• Integrated analysis of differential gene expression, previously reported quantitative trait loci, and genome-wide association studies indicated that TRIB3 , SAA ( SAA1 , SAA3 , and M-SAA3.2 ), VEGFA, PTHLH , and RPL23A were the most promising candidate genes affecting milk protein and fat percentage. (biomedcentral.com)
  • By studying 1,133 children with severe, undiagnosed developmental disorders, and their parents, using a combination of exome sequencing and array-based detection of chromosomal rearrangements, we discovered 12 novel genes associated with developmental disorders. (nih.gov)
  • Clustering of missense mutations in six of these newly implicated genes suggests that normal development is being perturbed by an activating or dominant-negative mechanism. (nih.gov)
  • The updated nomenclature has also been applied to orthologous histone genes in chimpanzee, rhesus macaque, dog, cat, pig, horse and cattle, and can serve as a framework for naming other vertebrate histone genes in the future. (biomedcentral.com)
  • In metazoans, these histone proteins are encoded by the set of replication-dependent histone genes, which encode representatives of all five classes of histone proteins [ 1 ]. (biomedcentral.com)
  • The replication-dependent histone genes encode messenger RNAs (mRNAs) which differ from all other cellular mRNAs: instead of being polyadenylated, these mRNAs end in a stem-loop structure. (biomedcentral.com)
  • These genes do not contain introns, and the only processing event is cleavage of the nascent transcript to form the 3' end of the histone mRNA. (biomedcentral.com)
  • Some of the "replication-dependent" histone genes can also produce polyadenylated mRNAs. (biomedcentral.com)
  • For example, analysis of global gene expression in normal non-dividing tissues revealed that a subset of 10 human replication-dependent histone genes produced polyadenylated mRNAs in all non-dividing tissues analyzed [ 2 ]. (biomedcentral.com)
  • In the human genome the largest cluster is on chromosome 6 and contains more than 60 genes, and the second cluster on chromosome 1 contains 10-12 genes. (biomedcentral.com)
  • There are 4 genes in a third distinct locus on chromosome 1, and a single replication-dependent histone H4 gene on chromosome 12 (with a neighboring H2A gene for which replication dependency is uncertain). (biomedcentral.com)
  • In other vertebrates, the organization of histone genes is variable. (biomedcentral.com)
  • In chicken, there is a single large cluster, analogous to the largest mammalian cluster, which contains genes for all five histone types, all of which encode mRNAs ending in a stem loop. (biomedcentral.com)
  • Integral nuclear pore proteins bind to Pol III-transcribed genes and are required for Pol III transcript processing in C. elegans. (cincinnatichildrens.org)
  • The involvement of viral DNA-binding proteins in the regulation of virulence genes, transcription, DNA replication, and repair make them significant targets. (mdpi.com)
  • This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. (multxpert.com)
  • Epigenetic components (for example, Polycomb PRC1/2 and Trithorax group proteins) maintain the 'off' states of certain genes and the 'on' states of others, in a cell-type- and time-specific manner (the bottom panels show three genes, depicted schematically as chromatinized templates, in which transcription is triggered by specific transcription factors and silent or active states are maintained by PRC1/2 or Trithorax proteins, respectively). (nature.com)
  • Operons Operons are groups of genes that function to produce proteins needed by the cell. (pdfcoffee.com)
  • There are two different kinds of genes in operons: Structural genes code for proteins needed for the normal operation of the cell. (pdfcoffee.com)
  • Regulator genes code for proteins that regulate other genes. (pdfcoffee.com)
  • In the normal condition, the genes do not function because a repressor protein is active and bound to the DNA preventing transcription. (pdfcoffee.com)
  • The protein must be removed before the genes can be transcribed. (pdfcoffee.com)
  • Tryptophan is an amino acid needed by E. coli and the genes that code for proteins that produce tryptophan are continuously transcribed as shown below. (pdfcoffee.com)
  • However, genes expressed early in development may preferentially retain histones. (i-sis.org.uk)
  • Using a combination of miRNA hairpin predictions and co-mapping with miRBase entries, we identified a highly conserved cluster of miRNA genes on the X chromosome in the tammar and a total of 94 other predicted miRNA producing genes. (biomedcentral.com)
  • Furthermore, Omics.org indicated that the main focus of omics is on 1) mapping information objects such as genes, proteins and ligands, 2) finding interaction relationships among the objects, 3) engineering the networks and objects to understand and manipulate the regulatory mechanisms and 4) integrating various omes and omics subfields. (scialert.net)
  • The interacting genes are involved in a range of cellular processes including gene expression, mitochondrial function, and membrane sorting/protein trafficking. (biomedcentral.com)
  • Genes involved in transcription, RNA processing, mitochondrial function and membrane sorting/protein trafficking were prevalent. (biomedcentral.com)
  • The human and mouse ART genes map to chromosomal regions with conserved linkage synteny. (indexindex.com)
  • Interestingly, these organisms also lack genes for ADP-ribosylhydrolases, the enzymes that reverse protein ADP-ribosylation. (indexindex.com)
  • Like Rb protein, many of the proteins encoded by tumor suppressor genes act at specific points in the cell cycle. (medscape.com)
  • This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. (wikipedia.org)
  • This gene is found in the large histone gene cluster on chromosome 6. (nih.gov)
  • These results suggested that the testis-specific linker histone, H1T, possesses a specific function to produce the chromatin architecture required for proper chromosome regulation, such as homologous recombination. (nih.gov)
  • This gene is found in a histone cluster on chromosome 1. (anticorps-enligne.fr)
  • The centromere is an essential chromosomal region required for accurate chromosome segregation. (researchgate.net)
  • B) Recombination rate of recurrence was mapped in two hereditary intervals in the chromosome I gene cluster described by (hereditary map placement -2.51 to 0.00) and (genetic map placement 0.00 to +2.07). (estme.org)
  • Cytosine modifications directly affect the positioning of nucleosomes (the first level of chromatin organization into chromosome involving the DNA chain wound around a core of 8 histone proteins), and recruit chromatin-modifying complexes that modify histones. (i-sis.org.uk)
  • Mosaic) aneuploidies and chromosomal rearrangements are a frequent cause of idiopathic MCA/MR. Starting in 1959 with the identification of trisomy-21 as the genetic basis of Down syndrome [ 10 ], microscopic observation of metaphase chromosomes has for several decades been the method of choice for detecting chromosome abnormalities in MCA/MR patients. (biomedcentral.com)
  • Methylated and non methylated DNA sequences are involved in gene expression of RNA and proteins, beside their role in the structural organization of the DNA sequence and the chromosome. (scialert.net)
  • EDMD1 is caused by mutations in the EMD gene on the X chromosome that codes for the nuclear envelope protein emerin. (medscape.com)
  • For example, the TP53 gene, located on chromosome 17, encodes a 53-kd nuclear protein that functions as a cell cycle checkpoint. (medscape.com)
  • Poly(ADP-ribose) binding properties of histone H1 variants. (nih.gov)
  • Community-led discussions at the EMBO Workshop on Histone Variants in 2011 resulted in agreement amongst experts on a revised systematic protein nomenclature for histones, which is based on a combination of phylogenetic classification and historical symbol usage. (biomedcentral.com)
  • There are multiple histone H3, H2A and H1 protein variants which replace the canonical histones at specific sites in the genome. (biomedcentral.com)
  • Recent achievements highlight the accelerated development of epigenetics, such as the definition of a human DNA methylome at single-nucleotide resolution, the various discoveries of histone variants and modifications, the study of the CpG island in the genome, and the progress of genome-wide nucleosome positioning maps ( Baldi, 2019 ). (frontiersin.org)
  • For example, histone variants and histone modifications can influence local chromatin structure, either directly or indirectly. (nature.com)
  • In such a crowded molecular picture, recent exciting insights have uncovered the role of histone variants as key regulators of the chromatin structure. (aging-us.com)
  • Compared to the canonical ones, histone variants contain limited amino acid differences or unique domains with distinct biochemical properties. (aging-us.com)
  • Incorporation of histone variants confers variability to the chromatin and expands the repertoire of epigenetic marks in a functional alphabet that controls genome plasticity and dynamics [ 4 ]. (aging-us.com)
  • Binding of sequence-specific transcription factors and associated chromatin-modifying enzymes can induce post-translational modification of histone tails and can facilitate nucleosome removal [ 3 - 5 ], which can turn functional sequences such as promoters and enhancers into active, nucleosome-depleted sites [ 2 ]. (biomedcentral.com)
  • Here, we summarize the different types of epigenetic enzymes which target corresponding protein domains, emphasize DNA methylation , histone modifications, and microRNA-mediated cooperation with epigenetic modification, and highlight recent achievements in developing targets for epigenetic inhibitor therapy. (frontiersin.org)
  • Epigenetics, such as DNA methylation and post-translational histone modifications, plays a vital role in Down syndrome. (lncrnablog.com)
  • Integration of the massive amounts of epigenomic data, including DNA methylation and histone modifications, thus represents a major hurdle for understanding how chromatin organization governs cell identity epigenetically. (biomedcentral.com)
  • In this issue of Genome Biology, Fortin and Hansen report how they have used such a principle to predict chromosomal compartments from epigenetic domains as defined by DNA methylation data [ 9 ]. (biomedcentral.com)
  • Conversely, maternal cytosine methylation is protected from hydroxylation by the PGC7/Dppa3/Stella protein and methylation pattern is effectively maintained. (i-sis.org.uk)
  • H3K9me2 was found at several paternally methylated imprinted regions in sperm, suggesting that this histone mark signals special sites of the paternal genome where methylation is maintained. (i-sis.org.uk)
  • Small RNAs including short-interfering (si)RNAs and piRNAs, and long RNAs such as long intergenic noncoding (linc)RNAs can direct histone modifications and cytosine methylation. (i-sis.org.uk)
  • Histone lysine methylation is part of the histone code that regulated chromatin function and epigenetic control of gene function. (embl-heidelberg.de)
  • This gene is intronless and encodes a member of the histone H4 family. (wikipedia.org)
  • Electrophoretic mobility shift analysis using nuclear extracts obtained from RAW264 cells and from the promonocytic cell line U-937 revealed the formation of at least three distinct protein-DNA complexes at each of these sites, one of which was found to contain the transcription factor Sp1. (uni-frankfurt.de)
  • Membrane presentation of PCP complexes containing Van Gogh-like (VANGL) transmembrane proteins is central to PCP and can be directed by the scaffold protein scribble (SCRIB). (bvsalud.org)
  • In Madin-Darby canine kidney cells, in which the enrichment of VANGL2-GFP proteins at cell-cell contacts represents activated PCP complexes, endogenous OTULIN was recruited to these sites. (bvsalud.org)
  • In humans and other eukaryote organisms, normal DNA is packed into cell nuclei by tightly wrapping it around closely bunched clusters of protein complexes called histone octamers. (genengnews.com)
  • Here, we focus essentially on the histone variant H3.3 and the associated complexes that selectively regulate its homeostasis and dynamics. (aging-us.com)
  • Tra1 is an essential 437-kDa component of the Saccharomyces cerevisiae SAGA/SLIK and NuA4 histone acetyltransferase complexes. (biomedcentral.com)
  • The p16INK4A protein is a cell-cycle inhibitor that acts by inhibiting activated cyclin D:CDK4/6 complexes, which play a crucial role in the control of the cell cycle by phosphorylating Rb protein. (medscape.com)
  • The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. (wikipedia.org)
  • Relaxed Chromatin Formation and Weak Suppression of Homologous Pairing by the Testis-Specific Linker Histone H1T. (nih.gov)
  • Linker histone variant H1T targets rDNA repeats. (nih.gov)
  • The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. (anticorps-enligne.fr)
  • In multicellular organisms, there is a histone H1 bound to the linker region between two nucleosomes, which binds to the region where DNA enters and exits the nucleosome. (biomedcentral.com)
  • Among these regulatory processes, core and linker histones are subjected to a large pattern of posttranslational modifications (PTMs) that influence chromatin state and DNA accessibility [ 4 - 7 ]. (aging-us.com)
  • In 5 of 6 gene mutations that have been shown to cause EDMD, the affected protein is present in the LINC (linker of nucleoskeleton and cytoskeleton) complex. (medscape.com)
  • The core histones can be extensively modified on their N- and C-terminal tails and globular domains, and these modifications may change binding sites for regulatory factors or neutralize the charge of lysine residues via acetylation. (biomedcentral.com)
  • The three-dimensional organization of chromosomes into TADs corresponds with epigenetically defined domains that are marked by specific histone modifications [ 2 ]. (biomedcentral.com)
  • The machine learning technique known as 'random forests' applied to genomic data profiling histone modifications by means of chromatin immunoprecipitation and sequencing (ChIP-Seq) has recently allowed the prediction of Hi-C matrices and TAD borders [ 7 ]. (biomedcentral.com)
  • Conversely histone modifications can affect recruitment of cytosine methylases and demethylases. (i-sis.org.uk)
  • Similarly, the large ribosomal RNA gene clusters that reside on different chromosomes manage to find each other in almost every cell nucleus to form another easily discernable nuclear entity, the nucleolus [ 27 - 29 ]. (biomedcentral.com)
  • We have classified these motifs into three types according to their sequence similarity and have found that they are prevalent in many eukaryotic nuclear proteins in single or multiple copies. (embl.de)
  • This complex includes nuclear membrane integral and associated proteins including emerin, lamin A/C, SUN1, SUN2, nesprin-1, and nesprin-2 that are proposed to form a mechanical link between the nucleoskeleton and cytoskeleton. (medscape.com)
  • Emerin is a ubiquitous inner nuclear membraneprotein, presentin nearly all cell types, although its highest expression is in skeletal and cardiacmuscle.Emerin binds to many nuclear proteins, including several gene-regulatory proteins (eg, barrier-to-autointegration factor, germ cell-less, Btf), nesprins (proteins that act as molecular scaffolds), F-actin, and lamins. (medscape.com)
  • New mutations have been found in the synaptic nuclear envelope protein 1 ( SYNE1 ) gene and in the synaptic nuclear envelope protein 2 ( SYNE2 ) gene in a few families, also termed Nesprin-1 and Nesprin-2, respectively. (medscape.com)
  • Whatever the true mechanism, the discovery of mutations in several different nuclear membrane proteins that cause similar diseases will likely eventually lead to a better understanding of nuclear membrane physiology and the pathophysiology of diseases caused by mutations in these proteins. (medscape.com)
  • Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. (wikipedia.org)
  • This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). (anticorps-enligne.fr)
  • The basic unit of chromatin in eukaryotes, the nucleosome, consists of 147 base pairs (bp) of DNA wrapped around an octamer of four core histones, comprising an H3-H4 tetramer and two H2A-H2B dimers. (biomedcentral.com)
  • Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). (multxpert.com)
  • This prompted a collaboration between histone experts, the Human Genome Organization (HUGO) Gene Nomenclature Committee (HGNC) and Mouse Genomic Nomenclature Committee (MGNC) to revise human and mouse histone gene nomenclature aiming, where possible, to follow the new protein nomenclature whilst conforming to the guidelines for vertebrate gene naming. (biomedcentral.com)
  • This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl-heidelberg.de)
  • Human and mouse histone gene symbols previously followed a genome-centric system that was not applicable across all vertebrate species and did not reflect the systematic histone protein nomenclature. (biomedcentral.com)
  • PGC7/Dpp3a/Stella is targeted to the genome via binding to the heterochromatic histone mark H3K9me2 (this refers to a specific amino acid lysine in position 9 on histone H3 that has 2 methyl groups added). (i-sis.org.uk)
  • After fertilization, the sperm genome is rapidly stripped of protamines and most, but not all histones. (i-sis.org.uk)
  • To fit it into a nucleus with a diameter of ~10 μm, DNA is wrapped around histone octamers, creating strings of nucleosomes that can be further organized into higher-order levels of compaction [ 1 ]. (biomedcentral.com)
  • The HMG family of proteins comprises members with multiple HMG domains that bind DNA with low sequence specificity, and members with single HMG domains that recognize specific nucleotide sequences. (embl.de)
  • It belongs to a family of proteins called collectins, which consists of collagenous region and a carbohydrate recognition domain (Taylor et al. (springeropen.com)
  • The DNA in all eukaryotic cells is packaged with histones to form chromatin. (biomedcentral.com)
  • Most eukaryotic centromeres are defined epigenetically by the histone H3 variant, centromere protein (CENP)-A, yet how its self-propagation is achieved remains poorly understood. (researchgate.net)
  • Given the considerable stability of the nucleosome, eukaryotic cells employ a staggering array of interconnected molecular mechanisms that locally modify the electrostatic interaction between the highly basic histones and the negatively charged DNA molecules. (aging-us.com)
  • The human hemopoietic cell kinase (HCK) is a member of the src family of protein tyrosine kinases specifically expressed in myeloid cells and to a minor extent in B-lymphoid cells. (uni-frankfurt.de)
  • Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
  • Most benefits were demonstrated in cyclin dependent-kinase 12 ( CDK12) mutated cell lines when treated with anti-programmed cell death protein 1 (PD1) therapy. (bjbms.org)
  • In addition, calcofluor white sensitivity of the strain was enhanced by the protein kinase inhibitor staurosporine, a phenotype shared with the Ada components of the SAGA/SLIK complex. (biomedcentral.com)
  • They bind to structural components (emerin, nesprin), chromatin components (histone), signal transduction molecules (protein kinase C), and several gene regulatory molecules. (medscape.com)
  • Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
  • High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. (embl.de)
  • The 32-aa MYND domain (for myeloid, Nervy, and Deaf-1) contains non-DNA-binding zinc fingers that are thought to mediate protein-protein interactions (Gross, 1996). (sdbonline.org)
  • Throughout evolution, eukaryotes adopted a network of highly conserved proteins that buffer the positive charges of histones, maintaining their solubility and, therefore, avoiding aberrant interactions with other cellular components. (aging-us.com)
  • FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
  • The structured post-SET region brings in the C-terminal residues that participate in S-adenosylmethine-binding and histone tail interactions. (embl-heidelberg.de)
  • A hierarchal cluster analysis revealed that the pattern of SSL interactions for tra1 SRR 3413 most closely resembles deletions of a group of regulatory GTPases required for membrane sorting/protein trafficking. (biomedcentral.com)
  • Chromatin Immunoprecipitation (ChIP)-Sequencing is a method use to analyse protein interactions with DNA. (frontlinegenomics.com)
  • In vitro DNA repair assays demonstrated that both BCL11B and a small recombinant BCL11B213-560 protein lacking transcription regulation potential can stimulate the enzymatic activities of two base excision repair (BER) enzymes: NTHL1 and Pol ß. (bvsalud.org)
  • We confirmed the predicted extracellular location of the ART proteins by expressing recombinant ARTs in insect cells. (indexindex.com)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • Histone cluster 1, H4j is a protein that in humans is encoded by the HIST1H4J gene. (wikipedia.org)
  • In spite of the clear association between large ( de novo ) CNVs and other SVs (collectively known as chromosomal aberrations) with MCA/MR phenotypes [ 9 ], precise characterization of molecular mechanisms that cause disease in individual patients is often unknown. (biomedcentral.com)
  • Bano D , Piazzesi A , Salomoni P , Nicotera P , . The histone variant H3.3 claims its place in the crowded scene of epigenetics. (aging-us.com)
  • Using pattern searches and position-dependent matrices, we have extracted the AT-hook motifs present in a non-redundant protein sequence database. (embl.de)
  • Remaining, the gonad arm didn't extend, and a little cluster of germ cells exists next to the vulva. (estme.org)
  • The p.Arg215Trp variant, suggested to impair NBN binding to histone γ-H2AX, was observed in one breast cancer case and one healthy control. (biomedcentral.com)
  • Protein structural analysis with this amino acid variant was performed by using I-TASSER, RAMPAGE, Swiss-PdbViewer, Chimera and I-mutant. (springeropen.com)
  • They underlie genetic disease in roughly 15% of patients with multiple congenital abnormalities and/or mental retardation (MCA/MR). In genetic diagnostics, the pathogenicity of chromosomal aberrations in these patients is typically assessed based on criteria such as phenotypic similarity to other patients with the same or overlapping aberration, absence in healthy individuals, de novo occurrence, and protein coding gene content. (biomedcentral.com)
  • In the following sections we first provide an overview of current methods for diagnostic detection and interpretation of chromosomal aberrations in MCA/MR patients. (biomedcentral.com)
  • Subsequently, the introduction and relevance of new methods for high-resolution dissection of breakpoints of chromosomal aberrations is discussed. (biomedcentral.com)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • Furthermore, proteomics and functional assays revealed an N-glycan-dependent clustering of the SLC3A2*SLC7A5 heterodimer with amino-acid /Na+ symporters (SLC1A4, SLC1A5) that balances branched-chain amino acids and Gln levels, at the expense of ATP to maintain the Na+/K+ gradient. (bvsalud.org)
  • ADP-ribosyltransferases including toxins secreted by Vibrio cholera, Pseudomonas aerurginosa, and other pathogenic bacteria inactivate the function of human target proteins by attaching ADP-ribose onto a critical amino acid residue. (indexindex.com)
  • It encodes a 248 amino acid residue transmembrane protein, MBL (NCBI accession number XP_011538118.1) which is encoded via a 3570 bp long mRNA (NCBI accession number NM_000242.21). (springeropen.com)
  • In particular, we show that the erythorid miR144/451 cluster is epigenetically repressed by RUNX1 during megakaryopoiesis. (uni-frankfurt.de)
  • A synthetic peptide of Human Acetyl-Histone H3-K27. (abclonal.com)
  • Synthetic peptide corresponding to Human Histone H3 (phospho S10). (abcam.com)
  • A prenatal diagnostic procedure in which a small amount of amniotic fluid is extracted from the amniotic sac surrounding the developing fetus to obtain information about genetic conditions, chromosomal abnormalities and fetal well-being. (frontlinegenomics.com)
  • Etiology is unknown, although chromosomal and genetic factors, radiation, and chemicals have been suggested. (msdmanuals.com)
  • Xenopus), as well as invertebrates like sea urchins and Drosophila, store large amounts of histone mRNA and proteins in the egg and start development with a series of rapid cell cycles in the absence of zygotic transcription. (biomedcentral.com)
  • Transcriptional mechanisms control the synthesis of mRNA and translational mechanisms control the synthesis of protein after mRNA has been produced. (pdfcoffee.com)
  • The activator protein itself must be bound to an inducer molecule before it attaches to mRNA. (pdfcoffee.com)
  • The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)
  • In mammalian cells this requires synthesis of about 10 8 molecules of each of the four core histone proteins. (biomedcentral.com)
  • Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the heterochromatin component M31. (embl-heidelberg.de)
  • Immunodetection of endogenous Suv39h1/SUV39H1 proteins in a variety of mammalian cell lines reveals enriched distribution at heterochromatic foci during interphase and centromere-specific localization during metaphase. (embl-heidelberg.de)
  • In addition, Suv39h1/SUV39H1 proteins associate with M31, currently the only other characterized mammalian SU(VAR) homologue. (embl-heidelberg.de)
  • The C-terminal domain shows strong sequence similarity to human, frog, and yeast Orc4 proteins, including conserved ATP-binding motifs. (embl.de)
  • The origin recognition complex (ORC) was originally identified in the yeast Saccharomyces cerevisiae as a protein that specifically binds to origins of DNA replication. (embl.de)
  • HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. (embl.de)
  • Lastly, mutations in the transmembrane protein 43 (TMEM43), also termed LUMA, which binds to emerin and SUN2, has also been reported to cause an EDMD phenotype in a few families. (medscape.com)
  • In consecutive, unselected MCA/MR patients karyotyping enables the detection of pathogenic chromosomal abnormalities in about 4% of cases (excluding Down syndrome), despite its limited resolution to about 5-10 Mb. (biomedcentral.com)
  • Structure and expression of the human gene encoding testicular H1 histone (H1t). (nih.gov)
  • This Histone H4 acetyl Lys8 antibody was raised against a peptide containing acetyl Lys8 of human Histone H4. (fishersci.com)
  • Trouvez Histone H4 Anticorps pour une variété d'espèces telles que anti-Human Histone H4, anti-Rat Histone H4, anti-Mouse Histone H4. (anticorps-enligne.fr)
  • In addition, we review the importance of histone H3.3 turnover in human health as well as its emerging role in disorders. (aging-us.com)
  • Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
  • Hence, TADs are believed to represent structural chromosomal units that are of functional importance for the regulatory cross talk that determines gene expression programs. (biomedcentral.com)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • Small DNA-binding motif first described in the high mobility group non-histone chromosomal protein HMG-I(Y). (embl.de)
  • The N-terminal domain contains nine copies of the AT-hook motif found in a number of DNA-binding proteins, including the members of the HMG-I(Y) family of chromatin proteins. (embl.de)
  • The AT-hook is a small DNA-binding protein motif which was first described in the high mobility group non-histone chromosomal protein HMG-I(Y). Since its discovery, this motif has been observed in other DNA-binding proteins from a wide range of organisms. (embl.de)
  • In general, it appears that the AT-hook motif is an auxiliary protein motif cooperating with other DNA-binding activities and facilitating changes in the structure of the DNA either as a polypeptide on its own [e.g. (embl.de)
  • It is most interesting that this motif seems to be quite specific to known or predicted chromosomal/DNA-binding proteins, suggesting that it may act as a versatile minor groove tether. (embl.de)
  • The high-mobility group (HMG) domain is a DNA-binding motif that is shared abundant non-histone components of chromatin and by specific regulators of transcription and cell differentiation. (embl.de)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Free shipping on catalog antibody and protein orders over $999. (abclonal.com)
  • Diagnosis typically requires demonstration of M-protein (sometimes present in urine and not serum but rarely absent entirely) and/or light-chain proteinuria, and excessive plasma cells in the bone marrow. (msdmanuals.com)
  • The model used to generate molecules in the proposed model was the Stacked Conditional Variation AutoEncoder (Stack-CVAE), which acts as an agent in reinforcement learning so that the resulting chemical formulas have the desired chemical properties and show high binding affinity with specific target proteins. (bvsalud.org)
  • Through gene set enrichment analysis and bi-clustering, the researchers also found that most of the differential expressed lncRNAs were closely associated with mitochondrial functions. (lncrnablog.com)
  • Adding chemical groups to the DNA backbone and modifying histone proteins impart distinct characteristics on chromatin architecture. (frontiersin.org)
  • Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
  • nsSNPs may affect the protein function by reducing protein solubility or by destabilizing protein structure (Chasman and Adams 2001 ). (springeropen.com)
  • Rarely, patients have no M-protein in blood and urine, although the currently used serum free light chain assay now demonstrates monoclonal light chains in many of these formerly so-called nonsecretory patients. (msdmanuals.com)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Transcription occurs continuously and the repressor protein must be activated to stop transcription. (pdfcoffee.com)
  • The CDK4-cyclinD complex normally phosphorylates the retinoblastoma protein (Rb protein), leading to release of the E2F transcription factor and cell cycle progression. (medscape.com)
  • TIF) pgen.1007992.s004.tif (1.3M) GUID:?0A483216-CC7A-4068-BB5D-FB71DA7EC401 S5 Fig: SMRC-1 sign in distal germline nuclei normalized to histone H3. (estme.org)
  • Many of these proteins are regulators of gene expression. (embl.de)
  • Beyond this protective role, Mrr can inflict chromosomal DNA damage that elicits the SOS response in the host cell upon heterologous expression of specific methyltransferases such as M.HhaII, or after exposure to high pressure (HP). (uci.edu)
  • One nsSNP Gly54Asp (rs1800450) was found to be deleterious and damaging by both SIFT and Polyphen-2 servers and thus affecting MBL2 protein stability and expression. (springeropen.com)