• Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants, including alcohol, may result in profound sedation, respiratory depression, coma, and death. (drugs.com)
  • Increased risk for serious respiratory depression when concomitant CNS depressants, opioids. (empr.com)
  • 11 Its toxicity is similar to that of other opioids, with lethargy progressing to coma, respiratory depression leading to apnea, bradycardia, and hypotension. (uspharmacist.com)
  • The effects of acetyl fentanyl can be potentiated by other central nervous system (CNS) depressants, including other opioids. (uspharmacist.com)
  • Coadministration with other CNS depressants, especially opioids, should be avoided unless no other alternatives are available as coadministration significantly increases the risk for profound sedation, respiratory depression, coma, and death. (pdr.net)
  • As with other potent opioids, clinically significant respiratory depression may occur within the recommended dose range in patients receiving therapeutic doses of buprenorphine. (druglib.com)
  • All opioids share nausea to varying degrees as a possible side effect, however routine co-administration of antiemetics is not necessary. (saem.org)
  • Naloxone is a medication that reverses the effects of opioids, including heroin and fentanyl when the first symptoms of respiratory arrest or coma occur. (ottawa.edu)
  • Benzo dope poses significant health threats because of the combination of two central nervous system depressants, benzos and opioids. (whiteoakrecovery.com)
  • Benzodiazepines cause more intense CNS depressant effects when taken with opioids. (whiteoakrecovery.com)
  • CNS Depressant/Alcohol Interaction Additive pharmacodynamic effects may be expected when KADIAN is used in conjunction with alcohol, other opioids, or illicit drugs that cause central nervous system depression. (clustermed.info)
  • Effects on the Endocrine System Opioids inhibit the secretion of ACTH, cortisol, and luteinizing hormone (LH) in humans. (clustermed.info)
  • Effects on the Immune System Opioids have been shown to have a variety of effects on components of the immune system in in vitro and animal models. (clustermed.info)
  • Overall, the effects of opioids appear to be modestly immunosuppressive. (clustermed.info)
  • It is not always easy to discern overdose symptoms from mere drug use, because some of the drug's innate effects-for example, pupillary miosis or constriction with opioids-will be present in both situations. (scadky.org)
  • Effects of this can be additive (outcome is greater than those of one individual drug), less than additive (therapeutic effects are less than those of one individual drug), or functional alterations (one drug changes how another is absorbed, distributed, and metabolized). (wikipedia.org)
  • Comment: Coadministration of anticholinergic drugs and glucagon increase the risk of gastrointestinal adverse reactions due to additive effects on inhibition of gastrointestinal motility. (medscape.com)
  • 5 When mixed with other substances, such as heroin, it can have additive toxic effects. (uspharmacist.com)
  • Benzodiazepines also have an additive and possibly synergistic effect on CNS and respiratory depression. (uspharmacist.com)
  • Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression. (medscape.com)
  • If tizanidine is prescribed in conjunction with baclofen or benzodiazepines, the patient will experience possible additive effects, including sedation (6) . (serendipstudio.org)
  • DRUG INTERACTIONS CNS depressants, including alcohol: Possible adverse additive CNS-depressant effects (5.1, 7.1) Imipramine: Decreased alertness observed (7.1) Chlorpromazine: Impaired alertness and psychomotor performance observed (7.1) Rifampin: Combination use may decrease effect (7.2) Ketoconazole: Combination use may increase effect (7.2) USE IN SPECIFIC POPULATIONS Pregnancy: Based on animal data, zolpidem may cause fetal harm (8.1) Pediatric use: Safety and effectiveness not established. (drugs-library.com)
  • To avoid potential additive effects, avoid use of Barhemsys in patients taking droperidol. (eagleus.com)
  • When administered intravenously or subcutaneously, it rapidly reverses the respiratory depression and sedation caused by heroin intoxication. (medscape.com)
  • limit dosages and durations to the minimum required and follow patients for signs and symptoms of respiratory depression and sedation ( 5.4 ). (drugs.com)
  • Monitor closely for signs of respiratory depression and sedation. (medscape.com)
  • Monitor for hypotension, respiratory depression, and profound sedation. (medscape.com)
  • Measures including oxygen saturation, transcutaneous CO 2 , respiratory rate, QTc interval, subjective effects (sedation, drug liking, craving), plasma levels (baclofen, methadone), and adverse events will be obtained using validated questionnaires and examinations periodically for 5 h after dosing. (biomedcentral.com)
  • In man, morphine produces a variety of effects including analgesia, constipation from decreased gastrointestinal motility, suppression of the cough reflex, respiratory depression from reduced responsiveness of the respiratory centre to CO2, nausea and vomiting via stimulation of the CTZ, changes in mood including euphoria and dysphoria, sedation, mental clouding, and alterations of the endocrine and autonomic nervous systems. (rxmed.com)
  • Respiratory depression, hypotension and profound sedation or coma may result. (rxmed.com)
  • Dose-related effects of the drug include sedation and ataxia. (medscape.com)
  • At high dosages, oral medications can cause unwanted side effects that include sedation, as well as changes in mood and cognition (5) . (serendipstudio.org)
  • Side effects are predominantly from central depressant properties including sedation, ataxia, weakness and fatigue. (serendipstudio.org)
  • Effects on the Central Nervous System The principal actions of therapeutic value of morphine are analgesia and sedation. (clustermed.info)
  • Symptoms of chronic overdose include hypotension, cardiac arrhythmias, respiratory depression, and liver/kidney dysfunction. (pharmacycode.com)
  • Effects on the Cardiovascular System Morphine produces peripheral vasodilation which may result in orthostatic hypotension or syncope. (clustermed.info)
  • A range of respiratory, cardiovascular, and sedative measures including the National Early Warning Score (NEWS2) and Glasgow Coma Scale will determine DLT. (biomedcentral.com)
  • Abuse or misuse of illegal GHB alone or with other drugs that cause changes in consciousness has caused serious side effects including seizures, respiratory depression, drowsiness, coma, and death. (medpagetoday.com)
  • Other manifestations that occur with more significant toxicity include seizures, respiratory depression, and coma, which have been observed at serum levels of greater than 40 mg/L. One cardiac manifestation of overdose is sinus tachycardia. (medscape.com)
  • Fentanyl drug users may experience seizures, coma, respiratory depression, and low blood pressure leading to an increased risk of death. (whiteoakrecovery.com)
  • The concomitant use of Oxycodone Hydrochloride and Acetaminophen Tablets with all cytochrome P450 3A4 inhibitors may result in an increase in oxycodone plasma concentrations, which could increase or prolong adverse reactions and may cause potentially fatal respiratory depression. (nih.gov)
  • Avoid or minimize concomitant use of CNS depressants or other medications associated with addiction or abuse. (pdr.net)
  • Abuse and misuse of benzodiazepines commonly involve concomitant use of other medications, alcohol, and/or illicit substances, which is associated with an increased frequency of serious adverse outcomes, including respiratory depression, overdose, and death. (pdr.net)
  • CNS Depression: Morphine should be used only with caution and in reduced dosage during concomitant administration of other opioid analgesics, general anesthetics, phenothiazines and other tranquilizers, sedative-hypnotics, tricyclic antidepressants and other CNS depressants (including alcohol). (rxmed.com)
  • Concomitant other CNS depressants: initiate at ⅓-½ of usual starting dose and monitor. (renalandurologynews.com)
  • Risk increases with dose and use with other CNS depressants and alcohol. (nih.gov)
  • Potentiates CNS depression with alcohol, other CNS depressants. (empr.com)
  • When it is used with alcohol, synergistic effects occur. (uspharmacist.com)
  • Patients receiving Buprenex in the presence of other narcotic analgesics, general anesthetics, antihistamines, benzodiazepines, phenothiazines, other tranquilizers, sedative/hypnotics or other CNS depressants (including alcohol) may exhibit increased CNS depression. (druglib.com)
  • The effects of Buprenex, particularly drowsiness, may be potentiated by other centrally acting agents such as alcohol or benzodiazepines. (druglib.com)
  • What Are the Effects of Mixing Alcohol and Gabapentin? (alcoholism.org)
  • Gabapentin and Alcohol both act as depressants for the central nervous system (CNS). (alcoholism.org)
  • Some of the most common side effects of gabapentin that can become amplified with alcohol are unsteadiness, drowsiness, and low energy/fatigue. (alcoholism.org)
  • Severe side effects and reactions (respiratory depression) can also become a concern when mixing alcohol and gabapentin. (alcoholism.org)
  • Does Gabapentin Affect the Effect of Alcohol? (alcoholism.org)
  • Alcohol and gabapentin are both central nervous system depressants. (alcoholism.org)
  • Therefore, the intoxicating effects of alcohol become worse and the side effects of gabapentin become worse. (alcoholism.org)
  • When taking CNS depressants with alcohol there is also an increased risk of alcohol poisoning. (alcoholism.org)
  • While no one should take Alcohol with gabapentin due to the potential side effects, some people are more at risk for severe side effects. (alcoholism.org)
  • Because gabapentin and alcohol slow down the respiratory system, conditions like COPD can become deadly when alcohol and gabapentin are combined. (alcoholism.org)
  • Consumption of alcohol is not recommended during treatment with Gabantin 400 MG Capsule since it increases the risk of side effects like dizziness, difficulty in concentration, etc. (practo.com)
  • Warn patients of the dangers of using CNS depressants, including sedatives, alcohol, or illicit drugs. (ottawa.edu)
  • It is more risky when combined with other CNS depressants (e.g. benzodiazepines and alcohol. (neededmedicines.com)
  • More severe side effects such as seizures, hypertension, and tachycardia also have an increased chance of occurring. (alcoholism.org)
  • Baclofen must be slowly weaned to prevent withdrawal effects such as seizures, hallucinations and increased spasticity. (serendipstudio.org)
  • Respiratory Depression: Consider this risk before prescribing in patients with compromised respiratory function. (nih.gov)
  • Closely monitor patients with compromised respiratory function. (pdr.net)
  • Buprenex should be used with caution in patients with compromised respiratory function (e.g., chronic obstructive pulmonary disease, cor pulmonale, decreased respiratory reserve, hypoxia, hypercapnia, or preexisting respiratory depression). (druglib.com)
  • Phosphine gas produces no adverse effects on the skin or eyes, and contact does not result in systemic toxicity. (cdc.gov)
  • In this case, pharmaceuticals can produce adverse effects not only in humans, but also in organisms that are unintentionally exposed. (wikipedia.org)
  • Adverse effects at targets other than those desired for pharmaceutical treatments often occur with drugs that are nonspecific. (wikipedia.org)
  • In other cases, bioactivation is not necessarily needed for drugs to be active and can instead produce reactive intermediates that initiate stronger adverse effects than the original form of the drug. (wikipedia.org)
  • There are many different pharmaceutical drugs that can produce adverse effects after biotransformation, interaction with alternate targets, or through drug-drug interactions. (wikipedia.org)
  • Adverse effects of fentanyl may include nausea, itching, dizziness, or altered mental status, and may progress to more severe toxicity. (uspharmacist.com)
  • The reported adverse effects of phenibut are just the tip of an iceberg of an unregulated buy online designer drug market with no standards of quality assurance. (vumc.org)
  • Consider dose reduction of either or both agents to avoid serious adverse effects. (medscape.com)
  • Objective measures of muscle strength demonstrate no adverse effects from tizanidine. (serendipstudio.org)
  • Morphine produces both its therapeutic and its adverse effects by interaction with one or more classes of specific opioid receptors located throughout the body. (clustermed.info)
  • Dosages of morphine should be chosen and must be titrated on the basis of clinical evaluation of the patient and the balance between therapeutic and adverse effects. (clustermed.info)
  • There are no reports of adverse effects on the breastfed child and no information on the effects of amisulpride on milk production. (eagleus.com)
  • Serious, life-threatening, and/or fatal respiratory depression has occurred. (drugs.com)
  • Serious, life-threatening, or fatal respiratory depression may occur with use of Oxycodone Hydrochloride and Acetaminophen Tablets. (nih.gov)
  • Serious, life-threatening, or fatal respiratory depression may occur with use of MORPHABOND ER. (guidelinecentral.com)
  • For instance, combining ketamine and other CNS (central nervous system) depressants might cause fatal respiratory depression. (riverofchange.org)
  • Gabantin 400 MG Capsule causes side effects like fatigue, loss of coordination, dizziness, and drowsiness. (practo.com)
  • It is less likely that the other agents to cause drowsiness, confusion and other central effects because of its mechanism of action. (serendipstudio.org)
  • Rohypnol is known for its strong sedative properties, which can induce drowsiness, muscle relaxation, and a calming effect on the central nervous system. (welevelup.com)
  • Life-threatening respiratory depression and death have occurred in children who received codeine. (medscape.com)
  • Most phosphine exposures occur by inhalation of the gas or ingestion of metallic phosphides, but dermal exposure to phosphides can also cause systemic effects. (cdc.gov)
  • This document does not contain all possible side effects and others may occur. (rxlist.com)
  • If signs and symptoms of respiratory depression or apnea occur, consider discontinuation. (pdr.net)
  • Serious side effects are more likely to occur in individuals with a history of respiratory problems. (alcoholism.org)
  • Significant inhalation exposure does not occur at room temperature, but respiratory tract irritation is possible when the liquid is heated, agitated, or sprayed. (cdc.gov)
  • The peak effects of hydrocodone usually occur around 30 to 60 minutes after taking medicine. (xcode.life)
  • Ingestion of ethylene glycol leads to systemic toxicity beginning with CNS effects, followed by cardiopulmonary effects, and finally renal failure. (cdc.gov)
  • Background Naloxone, an opioid antagonist, is commonly used in acute care settings to reverse the effects of opioid toxicity. (bmj.com)
  • Discussion In our hospital the use of naloxone to reverse the effects of opioid toxicity is inconsistent, with wide variations in practice. (bmj.com)
  • It is indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression. (medscape.com)
  • The majority of heroin overdose symptoms stem from heroin's effects as a central nervous system (CNS) depressant. (thefreedomcenter.com)
  • This almost immediately enables respiratory functions to resume, which are typically the cause of most overdose symptoms. (thefreedomcenter.com)
  • Therefore, it can help with an opioid overdose reversal, but it doesn't treat the effects of benzodiazepines. (whiteoakrecovery.com)
  • It is nevertheless recognised that managing respiratory depression in patients on long-term opiates should be different to managing an acute opioid overdose in adults. (bmj.com)
  • An oxycodone overdose can be very dangerous and even deadly, with a notably problematic effect being respiratory depression. (neededmedicines.com)
  • Different drugs are associated with various overdose effects. (scadky.org)
  • What are ketamine's overdose effects? (riverofchange.org)
  • Numerous unsettling side effects of ketamine overdose might affect mental and physical health. (riverofchange.org)
  • further investigation of xylazine's effects on humans is necessary to characterize morbidity and overdose risk. (cdc.gov)
  • It is important for overdose prevention and response messages to highlight the potential presence of xylazine in IMF products and emphasize the need for respiratory and cardiovascular support to address the sedative effects of xylazine. (cdc.gov)
  • Similar to other opioid agents, repeated use can lead to tolerance, with escalating doses required for an effect. (uspharmacist.com)
  • There have been reports of respiratory and cardiovascular collapse in patients who received therapeutic doses of diazepam and Buprenex. (druglib.com)
  • Monitor for respiratory depression, especially during initiation of Oxycodone Hydrochloride and Acetaminophen Tablets or following a dose increase [see WARNINGS ]. (nih.gov)
  • The correct dose for every patient is a dose that is sufficient to control pain with no or tolerable side effects for 12 hours. (who.int)
  • Due to "first-pass" metabolism in the liver, the effect of an oral dose is less than after parenteral administration. (rxmed.com)
  • Monitor for respiratory depression, especially during initiation of MORPHABOND ER or following a dose increase. (guidelinecentral.com)
  • The effects of Rohypnols (flunitrazepam) can vary depending on the dose, individual tolerance, and mode of administration. (welevelup.com)
  • Phosphine is a respiratory tract irritant that attacks primarily the cardiovascular and respiratory systems causing peripheral vascular collapse, cardiac arrest and failure, and pulmonary edema. (cdc.gov)
  • These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system. (drugs.com)
  • Chronic opioid exposure is associated with impaired respiratory function, lethal disorders of sleep, cardiovascular disorders, and compromised immune function, particularly when comorbid with HIV [ 6 ]. (biomedcentral.com)
  • In addition to triggering abnormally large amounts of dopamine to be released into the body, heroin slows CNS activity which includes cardiovascular, respiratory, and gastrointestinal functions. (thefreedomcenter.com)
  • This new drug is apparently devoid of any cardiovascular or autonomic activity and shows a moderate CNS depressant effect. (curehunter.com)
  • This fume is a severe respiratory tract irritant due to the rapid formation of orthophosphoric acid, H 3 PO 4 , on contact with water. (cdc.gov)
  • If a drug can bind to unexpected proteins, receptors, or enzymes that can alter different pathways other than those desired for treatment, severe downstream effects can develop. (wikipedia.org)
  • Users may be at greater risk of severe effects if they believe they are using heroin but have actually purchased the more potent acetyl fentanyl or a mixture of the two. (uspharmacist.com)
  • Participants will be medically healthy with no severe chronic obstructive pulmonary disease or type 2 respiratory failure, no current dependence on other substances (excluding nicotine), no current severe DSM-5 psychiatric disorders, and no contraindications for baclofen or 4800 IU vitamin D (placebo). (biomedcentral.com)
  • Ingestion of ethylene glycol produces CNS depression which may be accompanied by nausea, vomiting, and abdominal cramps. (cdc.gov)
  • Buprenex has some pharmacologic effects similar to morphine which in susceptible patients may lead to self-administration of the drug when pain no longer exists. (druglib.com)
  • Dissolving or dividing of the tablets wil damage the prolonged-release system, leading to a rapid release of morphine which may cause substantial side effects. (who.int)
  • Morphine is an opioid analgesic which exerts an agonist effect at specific, saturable opioid receptors in the CNS and other tissues. (rxmed.com)
  • Specific CNS opiate receptors and endogenous compounds with morphine-like activity have been identified throughout the brain and spinal cord and are likely to play a role in the expression of analgesic effects. (clustermed.info)
  • Morphine produces respiratory depression by direct action on brainstem respiratory centers. (clustermed.info)
  • Morphine depresses the cough reflex by direct effect on the cough center in the medulla. (clustermed.info)
  • Morphine causes miosis, even in total darkness, and little tolerance develops to this effect. (clustermed.info)
  • Effects on the Gastrointestinal Tract and Other Smooth Muscle Gastric, biliary and pancreatic secretions are decreased by morphine. (clustermed.info)
  • Outside of those settings, it has long been used recreationally, with its effects compared to morphine and heroin. (neededmedicines.com)
  • CNS-Depressant Effects: Impairs alertness and motor coordination including risk of morning impairment. (nih.gov)
  • Abuse or misuse of illegal GHB alone or with other CNS depressants (drugs that cause changes in alertness or consciousness) have caused serious side effects. (tipranks.com)
  • Tablets not scored (3)CONTRAINDICATIONS Known hypersensitivity to zolpidem (4)WARNINGS AND PRECAUTIONS CNS depressant effects: Impaired alertness and motor coordination, including risk of morning impairment. (drugs-library.com)
  • Effect of coadministration of a dual CYP3A4 and CYP2C19 inhibitor with fedratinib has not been studied. (medscape.com)
  • Benzo dope contains two potent sedatives that cause respiratory depression, making it hard to breathe. (whiteoakrecovery.com)
  • 11 When these are taken with stimulants, rapid respiratory depression may ensue at the point that the stimulant properties resolve. (uspharmacist.com)
  • Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of lidocaine required to produce overt systemic effects. (drugs.com)
  • This type of adverse effect that results from pharmaceutical drug exposure is commonly due to interactions of the drug with its intended target. (wikipedia.org)
  • Codeine is readily absorbed from the gastrointestinal tract with the maximum analgesic effect occurring 60 minutes post administration. (globalrph.com)
  • Use triazolam with caution in individuals with significant pulmonary disease or respiratory insufficiency, such as chronic obstructive pulmonary disease (COPD) or sleep apnea because the drug can exacerbate respiratory depression. (pdr.net)
  • These practices and approaches will help you minimize the harmful effects of addiction while maintaining your dignity and free will. (whiteoakrecovery.com)
  • Particular caution is advised if Buprenex is administered to patients taking or recently receiving drugs with CNS/respiratory depressant effects. (druglib.com)
  • When taken together, Tramadol and Ibuprofen can offer synergistic effects that may provide more comprehensive pain relief. (iloveherbalism.com)
  • Both drugs can interact with other medications, potentially reducing their efficacy or increasing risks of side effects. (iloveherbalism.com)
  • This could change the effects and side effects of these medications. (medlineplus.gov)
  • Either increases effects of the other by pharmacodynamic synergism. (medscape.com)
  • dihydroergotamine increases effects of pseudoephedrine by pharmacodynamic synergism. (medscape.com)
  • ergotamine increases effects of pseudoephedrine by pharmacodynamic synergism. (medscape.com)
  • amitriptyline increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. (medscape.com)
  • The mechanism of respiratory depression involves a reduction in the responsiveness of the brainstem respiratory centers to increases in carbon dioxide tension, and to electrical stimulation. (clustermed.info)
  • Enflurane principle action in the CNS is general anaesthesia with little analgesic effect. (pharmacycode.com)
  • When combined with baclofen, tizanidine presents the opportunity to maximize side effects by reducing the dosage of both drugs. (serendipstudio.org)
  • This is a controversial treatment that raises concerns about condoning heroin use, discouraging medical care, and producing side effects that cannot be managed at home. (medscape.com)
  • What Are Side Effects of Vantrela ER? (rxlist.com)
  • Check with your physician for additional information about side effects. (rxlist.com)
  • Our Vantrela ER (hydrocodone bitartrate) Extended-Release Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • The field of pharmacotoxicology also involves the treatment and prevention of pharmaceutically induced side effects. (wikipedia.org)
  • Read on to learn more about buprenorphine uses, its side effects, and other important information about the drug. (healthline.com)
  • When CNS depressants are mixed, the side effects of both substances become amplified. (alcoholism.org)
  • Report a suspected side effect or falsified product to the MHRA Yellow Card scheme. (medicines.org.uk)
  • Symptomatic side effects respond well to antihistamines or antiemetics. (saem.org)
  • Other, more serious side effects are caused by a lack of oxygen (asphyxiation) and are usually much more apparent. (thefreedomcenter.com)
  • These side effects are temporary and usually resolve on their own. (practo.com)
  • Consult your doctor if these side effects are worrying you. (practo.com)
  • If this medicine is used, your doctor may advise you to closely monitor your baby for any undesired side effects. (practo.com)
  • 60mg fail to give commensurate relief of pain but merely prolong analgesia and are associated with an appreciably increased incidence of side effects. (globalrph.com)
  • Potential side effects include death due to respiratory depression. (ottawa.edu)
  • One of the side effects of carbamazepine, syndrome of inappropriate antidiuretic hormone secretion , results from the drug's central antidiuretic effects. (medscape.com)
  • Bupropion has low incidence of this side effect compared to other antidepresants? (tutioncentral.com)
  • Snorting hydrocodone may worsen the side effects due to the drug. (xcode.life)
  • Like any other opioid drug, hydrocodone may cause side effects. (xcode.life)
  • The patient is forced to decide if decreasing spasticity is worth the side effects from drugs or loss of some movement and feeling from surgery. (serendipstudio.org)
  • The challenge is to establish a treatment plan that will strike a vital balance between improved function, patient satisfaction, and possible side effects. (serendipstudio.org)
  • This article delves into the effects, hazards, and methods of abuse associated with Rohypnol, shedding light on the dark side of its misuse. (welevelup.com)
  • The following article will shed light on what ketamine is, its side effects, its relation to anxiety, depression, and chronic pain, and the importance of taking a psychiatrist's advice. (riverofchange.org)
  • Recognizing the potential side effects of using this substance is essential, as recent studies have shown a global rise in its overuse. (riverofchange.org)
  • Using it along with other supplements with similar effects might increase estrogen-like effects and side effects. (medlineplus.gov)
  • Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. (medscape.com)
  • The major effects of codeine are on the central nervous system and the bowel. (globalrph.com)
  • Avoid the use of codeine sulfate tablets in adolescents 12 to 18 years of age who have other risk factors that may increase their sensitivity to the respiratory depressant effects of codeine. (medscape.com)
  • The clinical effects of diazem include improved passive range of motion and reduction in hyperreflexia as well as painful spasms. (serendipstudio.org)
  • Examples of supplements with this effect include black cohosh, kudzu, peony, and red clover. (medlineplus.gov)
  • Due to its sedative effects, Rohypnol has gained infamy as a "date rape" or "roofie" drug. (welevelup.com)