Cluster genes and gene. Medical search. Frequent questions

These clusters are critical for the function of many different proteins, including those needed for DNA repair and the regulation of iron levels. (medlineplus.gov)
The LCR interacts with β-globin gene cluster involving long range DNA interactions mediated by various transcription factors to drive the regulation of globin genes expression. (kcl.ac.uk)
Therefore, identifying the mechanisms responsible for the regulation of these genes in patients with COAD has become important. (bvsalud.org)
Ribosomes have been suggested to directly control gene regulation, but regulatory roles for ribosomal RNA (rRNA) remain largely unexplored. (nih.gov)
Together, these studies unravel unexpected gene regulation directly mediated by rRNA and how ribosome evolution drives translation of critical developmental regulators. (nih.gov)
Transcriptomics focuses on gene transcription and regulation of transcription in cells [ 25 , 26 ]. (hindawi.com)

A gene cluster is a group of two or more genes found within an organism's DNA that encode similar polypeptides, or proteins, which collectively share a generalized function and are often located within a few thousand base pairs of each other. (wikipedia.org)
If only a single copy of a gene existed in the genome of a species, the proteins transcribed from this gene would be essential to their survival. (wikipedia.org)
however, over a long, evolutionary time period, the genetic information in the duplicated copy may undergo additional and drastic mutations in which the proteins of the duplicated gene served a different role than those of the original essential gene. (wikipedia.org)
Over the long, evolutionary time period, the two similar genes would diverge so the proteins of each gene were unique in their functions. (wikipedia.org)
The four genes encode four of the five major third instar larval cuticle proteins. (caltech.edu)
A shortage of this enzyme prevents the normal production of proteins that contain Fe-S clusters, which disrupts a variety of cellular activities. (medlineplus.gov)
They attract transcription factor proteins that start the expression of genes, thereby "enhancing" their activity. (mpg.de)
There were 3954 correlations and a total of 15 correlations for differentially expressed proteins (DEPs) and differentially expressed genes (DEGs) from proteomics and transcriptomics. (hindawi.com)

Downstream of the retron sequence is the yidY gene, which is also found in the chromosome of other S. enterica serovars ( 7 ). (cdc.gov)
Sequence comparisons indicate it arose by an unequal crossing over event involving two closely related and adjacent cuticle genes. (caltech.edu)
This family is comprised of three genes that are 55-60% homologous in DNA sequence and clustered within 8 kb of DNA. (caltech.edu)
The nucleotide sequence of the methylamine utilization (mau) gene region from Methylobacterium extorquens AM1 was determined. (caltech.edu)
Epigenetics refers to the study of heritable changes in gene function without alterations in DNA sequence ( Bird, 2007 ). (frontiersin.org)
Researchers now tested how much information can be extracted from sequence data to predict which gene is active in which tissue. (mpg.de)
The sequence of this gene is defined by 16 cDNA clones and 18 elements defined by RNA-seq, some from mixed (seen 7 times), embryo (5), l2 (once). (nih.gov)
Analysis of Expressed Sequence Tag (EST) abundance led to the discovery of a number of previously uncharacterized genes that are expressed in the HN1 variety but are completely absent from the HM1 and HT1 EST libraries ( Fig. 1B ). (ampliconexpress.com)
Prior to the "genomic era," when the acquisition of DNA sequence involved significant labor and expense, the sequencing of genes was strongly linked to the experimental characterization of their products. (plos.org)
Extensive DNA sequence comparisons between various Xenopus histone gene clusters were undertaken. (bl.uk)
D ) Comparison of fractions of sequence covered by hydrophobic clusters between de novo and all other protein-coding genes. (elifesciences.org)
Molecular genetic testing for sequence variants in the GJB3 , GJB4 , and GJA1 genes is available (also as next-generation sequencing panel) and expected to yield a positive result in at least two thirds of patients. (medscape.com)

Salmonella genomic island 1 (SGI1) contains an antibiotic resistance gene cluster and has been previously identified in multidrug-resistant Salmonella enterica serovars Typhimurium DT104, Agona, and Paratyphi B. We identified a variant SGI1 antibiotic-resistance gene cluster in a multidrug-resistant strain of S. enterica serovar Albany isolated from food fish from Thailand and imported to France. (cdc.gov)
Genetic organization of the antibiotic resistance gene cluster of Salmonella genomic island 1 (SGI1) of Salmonella enterica serovar Typhimurium DT104 and serovar Albany strain 7205.00. (cdc.gov)
The antibiotic resistance genes are clustered in part of a 43-kb genomic island called Salmonella genomic island 1 (SGI1), located between the chromosomal thdf and int2 genes ( 6 , 7 ). (cdc.gov)
Importantly, multiple genomic innovations including gene losses, independent contraction and expansion of specific gene families and their associated regulatory networks likely moulded the evolution of the nautilus pinhole eye. (nature.com)
Therefore it is not surpris- pansion of biological understanding from the analysis of in- ing that the advent of high-throughput genomic and pro- dividual genes to the analysis of systems of genes (and pro- teomic technologies is drawing a growing interest from the teins). (lu.se)

Genes found in a gene cluster may be observed near one another on the same chromosome or on different, but homologous chromosomes. (wikipedia.org)
In the course of subsequent evolution, they diverge, so that the products they code for have different but related functions, with the genes still being adjacent on the chromosome. (wikipedia.org)
however, rather than the Hox cluster and the ParaHox cluster resulting from a cluster containing three genes, the Hox cluster and ParaHox cluster were as a result of single gene tandem duplication, identical genes found adjacent on the same chromosome. (wikipedia.org)
Cis-duplication, or intrachromosomal duplication, entails the duplication of genes within the same chromosome whereas trans duplication, or interchromosomal duplication, consists of duplicating genes on neighboring but separate chromosomes. (wikipedia.org)
This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. (nih.gov)
Thus two small gene families can lie adjacent on the chromosome and exhibit different patterns of developmental expression, even though individual genes within a clustered family are coordinately expressed. (caltech.edu)
CYP2D6 belongs to the CYP2D subfamily, a gene cluster located on chromosome 22, which comprises the CYP2D6 gene and pseudogenes CYP2D7P and CYP2D8P . (go.jp)
Analysis of an F2 mapping population indicated the genes are tightly linked in HN1, and bacterial artificial chromosome sequencing confirmed they exist as a complex gene cluster for plant alkaloids. (ampliconexpress.com)
The Symposium Proceedings addresses 21st Century Genetics: Genes at Work, and provides a current synthesis of genetic mechanisms and genome/chromosome biology. (cshlpress.com)
A 'chromosome walk' experiment allowed the isolation of clones indicating a tandem of arrangement of clusters on the chromosome. (bl.uk)

Our analyses also show that reported chimeric sequences of the CYP2D6 and CYP2D7 genes in the chimpanzee genome appear to be exchanged in its genome database. (go.jp)
BGDM Docker integrates a software for genome annotation (Prokka), a software for pan-genome analysis and classification (PanX) and a software dedicated to identify clusters of biosynthetic genes, along with the metabolites that can be produced from such clusters (anti-SMASH). (peerj.com)
Nautilus shows a compact, minimalist genome with few encoding genes and slow evolutionary rates in both non-coding and coding regions among known cephalopods. (nature.com)
DNA snippets scattered across the genome harbor the code that directs the script of a cell's life, successively switching genes on and off. (mpg.de)
Some cross-references in the storybook of the genome might still hide in other regulatory sequences, like promoter regions that are in close proximity to the gene itself. (mpg.de)
This diagram shows in true scale the gene on the genome, the mRNAs and the cDNA clones. (nih.gov)
PCR analysis revealed that the genes exclusively expressed in the HN1 variety are present as expected in the genome of HN1 but absent from the genomes of the HM1 and HT1 varieties ( Fig. 1B and fig. S6). (ampliconexpress.com)
Identification of genes exclusively present in the genome of a noscapine producing poppy variety, HN1 (High Noscapine 1). (ampliconexpress.com)
A previous study showed that unlike X. laevis, X. borealis contains a predominant or major histone gene cluster, which contains 70% of the 80-90 copies of the H4 genes in the genome (Turner & Woodland 1983 (Nucl. (bl.uk)
This allowed the complete 'repeat' to be mapped in detail, further studies confirmed that the majority of clusters are tandemly repeated in the genome. (bl.uk)

Then, the differentially expressed platelet adhesion-related genes of COAD were analyzed using the TCGA database, and patients were further classified by employing the non-negative matrix factorization (NMF) analysis method . (bvsalud.org)
The gene copy number and enrichment analysis results revealed that two pathways were differentially enriched. (bvsalud.org)
In addition, the differentially expressed genes between these two clusters were enriched for POU6F1 in the transcription factor signaling pathway, and for MATN3 in the ceRNA network. (bvsalud.org)
We found that the most significant differentially methylated sites had a remarkable enrichment in type I interferon (IFN) pathway genes. (frontiersin.org)

First, genes are clustered into gene groups with a clustering algorithm so that genes belonging to the same cluster have similar expression profile. (mun.ca)
Significance of platelet adhesion-related genes in colon cancer based on non-negative matrix factorization-based clustering algorithm. (bvsalud.org)
Firstly, we used clustering algorithms, Markov cluster algorithm (MCL), Molecular complex detection (MCODE) and Clique percolation method (CPM) to decompose human PPI network into dense clusters as the candidates of disease-related clusters, and then a log likelihood model that integrates multiple biological evidences was proposed to score these dense clusters. (ijbs.com)
Parallel Hash-Based EST Clustering Algorithm for Gene Sequencing" by Rameshreddy Mudhireddy, Fikret Erçal et al. (mst.edu)
In this paper, we present HECT (Hash based EST Clustering Tool), a novel time- and memory-efficient algorithm for EST clustering. (mst.edu)
We report that HECT can cluster a 10,000 Human EST dataset (which is also used in benchmarking d2_cluster), in 207 minutes on a 1 GHz Pentium III processor which is 36 times faster than the original d2_cluster algorithm. (mst.edu)

In the case of the Hox gene, a shared ancestral ProtoHox cluster was duplicated, resulting in genetic clusters in the Hox gene as well as the ParaHox gene, an evolutionary sister complex of the Hox gene. (wikipedia.org)
Integrating known disease genes with physical or biomolecular networks and gene expression data to identify disease-related subnetworks can help us explain many genetic and environmental factors influencing a disease in the context of a smaller number of discrete subnetworks as well as the causes or effects of the disease phenotype. (ijbs.com)
The deletion encompassed 74 genes and caused haploinsufficiency (or loss of allele) of 6 genes known to be implicated in different autosomal dominant genetic disorders: TWIST, DFNA5, CYCS, HOXA11, HOXA13, and GARS. (elsevierpure.com)

At least five genes were shown to be essential for the synthesis of AHBA, five genes were determined to encode the modular type I PKS that uses AHBA as the starter unit, and 20 or more genes appear to govern modification of the polyketide-derived framework, and rifamycin resistance and export. (nih.gov)
Disruption of the PKS genes at the end of rifA abolished rifamycin B production and resulted in the formation of P8/1-OG, a known shunt product of rifamycin biosynthesis, whereas disruption of the orf6 and orf9 genes, which may encode deoxysugar biosynthesis enzymes, had no apparent effect. (nih.gov)
The mauB, mauA, and mauC genes encode the periplasmic methylamine dehydrogenase (MADH) large and small subunit polypeptides and amicyanin, respectively. (caltech.edu)
Excel file with five tabs, providing (i) the legends for the tissue sources, (ii) the table for the gene lists, (iii) the information for the reassembled transcripts, (iv) the proteomic evidence shown in detail, and (v) the accession numbers for the ENCODE data. (elifesciences.org)

Cancer datasets normally contain a small size of samples while each sample has a large number of genes as features. (mun.ca)
This takes little RAM, allowing you to cluster a large number of genes, but the clustering results could be inferior to those obtained with e.g. average linkage. (lu.se)

An example of a gene cluster is the Hox gene, which is made up of eight genes and is part of the Homeobox gene family. (wikipedia.org)
NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. (biomedcentral.com)
Although these genes are found in various metazoans, plants, fungi and even unicellular eukaryotes, bilaterians have evolved the largest diversity of homeobox genes that arose predominantly due to extensive tandem duplications [ 2 , 4 , 5 ]. (biomedcentral.com)
The homeobox genes of animals are categorized into eleven classes, with the Antennapedia class (ANTP) being one of the largest, comprising the Hox, ParaHox and NK gene families [ 5 , 9 ]. (biomedcentral.com)

This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. (nih.gov)
The human H2A and H2B histone gene complement. (nih.gov)
An extensive analysis of the hereditary hemochromatosis gene HFE and neighboring histone genes. (tripod.com)
This prompted more detailed analysis of histone gene arrangements in X. borealis, which is the subject of this thesis. (bl.uk)
Clones containing histone genes were isolated from a library prepared for this purpose. (bl.uk)
The picture of histone gene cluster structure in X. borealis that emerges from these studies, is compared at the nucleotide, gene, and chromosomal levels with X. laevis. (bl.uk)

Comparison of amino acid sequences of polypeptides encoded by mau genes from M. extorquens AM1, P. denitrificans, and Thiobacillus versutus shows that they have considerable similarity. (caltech.edu)
The researchers developed a program that is able to identify DNA sequences that are recognized by the cell in order to activate genes in a tissue-specific way. (mpg.de)
A parallel version of HECT (PECT) is also developed and used to cluster 269,035 soybean EST sequences on IA-32 Linux cluster at National Center for Supercomputing Applications at UIUC. (mst.edu)

AceView: gene:dpy-21, a comprehensive annotation of human, mouse and worm genes with mRNAs or ESTsAceView. (nih.gov)

In this patient, the observed transcription from the duplicated, distally displaced HBB A cluster demonstrates that the loss of LCR and flanking 3′HS sites do not lead to complete silencing of HBB transcription. (kcl.ac.uk)
eling require a broad range of signal processing approaches, Two salient goals of functional genomics are to screen for including signal representation relevant to transcription and key genes and gene combinations that explain specific cel- system modeling using nonlinear dynamical systems. (lu.se)

The overall IFN-related gene panel annotated by gene ontology (GO) showed an excellent diagnostic capacity in CD4+ T cells (Sensitivity = 0.82, specificity = 0.82 and AUC = 0.90), while IFI44L , another IFN-related gene not annotated by GO, showed high prediction ability in both CD4+ (AUC = 0.86) and CD8+ (AUC = 0.75) T cells. (frontiersin.org)
We found that the clusters decomposed by CPM outperformed MCL and MCODE as the candidates of disease-related clusters with well-supported biological significance in biological process, molecular function and cellular component of Gene Ontology (GO) and expression of human tissues. (ijbs.com)

When gene duplication occurs to produce a gene cluster, one or multiple genes may be duplicated at once. (wikipedia.org)
Although common diseases tend to cluster within families, they are influenced by an interaction of environmental factors and multiple genes. (the-scientist.com)

The antibiotic resistance gene cluster represents approximately one third of SGI1 and is located at the 3´ end of the structure ( 6 , 7 ). (cdc.gov)
Moreover, variant SGI1 antibiotic resistance gene clusters have recently been reported for serovars Typhimurium DT104 and Agona variant SGI1 ( 12 , 15 ). (cdc.gov)
Moreover, hog worker isolates harbored more diverse antibiotic resistance genes, with a higher prevalence of carriage of multiple resistance genes, than community resident isolates (75.8% vs. 29.2%, BH p = 0.021). (cdc.gov)

The NKL gene complement of E. rowelli comprises eight genes, including BarH , Bari , Emx , Hhex , Nedx , NK2.1 , vax and NK2.2 , of which only NK2.2 was studied previously. (biomedcentral.com)

however, gene duplication allows essential genes to undergo mutations in the duplicated copy, which would ultimately give rise to new genes over the course of evolution. (wikipedia.org)
Myopathy with deficiency of iron-sulfur cluster assembly enzyme is caused by mutations in the ISCU gene. (medlineplus.gov)
Mutations in the ISCU gene severely limit the amount of iron-sulfur cluster assembly enzyme that is made in cells. (medlineplus.gov)
which means both copies of the gene in each cell have mutations. (medlineplus.gov)
These researchers have successfully identified many rare Mendelian disorders that are caused by mutations in one gene. (the-scientist.com)
Molecular diagnostic testing for mutations in the connexin genes GJB3, GJB4 , and GJA1 is available. (medscape.com)

Is the Subject Area "Hierarchical clustering" applicable to this article? (plos.org)
Hierarchical clustering, bottom-up. (lu.se)
Hierarchical clustering is now supported through MeV ( http://www.tm4.org ). (lu.se)
The main objective was to get Hierarchical clustering working. (lu.se)

The three genes are expressed together in larval stages and adults but show a different pattern of developmental expression from the third instar larval cuticle protein genes. (caltech.edu)

The performance of the proposed clustering algorithms is compared against other known clustering techniques and results are reported in the paper. (mst.edu)

A molecular characterization of this strain is reported, which includes the finding of a transposable element in the promoter region of the unexpressed gene. (caltech.edu)

The mRNA expression-based NMF was used to reveal the potential role of platelet adhesion-related genes in COAD . (bvsalud.org)
To make the gene signature and risk cutoff widely applicable, we developed a novel analytic approach based on mRNA expression levels of gene-pairs to construct a robust prognostic model, and show how one-hot binary encoding of the gene-pairs effectively eliminates the influence of batch effects. (nature.com)

These cuticle genes are coordinately expressed in the integument of third instar larvae, and they are not abundantly expressed in other developmental stages. (caltech.edu)

Species who have gene clusters have a selective evolutionary advantage because natural selection must keep the genes together. (wikipedia.org)
The lack of comparative data for many of the remaining NKL genes, including Bari , Hhex and Nedx currently hampers further evolutionary conclusions. (biomedcentral.com)

This segment lies at chromosomal location 44D and contains two small gene families. (caltech.edu)
Attention was then turned to the chromosomal organisation of the major cluster. (bl.uk)

In the four gene model, the ProtoHox cluster contained four genes which resulted in two twin clusters: the Hox cluster and the ParaHox cluster. (wikipedia.org)
As its name indicates, the two gene model gave rise to the Hox cluster and the ParaHox cluster as a result of the ProtoHox cluster which contained only two genes. (wikipedia.org)
The formations of the Hox cluster and of the ParaHox cluster were results of intrachromosomal duplication, although they were initially thought to be interchromosomal. (wikipedia.org)

Both isolates had active-on-imipenem metallo-beta-lactamase emase genes. (cdc.gov)
CRPA isolates for carbapenemase genes and implementation of occupied room X while receiving mechanical ventilation for sink hygiene interventions, was critical in the identification of 4 weeks. (cdc.gov)
Hog worker isolates had a lower prevalence and diversity of enterotoxins than community resident isolates, particularly lacking the enterotoxin gene cluster (39.4% vs. 70.8%, BH p = 0.125). (cdc.gov)

A gene family is a set of homologous genes within one organism. (wikipedia.org)

The single-nucleotide polymorphism rs1582763 modified expression of the MS4A4A and MS4A6A genes in multiple tissues, suggesting that one or both of these genes are important for modulating sTREM2 production. (lu.se)
We also found that most of the disease-related clusters consisted of tissue-specific genes that were highly expressed only in one or several tissues, and a few of those were composed of housekeeping genes (maintenance genes) that were ubiquitously expressed in most of all the tissues. (ijbs.com)
B ) Comparison of overall expression levels (represented as the highest FPKM values in the 35 tissues) between de novo and all other protein-coding genes ('De novo' and 'Other' on the x-axis). (elifesciences.org)

Currently bioassay sets must be exported (support exists already in BASE 2.1) for clustering. (lu.se)

Computer analysis showed that the MauG polypeptide contains two putative heme binding sites and that the MauM and MauN polypeptides have four and two FeS cluster signatures, respectively. (caltech.edu)
We report an infant with sickle cell disease phenotype by biochemical analysis whose β-globin gene (HBB) sequencing showed sickle cell mutation (HBB S ) heterozygosity. (kcl.ac.uk)
Based on platelet adhesion-related genes , patients with COAD were classified into two clusters by NMF-based clustering analysis . (bvsalud.org)
Gene coexpression analysis refers to the en masse discovery of coexpressed genes from a large variety of transcriptomic experiments. (mdpi.com)
Sun PG, Gao L, Han S. Prediction of Human Disease-Related Gene Clusters by Clustering Analysis. (ijbs.com)
Since genes associated with similar diseases/disorders show an increased tendency for their protein products to interact with each other through protein-protein interactions (PPI), clustering analysis obviously as an efficient technique can be easily used to predict human disease-related gene clusters/subnetworks. (ijbs.com)
In addition, important genes related to osmoregulation, such as ion transport and carbonic anhydrase, were also detected in the correlation analysis for same trend DEPs_DEGs. (hindawi.com)
Transcriptomic analysis revealed the exclusive expression of 10 genes encoding five distinct enzyme classes in a high noscapine-producing poppy variety, HN1. (ampliconexpress.com)
Analysis of these clones indicated one class containing the major cluster, and a second, minor class which appeared to be cloned at high frequency. (bl.uk)
Microinjection analysis again showed the genes were functional. (bl.uk)

This method decreases the computational complexity and redundancy of genes which leads to a better classification accuracy. (mun.ca)
In this project, we conduct a comprehensive study by examining widely used clustering, feature selection, and classification methods, and applying them to different cancer datasets including Colon, Leukemia and, Lymphoma. (mun.ca)
Results in this study will show that by incorporating feature clustering to gene selection, computational complexity will be reduced and better classification accuracy will be achieved. (mun.ca)
In this retrospective multi-cohort study, we investigated whether combining pyroptosis- and immune-related genes improves prognostic classification of AML patients. (nature.com)

thus it is located between the thdf gene and the yidY gene of their chromosomes ( 6 , 14 ). (cdc.gov)

We want to know what kind of cells are present in our dataset, so we cluster the cells, and study the similarities in expression within these clusters. (csc.fi)

Using a robust gene pairing approach, which effectively eliminates batch effects across heterogeneous patient cohorts and transcriptomic data, we developed an immunity and pyroptosis-related prognostic (IPRP) signature that consists of 15 genes. (nature.com)

For example, variants of the ADIPOQ gene (the rs266729 single-nucleotide polymorphism) are associated with obesity and diabetes in various Arab countries. (who.int)

Virus-induced gene silencing resulted in accumulation of pathway intermediates allowing gene function to be linked to noscapine synthesis and a novel biosynthetic pathway to be proposed. (ampliconexpress.com)
In contrast a number of other functionally characterized genes associated with benzylisoquinoline alkaloid synthesis, including Berberine Bridge Enzyme ( BBE ), Tetrahydroprotoberberine cis-N-MethylTransferase ( TNMT ), Salutaridine Reductase ( SalR ), Salutaridinol 7-O-AcetylTransferase ( SalAT ) and Thebaine 6-O-demethylase ( T6ODM ) were expressed in all three varieties ( Fig. 1B ). (ampliconexpress.com)

however, the resulting protein of each gene is distinctive from the resulting protein of another gene within the cluster. (wikipedia.org)
Eleven kb away from the cuticle gene cluster lies another gene family. (caltech.edu)

3 ] proposed a method to detect disease-related gene modules or dysfunctional pathways based on global characteristics of interactome coupled with gene expression data. (ijbs.com)

We identified several SM-encoding biosynthetic gene clusters (BGCs) from the metagenomic data of lean and obese individuals and found significant association between some BGCs, including those that produce hitherto unknown SM, and obesity. (hindawi.com)
High platelet counts are associated with worse survival in real-world patients , and alternations to platelet adhesion-related genes have resulted in poorer prognoses , based on online data. (bvsalud.org)
Inconsistent data formats and batch effects between different profiling platforms often challenge the development and application of prognostic gene signatures. (nature.com)
With the increase in availability of human protein interaction data and gene expression data, the focus of bioinformatics development has shifted from understanding networks encoded by model species to understanding the networks underlying human disease [ 1 ]. (ijbs.com)
4 ] presented an approach to causal gene prediction that was based on integrating PPI network data with gene expression data under a condition of interest. (ijbs.com)
Although using ESTs is a cost-effective approach in gene discovery, the amount of data, and hence the computational resources required, make it a very challenging problem. (mst.edu)
with the rapid growth of EST data we need better and faster clustering tools. (mst.edu)
While the NKC genes have been studied in various bilaterians, corresponding data of many NKL genes are missing to date. (biomedcentral.com)
Our data for the remaining seven NKL genes revealed expression in different structures associated with the developing nervous system in embryos of E. rowelli . (biomedcentral.com)

Putative regulatory genes were also identified. (nih.gov)
Rifamycin production in A. mediterranei is governed by a single gene cluster consisting of structural, resistance and export, and regulatory genes. (nih.gov)
Dr. Rossmann will also be presenting a seminar in the Department of Biochemistry & Biophysics series on *Wednesday, October 11th* titled "Dissecting Metabolic Gene Regulatory Networks in Hematopoiesis" at 2 p.m. in K-307 (3-6408). (rochester.edu)

Here, we conducted a preliminary study to investigate the evolution and gene organization of the CYP2D subfamily, focused on humans and four non-human primates (chimpanzees, orangutans, rhesus monkeys, and common marmosets). (go.jp)

found that pyroptosis-related genes can be used for prognostic prediction of skin cutaneous melanoma and lung adenocarcinoma, respectively. (nature.com)

The mauA, mauD, and mauE genes from Paracoccus denitrificans and the mauD and mauG genes from Methylophilus methylotrophus W3A1 were able to complement corresponding mutants of M. extorquens AM1, confirming their functional equivalence. (caltech.edu)

In this strain, the streptomycin resistance aadA2 gene cassette in one of the SGI1 integrons was replaced by a dfrA1 gene cassette, conferring resistance to trimethoprim and an open reading frame of unknown function. (cdc.gov)
All resistance genes are clustered and are bracketed by two integron structures ( Figure 1 ) ( 6 - 10 ). (cdc.gov)
The first integron carries the aadA2 gene, which confers resistance to Sm and Sp, and a truncated sul1 ( sul1delta ) gene. (cdc.gov)
The second integron contains the β-lactamase gene pse-1 conferring resistance to Ap and a complete sul1 gene conferring resistance to Su. (cdc.gov)
Flanked by these two integron structures are the floR gene ( 8 ), also called floSt ( 11 ) or cmlA -like (9), which confers cross-resistance to Cm and Ff, and the tetracycline-resistance genes tetR and tet (G). (cdc.gov)

In conclusion, our study demonstrated that hypomethylation of IFN-related genes is a common feature of GD/RA/SLE/SSc patients in CD4+ T cells, and the DNA methylation profile of IFN-related genes could be promising biomarkers for the diagnosis of GD, RA, SLE, and SSc. (frontiersin.org)

Common, complex diseases such as diabetes, asthma, and cardiovascular conditions are the next challenge gene hunters face. (the-scientist.com)
Analytical strategies that have successfully mapped the rare monogenic disorders have not definitively identified any genes involved in complex diseases. (the-scientist.com)

The present study aims to investigate the underlying mechanisms of platelet adhesion-related genes in COAD patients . (bvsalud.org)
DNA methylation is one of the major epigenetic mechanisms, and it plays an important role in determining gene function ( Hedrich and Tsokos, 2011 ). (frontiersin.org)
Predicting human disease-related clusters/subnetworks using a biomolecular network is critical to gain an understanding of disease mechanisms, and is also essential for the development of new diagnostics and therapeutics. (ijbs.com)

Also, clustering with absolute correlation as the distance metric does not work very well at all. (lu.se)

The stx1 gene abundance was only detected in tissue samples collected in year 2 and did not differ among breeds. (frontiersin.org)

To explore this biosynthetic potential, we developed a novel "semi-targeted" approach focusing on activating "silent" BGCs by concurrently introducing a group of regulator genes into streptomycetes of the Tübingen strain collection. (dtu.dk)
To explore this biosynthetic potential, we developed a novel "semi-targeted" approach focusing on activating "silent" BGCs by concurrently introducing a group of regulator genes into streptomycetes of the T{\"u}bingen strain collection. (dtu.dk)

The size of gene clusters can vary significantly, from a few genes to several hundred genes. (wikipedia.org)

This study assessed the abundance and expression of Stx genes and the expression of host immune genes, aiming to determine factors affecting these measures and potential gene markers to differentiate Stx gene expression in the recto-anal junction of feedlot beef cattle. (frontiersin.org)

EST clustering is a simple, yet effective method to discover all the genes present in a variety of species. (mst.edu)

Genes whose expression levels rise and fall similarly in a large set of samples, may be considered coexpressed. (mdpi.com)

Organisms5

Diseases1

Chemicals and Drugs22

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes36

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Health Care4

Regulation6

Proteins8

Sequence12

Genomic5

Chromosome10

Genome10

Differentially4

Algorithm6

Genetic3

Encode4

Large number of genes2

Homeobox4

Histone6

Sequences3

Annotation1

Transcription2

Ontology2

Multiple genes2

Antibiotic3

Eight genes1

Mutations6

Hierarchical4

Protein genes1

Algorithms1

Molecular1

MRNA2

Developmental1

Evolutionary2

Chromosomal2

ParaHox3

Isolates3

Homologous1

Tissues3

BioAssay1

Analysis10

Classification4

Chromosomes1

Dataset1

Transcriptomic1

Variants1

Synthesis2

Another gene2

Pathways1

Data9

Regulatory3

Organization1

Prediction1

Complement1

Resistance5

Biomarkers1

Diseases2

Mechanisms3

Correlation1

Tissue1

Strain2

Several hundred1

Markers1

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Similarly1