Clorgyline, an MAO-A inhibitor, induces secretory differentiation of normal prostate cells. (biomedcentral.com)
Chronic (21 days) treatment with the selective monoamine oxidase (MAO)-A inhibitor clorgyline, but not with the MAO-B inhibitor deprenyl in pithed rats leads to increased blood pressure responses to sympathetic stimulation and intravenous tyramine, and to elevated unstimulated heart rates. (johnshopkins.edu)
1998). On the other hand, the MAO-A inhibitor clorgyline, which raises serotonin amounts, stimulates TrkB activation in the C3H/f+/+ mice however, not in the C57BL/6 mice (Jang et al. (imacst.com)
2010). Oddly enough, clorgyline just activates TrkB in C3H/f+/+.Because deprenyl, an MAO-B inhibitor will not stimulate NAS or serotonin amounts, it is struggling to result in TrkB activation if the light is on or off. (imacst.com)
Clorgyline is definitely a book broad-spectrum inhibitor of two classes of fungal efflux pushes that functions synergistically with azoles against azole-resistant and strains. (gasyblog.com)
Supplementary assays of pump function verified that clorgyline is definitely a broad-spectrum inhibitor of many fungal efflux pushes, including Mdr1p, that are believed to lead to azole resistance. (gasyblog.com)
The enzyme activity was sensitive to the specific inhibitor clorgyline in a concentration dependant manner, particularly in the late incubation period. (bvsalud.org)
Similar abnormalities were observed when embryos were cultured in the presence of the MAO-A inhibitor clorgyline or when the transcriptional inhibitor of MAO-A expression Rl was overexpressed. (ntu.ac.uk)
Rat pheochromocytoma PC12 cells were incubated with hydroxytyrosol (10 µM, 180 min) alone or with the MAO-A inhibitor clorgyline (1 nM) or the MAO-B inhibitors rasagiline or selegiline (0.5 µM). (tau.ac.il)
Monoamine1
Combining the monoamine oxidase inhibitors, clorgyline (MAOn selective) or deprenyl (MAOB selective) with MDAI did not result in any long-term reductions of serotonergic markers. (erowid.org)
Deprenyl1
Both the cytotoxic and neurotoxic effects of MPTP were reduced by the MAO inhibitors deprenyl and, to a lesser extent, clorgyline.Alleviation of both neurotoxicity and cytotoxicity was also achieved by glial conditioned medium, derived from C6 cells. (ntu.ac.uk)
Pargyline1
Most MAO inhibitors increase 5-HT content of the different brain regions to a greater extent than NA e.g. iproniazid, tranylcy promine, malamide, phenelzine pargyline, pheniprazine (Catron), phenyli sobutylhydrazine (JB 835j, y -morpholinobutyrophenone, isocarboxazide and clorgyline. (erowid.org)
We examined the effects of clorgyline on the transcriptional program of epithelial cells cultured from high grade PCa (E-CA). (biomedcentral.com)
Effect3
In addition, genes downregulated ≥ 2-fold by clorgyline were significantly enriched with those upregulated by key oncogenes including beta-catenin and ERBB2, indicating an anti-oncogenic effect of clorgyline. (biomedcentral.com)
Another striking effect of clorgyline was the induction of androgen receptor (AR) and classic AR target genes such as prostate-specific antigen together with other secretory epithelial cell-specific genes, suggesting that clorgyline promotes differentiation of cancer cells. (biomedcentral.com)
Indeed, many genes in the PcG repression signature that predicts PCa outcome were upregulated by clorgyline, suggesting that the differentiation-promoting effect of clorgyline may be mediated by its downregulation of EZH2. (biomedcentral.com)
Administration2
Autonomic and Behavioral Thermoregulation in the Golden Hamster during Subchronic Administration of Clorgyline. (epa.gov)
Identical raises of spontaneously AZD3463 energetic neurons have been reported pursuing chronic administration of varied antidepressants such as for example citalopram clorgyline fluoxetine and paroxetine (Chenu et al 2009 Sekine et AZD3463 al 2007 The long term administration of agomelatine also induced an adjustment of the design of release of VTA-DA neurons. (tech-strategy.org)
Expression3
We systematically assessed gene expression changes induced by clorgyline in E-CA cells using high-density oligonucleotide microarrays. (biomedcentral.com)
The expression of 156 genes was significantly increased by clorgyline at all time points over the time course of 6 - 96 hr identified by Significance Analysis of Microarrays (SAM). (biomedcentral.com)
Moreover, clorgyline downregulated EZH2, a critical component of the Polycomb Group (PcG) complex that represses the expression of differentiation-related genes. (biomedcentral.com)
Iproniazid1
Following pretreatment with iproniazid, clorgyline, or deprenyl, 5-HT and 5-MT produced a marked disruption of the CAR, with 5-HT also decreasing the number of Pits. (erowid.org)
Phenelzine1
17. The MAO inhibitors phenelzine and clorgyline revert enzalutamide resistance in castration resistant prostate cancer. (nih.gov)