• Three-dimensional imaging of the intact mouse cochlea by fluorescent laser scanning confocal microscopy. (nih.gov)
  • A maximum intensity projection (MIP) from an intact mature mouse cochlea imaged through its entire volume. (nih.gov)
  • The risks and efficacy of transplanting two varieties of stem cells into mouse cochlea have been evaluated by Japanese researchers. (medindia.net)
  • Using TCF/Lef:H2B-GFP reporter mice and transfection of an independent TCF/Lef reporter construct, we describe the pattern of canonical Wnt activity in the developing mouse cochlea. (biologists.org)
  • We investigated functional expression of transient receptor potential vanilloid 4 in inner hair cells, outer hair cells, and spiral ganglion neurons of the mouse cochlea. (ovid.com)
  • Methodology/Principal Findings: A combination of quantitative RT-PCR, subcellular fractionation and Western blotting, along with in situ hybridization studies show IGF-I and its high affinity receptor to be strongly expressed in the embryonic and postnatal mouse cochlea. (whiterose.ac.uk)
  • Canonical Notch signaling is not necessary for prosensory induction in the mouse cochlea: insights from a conditional mutant of RBPjkappa. (semanticscholar.org)
  • The role of Rspo2 in the development of the mouse cochlea was investigated in this study by examining the Rspo2-/- mice. (escholarship.org)
  • ResultsOrganic cation transporter 2 was found in the supporting cells and in type I spiral ganglion cells in the cochlea of all species studied. (diva-portal.org)
  • It has been demonstrated that INS can be utilized to stimulate spiral ganglion cells in the cochlea. (ovid.com)
  • The motion of the stapes against the oval window sets up waves in the fluids of the cochlea, causing the basilar membrane to vibrate. (britannica.com)
  • Model showing the distribution of frequencies along the basilar membrane of the cochlea. (britannica.com)
  • Bob - Yes, that's a membrane called the basilar membrane inside the cochlea. (thenakedscientists.com)
  • As the cochlea spirals, the basilar membrane becomes less stiff and wider, so lower frequency sound waves are funneled further along the basilar membrane. (hubpages.com)
  • B) A decalcified cochlea cleared in MSBB and imaged by oblique lighting clearly displays the modiolus, basilar lamina, spiral limbus and other structures. (nih.gov)
  • The variation of dynamic structural properties of the basilar membrane contributes to the frequency-mapping and sensitivity of the cochlea. (ntu.edu.sg)
  • The present research analyses the mechanism of an arched basilar membrane in contributing to the sharp frequency tuning in a gerbil cochlea. (ntu.edu.sg)
  • Among the more commonly researched species, the basilar membrane in human cochlea varies significantly in width (300% increase) and thickness (75% decrease) from its basal to apical end. (ntu.edu.sg)
  • In order to understand the difference between the two types of basilar membranes, effects of the bending stiffness and radial tension on the acoustic traveling wave in the passive gerbil cochlea is analyzed. (ntu.edu.sg)
  • For integration of cochlea mechanics design into microfluidic applications and the development of artificial cochlea, a method of fabricating and bonding the thin, flexible, anisotropic, 3-dimensional basilar membrane is required as the boundary conditions and properties of the basilar membrane are critical to the frequency tuning of the cochlea. (ntu.edu.sg)
  • Four weeks after transplantation, the researchers found that the majority of cochleae that had been transplanted exhibited the settlement of iPS or ES-derived neurons. (medindia.net)
  • Increasing evidence suggests that hearing loss also results from damage to the synapses that connect the hair cells and the neurons in the cochlea. (elifesciences.org)
  • Consistent with this, mice that were genetically modified to lack a growth factor called neurotrophin-3 had cochleae that did not work properly and had fewer synapses between hair cells and neurons compared to control mice. (elifesciences.org)
  • Transient receptor potential vanilloid 4 mRNA and protein were expressed in inner hair cells, outer hair cells, and spiral ganglion neurons on the basis of the findings of reverse transcriptase-polymerase chain reaction, single-cell reverse transcriptase-polymerase chain reaction, and immunohistochemistry, whereas they were negative in transient receptor potential vanilloid 4 −/− mice cochleae. (ovid.com)
  • human cochlea and semicircular canals Dissection of the human cochlea and semicircular canals. (britannica.com)
  • KIAA1199 was later identified by cDNA microarray analysis as a cochlea-specific gene that was abundantly expressed in the human cochlea [ 4 ], and the protein it encodes has been found to play a central role in hyaluronan binding and depolymerization [ 5 ]. (hindawi.com)
  • The electrical, acoustical, and mechanical elements of the cochlea are explicitly integrated into a transmission-line model to develop a physiological interpretation of the human cochlea insofar. (diva-portal.org)
  • The results show comparative sensitivity between gerbil and human cochlea. (ntu.edu.sg)
  • Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. (nih.gov)
  • In addition, we demonstrated that ATP-dependent Ca2+ signaling activity in cochlear non-sensory cells is spatially graded from the apex to the base of the cochlea during the first postnatal week. (unipd.it)
  • Parvalbumin-β was also found in both inner and outer hair cells of the guinea pig cochlea. (jneurosci.org)
  • ObjectiveTo locate the organic cation transporter 2 (OCT2) in the cochlea of three different species and to modulate the ototoxicity of cisplatin in the guinea pig by pretreatment with phenformin, having a known affinity for OCT2. (diva-portal.org)
  • Histological reconstructions and microCT of guinea pig cochleae stimulated with an infrared laser suggest that the orientation of the beam from the optical fiber determined the site of stimulation in the cochlea. (ovid.com)
  • AP tuning curves from normal and pathological human and guinea pig cochleas. (semanticscholar.org)
  • This type I SGN (guinea-pig cochlea) is ensheathed by processes from a satellite glial cell, which form a thin myelin sheath (note the difference with the axons myelin sheaths below). (cochlea.eu)
  • Type II SGN (guinea-pig cochlea). (cochlea.eu)
  • Brain Research Protocols Volume 6, Issue 3, February 2001, Pages 159-166 Cryoembedding and sectioning of cochleas for immunocytochemistry and in situ hybridization Donna S. Whitlon, Renee Szakaly, Mary A. Greiner Abstract Current emphasis on biochemical and molecular aspects of cochlear anatomy underscores the necessity for high quality cryostat sections of the inner ear. (histosearch.com)
  • Cochlea Diagram - We have learnt about the anatomy of ear. (humandiagram.info)
  • One of the ear parts, inner ear anatomy that we will discuss is cochlea. (humandiagram.info)
  • Four rows of hair cells (called stereocilia) are located along the length of the cochlea. (hubpages.com)
  • There are approximately 20,000 hair cells located along the entire length of the cochlea, which detect a wide range of frequencies: the human ear has the capability of detecting sounds from approximately 200Hz-20,000Hz. (hubpages.com)
  • Not only does this help to give a better understanding of the structure of the cochlea, but also of the localization. (keyence.com)
  • Recent studies have demonstrated the importance of R- spondins, a novel family of secreted proteins, in canonical Wnt signaling and FGF signaling, two pathways that play significant roles in the development of the cochlea, the hearing organ. (escholarship.org)
  • Researchers at the Washington University School of Medicine in St. Louis, MO have used this mouse model to identify two signaling molecules called fibroblast growth factors (FGFs), which are required for the overall development of the cochlea. (entalexandria.com)
  • Hydrogen-rich water, which is a potent antioxidant agent, was investigated for its protective effects against ischemic damage of the cochlea in gerbils. (readbyqxmd.com)
  • The cochlea is spiraled around a bony structure called the modiolus. (hubpages.com)
  • Modiolus not labeled, but is represented at the axis of the spiral of the cochlea at the left. (wikidoc.org)
  • The modiolus is a conical shaped central axis in the cochlea . (wikidoc.org)
  • A) Shadows of the modiolus and pigmentation of the stria vascularis are the only internal structures visible from a non-cleared cochlea lying in PBS. (nih.gov)
  • The cochlea makes 3.25 turns in the dog (2.5 in man) around a core of bone (called the modiolus) through which the cochlear nerve passes. (vdocuments.site)
  • Altogether, our findings suggest that LGR4 and LGR5 play an important role in the regulation of hair cell differentiation in the embryonic cochlea. (frontiersin.org)
  • The expression of both proteins decreases after birth and in the cochlea of E18.5 embryonic Igf1(-/-) null mice, the balance of the main IGF related signalling pathways is altered, with lower activation of Akt and ERK1/2 and stronger activation of p38 kinase. (whiterose.ac.uk)
  • The cochlea contains the spiral organ of Corti, which is the receptor organ for hearing. (medlineplus.gov)
  • As the stapes rocks back and forth against the oval window, it transmits pressure waves of sound through the fluid of the cochlea, sending the organ of Corti in the cochlear duct into motion. (medlineplus.gov)
  • A core component of the cochlea is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating fluid chambers in the coiled tapered tube of the cochlea. (wikipedia.org)
  • While β-catenin-deficient cochleae expressed FGF8 and FGFR3, both of which are essential for pillar cell specification, the radial patterning of organ of Corti was disrupted, revealed by aberrant expression of cadherins and the pillar cell markers P75 and Lgr6. (pnas.org)
  • The capsule may be trimmed to allow the cochlea to lie on the coverslip, or sliced (e.g., along the dashed line) to open the capsule to allow the organ of Corti to be viewed by high NA objectives with short working distances. (nih.gov)
  • This is demonstrated by the presence of nitric oxide synthase (NOS) and nitric oxide (NO) in the blood vessels and the organ of Corti in the cochlea. (nus.edu.sg)
  • These cells are found in a small area in the cochlea called the organ of Corti. (neuronbank.org)
  • The cochlear hair cells are located in the organ of Corti, a small organ found in the scala media within the cochlea in the ear. (neuronbank.org)
  • In the cochlea channel, there is the organ of Corti, who receives the sound. (knowledgist9.com)
  • Sox2haplo amplified and expanded domains of damage-induced Atoh1+ transitional cell formation in neonatal cochlea. (jci.org)
  • By contrast, β-cateninGOF caused proliferation when either Sox2haplo or damage was present, and transitional cell formation when both were present in neonatal, but not mature, cochlea. (jci.org)
  • Mechanistically, Sox2haplo or damaged neonatal cochleae showed lower levels of Sox2 and Hes5, but not of Wnt target genes. (jci.org)
  • Sox2 haploinsufficiency results in continued proliferation and formation of supernumerary hair cells in the neonatal cochlea. (jci.org)
  • Our results demonstrated that when electrodes were completely sealed into the cochlea, the rate of longitudinal volume flow in scala tympani was extremely slow, approximately 1.6 nl/min in the apical direction. (biomedsearch.com)
  • There are three chambers of cochlea: the so called scala vestibuli, the scala tympani and the scala media. (johnsonlawoffices.net)
  • B ) Whole-mount preparation of cochlea from P4 Sox2 CreERT2/+ R26R tdTomato/+ mice given tamoxifen on P2, showing tdTomato expression in supporting cells and some hair cells. (jci.org)
  • Expression analysis of KIAA1199 protein in the cochlea has been performed in mice and rats [ 1 , 11 ], where different distribution patterns for each species were described, suggesting the possibility of an even greater difference in primates. (hindawi.com)
  • We demonstrate that this axon turning event requires planar cell polarity (PCP) signaling and is disrupted in Vangl2 and Celsr1 knockout mice, and that VANGL2 acts non-autonomously from the cochlea to direct turning. (biologists.org)
  • Vice versa, we found defective gap junction coupling and intercellular IP3-dependent Ca2+ signaling the cochlea of mice with targeted ablation Cx26 or Cx30, as well as in mice knock in for a point mutation (Cx30T5M) associated with human congenital deafness. (unipd.it)
  • Current estimates of cochlear concentration, either through models or through laboratory exposures, assume that solvent concentrations found in the brain are representative of concentrations in other neural tissues including the cochlea. (epa.gov)
  • c ) The three-dimensional equivalent electrical circuit of the whole cochlea built from the element circuit in ( b ) by its longitudinal electrical coupling in the selected nodes. (royalsocietypublishing.org)
  • A fine fissure in the lower part of the first turn of the cochlea , formed by a spiral lamina which projects from the outer wall of the cochlea but does not quite reach the osseous spiral lamina , thus leaving a narrow gap . (biology-online.org)
  • The cochlea was completely destructed after 1 month, however acoustic stimuli induced no response at the maximum sound intensity. (nii.ac.jp)
  • Ponder the uncomfortable sexuality of the twins, Cochlea & Eustachia. (webcomic.ws)
  • Among their protagonists, a bear-headed man in a long coat and high boots and identical teen sisters Cochlea and Eustachia, who wear only black masks and very short-skirted tops, recur often. (webcomic.ws)
  • The long-awaited collection of the first online Cochlea & Eustachia story arc in glorious full color! (webcomic.ws)
  • The cochlea also contains a specific population of hair cells, the outer hair cells (OHCs), which is thought to amplify the BM motion. (royalsocietypublishing.org)
  • In the Rspo2 mutant cochleae, there was an extra row of outer hair cells along with an extra row of support cells in the apical half of the cochlea. (escholarship.org)
  • β-Catenin-deleted cochleae displayed disrupted compartment borders containing ectopic hair cell and supporting cell subtypes, whereas inhibiting transcriptional and preserving cell adhesion-mediated activities of β-catenin maintained radial patterning and cell identity. (pnas.org)
  • A ) Immunostaining of P5 WT cochlea shows Sox2 expression in Hensen's cells, Deiters' cells, pillar cells, and the lateral portion of the greater epithelial ridge. (jci.org)
  • C ) GFP + supporting cells in the P5 Sox2 GFP/+ cochlea. (jci.org)
  • F ) Confocal images show no EdU + hair cells or supporting cells in the P5 WT cochlea. (jci.org)
  • H ) Quantification of extranumerary hair cells in WT, Sox2 CreERT2/+ , and Sox2 GFP/+ cochleae. (jci.org)
  • In the common marmoset cochlea, KIAA1199 protein expression was more widespread than in rodents, with all epithelial cells, including hair cells, expressing KIAA1199. (hindawi.com)
  • However, there is a risk of tumor growth associated with transplanting iPS cells into mouse cochleae. (medindia.net)
  • They noted that the number of cells able to be transplanted into cochleae is limited because of the cochleae's tiny size. (medindia.net)
  • Thus, the number of settled cells is low.They also noted the formation of a teratoma (encapsulated tumor) in some cochlea after transplantation with one group of iPS cells. (medindia.net)
  • Stem Cells and the Bird Cochlea-Where Is Everybody? (cshlpress.com)
  • In the developing cochlea, Wnt/β-catenin signaling positively regulates the proliferation of precursors and promotes the formation of hair cells by up-regulating Atoh1 expression. (frontiersin.org)
  • The primary transducers of sound are the mechanosensory hair cells, residing within the sensory epithelia of the hearing organ, the cochlea. (frontiersin.org)
  • The cochlea contains many thousands of hair cells organized in extensive arrays, embedded in an electrically coupled system of supporting cells. (royalsocietypublishing.org)
  • However, it is unresolved how Notch signaling functions in the hair cell-damaged cochlea and the molecular and cellular changes induced in supporting cells in response to hair cell trauma are poorly understood. (pubmedcentralcanada.ca)
  • This causes hair cells inside the cochlea to be susceptible to fluorescence blurring during fluorescence observation, and are therefore observed mainly with laser confocal microscopes. (keyence.com)
  • E13.5 cochlea electroporated with Eya1.GFP (A), Six1.GFP (B) or both (C) stained with anti-Myo7a antibody after 6 DIV. Transfected cells are identified as GFP + (green) and hair cells are identified as Myo7a + (red). (nih.gov)
  • There are two types of cochlea hair cells, outside hair cells and inside hair cells. (neuronbank.org)
  • Our method for cryoembedding of cochleas for immunocytochemistry and in situ hybridization uses slow infiltration with increasing concentrations of sucrose followed by degassed embedding medium before final orientation and freezing. (histosearch.com)
  • subunits of Na,K-ATPase were studied in the rat cochlea using in situ mRNA hybridization. (eurekamag.com)
  • The aim of this study is to assess the influence of experimental sepsis on hearing thresholds and to evaluate pathological changes in the cochlea. (biologists.org)
  • Bone remodeling within the otic capsule has been reported to be inhibited especially at or near the cochlea, except under some pathological conditions such as otosclerosis, Paget's disease, or mastoiditis, when bone remodeling can occur. (readbyqxmd.com)
  • This micromechanical microphone mimics the cochlea, the tapered part of the biological ear that distinguishes different frequencies. (trnmag.com)
  • The detection location for various sound frequencies along the length of an uncoiled cochlea. (hubpages.com)
  • The present study aimed to examine Cx26 expression and aberrant methylation the Cx26 promoter region in the cochlea from rats exposed to chronic prenatal hypoxia. (readbyqxmd.com)
  • The cochlea (plural is cochleae) is a spiralled, hollow, conical chamber of bone, in which waves propagate from the base (near the middle ear and the oval window) to the apex (the top or center of the spiral). (wikipedia.org)
  • Contributions of the middle ear to the development of function in the cochlea. (biomedsearch.com)