Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. (frontiersin.org)
However, the existence of specific transcriptional repressors responsible for the silencing of lineage inappropriate genes remains elusive. (eur.nl)
Thus, in B cells HDAC7 is a transcriptional repressor of undesirable genes. (eur.nl)
In lower multicellular fungi, the C2H2 zinc finger CreA/CRE1 protein has been shown to act as the transcriptional repressor in this process. (biomedcentral.com)
Transcriptional dysregulation is a hallmark of Huntington's disease (HD) and one cause of this dysregulation is enhanced activity of the REST-mSIN3a-mSIN3b-CoREST-HDAC repressor complex, which silences transcription through REST binding to the RE1/NRSE silencer. (ox.ac.uk)
A cell type-specific expression map of NCoR1 and SMRT transcriptional co-repressors in the mouse brain. (escholarship.org)
Nuclear receptor corepressor 1 (NCoR1) and silencing mediator for retinoid or thyroid-hormone receptors (SMRT) are the best characterized transcriptional co-repressors from a molecular point of view. (escholarship.org)
The Drosophila extra sex combs (esc) protein, a member of the Polycomb group (PcG), is a transcriptional repressor of homeotic genes. (umn.edu)
We confirm that Aiolos and Ikaros are transcriptional repressors of interleukin-2 expression. (ox.ac.uk)
DI-fusion Holdings: Dnmt3L is a transcriptional repressor that recruits. (ac.be)
The Engrailed homeodomain protein is an 'active' or dominant transcriptional repressor in cultured cells. (biologists.com)
Furthermore, miR-221/222-mediated reduction in E-cadherin abundance depended on their targeting the 3' untranslated region of the GATA family transcriptional repressor TRPS1 (tricho-rhino-phalangeal syndrome type 1), which inhibited EMT by decreasing ZEB2 (zinc finger E-box-binding homeobox2) expression. (nih.gov)
Protein14
In molecular genetics, a repressor is a DNA- or RNA-binding protein that inhibits the expression of one or more genes by binding to the operator or associated silencers. (wikipedia.org)
An RNA-binding repressor binds to the mRNA and prevents translation of the mRNA into protein. (wikipedia.org)
If an inducer, a molecule that initiates the gene expression, is present, then it can interact with the repressor protein and detach it from the operator. (wikipedia.org)
One type of aporepressor is the trp repressor, an important metabolic protein in bacteria. (wikipedia.org)
The lacI gene codes for a protein called "the repressor" or "the lac repressor", which functions to repressor of the lac operon. (wikipedia.org)
The lacI gene synthesizes LacI repressor protein. (wikipedia.org)
The LacI repressor protein represses lacZYA by binding to the operator sequence lacO. (wikipedia.org)
An example of a repressor protein is the methionine repressor MetJ. (wikipedia.org)
What percentage of time this DNA sequence spends in a kinked state, in the absence of bound lac repressor protein, is not known, but it may be a significant percentage (see next section below). (proteopedia.org)
In Arabidopsis (Arabidopsis thaliana), the miP1a/b microProteins delay floral transition by forming a complex with CONSTANS (CO) and the co-repressor protein TOPLESS. (bibbase.org)
The lambda repressor is a dimer also known as the cI protein . (wikidoc.org)
The c-Jun dimerization protein 2, JDP2 is an AP-1 repressor protein that potently inhibits AP-1 transcription. (biomedcentral.com)
Cd did not affect the protein levels of Keap1, which is a repressor of the cytoplasmic Nrf2, or Cul-3, an E3 ligase involved in the proteasomal degradation of Nrf2. (cdc.gov)
To understand the role of the epigenetic co-repressor protein TRIM28 in the control of transposable elements (TEs) and how TEs control gene regulation in the developing and adult brain. (lu.se)
A DNA-binding repressor blocks the attachment of RNA polymerase to the promoter, thus preventing transcription of the genes into messenger RNA. (wikipedia.org)
The operon consists of a regulatory repressor gene (araC), three control sites (ara02, ara01, araI1, and araI2), two promoters (Parac/ParaBAD) and three structural genes (araBAD). (wikipedia.org)
Each repressor targets a specific co-regulated group of genes by recognizing a specific sequence of DNA, called the operator in bacteria . (proteopedia.org)
The lac repressor, and the group of genes it controls, which is called an operon , were the first such gene regulatory system to be discovered. (proteopedia.org)
The mammalian Hes basic helix-loop-helix repressor genes play central roles in these processes by maintaining progenitor cells in an undifferentiated state and by regulating binary cell fate decisions. (biologists.com)
In many organs, cell proliferation and differentiation are antagonistically regulated by multiple basic helix-loop-helix (bHLH) activator and repressor genes. (biologists.com)
In particular,the Hes bHLH repressor genes play an essential role in the development of many organs by maintaining progenitor cells and by regulating binary cell fate decisions. (biologists.com)
In Rosetta(DE3)pLacI, the rare tRNA genes are present on the same plasmid that carries the lac repressor gene. (sigmaaldrich.com)
Molecule2
A co-repressor is a molecule that can bind to the repressor and make it bind to the operator tightly, which decreases transcription. (wikipedia.org)
For a general introduction to the lac repressor, please see David Goodsell's Introduction to the lac repressor in his series Molecule of the Month , and the article in Wikipedia on the lac repressor . (proteopedia.org)
Moreover, targets of the polycomb repressor complex in breast cancer and embryonic stem cells were more methylated in luminal B tumours than in other tumours. (lu.se)
Binds3
A repressor that binds with a co-repressor is termed an aporepressor or inactive repressor. (wikipedia.org)
When the lac repressor binds lactose, it changes to an inactive conformation that cannot repress the production of these enzymes. (proteopedia.org)
GATA1
Is ROG, repressor of GATA, a specific regulator of Th2-type immune response? (elsevierpure.com)
Adepta Sororitas1
The Repressor is a heavily armored personnel carrier, used by the Adeptus Arbites and the Adepta Sororitas . (lexicanum.com)
Metabolism1
The lactose ("lac") repressor controls the expression of bacterial enzymes involved in the metabolism of of the sugar lactose. (proteopedia.org)
Inhibit1
The pLacI plasmid confers chloramphenicol resistance and provides enough lac repressor to inhibit transcription from the T7 lac promoter in the absence of inducer. (sigmaaldrich.com)
Sisters of Bat1
The Sisters of Battle first used the Repressor on the Cardinal World of Avignor during the Avignor Uprising , when agent-provocateurs of a heretical sect caused a crowd of a million pilgrims to riot. (lexicanum.com)
Conformation1
In the presence of the inducer allolactose, the repressor changes conformation, reduces its DNA binding strength and dissociates from the operator DNA sequence in the promoter region of the lac operong. (wikipedia.org)
Binding5
Repressors can also have two binding sites: one for the silencer region and one for the promoter. (wikipedia.org)
Binding of the repressor complex REST-mSIN3b by small molecules restores neuronal gene transcription in Huntington's disease models. (ox.ac.uk)
Overall, this study reveals that AHR and AHRR exhibit similar but also distinct genome-wide binding profiles, supporting the notion that AHRR is a context- and gene-specific repressor of AHR activity. (diagenode.com)
Three-dimensional structure of the DNA-binding domain of the fructose repressor from Escherichia coli by 1H and 15N NMR. (expasy.org)
The tox gene is regulated by a corynebacterial iron-binding repressor (DtxR). (medscape.com)
Gene expression3
Throughout development, or in response to environmental stimuli, gene expression patterns are tightly regulated by the dynamic interplay between transcription activators and repressors. (escholarship.org)
Interestingly, p30 II is an overall repressor of cellular gene expression, while selectively favoring the expression of regulatory gene pathways important to T lymphocytes. (biomedcentral.com)
The repressor found in the phage lambda is a notable example of the level of control possible over gene expression by a very simple system. (wikidoc.org)
Tumour1
The action of Ets2 as a repressor when it is overexpressed differs from tumour suppression, which requires normal gene function to prevent cellular transformation. (nature.com)
Cells2
Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN. (ox.ac.uk)
The transcription repressor Tramtrack (TTK) is found in cone cells but not photoreceptor cells of the Drosophila eye. (psu.edu)
Cuba1
In collaboration with the democratic activists in Cuba, the personal identification of the repressors is carried out and individual complaints or organizations that are supported with appropriate documentation are collected. (fhrcuba.org)
Differentiation1
These results argue that photoreceptor differentiation is regulated by the RAS pathway through targeted proteolysis of the TTK repressor. (psu.edu)
Complex4
Altogether, our results suggest that a repressor complex operates in the SAM, likely to maintain it in an undifferentiated state until leaf-derived florigen signals induce SAM conversion into a floral meristem. (bibbase.org)
article{rodrigues_microprotein_2021, title = {A {microProtein} repressor complex in the shoot meristem controls the transition to flowering}, volume = {187}, issn = {0032-0889}, url = {https://doi.org/10.1093/plphys/kiab235}, doi = {10.1093/plphys/kiab235}, abstract = {MicroProteins are potent post-translational regulators. (bibbase.org)
17-mer used in this work and for the crystal structure of the 2:1 trp repressor/operator complex by Lawson & Carey (1993). (lu.se)
1988) for the d-(ACT)Ád-(AGT) halfsites contacting the repressor in the 1:1 complex. (lu.se)
Bound1
The lac repressor is constitutively expressed and usually bound to the operator region of the promoter, which interferes with the ability of RNA polymerase (RNAP) to begin transcription of the lac operon. (wikipedia.org)
Operator2
When SAM concentration becomes low, the repressor dissociates from the operator site, allowing more methionine to be produced. (wikipedia.org)
Chemistry Department be a major determinant of trp repressor/operator recognition. (lu.se)
Suppression1
The Repressor was originally used as an armoured personnel carrier by the Adeptus Arbites as a means of crowd suppression. (lexicanum.com)
Found4
While repressors are more commonly found in prokaryotes, they are rare in eukaryotes. (wikipedia.org)
Furthermore, most known eukaryotic repressors are found in simple organisms (e,g. yeast), and act by interacting directly with activators. (wikipedia.org)
Gene repressor list is based on the information found in the litterature together with the data available from the EST library conditions. (inra.fr)
The list of the repressors is not fixed and can evolve depending of the expression data found. (inra.fr)
Expression1
Expression host strains for pETBlue and pTriEx vectors are lDE3 lysogens that also carry the compatible pLacI plasmid, encoding the lac repressor. (sigmaaldrich.com)
Mechanism1
who also correctly proposed the general mechanism of regulation by the lac repressor. (proteopedia.org)
Role1
Detailed analysis of the genetic interaction among CO, JMJ14, miP1a/b, and TPL revealed a potential role for CO as a repressor of flowering in the shoot apical meristem (SAM). (bibbase.org)
Structure1
This contrasts prokaryotic repressors which can also alter DNA or RNA structure. (wikipedia.org)
List1
Eventually it was decreed that the victory on Avignor had been the Emperor 's divine will, and that the Repressor should be included in the canon list of sanctioned vehicles. (lexicanum.com)
Sites1
In midfrontal and lateral frontal sites, repressors demonstrated relative left hemisphere activation when compared with other groups. (virginia.edu)
Extra1
Contains the pLacI plasmid producing extra Lac repressor. (sigmaaldrich.com)
Basis1
Subjects were classified as repressors or nonrepressors on the basis of scores on the Marlowe-Crowne Social Desirability Scale (MC), the State-Trait Anxiety Inventory (STAI), and the Beck Depression Inventory (BDI). (virginia.edu)
Activity1
You are notified - privately or publicly - of those repressors who have already been identified, who know their actions, their activity is unacceptable and they will have to face different consequences if they do not rectify in time. (fhrcuba.org)