• Chelating agents offer a versatile and effective means of removing toxic metal ions from the human body. (unict.it)
  • Both cobalt and titanium ions can trigger inflammatory responses in the body. (prime.sg)
  • Excessive release of cobalt ions can lead to osteolysis, a process where bone tissue is broken down and resorbed. (prime.sg)
  • To investigate the mobilisable metal fraction, representing the amount of easily remobilisable complexed and carbonated metal ions, a DTPA (di-ethylene-triamine-pentaacetic acid) extraction was conducted. (sun.ac.za)
  • Both essential and non-essential metal ions can cause toxicity. (rsc.org)
  • The essential metal ions for humans are the bulk metals sodium, potassium, calcium and magnesium and the trace metals manganese, iron, cobalt, copper, zinc and molybdenum, and, after outlining why they are required, we summarise the circumstances in which certain of them can be toxic. (rsc.org)
  • The toxicity of non-essential metal ions is a consequence of environmental exposure leading to their accumulation within the body, where they interfere with the functions of the essential metal ions. (rsc.org)
  • Metal toxicity 1 can be caused by both metal ions, which are considered to be essential for humans, like iron and copper, as well as by non-essential metals, like cadmium, lead and mercury, which are not at all necessary for life but which, when introduced into the human environment, can have toxic effects, often with disastrous consequences. (rsc.org)
  • So, we begin by asking what are the essential metal ions, why they are required, and under what circumstances certain of them can be toxic. (rsc.org)
  • We then discuss which are the non-essential metal ions which pose toxicity problems to the human population. (rsc.org)
  • For each of these two groups of metal ions, general chemical considerations and the basic principles involved in their toxicity are briefly considered, as well as how the metal ion is bound within cells or tissues, since this is a key element in devising strategies for its removal by chelation. (rsc.org)
  • Whereas essential metal ion toxicity can be attributed to accumulation of excessive concentrations of the metal ion, often in specific tissues or organs, the toxicity of non-essential metal ions is a consequence of environmental exposure leading to their accumulation within the body. (rsc.org)
  • There are around twenty five elements that are required by most biological systems, including an important number of metal ions. (rsc.org)
  • However, for humans, there are ten essential metal ions. (rsc.org)
  • The two essential alkali metal ions Na + and K + (together with H + and Cl − ) are only weakly bound to organic ligands and are extremely mobile. (rsc.org)
  • NTA and IDA fix transition metal ions to the matrix, where they complex polyhistidine sequences on proteins of interest. (genengnews.com)
  • Based on summarizing the effect and mechanism of HS on heavy metals in soil, the potential of phytoremediation of heavy metal pollution in soil was analyzed by literature investigation:(1) Macromolecule humin (HM) and humic acid (HA) could passivate heavy metal ions and reduce the toxicity of heavy metals to crops. (ere.ac.cn)
  • 2) In addition to the physical and chemical properties of soil, the binding of HS with metal ions was mainly influenced by the ionic strength, molecular weight and the quantity of active functional groups and the pH of HS. (ere.ac.cn)
  • MA Ming-guang,ZHOU Min,JIANG Yu-feng,et al.Study on Adsorption of Heavy Metal Ions Onto Insolublized Humic Acid[J].Journal of Safety and Environment,2006,6(3):68-71. (ere.ac.cn)
  • In addition, metal surfaces can corrode, giving off metal ions. (nashfranciskato.com)
  • Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic , edited by Peggy L. Carver, Berlin, Boston: De Gruyter, 2019, pp. 267-302. (degruyter.com)
  • In P. Carver (Ed.), Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic (pp. 267-302). (degruyter.com)
  • May 12, 2015 - DePuy ASR Hip Metallosis and DePuy ASR Hip Metal Toxicity - When the metal ions delve into the surrounding hip tissues, symptoms of metallosis can occur. (sullolaw.com)
  • A conclusion Cobalt oxide contaminants are easily internalized by pulmonary cells via the endo-lysosomal path and can business lead, through a Trojan-horse system, to intracellular discharge of dangerous steel ions over lengthy intervals of period, regarding particular toxicity. (insulin-receptor.info)
  • Solubilization of the contaminants, leading to cytotoxic results related to the free of charge steel ions released and/or the immediate dangerous results of steel oxide mini- and nanoparticles through oxidative tension, are among the main systems recommended to end up being included at the mobile level. (insulin-receptor.info)
  • The more-soluble iron cobalt nanoparticles induce cytotoxicity, ROS formation, and genotoxicity to a better level than cobalt ions [6,8,9]. (insulin-receptor.info)
  • The less-soluble cobalt oxide nanoparticles possess been proven to end up being much less dangerous than cobalt ions [10], but to trigger speedy induction of ROS, with ROS amounts higher 1190215-03-2 IC50 than those activated by cobalt ions [10,11,13]. (insulin-receptor.info)
  • As it is known that earthworms do occur in ultramafic soils, the aims of the present study were to investigate the abilities of earthworms to survive in these soils and the influences of elevated chromium, cobalt, copper, manganese and nickel levels. (sun.ac.za)
  • For the evaluation of the metal background conditions, soils originating from ultramafic rocks of the Barberton Greenstone Belt, Mpumalanga, South Africa were collected and different fractions representing different levels of bioavailability were analyzed for arsenic, chromium, cobalt, copper, manganese and nickel. (sun.ac.za)
  • Focussing on manganese and nickel, the uptake by E. fetida of these metals was investigated with the exclusion of soil related properties using an artificial aqueous medium to draw comparisons to the uptake of these metals in natural soils. (sun.ac.za)
  • More recently, a parkinsonian syndrome among Latvian injection drug users of methcathinone was linked to manganese toxicity. (medscape.com)
  • Non-functional ceramic glazes having very high percentages of metallic oxides/carbonates (manganese, copper, cobalt, chrome). (digitalfire.com)
  • Other metal oxides like copper and cobalt are also active fluxes and melt even better than manganese, but they are prone to forming crystals during cooling (the micro-crystals of copper completely matte the surface). (digitalfire.com)
  • It can thus be beneficial to incorporate some copper or cobalt with the manganese in the recipe to promote the desired amount of crystallization. (digitalfire.com)
  • Cobalt and copper have crystallized during cooling, manganese has formed an iridescent glass. (digitalfire.com)
  • Perhaps one of the most frightening side effects of Biomet hip replacement devices, which contain both chromium and cobalt, is that they can lead to metal toxicity . (johnfoy.com)
  • The Zimmer VerSys Femoral Stem has been connected to instances of mechanically assisted crevice corrosion which occur when the femoral stem sheds chromium and cobalt particles into the bloodstream, resulting in metal poisoning. (faleslaw.com)
  • Ms. Robare contends that the product caused higher than normal levels of chromium and cobalt in her blood, a number of painful surgeries, and an increased risk of failure in her prosthetic hip replacement . (injurylawyer-news.com)
  • The tolerance limits of Nile water phytoplankton to cobalt, zinc and copper was investigated. (scialert.net)
  • Although many metals such as cobalt, copper, iron and zinc are essential to living organisms, at elevated concentrations most metals are toxic to organisms living in and on soils. (sun.ac.za)
  • Copper shows low specificity and high yield, whereas cobalt is on the other end of the spectrum, generating extremely pure proteins but lower yield. (genengnews.com)
  • It is also possible to capture the entire population of proteins in cells that bind to metals such as copper or iron, the so-called metalloproteome," adds Dr. Boronowsky. (genengnews.com)
  • Chrome and rutile have not melted, copper and cobalt are extremely active melters. (digitalfire.com)
  • Working with copper materials for a long time can result in metal poisoning. (personalabs.com)
  • List of minerals named after people Nickel-cadmium battery Nickel-hydrogen battery Nickel-metal hydride battery Nickel-iron battery CRC Handbook of Chemistry and Physics (84 ed. (wikipedia.org)
  • A number of non-essential metals, like cadmium, lead and mercury are not at all necessary for life but, when introduced into the human environment, they pose serious problems on account of their toxicity. (rsc.org)
  • Lead, mercury, and cadmium are prime examples of such "toxic metals. (medscape.com)
  • The effect of the structure and the magnetic charge is that zeolite draws heavy metals (including mercury, cadmium, lead, arsenic, aluminum, tin, excess iron, and even radioactive metals like cesium and strontium-90) and toxins to it and simply engulfs them. (nutrimedical.com)
  • It is well known that infections cause depletion of these metals, especially zinc, and that supplementation of zinc during acute infection stages along with vitamin C assists in shortening recovery times and reducing symptoms for colds. (ra-infection-connection.com)
  • For example, zinc is an important cofactor for several enzymatic reactions in the human body, vitamin B-12 has a cobalt atom at its core, and hemoglobin contains iron. (medscape.com)
  • In some cases, ultrafine particle surface area has provided an effective metric-relating exposure and response: TiO2 ultrafine particles and carbon black dust were active for tumor induction in the rat with toxicity increasing with dust surface area (1). (cdc.gov)
  • Mounting evidence suggests that exposure to nickel and cobalt causes a number of adverse nasal/pulmonary health effects, skin hazards and allergies. (unict.it)
  • Chromium exposure has been associated with cell toxicity and oxidative stress, affecting bone cells' normal functions. (prime.sg)
  • Occupational quartz and particle exposure affect systemic levels of inflammatory markers related to inflammasome activation and cardiovascular disease. (oru.se)
  • Finally, we briefly review the sources and routes of exposure to metal toxicity, with particular reference to non-essential metals. (rsc.org)
  • Toxicity due to over exposure can lead to a variety of health concerns. (requestatest.com)
  • Customers testing due to workplace exposure should order the individual Cobalt and Chromium blood tests. (requestatest.com)
  • With the possible exceptions of acute iron toxicity from intentional or unintentional ingestion and suspected lead toxicity , emergency physicians will rarely be alerted to the possibility of metal exposure. (medscape.com)
  • Yet, if unrecognized or inappropriately treated, heavy metal exposure can result in significant morbidity and mortality. (medscape.com)
  • Specific clinical manifestations vary according to the metal in question, the total dose absorbed, and whether the exposure was acute or chronic. (medscape.com)
  • Exposure to metals may occur through the diet, from medications, from the environment, or in the course of work or play. (medscape.com)
  • Where heavy metal toxicity is suspected, time taken to perform a thorough dietary, occupational, and recreational history is time well spent, since identification and removal of the source of exposure is frequently the only therapy required. (medscape.com)
  • A full dietary and lifestyle history may reveal hidden sources of metal exposure. (medscape.com)
  • Occupational exposure assessment of metals. (mcmaster.ca)
  • Cobalt dust exposure can lead to an asthma-like allergy and irritation of the skin, nose, and throat. (personalabs.com)
  • This MDHS describes a method for measuring exposure to a range of metal and metalloid elements in workplace air using inductively coupled plasma-atomicemission spectrometry (ICP-AES). (speciation.net)
  • Occupational exposure to cobalt occurs predominantly during the refining of cobalt, in the production of alloys, and in the hard-metal industry where workers may be exposed during the manufacture and maintenance of hard-metal tools and during the use of diamond-cobalt tools. (who.int)
  • Exposure to hard-metal dust takes place at all stages of the production of hard metals, but the highest levels of exposure to cobalt have been reported to occur during the weighing, grinding and finishing phases (Reber and Burckhardt 1970, McDermot 1971, NIOSH 1981, Sprince et al. (who.int)
  • 1994). The importance of OELs is highlighted by the occupational exposure limits (OELs) for metals and fact that many organizations around the world develop other mining-related chemicals were surveyed, and them. (cdc.gov)
  • The biomarkers with larger smoking-nonsmoking population mean ratios had greater regression coefficients related to recency of exposure. (cdc.gov)
  • We measured blood metals in AI communities to assess historical exposure and identify participant characteristics associated with these levels in the Strong Heart Study (SHS) cohort. (cdc.gov)
  • exposure to HMs has been studied mainly by monitoring the concentrations in body fluids such as blood or urine, Heavy metals (HMs) are metals with specific densities or by studying their concentrations in ambient air. (who.int)
  • exposure to several HMs and their adverse effects on Among these, the metals most commonly associated the respiratory system. (who.int)
  • Your health care provider may order a heavy metal blood test if you had a possible exposure to heavy metal or if you have symptoms of heavy metal poisoning. (medlineplus.gov)
  • Symptoms of heavy metal poisoning depend on the type of metal and how much exposure you had. (medlineplus.gov)
  • Even if you don't have symptoms, you may still need to avoid all exposure to that metal. (medlineplus.gov)
  • Dispersion of nanoparticle s in pulmonary surfactants for in vitro toxicity studies: lessons from ultrafine diesel exhaust particles and fine mineral dusts. (cdc.gov)
  • For instance, unexpected morbidity and mortality in the workforce of a hard metal fabrication plant using a new process were related to subtle surface structural features of the generated fine respirable dusts: ultrathin cobalt coatings on the tungsten carbide particles were strongly catalytic in aqueous media for toxic reactive oxygen species generation (4-6). (cdc.gov)
  • Insoluble particles can adsorb components of that pulmonary hypophase surfactant, resulting in fundamental changes in the particles' biological disposition and expression of toxicity. (cdc.gov)
  • Metallosis occurs when metal particles accumulate in the peri-implant tissues, causing inflammation, tissue damage, and potential bone resorption. (prime.sg)
  • Furthermore, said Maher: "We also observed other metal-bearing particles in the brain, such as platinum, cobalt and nickel. (truthdig.com)
  • Now there is a reason to go on and do the epidemiology and the toxicity testing, because these particles are so prolific and people are exposed to them. (truthdig.com)
  • Some toxicity issues are related to the form of the colloidal and nano particles, like Si. (ra-infection-connection.com)
  • The toxicity of radioactive metals like polonium, which was discovered by Marie Curie but only recently brought to public attention after the 2006 murder of Russian dissident Alexander Litvinenko, relates more to their ability to emit particles than to their ability to bind cell proteins. (medscape.com)
  • When the metal parts rub against each other, the release small particles of debris. (nashfranciskato.com)
  • A pseudotumor is a non-cancerous soft tissue growth that occurs when metal particles irritate tissue in the hip. (nashfranciskato.com)
  • These metal particles can cause bone and tissue damage over time. (ahwfirm.com)
  • Background The mechanisms of toxicity of metal oxide particles towards lung cells are far from being understood. (insulin-receptor.info)
  • Exposures depend on composition of raw materials but may commonly include silica (SiO 2 ), clay, alumina, limestone, alkaline dusts, metal oxides, heavy metals and nuisance particulate. (cloudaccess.net)
  • 1984), and in powder rooms with poorly-regulated control of cobalt dusts, concentrations of cobalt in air ranged from between 10 µg/m3 and 160 µg/m3 (Auchincloss et al. (who.int)
  • Like cobalt, it can contribute to metallosis and damage surrounding tissues. (prime.sg)
  • A severe cobalt leak from his Johnson & Johnson implant device had caused metallosis, which is a build-up of metal debris in the soft tissues of the body. (faleslaw.com)
  • A type of metal poisoning that occurs when toxic levels of metal build up in the body, metallosis can cause damage to tissue, bone and the nervous system. (nashfranciskato.com)
  • DePuy, a subsidiary of Johnson & Johnson, recalled the ASR in 2010 because of an extremely high failure rate as well as many consumers reporting symptoms of metallosis and metal toxicity. (sullolaw.com)
  • The extensive use in modern times of metallic alloys is related to the availability and success at the beginning of the 20th century of several different alloys made of the noble metals. (medscape.com)
  • 2001. Biocompatibility of nickel and cobalt dental alloys. (cdc.gov)
  • Cobalt metal is used to make corrosion- and wear- resistant alloys used in aircraft engines (superalloys), in magnets (magnetic alloys) and in high-strength steels and other alloys for many applications. (who.int)
  • Currently, because of growing evidence of lead toxicity at lower concentrations, the U.S. Ce. (speciation.net)
  • Cobalt sulfate and other soluble cobalt (II) salts are possibly carcinogenic to humans (Group 2B). (who.int)
  • In vitro toxicology studies can be designed to retain particle surface structure and composition and to model the conditioning of those surfaces upon particle deposition in the deep lung in order to analyze consequent effects on toxicity. (cdc.gov)
  • 1983. Correlation of metal toxicity with in vitro calmodulin inhibition. (cdc.gov)
  • Because the biocompatibility properties resulting from this new MIM cobalt alloy process are not well understood, we conducted tests to evaluate cytotoxicity (in vitro), hemolysis (in vitro), toxicity effects (in vivo), tissue irritation level (in vivo), and pyrogenicity count (in vitro) on such samples. (iospress.com)
  • This is an important consideration because it is the bioavailability and bioreactivity of metals that control their potential to cause adverse effects. (researchgate.net)
  • The BLM is a mathematical model developed to measure, assess, and understand how the chemical properties of a waterbody can affect metallic contaminant speciation, bioavailability, and consequent toxicity, comprising an important tool in understanding and predicting metal toxicity in different waterbodies [8,10]. (researchgate.net)
  • Chromium (Cr) is a naturally occurring element whose nutritional bioavailability and toxicity depends on its oxidation state. (cdc.gov)
  • The collected information may provide new insights and suggest further strategiesfor the development of hydroxyquinoline derivatives for the control of cobalt and nickel toxicity. (unict.it)
  • In this dossier, the endpoint genetic toxicity is not addressed by substance-specific information, but instead by a weight of evidence approach based on collected information for all cobalt substances of the CoRC cobalt category. (europa.eu)
  • The assessment of the genotoxic properties of cobalt and its substances is related to the assumption that once inorganic cobalt compounds or cobalt metal become bioavailable, this will be in the form of the divalent cobalt cation. (europa.eu)
  • They are introduced into the aquatic system as a result of weathering of soil and rocks, from volcanic eruptions and from a variety of human activities involving mining, dredging, processing and use of metals and/or substances containing metal contaminants. (intechopen.com)
  • Humic Substances Amendments for Improving Phytoremediation of Heavy Metal Polluted Soils: A Review[J]. Journal of Ecology and Rural Environment, 2020, 36(3): 273-280. (ere.ac.cn)
  • The Agency for Toxic Substances and Disease Registry (ATSDR) lists cobalt as a possible carcinogen to animals due to research performed by the International Agency for Research on Cancer where direct contact with cobalt occurred (ATSRD 2000). (cdc.gov)
  • Depending on the toxicity level, these substances can lead to mild or severe poisoning. (personalabs.com)
  • Metals in medicinal products or human nutrition can be beneficial or problematic: On one hand, they are used directly as active substances in drug products to exert a beneficial effect, or they are necessary as minerals or trace elements. (pharmamanufacturing.com)
  • Metals used in drug substances still have importance in modern drug therapy. (pharmamanufacturing.com)
  • The guidelines define maximum acceptable concentrations limits for metal residues arising from the use of metal catalysts or metal reagents in the synthesis of pharmaceutical substances. (pharmamanufacturing.com)
  • The beginning of the toxicity of low-solubility substances such as cobalt oxide contaminants is certainly considerably from getting grasped and continues to be extremely complicated. (insulin-receptor.info)
  • During recent years, the biotic ligand model (BLM) has been proposed as a tool to evaluate quantitatively the manner in which water chemistry affects the speciation and biological availability of metals in aquatic systems. (researchgate.net)
  • Objective To investigate the biological effect of a new method to camouflage the cobalt-chromium (CoCr) metal structure of an RPD, onto which an electrostatic paint was applied. (bvsalud.org)
  • The level of metal toxicity is so high, there is a reasonable probability that patients will have an adverse biological response and require revision surgery. (ahwfirm.com)
  • The aim of this study was to compare nickel metal uptake by biological uptake methods with the help of bacterium and brown algae Sargasom, Focus and Grasilaria red algae and nanotechnology method. (magiran.com)
  • Contamination of medicinal products with heavy metals may arise from metals deliberately added as catalysts or reagents. (pharmamanufacturing.com)
  • Contamination may arise from metals deliberately added as catalysts or reagents. (pharmamanufacturing.com)
  • EMA guidelines on specification limits for residues of metal catalysts and reagents were put into place in 2008. (pharmamanufacturing.com)
  • The study and development of new homogeneous catalysts based on first-row metals (Mn, Fe, Co, Ni, and Cu) has grown significantly due to the economic and environmental advantages that non-noble metals present. (wiley-vch.de)
  • Recognized experts in organometallic chemistry and homogeneous catalysis, the authors present a comprehensive overview of the conceptual and practical aspects of non-noble metal catalysts. (wiley-vch.de)
  • This timely book demonstrates the efficacy of base metal catalysts in the pharmaceutical, fine-chemical, and agrochemical industries, addressing both environmental and economic concerns. (wiley-vch.de)
  • Other uses of cobalt include catalysts, batteries, dyes and pigments and related applications. (who.int)
  • Heavy metals entering natural water become part of the water-sediment system and their distribution processes are controlled by a dynamic set of physicochemical interactions and equilibria. (intechopen.com)
  • Heavy metals are distributed throughout soil and sediment components and associated with them in various ways, including adsorption, ion exchange, precipitation and complexation and so on [ 2 ]. (intechopen.com)
  • Further assuming that the anion of such inorganic cobalt compounds can be regarded as "inert" with regard to genetic toxicity, the subsequent discussion focuses on the cobalt cation. (europa.eu)
  • PCB methyl sulphones and related compounds: Identification of target cells and tissues in different species. (cdc.gov)
  • Although PM consists of various compounds, heavy metals are essential constituents because of their harmful effects on human health. (magiran.com)
  • METHODS: We performed multiple regression analysis of longitudinal measures of urinary biomarkers of alkaloids, tobacco-specific nitrosamines, polycyclic aromatic hydrocarbons, volatile organic compounds (VOC), and metals to examine the sample-to-sample consistency in Waves 1 and 2 of the Population Assessment of Tobacco and Health Study including demographic characteristics and use behavior variables of persons who smoked exclusively. (cdc.gov)
  • 2012). While it is essential at certain lower levels, exposures to high levels of cobalt can affect the heart and/or lungs. (cdc.gov)
  • In addition, iron oxide is inexpensive whereas the other metal oxides useful for this purpose are very, very expensive. (digitalfire.com)
  • How do metal oxides compare in their degrees of melting? (digitalfire.com)
  • Cobalt is widely distributed in the environment, occurring in the earth's crust mainly in the form of sulfides, oxides and arsenides. (who.int)
  • Introduction:Notwithstanding the possibilities of capillary gas chromatography (CGC) coupled to atomic emission detection (CGC-AED) for metal speciation, there are a number of features that make the h. (speciation.net)
  • Title: Explant Analysis of the Biomet Magnum/ReCap metal-on-metal hip joint Abstract Metal-on-Metal (MoM) hip resurfacing implants and MoM total hip arthroplasty (THA) implants have recently been questioned by the medical community because of their high revision rates. (mctlaw.com)
  • If you developed metal toxicity and required revision surgery after receiving the Zimmer VerSys Hip System, contact Fales & Fales, P.A. for a case review. (faleslaw.com)
  • The medical costs and lost wages related to a hip revision surgery may be recouped from Stryker Corporation, but hip replacement recipients are strongly encouraged to obtain the advice and representation of an injury attorney, as any information provided to Stryker Corporation or business associates may limit further legal action. (injurylawyer-news.com)
  • May 21, 2015 - How the DePuy ASR Hip Settlement May Affect You - Medical expenses related to the DePuy ASR hip revision surgery were also paid through the settlement. (sullolaw.com)
  • Heavy metal pollution is a serious and widely environmental problem due to the persistent and non-biodegradable properties of these contaminants. (intechopen.com)
  • In this context, the development of chelatorsthat are able to bind nickel and cobalt with high stabilityconstants is clearly crucial. (unict.it)
  • Metals may be contaminants in dietary supplements, or they may leach into food and drink stores in metal containers such as lead decanters. (medscape.com)
  • As anticipated from these low-solubility contaminants, the intracellular solubilized cobalt articles is certainly little likened with the intracellular particulate cobalt 1190215-03-2 IC50 articles, in the parts-per-thousand range or below. (insulin-receptor.info)
  • The participation of dissolution procedures in iron cobalt particle cytotoxicity provides been obviously proven for these easily soluble contaminants [6,8,9,11]. (insulin-receptor.info)
  • Although cobalt oxide contaminants display a low toxicity research [14,22]. (insulin-receptor.info)
  • In toxicological research, just the extracellular solubilized small 1190215-03-2 IC50 percentage of the cobalt oxide contaminants provides therefore much been 1190215-03-2 IC50 scored [10,13], displaying a extremely low quantity of cobalt released into the tradition moderate. (insulin-receptor.info)
  • Although the analysis of particle behavior in tradition press is definitely of unique relevance for toxicological research, deeper research related to the mobile subscriber base, intracellular solubilization, and behavior of contaminants are important to gain understanding into the connected particle toxicity systems. (insulin-receptor.info)
  • Excessive cobalt release might cause osteolysis, weakening bone around the implant. (prime.sg)
  • Implant-related chromium release might result in osteolysis and implant loosening. (prime.sg)
  • Article link: https://www.icij.org/investigations/implant-files/hidden-dangers-patients-doctors-not-informed-of-defective-implants/ Article title: Hidden Dangers: patients, doctors not informed of defective implants By Spencer Woodman This article begins with the story of Vijay Vojhala, an Indian man who received a Johnson & Johnson metal-on-metal hip in 2008. (mctlaw.com)
  • It featured the story of Dr. Stephen Tower, an orthopedic surgeon who, in 2006, received a Johnson & Johnson metal-on-metal hip implant after his right hip gave out. (faleslaw.com)
  • Officially known as total hip arthroplasty, it is an invasive surgical procedure in which an orthopedic surgeon replaces an affected hip joint with an artificial implant made from plastic or metal. (faleslaw.com)
  • The FDA's Metal-on-Metal Total Hip Replacement Implant webpage provides specific information on metal-on-metal total hip replacements. (nashfranciskato.com)
  • Metal-on-metal hip implant devices are not for everyone. (nashfranciskato.com)
  • The attorneys at Nash & Franciskato offer a free, no-obligation case review to individuals who have suffered complications allegedly associated with failed metal-on-metal hip implant systems. (nashfranciskato.com)
  • In another Stryker Rejuvenate hip lawsuit being litigated in the U.S. District Court of Southern New York, the plaintiff is seeking $20 million in damages related to the use of a Rejuvenate hip implant. (injurylawyer-news.com)
  • If there are elevated levels of chromium or cobalt in their blood, they are strongly urged to replace their hip prosthetic with another type of implant. (injurylawyer-news.com)
  • Evidence that cobalt sulfate heptahydrate was a weak inducer of mutations in Salmonella typhimurium strain TA100 when using the pre-incubation method was published by Zeiger et al (1992), when reporting on NTP studies. (europa.eu)
  • Pagano & Zeiger, 1992: Cobalt chloride induced mutations in TA97 when using the pre-incubation method with different aqueous (sterile water or buffers, including phosphate buffer) solvents. (europa.eu)
  • 1992). For example, in two factories in the USA producing hard metals, peak cobalt concentrations in air during weighing, mixing and milling exceeded 500 µg/m3 in more than half of all samples (Sprince et al. (who.int)
  • These differ significantly in their solubilities, for example even more than 50% of metal cobalt microparticles are solubilized in tradition moderate after 72?h [6], whereas cobalt oxide microparticles are nearly insoluble in lifestyle or drinking water moderate [1,14]. (insulin-receptor.info)
  • This explains some of the vaccine related hyper immune observations and reopens the serious question of combined-vaccination safety due to aluminum toxicity. (ra-infection-connection.com)
  • The increases in TA97 revertants were dose-related and reached 5-6-fold control levels at 800 µM, which is clearly biologically and statistically significant. (europa.eu)
  • The pigment fractions of Nile water phytoplankton under various levels of the three metals responded more or less in a similar trend to that of cell number. (scialert.net)
  • This test measures Cobalt and Chromium levels in the blood. (requestatest.com)
  • Elevated cobalt levels from MoM hip implants are serious conditions. (nashfranciskato.com)
  • Blood cobalt levels as low as 14μg/L can trigger this type of heart disease in patients with metal-on-metal hip implants. (nashfranciskato.com)
  • Base metals offer reduced cost, greater supply, and lower toxicity levels than noble metals-enabling greater opportunity for scientific investigation and increased development of practical applications. (wiley-vch.de)
  • Bivariate associations were conducted to examine associations between blood metal levels and selected socio-demographic and behavioral covariates. (cdc.gov)
  • Finally, multivariate regression models were used to assess the best model fit that predicted blood metal levels. (cdc.gov)
  • The potential association between heavy metal levels and childhood asthma was also investigated. (who.int)
  • Nevertheless, special attention should be paid to reducing high levels of heavy metals in classroom dust in this area. (who.int)
  • A heavy metal blood test is a group of tests that measures the levels of possibly harmful metals in your blood. (medlineplus.gov)
  • Higher than normal levels of a heavy metal in your blood may mean that you have heavy metal poisoning, but not always. (medlineplus.gov)
  • Earlier studies used materials with high levels of other forms of carbon such as carbon black and high levels of metal catalyst. (cdc.gov)
  • Cobalt with tungsten carbide by Bruce A. Fowler PhD and Damien M. McElvenny MSc. (who.int)
  • Cobalt metal with tungsten carbide is probably carcinogenic in humans (Group 2A). (who.int)
  • Cobalt metal without tungsten carbide is possibly carcinogenic to humans (Group 2B). (who.int)
  • Persons intentionally taking colloidal metals for their purported health benefits may ultimately develop toxicity. (medscape.com)
  • But antimicrobial silver has been used successfully for over 2,000 years, and modern-day products like electrically generated colloidal silver have been used successfully against infections and related diseases for over 110 years. (blogspot.com)
  • The modern versions of colloidal silver (oligodynamic silver) are shown to have little or no toxicity. (blogspot.com)
  • It is essential to get medical attention immediately if you think you have metal poisoning. (johnfoy.com)
  • Essential metal ion toxicity can be attributed to accumulation of excessive concentrations of the metal ion, often in specific tissues or organs. (rsc.org)
  • Yet, other metals are essential to human biochemical processes. (medscape.com)
  • Cobalt (Co) is considered essential because it is part of the B12 vitamin, which is important for the human brain and nervous center functioning and cell metabolism (ATSDR 2000, Burtis et. (cdc.gov)
  • Many of these metals are essential as parts of enzymes, vitamins or cofactors. (pharmamanufacturing.com)
  • Blue-colored masks also contained cobalt , a heavy metal commonly used to produce blue dyes. (naturalnews.com)
  • Sediments serve as the ultimate sink of heavy metals in the marine environment and they play an important role in the transport and storage of potentially hazardous metals. (intechopen.com)
  • For additional Heavy Metal tests, please see our Heavy Metals Category . (requestatest.com)
  • Some debate exists as to exactly what constitutes a "heavy metal" and which elements should properly be classified as such. (medscape.com)
  • Most recently, the term heavy metal has been used as a general term for those metals and semimetals with potential human or environmental toxicity. (medscape.com)
  • Regardless of how one chooses to define the category, heavy metal toxicity is an uncommon diagnosis. (medscape.com)
  • Many of the elements that can be considered heavy metals have no known benefit for human physiology. (medscape.com)
  • The toxicity of heavy metals depends on a number of factors. (medscape.com)
  • However, smaller molecular-weight fulvic acid (FA) could promote the migration of heavy metals from the underground part to the upper part of the plant. (ere.ac.cn)
  • Foliar spraying can inhibit the transport of heavy metals into plants and protect the photosynthetic system from heavy metals. (ere.ac.cn)
  • Adding low concentration of HS in soil can promote the transport of heavy metals, but high concentration will have a negative effect on plants. (ere.ac.cn)
  • 4) According to the ecotoxicological effects of the interaction of HS and heavy metals, the leaching effects of soil column and the growth development of plants, the secondary environmental risk caused by HS could be evaluated. (ere.ac.cn)
  • Therefore, HS can be used as an environmental friendly phytoremediation enhancer to expand the application of phytoremediation in heavy metal contaminated soils. (ere.ac.cn)
  • FAN Ting,YE Wen-ling,CHEN Hai-yan,et al.Review on Contamination and Remediation Technology of Heavy Metal in Agricultural Soil[J].Ecology and Environmental Sciences,2013,22(10):1727-1736. (ere.ac.cn)
  • This article will examine current research about diet and ADHD, review important potential mechanisms (including the role of the immune system, gut microbiome, and toxic heavy metals), and comment on promising new avenues for the treatment of ADHD. (psychiatrictimes.com)
  • They are completely unsuitable for use on functional surfaces as they are highly likely to leach heavy metals. (digitalfire.com)
  • Linus Pauling, winner of two Nobel Prizes, believed that 90% of all medical conditions are attributable to excessive heavy metals, toxins, toxic chemicals, and minerals and trace mineral deficiency. (nutrimedical.com)
  • For example, you can take a blood test for heavy metals. (personalabs.com)
  • The purpose of this study was to determine heavy metals concentrations in atmospheric PM10 in ambient air of Ahvaz, Iran. (magiran.com)
  • Further, the air sampling filters were analyzed by the acid digestion method and atomic emission spectroscopy to determine the concentration of 8 heavy metals in the particulates-namely Cu, As, Ni, Pb, Cd, Fe, Zn, and Cr. (magiran.com)
  • The con- centration of 10 heavy metals was measured in these dust samples by optical emission spectrometry. (who.int)
  • The concentration of heavy metals in classroom dust samples ranged from 7559 to 53 723.0 mg/kg (mean: 16 945.5 mg/kg) for Fe, 169.0 to 952.0 mg/kg (mean 288.9 mg/kg) for Mn, and 9.0 to 971.0 mg/kg (mean 258.8 mg/kg) for Pb. (who.int)
  • We found no correlation between heavy metals in classroom dust and childhood asthma. (who.int)
  • What is a Heavy Metal Blood Test? (medlineplus.gov)
  • Heavy metals are found naturally in the environment. (medlineplus.gov)
  • And chemicals used in industry and farming may contain heavy metals, which can end up in the air, soil, and water. (medlineplus.gov)
  • Heavy metals get into your body in different ways. (medlineplus.gov)
  • Because heavy metals are just about everywhere, it's normal to have some in your body. (medlineplus.gov)
  • But if too much heavy metal gets into your body, it can cause heavy metal poisoning . (medlineplus.gov)
  • Heavy metal poisoning can lead to organ damage, behavioral changes, or difficulties with thinking and memory. (medlineplus.gov)
  • The symptoms of heavy metal poisoning depend on the type of metal, how much is in your body, and your age. (medlineplus.gov)
  • Children and unborn babies have the highest risk for serious, long-term health problems from heavy metals. (medlineplus.gov)
  • Poisoning from heavy metals can happen slowly over time or suddenly if you are exposed to a large amount of heavy metal all at once. (medlineplus.gov)
  • You may have a heavy metal blood test for one type of metal, or you may have a test for a group of metals, called a "heavy metal panel. (medlineplus.gov)
  • Heavy metal testing is used to find out if you have been exposed to certain metals, and how much of the metal is in your system. (medlineplus.gov)
  • Why do I need a heavy metal blood test? (medlineplus.gov)
  • If your job involves heavy metals, your employer may require regular testing to help monitor workplace safety. (medlineplus.gov)
  • Depending on the heavy metal and your condition, you may also need treatment to help your body get rid of the heavy metal as quickly as possible. (medlineplus.gov)
  • Pasten M, Magis Escurra C, Pérez Bejarano D. Relevant aspects on biomonitoring of heavy metal concentration in environmental air in Asunción city. (bvsalud.org)
  • Bryophytes (mosses) have long been used to determine the concentration of heavy metals as an alternative to the collection of atmospheric aerosols. (bvsalud.org)
  • Relevant Aspects on Biomonitoring of Heavy Metal. (bvsalud.org)
  • "Approaches to Nanotechnology: An Information Exchange with NIOSH" reviews what is currently known about nanoparticle toxicity and control. (cdc.gov)
  • Elevated concentrations of metals are caused either by anthropogenic deposition following remobilisation from the earth crust or are of natural origin. (sun.ac.za)
  • Bronze-like surfaces can also be made by the addition of rutile (it contains high concentrations of metals and crystallizes to produce metallic appearances). (digitalfire.com)
  • They found that metals were actually escaping from the implants and settling into the nearby bone tissue. (prime.sg)
  • On individual level, growth, metal body burden and tissue distribution were investigated. (sun.ac.za)
  • In some cases, Stryker metal prosthetics have been known to corrode, which can contribute to swelling and tissue damage. (injurylawyer-news.com)
  • As these materials rub against each other, they have been shown to release metal shavings into surrounding joint tissue and eventually into the bloodstream. (ahwfirm.com)
  • As of May 16, 2016, the effective date of the final order requiring premarket approval applications for these devices, there are no FDA-approved metal-on-metal total hip replacement devices marketed for use in the US. (nashfranciskato.com)
  • However, there are some patients who received a metal-on-metal total hip replacement prior to May 16, 2016. (nashfranciskato.com)
  • Recipients of the Stryker Rejuvenate hip device should immediately contact their doctor to test their blood for the presence of toxic metals. (injurylawyer-news.com)
  • The presence of toxic metals in the environment has detrimental effects on human and animal health and disrupts the balance and order of the ecosystem. (magiran.com)
  • This method describes the collection and subsequent analysis of airborne metal and metalloid particulate by Inductively Coupled Argon Plasma-Atomic Emission Spectroscopy (ICAP-AES). (speciation.net)
  • oxide particle (Company3O4) toxicity on BEAS-2M human being lung cells, and utilized high-sensitivity analytical methods that allowed for the 1st period the splendour between intracellular solubilized cobalt and non solubilized cobalt in its particulate type. (insulin-receptor.info)
  • The properties of metals in soils and sediments depend on the physiochemical form in which they occur [ 1 ]. (intechopen.com)
  • Metals are natural elements of the earth crust usually present at low concentrations in all soils. (sun.ac.za)
  • Ultramafic soils do not only pose unfavourable living conditions such as drought and poor organic content, these soils are also characterized by extremely high concentrations of a range of metals known to be toxic under normal circumstances. (sun.ac.za)
  • In relation to non-ultramafic or anthropogenic contaminated soils, a far lower proportion of metals were extractable by the above mentioned extraction methods. (sun.ac.za)
  • Aporrectodea caliginosa and Eisenia fetida were long-term exposed to the ultramafic soils collected at the Barberton region and a control soil from a location at Stellenbosch with a known history of no anthropogenic metal contamination. (sun.ac.za)
  • Some papers report negative results for bacterial mutation tests with cobalt salts. (europa.eu)
  • The composition or structure of the particle surface can greatly affect toxicity. (cdc.gov)
  • The main queries that stay to end up being responded to are (i) what quantity of cobalt is certainly solubilized in individual lung cells, and (ii) is certainly this quantity accountable for particle toxicity? (insulin-receptor.info)
  • The jurors found that the metal-on-metal Pinnacle hip implants were defectively designed and that the companies failed to warn consumers about the risks. (the-rheumatologist.org)
  • NEW YORK (Reuters)-A U.S. judge has slashed a $500 million verdict against Johnson and Johnson and its DePuy unit over allegedly defective metal-on-metal Pinnacle hip implants to approximately $151 million. (the-rheumatologist.org)
  • NEW YORK (Reuters)-Johnson & Johnson and its DePuy unit were ordered by a Texas federal jury on Thursday to pay a total of about $500 million to five plaintiffs who said they were injured by Pinnacle metal-on-metal hip implants. (the-rheumatologist.org)
  • Metal has been used extensively in the manufacturing of orthopedic implants in a multitude of different forms. (medscape.com)
  • These joint implants, meant to bring back pain-free movement for folks with joint issues, are often made from a mix of metals. (prime.sg)
  • They used super-powerful X-rays to examine these samples, revealing a surprising concentration of metals like cobalt, chromium, and titanium from the implants. (prime.sg)
  • Cobalt and titanium's presence in bones, often due to implants, can lead to various effects. (prime.sg)
  • Metal-on-Metal total hip arthroplasty (MoM THA) implants consist of many metal parts that rub together over the course of normal use. (mctlaw.com)
  • Title: Modular to Monoblock: Difficulties of Detaching the M2a-Magnum Head Are Common in Metal-on-metal Revisions Abstract Metal-on-Metal total hip arthroplasty (MoM THA) implants are made up of a variety of components. (mctlaw.com)
  • The metal shavings from the metal-on-metal hip implants can fill the joint area and irritate the surrounding tissues. (nashfranciskato.com)
  • Metal-on-metal hip implants have also been known to fail at three times the rate of ceramic or plastic alternatives. (injurylawyer-news.com)
  • It is uncertain whether or not the effects seen in animals will also be seen in humans, and this uncertainty adds additional concerns with a problem seen with failed metal-on-metal (MoM) hip implants. (cdc.gov)
  • We present a comparative analysis between biocompatibility test results of wrought and Metal Injection Molded (MIM) ASTM F562-02 UNS R30035 (MP35N) and F1537 UNS R31538 (CCM) alloy samples that have undergone the same generic orthopedic implant's mechanical, chemical surface pre-treatment, and a designed pre-testing sample preparation method. (iospress.com)
  • It occurs because the two metal pieces in a hip replacement rub against each other and wear down over time. (johnfoy.com)
  • The toxicity and carcinogenesis of indium phosphide. (who.int)
  • The analytical methods presented in Environmental Sampling and Analysis for Metals will be useful to anyone who produces, uses, or evaluates analytical data, and will be a valuable tool in environmental education and training programs. (routledge.com)
  • These metals did not just stay where they were supposed to after surgery. (prime.sg)
  • These trace minerals include the important platinum group metals in association with the macro minerals such as magnesium and potassium. (nutrimedical.com)
  • Abnormal accumulation of brain metals is a key feature of Alzheimer's disease and a recent study showed that magnetite was directly associated with the damage seen in Alzheimer's brains," the Guardian notes. (truthdig.com)
  • Early developments in the aquatic chemistry of metals, the physiology of aquatic organisms and aquatic toxicology are reviewed first, and the degree to which each of these disciplines influenced the development of water quality regulations is discussed. (researchgate.net)
  • Acute beryllium disease in metal workers. (cdc.gov)
  • Herein, the interaction of cobalt(II) and nickel(II) with a 8-hydroxyquinoline-cyclodextrin conjugate was investigated in aqueous solution at neutral pH. (unict.it)