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FibrinolysisBlood CoagulationDisseminated Intravascular CoagulationCarboxypeptidase UBlood Coagulation TestsBlood Coagulation DisordersBlood Coagulation FactorsFibrinalpha-2-AntiplasminTissue Plasminogen ActivatorFibrin Fibrinogen Degradation ProductsPlasminogen Activator Inhibitor 1HemostasisPlasminogenFibrinolysinAntifibrinolytic AgentsFibrinogenThromboplastinThrombomodulinThrombelastographyProthrombin TimeAntithrombin IIIThrombinPartial Thromboplastin TimeFactor XIIIFibrinolytic AgentsProtein CFactor VIIProthrombinThrombosisPlasminogen ActivatorsWhole Blood Coagulation TimeCarboxypeptidase BFactor XaUrokinase-Type Plasminogen ActivatorFactor XIIFactor XSerum GlobulinsPlasminogen InactivatorsArgon Plasma CoagulationAntithrombinsFactor VIIaThrombolytic TherapyFactor VIIIThrombin TimeHeparinAnticoagulantsFactor VFactor IXCoagulation Protein DisordersHemorrhagic DisordersTranexamic AcidBlood PlateletsCarboxypeptidasesAminocaproic AcidLaser CoagulationFactor XIIaStreptokinaseBlood Coagulation Disorders, InheritedElectrocoagulationAfibrinogenemiaGravity SuitsBlood Coagulation Factor InhibitorsHemorrhageHemophilia AAminocaproatesThrombophiliaFactor XII DeficiencyTime FactorsFibrinopeptide APlatelet ActivationPeptide HydrolasesEnoxaparinRecombinant ProteinsPlatelet CountPrekallikreinvon Willebrand FactorCoagulantsMyocardial InfarctionFactor XI DeficiencyProtein SPlatelet AggregationBleeding TimeHypoprothrombinemiasSerine Proteinase InhibitorsThrombophlebitisThromboembolismBiological MarkersFactor XIIIaFactor XIaPlasmaKaolinAprotininbeta-ThromboglobulinShock, TraumaticTreatment OutcomeFactor VII DeficiencyAnnexin A2Endothelium, VascularSerpin E2
FibrinogenThrombosisBloodHypercoagulabilityIntravascular coagulationPlatelet functionFactorsTissue factorHemostaticFibrinolyticDisordersPlateletsPathwaysCascadeHemodilutionProteinsAssaysSepsisSolubleParametersAssessThrombinPatientsDeficienciesEnzymeProteinMeasurement2000AnticoagulationThromboelastographyFunctionEffectBalanceTests
Fibrinogen1
Thrombosis4
  • Blood Coagulation & Fibrinolysis is an international fully refereed journal that features review and original research articles on all clinical, laboratory and experimental aspects of haemostasis and thrombosis. (wkadcenter.com)
  • The journal is devoted to publishing significant developments worldwide in the field of blood coagulation, fibrinolysis, thrombosis, platelets and the kininogen-kinin system, as well as dealing with those aspects of blood rheology relevant to haemostasis and the effects of drugs on haemostatic components. (wkadcenter.com)
  • The subcommittee on DIC of the International Society on Thrombosis and Haemostasis has suggested the following definition for DIC: "An acquired syndrome characterized by the intravascular activation of coagulation with loss of localization arising from different causes. (medscape.com)
  • Levothyroxine administration is associated with altered fibrinolysis and coagulation, indicating it may increase the risk of venous thrombosis. (greenmedinfo.com)
Blood24
  • Disseminated intravascular coagulation (DIC) is characterized by systemic activation of blood coagulation, which results in generation and deposition of fibrin, leading to microvascular thrombi in various organs and contributing to multiple organ dysfunction syndrome (MODS). (medscape.com)
  • Acute DIC develops when sudden exposure of blood to procoagulants (eg, tissue factor [TF], or tissue thromboplastin) generates intravascular coagulation. (medscape.com)
  • Abnormalities of blood coagulation parameters are readily identified, and organ failure frequently results. (medscape.com)
  • Coagulation tests can be broadly divided into clot-based and chromogenic assays.1 In both techniques, whole-blood samples are centrifuged to obtain platelet-poor plasma. (openanesthesia.org)
  • Mishchenko V.P., Gol'denberg Iu.M., Novosel'tseva T.V. (1980) Effect of the antioxidant ionol on blood coagulation and fibrinolysis. (msk.ru)
  • Natural oestrogen in the female climacteric--influence on blood coagulation and fibrinolysis. (herbal-organic.com)
  • The aim of the present study was to investigate the effect on blood coagulation and fibrinolysis of a natural oestrogen preparation, piperazine oestrone sulphate, prospectively in menopausal women. (herbal-organic.com)
  • Coagulation changes during packed red cell replacement of major blood loss. (cams.cn)
  • Evaluation of selected parameters of blood coagulation and fibrinolysis system in patients undergoing total hip replacement surgery with normovolemic hemodilution procedure and standard enoxaparine prophylaxis. (cams.cn)
  • This gene encodes coagulation factor XII which circulates in blood as a zymogen. (nih.gov)
  • The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. (nih.gov)
  • Hemodilution was produced by mixing the blood with 40% Tris/saline solution, fibrinolysis by treating the blood with 160 ng/mL tPA, acidosis by adding 1.2 mg/mL lactic acid achieving pH 7.0 to 7.1, and hypothermia by running the assay at 31°C. Intact blood tested at 37°C served as control. (tau.ac.il)
  • The propagation phase of blood clotting was reduced by hemodilution, further reduced by additive hypothermia, and maximally reduced if additionally combined with fibrinolysis. (tau.ac.il)
  • This gene encodes coagulation factor XI of the blood coagulation cascade. (nih.gov)
  • This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. (nih.gov)
  • Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. (nih.gov)
  • Blood Coagul Fibrinolysis, 2021 Dec 1. (nih.gov)
  • The blood-coagulation cascade, inhibition of clotting. (muni.cz)
  • Effect of "classical" and "modified" adjuvant CMF-chemotherapy on blood coagulation fibrinolysis in patients with breast cancer. (bvsalud.org)
  • The coagulation of blood is maintained by cellular components and soluble plasma proteins. (medscape.com)
  • Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. (bvsalud.org)
  • Overview of Vascular Bleeding Disorders Bleeding may result from abnormalities in Platelets Coagulation factors Blood vessels Vascular bleeding disorders result from defects in blood vessels, typically causing cutaneous or mucosal. (msdmanuals.com)
  • The platelet count and tests of platelet function, blood coagulation, and fibrinolysis are normal. (msdmanuals.com)
  • May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. (lu.se)
Hypercoagulability1
Intravascular coagulation1
Platelet function1
  • CONCLUSION: The study revealed a differential effect of TIC constituents - hemodilution, hypothermia, fibrinolysis, and acidosis - on clot formation and platelet function. (tau.ac.il)
Factors4
  • The activated partial thromboplastin time (aPTT) measures the time it takes plasma to clot when exposed to substance that activate the contact factors coagulation and it assesses the intrinsic and common pathways of coagulation. (openanesthesia.org)
  • Like many other coagulation factors, it is a serine protease. (wikipedia.org)
  • It activates coagulation factors VII and XI. (nih.gov)
  • The coagulation system leans on a delicate balance between coagulant and anticoagulant factors. (csuohio.edu)
Tissue factor1
Hemostatic1
  • The theoretical mechanism for the coagulation and hemostatic effects of rFVIIa are discussed. (medscape.com)
Fibrinolytic7
  • Derangement of the fibrinolytic system further contributes to intravascular clot formation, but in some cases, accelerated fibrinolysis may cause severe bleeding. (medscape.com)
  • Levels of various coagulation and fibrinolytic parameters were determined in pre- and post-exposure plasma samples from HAE patients included in a randomized clinical trial. (chaen-rcah.ca)
  • Coagulation and fibrinolytic systems are activated in HAE patients suffering from an acute angioedema attack. (chaen-rcah.ca)
  • Additional clinical trials are required to ascertain the need for early therapeutic anticoagulation or fibrinolytic therapy to address this state of fibrinolysis shutdown. (nih.gov)
  • The coagulable and fibrinolytic status of plasma was measured by Thrombin/Plasmin-Generation Assay (T/P-GA) and Clot-Fibrinolysis Waveform Analysis (CFWA). (isth.org)
  • In T/P-GA and CFWA, spiking PwHA plasma with emicizumab improved coagulation function but had no effect on fibrinolytic function. (isth.org)
  • Anti-coagulant agents exhibit inhibitory effects on the coagulation and fibrinolytic function in PwHA plasma spiked with emicizumab similar to those in normal reference plasma. (isth.org)
Disorders2
  • Ragni MV. Hemorrhagic disorders: coagulation factor deficiencies. (medlineplus.gov)
  • The drugs are used to control massive hemorrhage and in other coagulation disorders. (bvsalud.org)
Platelets1
  • [ 1 ] Consumption and subsequent exhaustion of coagulation proteins and platelets (from ongoing activation of coagulation) may induce severe bleeding, though microclot formation may occur in the absence of severe clotting factor depletion and bleeding. (medscape.com)
Pathways1
  • It assesses the extrinsic and common coagulation pathways (Figure 1). (openanesthesia.org)
Cascade2
  • Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. (wikipedia.org)
  • Recently several reports have cleotide (designated as 0/10 bp) in the pro- focused on the association between the moter region of the gene at position -323 factor VII of the cascade coagulation and [ 13,14 ]. (who.int)
Hemodilution2
  • Effects of Acute Normovolemic Hemodilution on Perioperative Coagulation and Fibrinolysis in Elderly Patients Undergoing Hepatic Carcinectomy[J].Chinese Medical Sciences Journal, 2010, 25(3): 146-150. (cams.cn)
  • No effect of fibrinolysis on clot propagation was observed at 37°C. Maximum clot firmness was reduced by hemodilution, further reduced by additive fibrinolysis, and maximally reduced if additionally combined with hypothermia. (tau.ac.il)
Proteins1
  • My laboratory has a great deal of expertise in the biochemistry of coagulation and especially in the biochemistry of proteins composing prothrombinase. (csuohio.edu)
Assays1
  • Conventional coagulation assays, d-dimer levels, and viscoelastic measurements were analyzed using a receiver operating characteristic curve to predict thromboembolic outcomes and new-onset renal failure. (nih.gov)
Sepsis1
  • The notable difference was a profound hyperfibrinogenemia, associated with a thrombogenic clot structure and a marked ex vivo resistance to fibrinolysis in patients with sepsis. (nih.gov)
Soluble1
  • Then coagulation function, soluble fibrin monomer complex (SFMC), prothrombin fragment (F1+2), and platelet membrane glycoprotein (activated GPIIb/GPIIIa and P-selectin) were measured. (cams.cn)
Parameters1
  • Ou-Yang SJ, Cui M. Detection of coagulation parameters in elderly. (cams.cn)
Assess2
  • Schematic representation of coagulation pathway and coagulation tests that assess each pathway. (openanesthesia.org)
  • Assess for evolving fibrinolysis in the immediate post-partum period. (drugs.com)
Thrombin4
  • Prior to rhC1INH treatment, the majority of patients had low to normal activated partial thromboplastin times (aPTT) and increased levels of prothrombin fragment 1+2, thrombin-antithrombin complexes, D-dimers and plasmin-antiplasmin complexes, all of which indicate activation of both coagulation and fibrinolysis. (chaen-rcah.ca)
  • In vivo markers of activation of coagulation (thrombin-antithrombin III, D-dimer) were similarly elevated in both groups compared to controls, but ex vivo thrombin-generating capacity was similar between patients and controls, despite a much more profound international normalized ratio elevation in ACLF. (nih.gov)
  • Ongoing activation of the coagulation system as well as thrombin-mediated platelet activation may both play a crucial role in this context. (herts.ac.uk)
  • The decrease in fibrinolysis might be due to an increase in thrombin-activatable fibrinolysis inhibitor and an increase in factor XIIIa. (medscape.com)
Patients3
  • Our aim is to evaluate the effects of rhC1INH on coagulation and fibrinolysis in symptomatic HAE patients. (chaen-rcah.ca)
  • Fibrinolysis shutdown, as evidenced by elevated d-dimer and complete failure of clot lysis at 30 minutes on thromboelastography predicts thromboembolic events and need for hemodialysis in critically ill patients with COVID-19. (nih.gov)
  • This position paper gives an overview of the current knowledge and possible role of biomarkers of coagulation and fibrinolysis for the diagnosis of AMI, risk stratification, and individualized treatment strategies in patients with AMI. (herts.ac.uk)
Deficiencies1
Enzyme1
  • This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. (nih.gov)
Protein2
  • The unknown functions of a known protein: the case of coagulation factor XI. (nih.gov)
  • RIXUBIS [Coagulation Factor IX (Recombinant)] is a purified protein produced by recombinant DNA technology. (globalrph.com)
Measurement1
  • Whether measurement of circulating biomarkers of coagulation and fibrinolysis could be useful for risk stratification in secondary prevention is currently not fully understood. (herts.ac.uk)
20002
  • Each vial contains nominally 250, 500, 1000, 2000 or 3000 international units of recombinant coagulation factor IX. (globalrph.com)
  • Afin de comparer les résultats obtenus à partir de plasma centrifugé pendant 5 minutes à 3000 g ou pendant 10 minutes à 2000 g, 46 échantillons de sang prélevés sur des adultes en bonne santé ont été analysés pour évaluer le temps de prothrombine, le rapport international normalisé et le temps de thromboplastine partielle activée. (who.int)
Anticoagulation1
  • The aPTT is commonly used to monitor heparin therapy, to target therapeutic anticoagulation, and as a part of a "coagulation panel" to evaluate a bleeding patient. (openanesthesia.org)
Thromboelastography1
  • we hypothesized that deranged thromboelastography measurements of coagulation would correlate with thromboembolic events. (nih.gov)
Function1
  • These results showed a tendency similar to the inhibitory effect of anti-coagulant agents on coagulation and fibrinolysis function in normal reference plasma. (isth.org)
Effect2
  • Onishi T, Harada S, Shimo H, Tashiro Y, Soeda T, Nogami K. The effect of anti-coagulant agents against in vitro hemophilia A plasma coagulation and fibrinolysis potential in the presence of emicizumab [abstract]. (isth.org)
  • No effect of hypothermia on clot strength was observed in the absence of fibrinolysis. (tau.ac.il)
Balance1
  • In this study, we investigated how anti-coagulant agents affect the balance of coagulation and fibrinolysis in PwHA plasma spiked with emicizumab. (isth.org)
Tests1