., 8th cranial) and blood vessels to the cochlea. (cdc.gov)
In SNHL, the disorder is situated either in the cochlea itself or in virtually any from the retrocochlear auditory buildings. (lavoixdesrroms.org)
We show that the amplitude of an elicited auditory startle response is greater when the startle stimuli are presented simultaneously with a low-frequency masker, including masker tones that are outside the sensitivity range of the cochlea. (figshare.com)
Masker-enhanced auditory startle responses were also observed in otoconia-absent Nox3 mice, which lack otoconia but have no obvious cochlea pathology. (figshare.com)
Sensorineural hearing loss occurs when there is a problem with the cochlea or the neural pathway to the auditory cortex. (ellevetsciences.com)
This means that a dog is born with a condition with a problem in the cochlea or the neural pathway to the auditory cortex. (ellevetsciences.com)
Mammals cannot regenerate lost hair cells or auditory neurons so hearing loss can be permanent [1]. (healthcare-arena.co.uk)
Humans interpret sound primarily through the auditory hair cells, located in a portion of the inner ear known as the cochlea . (ysjournal.com)
So, unlike other animals, when mammals damage their auditory hair cells, the resulting hearing loss is permanent.⁵ Gene therapy addresses this issue by reintroducing the ATOH1 gene to the cochlea to restart the development of hair cell growth. (ysjournal.com)
In order for birds and mammals to hear, hair cells in the cochlea-the auditory portion of the inner ear-vibrate in response to sounds and thereby convert sound into electrical activity. (lehigh.edu)
In the case of the auditory system, that mapping is called tonotopy, in which neurons tuned to specific frequencies map across structures, extending even to the cochlea, the primary sensory organ for hearing. (jneurosci.org)
Seals also have whiskers to help navigate and sensors in their skull to absorb sounds underwater and transmit them to the cochlea (the auditory portion of the inner ear). (animalcorner.org)
Next, in the middle ear, there are elements that conduct and amplify acoustic waves (including the auditory ossicles and the cochlea), while the inner ear is used to transform the received sounds into nerve impulses and is responsible for the sense of balance. (to2.us)

We can meet the best vertebrate hearers among the two groups with better-evolved ears - birds and mammals. (bioexplorer.net)
These bats can be found in the tropics and subtropics, where they predominantly feed on the blood of birds and large mammals. (bioexplorer.net)
Unlike their counterparts in other mammals and birds, human hair cells cannot regenerate. (themindunleashed.com)
Recent evidence from birds and mammals, including humans, has shown that the sacculus, a hearing organ in many lower vertebrates, has retained some of its ancestral acoustic sensitivity. (figshare.com)
In mammals the Atoh1 switch is turned off following birth but in birds and amphibians it remains on into adulthood. (healthcare-arena.co.uk)
In a side note to the heights post I wondered about balance in birds, and whether the ear played a similar role in birds- specifically a vestibular sense- as it does in mammals. (blogspot.com)
Outer ears are present in most species of mammals and birds, with exceptions in some species of dolphins. (zxc.wiki)
Acoustic overstimulation has very different outcomes in birds and mammals. (noiseandhealth.org)
We are therefore using a battery of molecular approaches to identify and compare changes in gene expression following noise trauma in birds and mammals. (noiseandhealth.org)

Whereas in monotremes there are many rows of both inner and outer hair cells in the organ of Corti, in therian (marsupial and placental) mammals the number of inner hair-cell rows is one, and there are generally only three rows of outer hair cells. (wikipedia.org)
In another anatomical study, researchers discovered that the sea otters' inner ears look the same as other placental mammals or eutherians . (floofmania.com)

The bony labyrinth can be subdivided into the vestibule, 3 semicircular canals, and the cochlea. (medscape.com)
Outer ear, middle ear and inner ear with cochlea, sacculus, utricle and semicircular canals (the eardrum belongs to the middle ear). (zxc.wiki)
The labyrinthine artery divides into: cochlear artery, for irrigation of the cochlea and vestibular arteries anterior and posterior semicircular canals to irrigate, utricle, saccule and part of the cochlea 8 . (bvsalud.org)

Within the mammalian cochlea exists the organ of Corti, which contains hair cells that are responsible for translating the vibrations it receives from surrounding fluid-filled ducts into electrical impulses that are sent to the brain to process sound. (wikipedia.org)
The physiology of the mammalian cochlea is much more complex, with hearing occurring via a travelling wave along a tapered, compartmentalised tube. (bris.ac.uk)

The organ of Corti is larger and the basilar membrane on which it sits is longer as it gets further away from the base of the cochlea. (bcm.edu)
The shorter, smaller structures near the base of the cochlea respond best to high frequencies, while the longer, larger structures near the top of cochlea respond best to low frequencies. (bcm.edu)
The wide base of the cochlea from which this segment comes is towards the bottom of the page. (bcm.edu)
But although the tonotopy pattern is well mapped out at the base of the cochlea, where high-frequency stimuli evoke the biggest responses, there is little evidence for what researchers have long assumed would be low-frequency tuning at the cochlear apex. (jneurosci.org)

In mammals, the anatomy of the inner ear consists of the bony labyrinth, a system of passages making up the following 2 main functional parts: (1) the cochlea, which is dedicated to hearing, and (2) the vestibular system, which is dedicated to balance. (medscape.com)
The vestibular wall separates the cochlear duct from the perilymphatic scala vestibuli, a cavity inside the cochlea. (medscape.com)
So, most of the success has been located in the vestibular portions of the inner ear, but we and others are working on the cochlea. (hearingreview.com)

The spiral shaped cochlea originates from one of the balance organs and contains the sensory epithelium for hearing. (bcm.edu)
Therefore, we at least know that it s possible to induce the first stage of regeneration to a limited extent in the inner ear sensory epithelium of mature mammals. (hearingreview.com)
The stria vascularis, an epithelium located on the outer wall of the cochlear duct, is unique in that it is the only vascularized epithelium in mammals. (digitalhistology.org)

While humans hear with the cochlea of the inner ear, the midshipman uses the sacculus, a part of the ear that in humans detects acceleration or linear movement. (scienceagogo.com)
Of these organs, the cochlea is involved in hearing, while the sacculus and utriculus serve to detect linear acceleration. (figshare.com)
Here we provide not only more evidence for the retained acoustic sensitivity of the sacculus, but we also found that acoustic stimulation of the sacculus has behavioral significance in mammals. (figshare.com)

In fact, a team of researchers has recently used new findings from research on development of the inner ear to induce a few new cells in the guinea pig cochlea to become hair cells again proving that hair cell regeneration will be possible. (hearingreview.com)
The goal of the experiments presented here was to assess the protective capability of the human GDNF transgene against noise trauma in the guinea pig cochlea. (noiseandhealth.org)

There are two sensory papillae involved in hearing, the basilar (higher frequency) and amphibian (lower frequency) papillae, but it is uncertain whether either is homologous to the hearing organs of lepidosaurs, archosaurs and mammals and it is uncertain when they arose. (wikipedia.org)

The definitive mammalian middle ear and the elongated cochlea allows for better sensitivity for higher frequencies. (wikipedia.org)
However, masker enhancement was not observed in otoconia-absent Nox3 mice if the low-frequency masker tones were outside the sensitivity range of the cochlea. (figshare.com)

1966). The cochlea can also be embedded in plastic before dissection of the cochlear duct (Bohne and Harding, 1997). (cdc.gov)
The cochlea is a bony, spiral-shaped chamber that contains the cochlear duct of the membranous labyrinth. (medscape.com)
The cochlear duct, part of the membranous labyrinth, is a triangular-shaped wedge located in the cochlea. (digitalhistology.org)
The cochlear duct, filled with endolymph, lies in the middle of the cochlea, dividing it into thirds, with the scala vestibuli above and the scala tympani below the cochlear duct. (digitalhistology.org)

Because of its small size, the mouse cochlea presents some advantages and disadvantages for cochlear preparation and microscopic evaluation. (cdc.gov)

This may provide clues for how to make it happen in humans and other mammals. (hearingreview.com)
When I started this work, somebody said to me that I d never be able to restore the complexity and intricacies of hair cells in humans or other mammals. (hearingreview.com)
Although tonotopy had been demonstrated previously in mice, the current work extends the findings to three mammals with low-frequency hearing similar to that of humans. (jneurosci.org)

This spiral-shaped cochlea is estimated to have originated during the early Cretaceous Period, around 120 million years ago. (wikipedia.org)

We now know that all vertebrates, except mammals, can regenerate new hair cells in the inner ear after native hair cells are damaged or destroyed. (hearingreview.com)
Mammals have the most complex ear structure compared to other tetrapod vertebrates. (bioexplorer.net)

Every hair cell in the cochlea is partnered with several neurons that convey information from the ear to the brain in an orderly way. (lehigh.edu)

In mammals, the structure is known as the organ of Corti and shows a unique arrangement of hair cells and supporting cells. (wikipedia.org)
Most of the bat skulls the scientists examined were about the size of a large blueberry, meaning that the tiny organ in the inner ear responsible for hearing, the cochlea, was about the size of a poppy seed. (sciencedaily.com)
The hearing organ in mammals is a spiraling structure called the "cochlea" from the Greek word for snail. (bcm.edu)
Figure 5 shows a short section of the organ of Corti as it spirals in the cochlea. (bcm.edu)
This difference in size is consistent with the fact that different frequencies of sound result in greater vibrations of the organ of Corti depending on where along the length of the cochlea you are measuring. (bcm.edu)
With sensorineural hearing loss (SNHL), the damaged hair cells of the organ of Corti within the cochlea interfere with typical hearing and, as a result, cause impaired language development. (intechopen.com)
The cochlea, which houses the sensory organ for hearing, consists of a triangular-shaped, fluid-filled channel, the membranous labyrinth, that is housed within the bony labyrinth (otic capsule). (cdc.gov)
Inside the cochlea, you can find the sensitive organ of Corti . (floofmania.com)

Next, the gene-carrying virus is injected into the inner ear through a small incision in the eardrum and an even smaller laser-drilled hole in the bone that rests against the inner ear.⁶ The insertion forces the supporting cells in the cochlea to ectopically express the non-silenced ATOH1 gene. (ysjournal.com)
Afterwards, the cochlea were injected with the adenoviral vectors containing the ATOH1 gene. (ysjournal.com)

Seals have shorter limbs than most other mammals. (animalcorner.org)

In mice, the cochlea expresses EGF receptors throughout the animal's life, but they apparently never drive regeneration of hair cells," said White. (regenerativemedicine.net)
First, they increased the levels of Activin A in the cochleas of normal mice. (themindunleashed.com)
In mice engineered to either overproduce follistatin or not produce Activin A at all, hair cells were late to form and appeared disorganized and scattered across multiple rows inside the cochlea. (themindunleashed.com)

It is widespread for senior dogs to gradually lose their hearing - with geriatric nerve degeneration in the cochlea beginning as young as 7-8 years of age. (ellevetsciences.com)

The evolution of the human cochlea is a major area of scientific interest because of its favourable representation in the fossil record. (wikipedia.org)
There are two and a half turns in the human cochlea and if you were to unwind the cochlea it would stretch to nearly an inch in length. (bcm.edu)
The good news is that, for the first time in history, there are teams of investigators worldwide exploring the possibility that hair cell regeneration can be induced in the mammal and human cochlea. (hearingreview.com)
This dataset is a manually curated database of genetic associations of gene expression signatures of aging from a meta-analysis of microarray studies in mammals that reflect current knowledge of the genetics of human aging and longevity. (johnsnowlabs.com)
This stage the cranial region of inward movement is formed from the human embryo and four osseous cochlea. (philcoffeeboard.com)
The preponderance of the biomedical data from human and laboratory mammal studies provide strong evidence of the toxic potential of exposure to PCBs. (cdc.gov)

It's funny, but mammals are the oddballs in the animal kingdom when it comes to cochlear regeneration," said Jingyuan Zhang, Ph.D., with the University of Rochester Department of Biology and a co-author of the study. (regenerativemedicine.net)
In the new study, which involved researchers from URMC and the Massachusetts Ear and Eye Infirmary, which is part of Harvard Medical School, the team tested the theory that signaling from the EGF family of receptors could play a role in cochlear regeneration in mammals. (regenerativemedicine.net)

The tone responses in the cochlea are, essentially, "remapped" to the cochlear nucleus, the first brain center to process sounds. (lehigh.edu)

This is the first physical evidence we have to support what genetic data tell us about the split of bats into two major groups," says Bruce Patterson, the Field Museum's MacArthur Curator of Mammals and one of the study's authors. (sciencedaily.com)
All mammals, including bats, are able to hear thanks to tiny hairs deep inside their cochlea. (sciencedaily.com)
Some mammals have huge ears, for instance, bats or some fox species. (bioexplorer.net)

Cochlea /ˈkoʊkliə/ is Latin for "snail, shell or screw" and originates from the Greek word κοχλίας kokhlias. (wikipedia.org)
The cochlea is the spiraling, snail-like structure that you might remember seeing in your science textbooks. (floofmania.com)
In order for mammals to hear, sound vibrations travel through a hollow, snail shell-looking structure called the cochlea. (themindunleashed.com)

Seals are able to resist more pain and fatigue caused by lactic acid accumulation than other mammals. (animalcorner.org)

Non-genetic congenital SNHL is thought to be the result of an injury to the cochlea typically from premature birth, infection, or exposure to ototoxic medications or noise. (intechopen.com)

Mammals are also known for a great diversity of outer ears. (bioexplorer.net)

Cladistic analysis employing a range of primitive eutherian mammals shows that nyctitheres are stem euarchontans, rather than lipotyphlans, with which they had previously been classified based on dental characters. (palaeo-electronica.org)

These vibrations are channeled to your cochlea and that's how you can hear what's playing. (googleusercontent.com)

We've studied so many things about these fish, and I never cease to be amazed by how similar the operation of their nervous system is to that of mammals," said Andrew Bass, author of the study published in the Journal of Neuroscience . (scienceagogo.com)
She speculated that this signaling pathway could potentially be manipulated to produce a similar result in mammals. (regenerativemedicine.net)

Molecular phylogenies also support an African root for Paenungulata, considering that they belong to a clade of extant African mammals, the so-called supercohort Afrotheria [2] , [5] . (plos.org)

I feel that, within 5-10 years, we could easily find out if it s possible to regenerate hair cells at robust levels sufficient to restore hearing in mammals. (hearingreview.com)
As a consequence of their discovery in hair cells, the focus of study of these subunits has largely been on their function in the cochlea. (frontiersin.org)
Along the spiral path of the cochlea, levels of Activin A increased where precursor cells were turning into hair cells. (themindunleashed.com)
90% of hearing loss is caused by damage to cells within the cochlea, particularly the sensory hair cells, and once these cells are damaged they degenerate and die. (healthcare-arena.co.uk)

The size of cochlea has been measured throughout its evolution based on the fossil record. (wikipedia.org)

Barn Owls, Tyto alba , can locate and catch small mammals in complete darkness using only their hearing. (earthlife.net)
They also have ossicles - small ear bones and a tympanum, and a cochlea with sensitive hair. (bioexplorer.net)

"The action of Activin A and follistatin is so precisely timed during development that any disturbance can negatively affect the organization of the cochlea," says Doetzlhofer. (themindunleashed.com)
Development and Patterning of the Cochlea: From Convergent Extension to Planar Polarity. (bordeaux-neurocampus.fr)

This is where, in mammals , you have an arrangement of three bones (Hammer, Anvil and Stirrup/Stypes). (earthlife.net)

In mammals, the cochlea is postmitotic at birth, and no spontaneous repair occurs thereafter. (intechopen.com)

primate Primates are a diverse order of mammals. (theinfolist.com)

In mammals, the gene is silenced during the first week after birth. (ysjournal.com)

A synthesis is presented of two recent studies on modelling the nonlinear neuro-mechanical hearing processes in mosquitoes and in mammals. (bris.ac.uk)

Anatomy37

Organisms8

Diseases12

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Psychiatry and Psychology2

Phenomena and Processes14

Disciplines and Occupations3

Information Science3

Health Care1

Marine mammals9

Auditory15

Birds9

Placental2

Semicircular canals3

Mammalian cochlea2

Base of the cochlea4

Vestibular3

Epithelium3

Sacculus3

Guinea pig cochlea2

Organs1

Sensitivity2

Cochlear duct4

Mouse cochlea1

Humans3

Spiral-shaped1

Vertebrates2

Neurons1

Organ8

Atoh12

Limbs1

Mice3

Nerve1

Human6

Regeneration2

Responses1

Bats3

Snail3

Seals1

Exposure1

Ears1

Stem1

Hear1

Similar2

Belong1

Cells4

Size1

Small2

Development2

Bones1

Occurs1

Order1

Birth1

Studies1