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  • auditory
  • In the cochlea (the specialized auditory end organ of the inner ear), the frequency of a pure tone is reported by the location of the reacting neurons in the basilar membrane, and the loudness of the sound is reported by the rate of discharge of nerve impulses. (britannica.com)
  • Unlike behavioral curves, however, the curves obtained by plotting the sound required to produce an arbitrary amount of electrical potential of the cochlea do not represent auditory thresholds. (britannica.com)
  • 9. An implantable apparatus of claim 6 wherein the prosthesis includes an electrode array that is implantable in the cochlea of the implantee and is adapted to deliver both plasticity informative stimuli and auditory informative stimuli to the cochlea of the implantee. (google.ca)
  • The sound waves travel through the cochlea and excite hair cells at specific locations along the cochlea, and the information from these cells is picked up by the auditory nerve and carried to the brain. (hubpages.com)
  • Animals with tightly coiled cochleae tend to have greater hearing ranges, but previous attempts to associate these auditory effects with the physical characteristics of the cochlea have proven unsatisfactory because they did not take a critical acoustic effect into account. (innovations-report.com)
  • The cochlea, the mammalian auditory organ, is a spiral-shaped structure in the inner ear that is responsible for hearing. (cshlpress.com)
  • They also consider the properties of other cochlear components, including the tectorial membrane, the synaptic connections with auditory neurons, and the resident macrophages, as well as the development and evolution of the cochlea as a whole. (cshlpress.com)
  • deafness
  • It turns out that it is the curvature of the cochlea, not its size, that is highly correlated to the low-frequency hearing limit," says Daphne Manoussaki, assistant professor of mathematics at Vanderbilt University, who headed the new study with Richard S. Chadwick, a section chief at the National Institute on Deafness and Other Communication Disorders (one of the National Institutes of Health, or NIH). (innovations-report.com)
  • Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments. (cshlpress.com)
  • apparatus
  • 4. An implantable apparatus of claim 1 wherein the stimuli is delivered to the cochlea, inferior colliculus, the Subthalamic Nucleus (STN), the Globus Pallidus (GPi), and/or the Thalamus of the implantee. (google.ca)
  • high frequency
  • The end of the cochlea nearest the oval window is stiff and narrow, which funnels high frequency sounds to the first sections of the cochlea. (hubpages.com)
  • The hair-cell concentration of calbindin-D28k but not of parvalbumin-β increased from the low- to high-frequency end of the cochlea. (jneurosci.org)
  • cells
  • In the common marmoset cochlea, KIAA1199 protein expression was more widespread than in rodents, with all epithelial cells, including hair cells, expressing KIAA1199. (hindawi.com)
  • Lgr5-positive supporting cells generate new hair cells in the postnatal cochlea. (nih.gov)
  • While hair cell differentiation in mice starts at embryonic day (E)14.5, beginning with the inner hair cells, Fgf20 expression precedes hair cell differentiation at E13.5 in the cochlea. (jneurosci.org)
  • However, there is a risk of tumor growth associated with transplanting iPS cells into mouse cochleae. (medindia.net)
  • They noted that the number of cells able to be transplanted into cochleae is limited because of the cochleae's tiny size. (medindia.net)
  • Thus, the number of settled cells is low.They also noted the formation of a teratoma (encapsulated tumor) in some cochlea after transplantation with one group of iPS cells. (medindia.net)
  • mice
  • Expression analysis of KIAA1199 protein in the cochlea has been performed in mice and rats [ 1 , 11 ], where different distribution patterns for each species were described, suggesting the possibility of an even greater difference in primates. (hindawi.com)
  • human
  • human cochlea and semicircular canals Dissection of the human cochlea and semicircular canals. (britannica.com)
  • KIAA1199 was later identified by cDNA microarray analysis as a cochlea-specific gene that was abundantly expressed in the human cochlea [ 4 ], and the protein it encodes has been found to play a central role in hyaluronan binding and depolymerization [ 5 ]. (hindawi.com)
  • travel
  • In 2006 Manoussaki and her NIH collaborators published a paper proposing that the helical shape of the cochlea enhances low-frequency sounds through an effect analogous to the well-known "whispering gallery effect" in which soft sounds that travel along curved walls in a large chamber remain loud enough that they can be heard clearly on the opposite side of the room. (innovations-report.com)
  • formation
  • To our knowledge, this is the first documentation of teratoma formation in cochleae after cell transplantation," said Dr. Nakagawa.The researchers concluded that the teratoma formation in one iPS cell line indicated the necessity for selecting appropriate iPS cell lines for avoiding tumorigenesis. (medindia.net)
  • found
  • Four weeks after transplantation, the researchers found that the majority of cochleae that had been transplanted exhibited the settlement of iPS or ES-derived neurons. (medindia.net)
  • Common
  • We performed immunohistochemical analysis of a nonhuman primate, common marmoset ( Callithrix jacchus ), cochlea with a KIAA1199-specific antibody. (hindawi.com)
  • We therefore examined expression of KIAA1199 protein by immunohistochemistry in cochlea from a nonhuman primate, the common marmoset ( Callithrix jacchus ). (hindawi.com)