• Clostridial gas gangrene is a highly lethal necrotizing soft tissue infection of skeletal muscle caused by toxin- and gas-producing Clostridium species. (medscape.com)
  • More than 150 Clostridium species have been identified, but only 6 have been demonstrated to be capable of producing the fulminant condition known as clostridial gas gangrene. (medscape.com)
  • Clostridium perfringens, previously known as Clostridium welchii, is the most common cause of clostridial gas gangrene (80-90% of cases). (medscape.com)
  • Similarly, extreme pain may be an indication of infection with clostridial species (ie, gas gangrene). (medscape.com)
  • Gas gangrene due to Clostridium species is a very serious infection, often resulting in amputation. (medscape.com)
  • Clostridium perfringens is the classic organism responsible for "gas gangrene" or clostridial myonecrosis, although any Clostridial species can produce such infections. (crashingpatient.com)
  • General Information: The species type strain, originally isolated from a human gas gangrene patient. (up.ac.za)
  • Anaerobic infections of soft tissue include anaerobic cellulitis, necrotizing fasciitis, clostridial myonecrosis (gas gangrene), anaerobic streptococcal myositis or myonecrosis, synergistic nonclostridial anaerobic myonecrosis, and infected vascular gangrene. (evexiadiagnostics.com)
  • Clostridium species are obligate anaerobic, endospore-forming bacilli that usually colonize in the gastrointestinal tracts of humans. (cdc.gov)
  • It was challenging to distinguish C. innocuum from other Clostridium species (especially C. ramosum and C. clostridioforme , together called the RIC group) because of their similar phenotypes of atypical clostridial colonial morphology, rare spore-forming features, and fatty acid pattern ( 3 - 5 ). (cdc.gov)
  • Although vancomycin is one of the recommended antimicrobial drugs to treat infections caused by Clostridium species, especially C. difficile , intrinsic resistance to vancomycin in C. innocuum poses the risk for inappropriate treatment for patients who acquire C. innocuum infection ( 12 ). (cdc.gov)
  • Clostridial necrotizing enteritis is necrosis of the jejunum and ileum caused by Clostridium perfringens . (msdmanuals.com)
  • Clostridium species, as a predominant cluster of commensal bacteria in our gut, exert lots of salutary effects on our intestinal homeostasis. (biomedcentral.com)
  • Up to now, Clostridium species have been reported to attenuate inflammation and allergic diseases effectively owing to their distinctive biological activities. (biomedcentral.com)
  • In turn, our diets and physical state of body can shape unique pattern of Clostridium species in gut. (biomedcentral.com)
  • In view of their salutary performances, Clostridium species have a huge potential as probiotics. (biomedcentral.com)
  • Given this, this review summarized the researches involved in benefits and potential risks of Clostridium species to our health, in order to develop Clostridium species as novel probiotics for human health and animal production. (biomedcentral.com)
  • Species of Clostridium cluster XIVa and IV, as the representatives of the predominant bacteria in gut, account for 10-40% of the total bacteria [ 5 ]. (biomedcentral.com)
  • It was reported that species of Clostridium clusters XIVa and IV were essential for normalization of germfree mice [ 6 ]. (biomedcentral.com)
  • Furthermore, Clostridium species are potent candidates to alleviate dysfunctions and disorders in intestine. (biomedcentral.com)
  • But it should be noted that there is still safety concern about the exotoxin secretion of some Clostridium species, like alpha-toxin and enterotoxin from Clostridium perfringens ( C. perfringens ), toxin A and toxin B from Clostridium difficile ( C. difficile ) [ 10 , 11 ]. (biomedcentral.com)
  • Meanwhile, the efficiency of Clostridium species must be considered when applied to animal production and diseases treatment. (biomedcentral.com)
  • So this review summarized the reports about both the benefits and underlying risks from Clostridium species on intestinal immune regulation and disease prevention to elucidate the potentials and challenges of their novel roles as probiotic. (biomedcentral.com)
  • But with the further in-depth studies of Clostridium species, the heterogeneities among them become more and more noteworthy. (biomedcentral.com)
  • The Clostridium species discussed in this review is based on this new criterion. (biomedcentral.com)
  • In the intestine of human and animals, Clostridium species, as one of the richest bacterial cluster, are mainly composed of Clostridium cluster IV and XIVa (Fig. 1 ). (biomedcentral.com)
  • cluster XIVa, also known as Clostridium coccoides group, consists of 21 species. (biomedcentral.com)
  • Dubbed "clostridial clusters," these microbes are distantly related to Clostridium difficile, a scourge of hospitals and an all too frequent cause of death by diarrhea. (lactobacto.com)
  • Spontaneous metastatic clostridial myonecrosis is a rare condition caused by Clostridium septicum . (oaepublish.com)
  • The heavy chain is responsible for both receptor some species of the genus Clostridium, in particular, Clostridium binding via its C-terminal (CT) binding domain [4,5] (HC) and botulinum, C. butyricum, C. baratii, and C. argentinense. (cdc.gov)
  • The synonym clostridial myonecrosis better describes both the causative agent and the target tissue. (medscape.com)
  • [ 1 ] Ninety percent of contaminated wounds demonstrate clostridial organisms, but fewer than 2% develop clostridial myonecrosis. (medscape.com)
  • Clostridial myonecrosis may occur following surgery, most often of the gastrointestinal or biliary tract, and following septic abortions. (medscape.com)
  • Clostridial myonecrosis infections develop rapidly, and patients present with symptoms of pain, sepsis, and delirium. (medscape.com)
  • Streptococcal myonecrosis infections develop more slowly than clostridial infections. (medscape.com)
  • The diagnosis was clostridial myonecrosis. (medscape.com)
  • Metastatic clostridial myonecrosis is an uncommon complication of malignancy, particularly of the gastrointestinal tract, and of leukemia. (oaepublish.com)
  • Biopsy culture is particularly useful in establishing the diagnosis of anaerobic osteomyelitis, 2 clostridial myonecrosis, intracranial actinomycosis, and pleuropulmonary infections. (evexiadiagnostics.com)
  • These infections, particularly clostridial myonecrosis, necrotizing fasciitis, and nonclostridial anaerobic myonecrosis, may be fulminant and are frequently characterized by the presence of gas and foul-smelling necrotic tissue. (evexiadiagnostics.com)
  • Overview of Clostridial Infections Clostridia are spore-forming, gram-positive, anaerobic bacilli present widely in dust, soil, and vegetation and as normal flora in mammalian gastrointestinal tracts. (msdmanuals.com)
  • C. botulinum is one of several species of clostridia that cause human disease. (merckmanuals.com)
  • Clostridia are the oldest known disease causing agent (pathogen) affecting livestock and other species. (msd-animal-health.ie)
  • C. innocuum -infected patients experienced more extraintestinal clostridial infection and gastrointestinal tract-related complications than did patients with CDI. (cdc.gov)
  • Although the bacterium was considered less pathogenic and seldom caused infections previously, more and more clinical evidence has emerged since 2000s, suggesting C. innocuum might be a potential cause of antibiotic-associated diarrhea and of extraintestinal clostridial infection (EICI), such as bacteremia, intra-abdominal infection, and endocarditis ( 8 - 10 ). (cdc.gov)
  • Clostridial necrotizing enteritis is a mild to severe clostridial infection, which can be fatal if not treated promptly. (msdmanuals.com)
  • Cats and dogs are reasonably resilient against Clostridial disease and infection is uncommon. (franklinvets.co.nz)
  • Noromectin Injection is to be given subcutaneously only, to reduce risk of potentially fatal clostridial infection of the injection site. (entirelypets.com)
  • It is not known how long the clostridial diseases whose principal infection site is the muscle have been recognized. (castrator.com)
  • have has been incorporated into vaccines, making it possible to vaccinate against all significant clostridial disease whose principal infection site is the muscle. (castrator.com)
  • The relationship between mothers, infants, and bifidobacterial species appears to have co-evolved over mammalian history [ 14 ], perhaps to aid the infant in avoiding infection. (biomedcentral.com)
  • Without treatment the mortality rate reaches 100% within 48 h. [ 1 - 4 ] A number of reports have demonstrated the association between atraumatic clostridial infection and internal malignancy. (oaepublish.com)
  • Most are exceptionally "clean" mice that have a defined microbial flora (which means they are gnotobiotic) consisting of 3 organisms: one Bacillus and two Clostridial species and are free of aerobic and Gram-negative bacteria. (uclahealth.org)
  • Bacterial pathogens of concern would be Clostridial organisms (such as C. perfringens, C. botulinum, or C. novyi ), Salmonella species, or E. coli . (ncsu.edu)
  • Clostridial organisms can cause a variety of disease syndromes, depending on the type you are dealing with. (ncsu.edu)
  • However detection of SIBO in cats is controversial as reliable criteria for diagnosis have not been established and it is recognised that particularly high numbers of bacteria exist in the small intestine of healthy cats compared to other species. (vin.com)
  • This showed significant changes in some bacteria with increased numbers of E.coli and Clostridial spp. (vin.com)
  • This bacteria is considered beneficial and is one of the most prevalent intestinal bacterial species in healthy adults. (lactobacto.com)
  • Diagnosis of clostridial necrotizing enteritis is based on clinical presentation plus the presence of C. perfringens type C toxin in stool. (msdmanuals.com)
  • A page about clostridial diseases describing cause, clinical signs, diagnosis and control. (msd-animal-health.ie)
  • Detection of 5 histotoxic clostridial species by the fluorescent antibody method. (tamu.edu)
  • Clostridial histotoxic infections. (edu.au)
  • A variant of necrotizing fasciitis type I is saltwater necrotizing fasciitis, in which an apparently minor skin wound is contaminated with saltwater containing a Vibrio species . (medscape.com)
  • Clostridial necrotic enteritis is a relatively common disease in avian species. (sklep.pl)
  • Campylobacter jejuni and Campylobacter coli are the most frequently isolated Campylobacter species in humans with gastroenteritis. (sklep.pl)
  • There are dozens of different Clostridial species, some of these diseases are common and well known such as tetanus and blackleg however, there are many diseases that you've never heard of and range from common to very rare. (franklinvets.co.nz)
  • Cultures grew Streptococcus milleri and anaerobes (Prevotella species). (medscape.com)
  • This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. (up.ac.za)
  • The ratio of anaerobes to facultative species is normally about 10:1 in the mouth, vagina, and sebaceous glands and at least 1000:1 in the colon. (evexiadiagnostics.com)
  • Different animal species vary in their susceptibility to Clostridial diseases. (franklinvets.co.nz)
  • C perfringens produces at least 17 identifiable exotoxins that are used for species typing (eg, type A, type B, type C). (medscape.com)
  • C. perfringens have been developed and the species became a model organism in clostridial genetic studies. (up.ac.za)
  • There are a large number of syndromes associated with clostridial disease in cattle and sheep, each with distinct risk factors, clinical signs and control. (msd-animal-health.ie)
  • C. difficile is one of the most representative clostridial species to cause human disease and has been well investigated. (cdc.gov)
  • C. difficile is a normal inhabitant of the gastrointestinal tract of many species of mammals and has been isolated from bird feces. (sklep.pl)
  • Conditions, irrespective of cause, that impede the circulation of oxygen-carrying blood, create an anaerobic environment that can result in the germination of local spores (one or all three clostridial species). (castrator.com)
  • This gap in protection has led to the development of several other Clostridial vaccines with a range of names. (franklinvets.co.nz)
  • It is important that Clostridial vaccines are stored in the fridge but must not be allowed to freeze as this will destroy the vaccinal components. (franklinvets.co.nz)
  • The Minor Use Minor Species (MUMS) law is supposed to make it easier for drug companies to get approvals for sheep. (sheep101.info)
  • This also alserviles text to be queried at a elevateder unembellished with (e.g. seeing that all protein kinases or Mycobacterium species). (upb.ro)
  • The latter species produce high amounts of toxins. (castrator.com)
  • In addition to using a drug that is not labeled for a particular species or class, giving a higher dosage of an 'approved' drug or administering it in a different manner (SQ vs. IM) also constitutes extra-label drug use. (sheep101.info)
  • Variable species sensitivity exists with horses the most sensitive and cattle the least. (msd-animal-health.ie)
  • The Covexin 10in1 vaccine is considered the Rolls Royce of clostridial control. (franklinvets.co.nz)
  • Antibodies from UC patients greatly enhanced the respiratory burst in PMN, in response to individual bacterial species. (bmj.com)
  • Clostridial diseases are a group of infections that cause sudden death in animals. (franklinvets.co.nz)
  • For example, goats and Camelids such as alpacas/llamas are very susceptible to contracting Clostridial diseases and protection is essential. (franklinvets.co.nz)
  • Usually, more than 1 species is isolated from clinical specimens. (medscape.com)
  • Clostridial spores can survive in the soil indefinitely and are very resistant to most disinfectants. (franklinvets.co.nz)
  • Clostridial diseases of the muscle group are widespread. (castrator.com)
  • Cultures revealed gram-negative Pseudomonas species and Bacteroides fragilis. (medscape.com)
  • Seldom does a stockman view the methods used to "prod" animals as a trigger for clostridial diseases of the muscle. (castrator.com)
  • Furthermore, feces containing different bifidobacterial species possessed differing amounts of oligosaccharides, suggesting differential consumption in situ . (biomedcentral.com)
  • However, if the newborn does not receive adequate amounts of colostrum or if the mother was not vaccinated, they will be vulnerable to sudden deaths from Clostridial disease. (franklinvets.co.nz)