• Our ongoing work on iron-sulfur cluster biogenesis has led to new insights into how mammalian iron-sulfur clusters are synthesized and transferred to appropriate recipient proteins. (nih.gov)
  • Several human diseases are now known to be caused by deficiencies in the iron-sulfur-cluster biogenesis machinery. (nih.gov)
  • Discovery of iron-sulfur cofactors will lead to breakthroughs in several research areas involving DNA repair, ribosomal biogenesis, mRNA translation, intermediary metabolism, and regulation of the growth and energy-sensing pathways that are critical for determining the fates of many cell types. (nih.gov)
  • The IRE-binding activity of IRP1 depends on the presence of an iron-sulfur cluster (see "Mammalian iron-sulfur cluster biogenesis" below). (nih.gov)
  • We study mammalian iron sulfur cluster biogenesis, which involves a complex interplay of biogenesis factors and factors that specify recipient proteins. (nih.gov)
  • The discovery of the iron-sulfur cluster in IRP1 led to extensive studies of mechanisms of iron-sulfur cluster biogenesis, which resulted in characterization of a mammalian cysteine desulfurase, NFS1, a primary scaffold known as ISCU, a secondary scaffold known as NFU1, an NFS1 binding partner, ISD11, and a cochaperone known as HSC20. (nih.gov)
  • Defective iron sulfur biogenesis causes several diseases, including Friedreich ataxia, and four new diseases that our group helped to discover and characterize, including ISCU myopathy, sideroblastic anemia from GLRX5 deficiency, and lactic acidosis caused by mutations in NFU1 and BOLA3. (nih.gov)
  • One such class of pathways is involved in the biogenesis of Iron-Sulfur Clusters (ISC). (biomedcentral.com)
  • As a test case, we reconstruct the topology of the reaction and regulatory network for the mitochondrial ISC biogenesis pathway in S. cerevisiae . (biomedcentral.com)
  • Predictions regarding how proteins act in ISC biogenesis are validated by comparison with published experimental results. (biomedcentral.com)
  • Using the Iron Sulfur cluster biogenesis in S. cerevisiae as a test case we indicate how this procedure can be used to analyze and validate the network model against experimental results. (biomedcentral.com)
  • Iron-Sulfur Cluster biogenesis) or complex pathways with an unclear reaction and regulation network, (e. g. cell cycle). (biomedcentral.com)
  • Moreover, a molecular-level understanding of iron-sulfur cluster biogenesis is crucial for understanding a variety of human diseases involving anemias, myopathies and ataxias that arise from defects in Fe-S cluster biogenesis proteins. (uga.edu)
  • IRP1 is an iron-sulfur protein that functions as an aconitase in iron-replete cells. (nih.gov)
  • The May 2007 RCSB PDB Molecule of the Month feature on Aconitase and Iron Regulatory Protein 1 by David S. Goodsell is 10.2210/rcsb_pdb/mom_2007_5 . (proteopedia.org)
  • Mn(II) has been shown to inhibit mitochondrial aconitase activity to a significant level, altering amino acid metabolism and cellular iron homeostasis. (selfdecode.com)
  • It is also believed that this direct disruption of the catalytic [4Fe-4S] cluster of aconitase by manganese produces iron regulary protein 1, resulting in alterations in cellular iron homeostasis. (selfdecode.com)
  • Early work involved cloning and characterization of iron regulatory proteins 1 and 2 (IRPs), and elucidation of how these proteins sense cytosolic iron levels and regulate expression of iron metabolism genes. (nih.gov)
  • IRPs bind to RNA stem-loops known as iron-responsive elements (IREs) in transcripts that encode iron metabolism genes, including ferritin, transferrin receptor 1, ferroportin, HIF2 alpha, and several other transcripts. (nih.gov)
  • Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
  • These findings help us understanding plant responses to Fe-deficiency stress, however, a number of novel genes involved in modulating iron homeostasis still need to be identified. (biomedcentral.com)
  • 185 genes in signature reported in the publication with PubMedID mRNA_KAT5_22196727 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset. (maayanlab.cloud)
  • protein_coding" "AAC73960","hcp","Escherichia coli","hybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases [Ensembl]. (ntu.edu.sg)
  • A further understanding of RNA binding proteins and their lncRNA partners in TCA cycle, as well as their molecular mechanisms in oncogenesis, will aid in developing novel layers of metabolic targets for cancer therapy in the near future.Abbreviations: CS: citrate synthase. (bvsalud.org)
  • Ni-Zn-[Fe4-S4] and Ni-Ni-[Fe4-S4] clusters in closed and open subunits of acetyl-CoA synthase/carbon monoxide dehydrogenase. (degruyter.com)
  • 38678) Cobalamin-independent synthase MetE domain protein CP001857 CDS Arcpr_0044 complement(38683. (go.jp)
  • Induction of the inducible NO synthase (iNOS) protein, the transcription factor IFN regulatory factor-1 involved in iNOS expression, and the transcription factor STAT-1 involved in regulating IFN regulatory factor-1 induction are all poorer in X-linked immunodeficient than in wild-type macrophages. (lookformedical.com)
  • In iron-depleted cells, the proteins bind to RNA stem-loops in transcripts known as iron-responsive elements (IRE). (nih.gov)
  • S. cerevisiae hypothetical protein YKR090w. (embl.de)
  • 9766 conserved hypothetical protein CP001857 CDS Arcpr_0009 complement(9767. (go.jp)
  • 10378) hypothetical protein CP001857 CDS Arcpr_0010 complement(10422. (go.jp)
  • 13428) hypothetical protein CP001857 CDS Arcpr_0013 complement(13425. (go.jp)
  • 13751) hypothetical protein CP001857 CDS Arcpr_0014 complement(13789. (go.jp)
  • 19702 hypothetical protein CP001857 CDS Arcpr_0022 complement(19723. (go.jp)
  • 21298 hypothetical protein CP001857 CDS Arcpr_0025 complement(21287. (go.jp)
  • 23242 hypothetical protein CP001857 CDS Arcpr_0028 23232. (go.jp)
  • 29158) hypothetical protein CP001857 CDS Arcpr_0035 complement(29143. (go.jp)
  • 29526) hypothetical protein CP001857 CDS Arcpr_0036 29596. (go.jp)
  • 36678) hypothetical protein CP001857 CDS Arcpr_0042 complement(36769. (go.jp)
  • 42520) hypothetical protein CP001857 tRNA Arcpr_R0002 complement(42639. (go.jp)
  • 43572) hypothetical protein CP001857 CDS Arcpr_0052 43655. (go.jp)
  • 47353) hypothetical protein CP001857 CDS Arcpr_0058 complement(47350. (go.jp)
  • 52977 conserved hypothetical protein CP001857 CDS Arcpr_0062 complement(52960. (go.jp)
  • 53727) hypothetical protein CP001857 CDS Arcpr_0063 complement(53793. (go.jp)
  • For example, in developing improved food crops, researchers must be able to measure the nutritional metal (iron and zinc) contents of the crops but also concentrations of toxic metals such as cadmium to ensure that increased metal levels are confined only to those of nutritional value. (ukri.org)
  • Zinc-binding domain present in Lin-11, Isl-1, Mec-3. (embl.de)
  • LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. (embl.de)
  • Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
  • Mammalian cysteine-rich intestinal protein (CRIP), a small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (embl.de)
  • Indian sorghum breeding focused on dual-purpose (grain and fodder), short-duration varieties with multiple resistance/tolerance to pests and diseases and improved nutritional quality (high protein, iron and zinc and low fat). (frontiersin.org)
  • Argentina Corned Beef is an established and the No. 1 corned beef brand that has the food qualities consumer most value - it is filling, deliciously flavorful, has meaty strands, is packed with protein, made with pure beef and fortified with zinc and iron to help boost the immunity. (securitest-grigny.fr)
  • Here, we also provide characterization of a nonheme metal coordination site occupied by zinc in an H-NOX protein. (rcsb.org)
  • The major nutrition problems in the Region are protein-energy malnutrition and high prevalence of low birth weight and of micronutrient deficiencies, including iodine deficiency disorders, vitamin A deficiency, iron deficiency anaemia in young children and women of childbearing age and calcium, zinc and vitamin D deficiencies. (who.int)
  • Runx2 is a critical regulatory factor promoting OB maturation in early differentiation. (frontiersin.org)
  • Iron-sulfur protein maturation in Helicobacter pylori:Identifying a Nfu-type cluster carrier protein and its iron-sulfur protein targets. (uga.edu)
  • protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
  • Aldehyde dehydrogenase family, Iron-containing alcohol dehydrogenase [Interproscan]. (ntu.edu.sg)
  • Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
  • protein_coding" "AAC74319","hns","Escherichia coli","global DNA-binding transcriptional dual regulator H-NS [Ensembl]. (ntu.edu.sg)
  • Klapholz-Brown Z, Walmsley GG, Nusse YM, Nusse R, Brown PO "Transcriptional program induced by wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. (openwetware.org)
  • In addition, plants have developed a number of regulatory mechanisms at both the transcriptional and post-transcriptional levels to maintain Fe homeostasis, owing to the crucial biological activities of Fe. (biomedcentral.com)
  • Interestingly, several TCA enzymes exhibit the characteristics of RNA binding properties, and their long non-coding RNA (lncRNA) partners play critical regulatory roles in regulating the function of TCA cycle and tumour progression. (bvsalud.org)
  • and Climate gases and bioenergy (theme 3), which focusses on the roles of iron containing monooxygenase enzymes that play key roles in the utilisation of methane and isoprene, two atmostpheric gases produced naturally on a massive scale. (ukri.org)
  • Fe-S clusters are present in more than 300 different types of enzymes or proteins and play crucial roles in fundamental life processes such as respiration, photosynthesis and nitrogen fixation. (uga.edu)
  • In addition we are investigating the mechanistic roles of Fe-S clusters in two rapidly emerging classes of Fe-S enzymes involved with disulfide reduction and radical generation. (uga.edu)
  • Most enzymes are proteins , though certain nucleic acids , called ribozymes , are also capable of catalytic activity. (newworldencyclopedia.org)
  • For instance, many household cleaners use enzymes to speed up the breakdown of protein or starch stains on clothes. (newworldencyclopedia.org)
  • Aspirin works by inhibiting COX-1 and COX-2, the enzymes that produce prostaglandin, a hormonal messenger that signals inflammation. (newworldencyclopedia.org)
  • Enzymes (and other proteins) are composed of amino acid chains called polypeptide chains. (newworldencyclopedia.org)
  • protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
  • Evolutionists should be able to trace how this amazing protein molecule originated-but they can't. (icr.org)
  • Representation of a human hemoglobin protein molecule. (icr.org)
  • To some, it suggests that quantum effects are at work even at the large distances (by atomic standards) spanned by a protein molecule. (newworldencyclopedia.org)
  • Finally, our docking simulations showed that the truncated PE species bound at least as good to several of the lantibiotic-identified proteins, as compared to the non-truncated parent molecule, stearoyl-arachidonoyl PE (SAPE), indicating that these oxidatively-truncated species favor/promote the formation of PEox-protein adducts. (cdc.gov)
  • Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)
  • Our data thus suggest that Bruton's tyrosine kinase participates in signaling for iNOS induction via IFN regulatory factor-1 in macrophages and that NO is an inhibitor of IL-12 induction. (lookformedical.com)
  • By identifying a tri-peptide motif common to many iron-sulfur recipient proteins, we developed an algorithm that facilitates discovery of previously unrecognized mammalian iron-sulfur proteins. (nih.gov)
  • Furthermore, levels of antibodies to matrilin 1, an extracellular matrix protein predominantly expressed in tracheal cartilage, were significantly higher in patients with relapsing polychondritis, especially in those with respiratory symptoms, than in patients with Wegener granulomatosis , systemic lupus erythematosus , or RA and in healthy controls. (medscape.com)
  • What is the downstream regulation mechanism of iron in ferroptosis? (nature.com)
  • Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. (frontiersin.org)
  • Based on previous studies, this review will summarize the regulatory network mechanism of ferroptosis on bone remodeling and reveal the role of ferroptosis in osteoporosis (OP). (frontiersin.org)
  • To Fe acquisition from the soil, most plants have developed two major ways to absorb Fe: (1) the reduction-based strategy (Strategy I) mechanism found in all dicots and non-graminaceous monocots, and (2) the chelation-based strategy (Strategy II) mechanism found only in graminaceous plants [ 4 , 5 , 6 ]. (biomedcentral.com)
  • An alternative mechanism of avian magnetoreception discussed in the thesis is based on the interaction of two iron minerals (magnetite and maghemite) which were only recently found in subcellular compartments within the sensory dendrites of the upper beak of several bird species. (uni-frankfurt.de)
  • Transferrins, the mechanism of iron release by ovotransferrin. (lookformedical.com)
  • In the structure, both empty iron binding clefts are in the open conformation, lending weight to the theory that Fe(3+) binding or release in transferrin proceeds via a mechanism that involves domain opening and closure. (lookformedical.com)
  • In previous years, our laboratory identified and characterized the cis and trans elements mediating iron-dependent alterations in the abundance of ferritin and the transferrin receptor. (nih.gov)
  • IRPs bind to IREs when iron levels are depleted, resulting in either inhibition of translation of ferritin mRNA and of other transcripts that contain an IRE in the 5′-untranslated regions (UTR) or stabilization of the transferrin receptor mRNA and possibly other transcripts that contain IREs in the 3′ UTR. (nih.gov)
  • a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
  • RANK binds to transmembrane protein nuclear factor-κB receptor activating factor ligand (RANKL) to activate RANK/RANKL, TRAF6/RANKL/MAPKs, TRAF6/ RANKL/NF-κB, Wnt/RANKL/RANKL, and JAK2/STAT3/RANKL. (frontiersin.org)
  • It has been suggested that the 'magnetic sense' in birds may be mediated by the blue light receptor protein- cryptochrome- which is known to be localized in the retinas of migratory birds. (uni-frankfurt.de)
  • The [Fe4S4] electron-transfer proteins ([Fe4S4] ferredoxins) may be further subdivided into low-potential (bacterial-type) and high-potential (HiPIP) ferredoxins. (wikipedia.org)
  • Our work suggests that there are hundreds of previously unrecognized mammalian iron-sulfur proteins. (nih.gov)
  • Through our discovery of a motif common in iron sulfur proteins, we are pursuing the hypothesis that hundreds of mammalian proteins are iron sulfur proteins that are presently unrecognized as such because iron sulfur cofactors are readily degraded during purification and laboratory studies. (nih.gov)
  • Dr. Rouault's laboratory has a long-standing interest in regulation of mammalian iron metabolism. (nih.gov)
  • Mammalian and avian cysteine-rich protein (CRP), a 192 amino-acid protein of unknown function. (embl.de)
  • The prevalence of these proteins on the metabolic pathways of most organisms leads some scientists to theorize that iron-sulfur compounds had a significant role in the origin of life in the iron-sulfur world theory. (wikipedia.org)
  • Discovery of iron sulfur proteins in many crucial pathways, from respiration to DNA and RNA metabolism and numerous metabolic pathways, may substantially add to our understanding of cellular homeostasis and function. (nih.gov)
  • Increasing amounts of data that can be mined for information about how proteins in cells assemble as metabolic pathways, signal transduction pathways, and gene circuits, are generated each day. (biomedcentral.com)
  • Iron-sulfur clusters are found in a variety of metalloproteins, such as the ferredoxins, as well as NADH dehydrogenase, hydrogenases, coenzyme Q - cytochrome c reductase, succinate - coenzyme Q reductase and nitrogenase. (wikipedia.org)
  • Evidence that MgATP accelerates primary electron transfer in a Clostridium pasteurianum Fe protein- Azotobacter vinelandii MoFe protein nitrogenase tight complex. (degruyter.com)
  • Our goal is to understand how mammals regulate intracellular and systemic iron metabolism to support processes that require iron and iron-sulfur clusters. (nih.gov)
  • Iron-regulatory proteins 1 and 2 (IRP1 and IRP2) regulate the expression of numerous proteins of iron metabolism. (nih.gov)
  • We aim to understand how mammals regulate intracellular and systemic iron metabolism. (nih.gov)
  • She came to NIH as a human genetics fellow in the NICHD, and was subsequently promoted to head of the Section on Human Iron Metabolism, and then to head of the Metals Biology and Molecular Medicine Branch. (nih.gov)
  • She was elected to the American Association of Physicians, received a distinguished alumnus award from Duke Medical Center, and has twice received the NIH Director's Award for outstanding accomplishments in iron metabolism. (nih.gov)
  • For quantitative determination of iron ions Fe 3+ and/or Fe 2+ and evaluation of drug effects on iron metabolism. (biotrend.com)
  • IRP2 also binds to IREs in iron-depleted cells but, unlike IRP1, in iron-replete cells it is selectively ubiquitinated and then degraded by the proteasome. (nih.gov)
  • Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)
  • Hemoglobin is an iron-containing respiratory protein in red blood cells that binds oxygen and then transports and releases it to cells that need oxygen. (icr.org)
  • Manganese binds to the prion protein, altering its conformation, displacing copper, and altering the redox chemistry of the metal-protein complex. (selfdecode.com)
  • A putative role for frataxin in directly regulating mitochondrial iron import is discarded from our analysis, which agrees with also published experimental results. (biomedcentral.com)
  • These clusters of tentative consensus sequences (TCs) serve as a valuable resource for putative gene products. (biomedcentral.com)
  • To serve their various biological roles, iron-sulfur proteins effect rapid electron transfers and span the whole range of physiological redox potentials from -600 mV to +460 mV. (wikipedia.org)
  • Iron-sulfur proteins are involved in various biological electron transport processes, such as photosynthesis and cellular respiration, which require rapid electron transfer to sustain the energy or biochemical needs of the organism. (wikipedia.org)
  • Iron (Fe) is an essential mineral element that involves in many biological processes important for most plants growth and development. (biomedcentral.com)
  • Recent research has revealed that carbohydrate-binding proteins, also known as agglutinins or lectins, are found in a wide range of plant species and have an important biological function in pathogen defense responses [ 23 ]. (biomedcentral.com)
  • Biological assembly 1 assigned by authors. (rcsb.org)
  • Given that mitochondrial energy production is required to maintain axonal integrity and that motor neurons have the longest and most vulnerable axons, we hypothesize that mitochondrial dysfunction resulting from iron deficiency causes axonal degeneration. (nih.gov)
  • The Rouault lab discovered that animals that lacked IRP2 developed adult-onset neurodegeneration with prominent motor neuron disease, and studies demonstrated that functional iron deficiency adversely affected mitochondrial function in neurons. (nih.gov)
  • Both Complex I and Complex II of oxidative phosphorylation have multiple Fe-S clusters. (wikipedia.org)
  • policy makers and commercial stakeholders, who are likely to be interested in the anticipated advances in understanding how microorganisms, including pathogens, sense nitric oxide and other oxidative/nitrosative stresses via iron-sulfur cluster regulatory proteins. (ukri.org)
  • Additionally, some Fe-S proteins regulate gene expression. (wikipedia.org)
  • This application for an inductively coupled plasma triple quadrupole mass spectrometer (ICP-QQQ-MS) instrument will support a range of projects at the University of East Anglia, John Innes Centre and Quadram Institute Bioscience that relate to themes in Metal and sulfur biochemistry underpinning life (theme 1), Human and animal nutrition (theme 2), and Climate gases and bioenergy (theme 3). (ukri.org)
  • Vertebrate insulin gene enhancer binding protein isl-1. (embl.de)
  • Consequently the process of Fe-S cluster biosynthesis is essential to almost all forms of life and is remarkably conserved in prokaryotic and eukaryotic organisms. (uga.edu)
  • Research on Fe-S cluster biosynthesis in the Johnson group currently involves investigating the molecular mechanisms of Fe-S cluster assembly on scaffold proteins and the subsequent intact cluster transfer to acceptor or carrier proteins. (uga.edu)
  • This may occur by manganese competing directly for an iron-binding site on the iron binding protein, disrupting the cellular mechanisms responsible for its iron-dependent degradation. (selfdecode.com)
  • As a result, understanding the molecular mechanisms underpinning iron absorption and trafficking is crucial for improving iron bioavailability and content in plants. (biomedcentral.com)
  • Plant mannose binding lectins detect specific protein-carbohydrate combinations on pathogen surfaces and serve a key role in plant defense mechanisms against pathogens [ 24 , 25 ]. (biomedcentral.com)
  • In most Fe-S proteins, the terminal ligands on Fe are thiolate, but exceptions exist. (wikipedia.org)
  • In almost all Fe-S proteins, the Fe centers are tetrahedral and the terminal ligands are thiolato sulfur centers from cysteinyl residues. (wikipedia.org)
  • The simplest polymetallic system, the [Fe2S2] cluster, is constituted by two iron ions bridged by two sulfide ions and coordinated by four cysteinyl ligands (in Fe2S2 ferredoxins) or by two cysteines and two histidines (in Rieske proteins). (wikipedia.org)
  • The electron density map unequivocally proved the presence of an iron atom with the coordination by the two protein ligands of Tyr92-OH and Tyr191-OH. (lookformedical.com)
  • Iron-sulfur proteins are proteins characterized by the presence of iron-sulfur clusters containing sulfide-linked di-, tri-, and tetrairon centers in variable oxidation states. (wikipedia.org)
  • Estates in the Kandy SHS: area were selected for the prevalence of protein energy malnutrition (PEM) i8 hisrne!3t in the Kandy SHS area and also because , out of the three island wide population sectors (viz. (who.int)
  • In this review, we will discuss the functional roles of RNA binding proteins and their lncRNA partners in TCA cycle, with emphasis placed on the cancer progression. (bvsalud.org)
  • Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. (cathdb.info)
  • Although iron is abundant in the earth's crust, it is highly insoluble and this severely limits its availability to living organisms, including humans, and, as a result, iron deficiency is the most widespread global nutritional deficiency. (ukri.org)
  • Cryptochromes are a class of photoreceptor signaling proteins that are found in a wide variety of organisms and which primarily perform regulatory functions, such as the entrainment of circadian rhythm in mammals and the inhibition of hypocotyl growth in plants. (uni-frankfurt.de)
  • The final model, which comprises 5312 protein atoms (residues 1 to 686) and 28 carbohydrate atoms (from two monosaccharides attached to Asn(473)), gives an R-factor of 0.231 for the 11,989 observed reflections between 20.0- and 3.0-A resolution. (lookformedical.com)
  • In addition to be helpful in order to distinguish between duplicate genome regions and in determining correct gene structures, FLIcs are an important resource for functional genomic studies and for investigation of regulatory elements controlling gene expression. (biomedcentral.com)
  • The problem of protein energy malnutrition that affects millions of children in the world is firmly rooted in the cultural pattern, dietary habits and the general soci.o-economic condition of the people. (who.int)
  • The paucity of information on some aspects of these factors prompted me to under this study In this project the epidemiology of protein energy malnutrition :was studied. (who.int)
  • Sorghum is considered as "healthy cereal" and is a good source of carbohydrates (68%), proteins (10%), micronutrients and phytochemicals with nutraceutical properties ( Visarada and Aruna, 2019 ). (frontiersin.org)
  • Low- and high-potential ferredoxins are related by the following redox scheme: In HiPIP, the cluster shuttles between [2Fe3+, 2Fe2+] (Fe4S42+) and [3Fe3+, Fe2+] (Fe4S43+). (wikipedia.org)
  • The potentials for this redox couple range from −0.3 to −0.7 V. The two families of 4Fe-4S clusters share the Fe4S42+ oxidation state. (wikipedia.org)
  • 32303) chromosome segregation and condensation protein%2C ScpB CP001857 CDS Arcpr_0039 complement(32287. (go.jp)
  • 32898) chromosome segregation and condensation protein ScpA CP001857 CDS Arcpr_0040 complement(32907. (go.jp)
  • 36314) chromosome segregation protein SMC CP001857 CDS Arcpr_0041 complement(36316. (go.jp)
  • We also collaborate with other groups for Mossbauer, electron-nuclear double resonance (ENDOR), X-ray absorption and X-ray crystallography studies of proteins prepared in our laboratory. (uga.edu)
  • Some 4Fe-4S clusters bind substrates and are thus classified as enzyme cofactors. (wikipedia.org)
  • Our knowledge has enabled us to develop a therapy for COVID 19, based on discovering that the SARs-CoV-2 replicase requires iron sulfur cofactors for function. (nih.gov)
  • Full-length sequenced inserts from cDNAs (FLIcs) are an important tool for correct annotation and clustering of the genomic sequence in any species. (biomedcentral.com)
  • Fe-S proteins are vulnerable to attack by biogenic nitric oxide, forming dinitrosyl iron complexes. (wikipedia.org)
  • Samples can then be solubilized in 6N nitric acid by heating at 100°C to release protein-associated iron. (biotrend.com)
  • Heme-nitric oxide/oxygen (H-NOX) binding domains are a recently discovered family of heme-based gas sensor proteins that are conserved across eukaryotes and bacteria. (rcsb.org)
  • We developed a treatment for the rare disease ISCU (iron-sulfur cluster assembly enzyme) myopathy. (nih.gov)
  • IRP1 acquires an iron-sulfur cluster in iron-replete cells that prevents it from binding to IREs, and enables it to function as a cytosolic aconite. (nih.gov)
  • Oxidoreductase FAD-binding domain, Oxidoreductase NAD-binding domain, 2Fe-2S iron-sulfur cluster binding domain [Interproscan]. (ntu.edu.sg)
  • Here, we found that the MNB1 (mannose-binding-lectin 1) gene is involved in the regulation of Fe-deficiency stress response in Arabidopsis thaliana . (biomedcentral.com)
  • Summary Background Atopic eczema is seen as a Th2-prominent immunity using the cytokine interleukin 13 as well as the transcription aspect GATA binding proteins 3 playing a crucial role. (mindunwindart.com)
  • A key molecular event during NO-dependent activation of H-NOX proteins is rupture of the heme-histidine bond and formation of a five-coordinate nitrosyl complex. (rcsb.org)
  • the occurrence of ferroptosis is iron-dependent. (nature.com)
  • Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. (nature.com)
  • Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
  • Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
  • In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
  • Recent studies have shown that ferroptosis plays an important regulatory role in the occurrence and development of many diseases and has become the focus and hotspot of research on the treatment and prognosis improvement of related diseases (Fig. 1 ). (nature.com)
  • Ubiquitin-like modifier activating enzyme 1 as a novel diagnostic and prognostic indicator that correlates with ferroptosis and the malignant phenotypes of liver cancer cells. (biotrend.com)
  • Ferroptosis was induced the programmed cell death with iron overload Fenton reaction. (frontiersin.org)
  • Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)
  • Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)
  • The identification of PEox-protein adducts during ferroptosis suggests that they are participants in the ferroptotic process preventable by 2-mercaptoethanol and may contribute to a point of no return in the ferroptotic death process. (cdc.gov)
  • The more than likely absence of known mechanistic and kinetic data for each of the individual proteins in a novel pathway hinders the process of translating network topology into a mathematical model. (biomedcentral.com)
  • The species for which myoglobin is used will cluster together far away from the related species for which hemoglobin is selected. (icr.org)
  • Proteins which are found in eggs (OVA) from any species. (lookformedical.com)
  • In mouse models, loss of IRP2 results in mild anemia, erythropoietic protoporphyria, and adult-onset neurodegeneration-all likely the result of functional iron deficiency. (nih.gov)
  • Patients with alpha-thalassemia trait or beta-thalassemia trait are asymptomatic but have mild microcytic hypochromic anemia, which often goes undiagnosed or is confused with iron deficiency anemia. (medscape.com)
  • protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
  • Enoyl-(Acyl carrier protein) reductase [Interproscan]. (ntu.edu.sg)
  • Ribosomal protein S20 [Interproscan]. (ntu.edu.sg)
  • Bor protein [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF1158) [Interproscan]. (ntu.edu.sg)
  • Translation initiation factor 1A / IF-1 [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF2526) [Interproscan]. (ntu.edu.sg)
  • Ribosomal protein L35 [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF441) [Interproscan]. (ntu.edu.sg)
  • LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
  • YebO-like protein [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF2511) [Interproscan]. (ntu.edu.sg)
  • Copper resistance protein D [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
  • Aldose 1-epimerase [Interproscan]. (ntu.edu.sg)
  • These include lead's ability to inhibit or mimic the actions of calcium (which can affect calcium-dependent or related processes) and to interact with proteins (including those with sulfhydryl, amine, phosphate, and carboxyl groups) [ATSDR 2010]. (cdc.gov)
  • The oxidized proteins contain two Fe3+ ions, whereas the reduced proteins contain one Fe3+ and one Fe2+ ion. (wikipedia.org)
  • A common motif features a four iron ions and four sulfide ions placed at the vertices of a cubane-type cluster. (wikipedia.org)
  • Thus elements such as iron, sulfur and phosphorus, which are very difficult to detect and quantify using a single quadrupole instrument due to interference ions (eg. (ukri.org)
  • IRP2 is homologous to IRP1 but undergoes iron-dependent degradation in iron-replete cells. (nih.gov)
  • These readily undergo iron-catalyzed secondary free radical reactions leading to truncated products which retain the signature PE headgroup and which can readily react with nucleophilic moieties in proteins via their truncated electrophilic acyl chains. (cdc.gov)
  • E7 from human papil omavirus type 16 cooperate to cancer: the European prospective investigation into doi:10.1093/carcin/bgp321 PMID:20047954 target the PDZ protein Na/H exchange regulatory cancer and nutrition study. (who.int)
  • Vertebrate homeobox proteins lim-1, lim-2 (lim-5) and lim3. (embl.de)
  • Vertebrate protein kinases LIMK-1 and LIMK-2. (embl.de)
  • Vertebrate paxillin, a cytoskeletal focal adhesion protein. (embl.de)
  • Saccharomyces cerevisiae (Baker's yeast) rho-type GTPase activating protein RGA1/DBM1. (embl.de)
  • Hemoglobin is an iron-containing oxygen-transport protein found in red blood cells. (icr.org)