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  • suggest that clozapine
  • Data from a retrospective chart review of patients admitted with a DSM-IV diagnosis of treatment-resistant dementia and symptoms of agitation suggest that clozapine may be beneficial for the treatment of this condition [Lee . (drugs.com)
  • Data from a meta-analysis evaluating several small randomized, controlled trials suggest that clozapine may be beneficial for the treatment of psychosis in patients in Parkinson disease [Frieling . (drugs.com)
  • There is evidence to suggest that clozapine may improve social and occupational functioning and quality of life and may reduce affective symptoms, hospitalizations, secondary negative symptoms, and tardive dyskinesia. (mentalhealth.com)
  • It is also of interest to DREADDs researchers - the DREADD ligand CNO is metabolised to clozapine, and recent reports suggest that clozapine itself may have high affinity and potency for DREADDs. (prweb.com)
  • 1990
  • Drew KL, O'Connor WT, Kehr J, Ungerstedt U (1990) Regional specificity of clozapine and haloperidol on GABA and dopamine release in rat basal ganglia. (springer.com)
  • acute
  • Clozapine-related myocarditis or acute viral myocarditis following a throat infection then was suspected, clozapine therapy was withdrawn, and the patient was transferred into the ICU. (redorbit.com)
  • Ivax
  • Meanwhile, IVAX Pharmaceuticals Inc., a Florida company, reached out to Reinstein to try to get him to switch his patients to its generic version of clozapine, the suit said. (dailypress.com)
  • symptoms
  • Also, the investigators should gain a greater understanding of the possible benefits of adding another antipsychotic to clozapine in relation to particular problem symptoms, and a person's ability to live and work in the community. (clinicaltrials.gov)
  • hypersensitivity
  • We report a case of hypersensitivity myocarditis secondary to clozapine administration that was diagnosed in vivo for the first time through endomyocardial biopsy and was successfully treated with corticosteroids. (redorbit.com)
  • patients
  • There is little guidance on the management of patients who discontinue clozapine for reasons such as lack of response, intolerance, or noncompliance. (biomedsearch.com)
  • effects
  • 4. What are the side effects and risks associated with clozapine? (mentalhealth.com)
  • While clozapine can provide great benefits, it can rarely cause serious, possibly fatal side effects. (webmd.com)
  • To describe the drug's effects on mortality, we compared rates of various causes of death in 67,072 current and former clozapine users. (rti.org)
  • The Tribune-ProPublica investigation documented how clozapine posed potential serious side effects, including enlargement of the heart and increased seizure risk. (dailypress.com)
  • side
  • Constipation is a common side effect from clozapine, but in rare cases this may develop into a very serious conditon, so it's important to seek treatment as soon as you can. (mind.org.uk)
  • unusual
  • We describe the first case of a sleep polygraphically documented rebound insomnia with an unusual somatic fatigue syndrome after long-term use of clozapine in a 30-year-old schizophrenic male. (springer.com)
  • cause
  • Clozapine can cause low blood pressure or a slow heartbeat, which can make you dizzy or cause you to faint when you stand up. (webmd.com)
  • people
  • Clozapine decreases hallucinations and helps prevent suicide in people who are likely to try to harm themselves. (webmd.com)
  • New Zealand-led research published this week says clozapine, which is used by 4300 people in this country for conditions including schizophrenia, can lead to constipation and, occasionally, complete bowel obstruction. (radionz.co.nz)
  • White blood cell count monitoring is mandatory for all people taking clozapine. (cochrane.org)