Clopidogrel platelet aggregation inhibitors. Medical search. Frequent questions

Thienopyridines include ticlopidine (first generation), clopidogrel (second generation), and the most recent addition, prasugrel (third generation). (jabfm.org)
The active metabolite of ticlopidine prevents binding of adenosine diphosphate (ADP) to its platelet receptor, impairing the ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. (lgmpharma.com)
By blocking the amplification of platelet activation by released ADP, platelet aggregation induced by agonists other than ADP is also inhibited by the active metabolite of ticlopidine. (lgmpharma.com)
Ticlopidine is a platelet aggregation inhibitor structurally and pharmacologically similar to clopidogrel. (lgmpharma.com)
When taken orally, ticlopidine causes a time- and dose-dependent inhibition of both platelet aggregation and release of platelet granule constituents, as well as a prolongation of bleeding time. (lgmpharma.com)
It has been proposed that 1 or more active metabolites may account for ticlopidine's activity, because ticlopidine itself is an extremely weak platelet aggregation inhibitor in vitro at the concentrations achieved in vivo. (lgmpharma.com)

Additionally, novel P2Y12 receptor antagonists such as prasugrel and ticagrelor are even recommended over clopidogrel in certain clinical guidelines. (nih.gov)
Despite the fact that clopidogrel is fraught with significant variability in on-treatment platelet reactivity, the novel P2Y12 receptor antagonists come at the price of increased side effects and cost. (nih.gov)
Cangrelor, sold under the brand name Kengreal among others, is a P2Y12 inhibitor FDA approved as of June 2015 as an antiplatelet drug for intravenous application. (wikipedia.org)
Some P2Y12 inhibitors are used clinically as effective inhibitors of adenosine diphosphate-mediated platelet activation and aggregation. (wikipedia.org)
Cangrelor is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. (wikipedia.org)
Thienopyridines are a group of drugs whose metabolites bind irreversibly to adenosine diphosphate (ADP) receptors on platelets (P2Y12 receptors), resulting in the inhibition of ADP-induced platelet activation and aggregation. (jabfm.org)
These drugs, unlike thienopyridines, bind reversibly, but directly without biotransformation, to P2Y12 receptors on platelets and hence inhibit platelet function. (jabfm.org)
Thienopyridines are converted to active metabolites ( Figure 1 ) that bind irreversibly to P2Y12 receptors on platelets and thereby inhibit ADP-induced platelet activation and aggregation. (jabfm.org)
P2Y12 inhibitors (thienopyridines), including clopidogrel, increase the risk of bleeding. (medlibrary.org)
P2Y12 inhibitors (thienopyridines), inhibit platelet aggregation for the lifetime of the platelet (7 to 10 days). (medlibrary.org)
It specifically inhibits the P2Y12 receptor on platelets, which is necessary for platelet activation and aggregation. (bairesdivan.com.ar)
Clopidogrel is an irreversible inhibitor of the platelet P2Y12 adenosine diphosphate receptor, leading to reduced platelet aggregation and reduced clot formation. (mapmygenome.in)
Sometimes this effect is incidental (eg, when the drugs are used to relieve pain and inflammation) and sometimes therapeutic (eg, when aspirin or the P2Y12 inhibitors are used for prevention of stroke or coronary thrombosis). (msdmanuals.com)

Clopidogrel is an anti-platelet agent that acts by a different mechanism, inhibiting adenosine diphosphate-induced platelet aggregation. (ox.ac.uk)

Compared with clopidogrel given around the time of stenting, intravenous ADP-receptor blockade with cangrelor significantly reduced the rate of stent thrombosis and myocardial infarction. (wikipedia.org)
There were numerically more vascular deaths in the clopidogrel arm versus the ticagrelor group related to myocardial infarction (14 vs. 10), heart failure (9 vs. 6), arrhythmia or sudden death (9 vs. 3), and bleeding, including hemorrhagic stroke (7 vs. 2). (acc.org)
Clopidogrel tablets are indicated to reduce the rate of myocardial infarction (MI) and stroke in patients with non-ST-segment elevation ACS (unstable angina [UA]/non-ST-elevation myocardial infarction [NSTEMI]), including patients who are to be managed medically and those who are to be managed with coronary revascularization. (medlibrary.org)
Clopidogrel tablets are indicated to reduce the rate of myocardial infarction and stroke in patients with acute ST-elevation myocardial infarction (STEMI) who are to be managed medically. (medlibrary.org)
In patients with established peripheral arterial disease or with a history of recent myocardial infarction (MI) or recent stroke clopidogrel tablets are indicated to reduce the rate of MI and stroke. (medlibrary.org)
Rationale, design and organization of the Second Chinese Cardiac Study (CCS-2): a randomized trial of clopidogrel plus aspirin, and of metoprolol, among patients with suspected acute myocardial infarction. (ox.ac.uk)
Assessing combined anti-platelet therapy in suspected acute myocardial infarction Aspirin has been shown to be effective in the emergency treatment of acute myocardial infarction. (ox.ac.uk)
The Second Chinese Cardiac Study (CCS-2) will reliably determine whether adding oral clopidogrel to aspirin for up to 4 weeks in hospital after suspected acute myocardial infarction can produce a greater reduction in the risk of major vascular events than can be achieved by giving aspirin alone. (ox.ac.uk)
Clopidogrel is an antiplatelet drug used in the management of angina ( heart attack), to reduce the risk of myocardial infarction, stroke, and peripheral artery disease. (mapmygenome.in)

As the glycoprotein GPIIb/IIIa complex is the major receptor for fibrinogen, its impaired activation prevents fibrinogen binding to platelets and inhibits platelet aggregation. (lgmpharma.com)
It irreversibly inhibits platelet cyclo-oxygenase and thereby prevents the formation of the platelet aggregating agent thromboxane A2. (ox.ac.uk)
While Plavix inhibits platelet activation, Advil reduces the production of pro-clotting prostaglandins. (bairesdivan.com.ar)

Clopidogrel , sold under the brand name, Plavix, is an antithrombotic medication used to prevent clot formation, strokes, and heart attacks in humans with heart diseases or at risk of such events. (raiseacat.com)

Moving forward, larger randomized controlled trials are required comparing TAPT versus DAPT (clopidogrel, prasugrel or ticagrelor on top of aspirin). (nih.gov)
The addition of prasugrel to aspirin for dual antiplatelet therapy has been shown to reduce the ischemic outcomes compared with clopidogrel and aspirin in combination. (jabfm.org)
Early clopidogrel versus prasugrel use among contemporary STEMI and NSTEMI patients in the US: insights from the National Cardiovascular Data Registry. (duke.edu)
Clopidogrel , prasugrel , and ticagrelor all can markedly reduce platelet function and increase bleeding. (msdmanuals.com)

In the PLATO (Platelet Inhibition and Patient Outcomes) trial, patients who were assigned to ticagrelor and underwent coronary artery bypass graft surgery (CABG) had significantly lower total and cardiovascular mortality compared with those assigned to clopidogrel. (acc.org)
The mortality reduction with ticagrelor versus clopidogrel following CABG in the PLATO trial was associated with fewer deaths from cardiovascular, bleeding, and infection complications. (acc.org)
The primary goal of the trial is to determine if the experimental arms (rivaroxaban or ticagrelor or both) are superior to the clopidogrel arm for lowering the 1-year rate of ischemic stroke, intracerebral hemorrhage, or vascular death. (clinicaltrials.gov)

Platelet activation and aggregation plays an integral role in the pathogenesis of acute coronary syndrome (ACS). (jabfm.org)
Dual anti-platelet therapy with aspirin and a thienopyridine (mainly clopidogrel) is recommended in the guidelines of national and international cardiology societies for patients with acute coronary syndrome and/or percutaneous coronary interventions. (biomedcentral.com)

Active Ingredient: Clopidogrel bisulfate. (rxegg.com)
Each pink, round, biconvex, film-coated tablet, engraved with 'CL' over '75' on one side and 'APO' on the other, contains clopidogrel bisulfate equivalent to 75 mg of clopidogrel. (rxhealthmed.ca)
Each light pink-to-pink, film-coated, capsule-shaped tablet, debossed with the number '93' on one side and the number '1717' on the other, contains 391.5 mg of clopidogrel bisulfate USP which is the molar equivalent of 300 mg of clopidogrel base. (mediresource.com)
On November 4, 2014, the Supreme Court of Canada was due to hear an appeal by generic drugs company Apotex against a decision that found it to have infringed a patent covering the blockbuster drug Plavix (clopidogrel bisulfate). (lifesciencesipreview.com)

Unlike clopidogrel (Plavix), which is a prodrug, cangrelor is an active drug not requiring metabolic conversion. (wikipedia.org)
Buy Plavix 'Clopidogrel' Online Without Prescriptions. (rxegg.com)
Order Plavix 'Clopidogrel' Online Without Prescriptions. (rxegg.com)
Cheap Plavix 'Clopidogrel' Online No Prescription. (rxegg.com)
Plavix is a platelet aggregation inhibitor. (rxegg.com)
Plavix may reduce the number of clot-forming cells (platelets) in your blood. (rxegg.com)
Plavix (generic name: clopidogrel) and Advil (generic name: ibuprofen) are both commonly used medications, but can they be taken together safely? (bairesdivan.com.ar)
Plavix works by preventing blood platelets from sticking together, while Advil can interfere with the blood's ability to clot. (bairesdivan.com.ar)
Both Plavix (clopidogrel) and Advil (ibuprofen) can affect blood clotting, but in different ways. (bairesdivan.com.ar)
Plavix is an antiplatelet medication that works by preventing blood platelets from sticking together and forming clots. (bairesdivan.com.ar)

The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole or esomeprazole. (medlibrary.org)
Generally, HIV uses CCR5 more during the initial years of the infection, however, as therapy is administered, a shift to using CXCR4 occurs.1 This means that therapy should be tailored to inhibit these receptors, since using a CCR5-specific inhibitor in the presence of dual/mixed CCR5/CXCR4 or CXCR4-only strains would be futile. (rhochistj.org)
FDA advises physicians to consider the importance of genetic testing to identify poor metabolizers of clopidogrel, who are at risk of therapeutic failure due to the inability of the drug to inhibit platelet aggregation leading to severe cardiovascular events. (mapmygenome.in)

Antiplatelets, such as aspirin and clopidogrel, prevent blood cells called platelets from clumping together to form a clot. (medlineplus.gov)

Aspirin, glycoprotein (GP) IIb/IIIa inhibitors, and clopidogrel have an inhibitory effect on platelet activation and aggregation. (medscape.com)

Further, cilostazol in addition to aspirin and clopidogrel versus DAPT in patients undergoing percutaneous coronary intervention showed that triple antiplatelet therapy (TAPT) was associated with a significantly greater platelet inhibition, reduced major adverse cardiovascular events, target lesion revascularization, and target vessel revascularization with no increased risk for a hemorrhagic event. (nih.gov)

The irreversible binding to the receptors makes these drugs capable of inhibiting platelet function for the life span of platelets (5-7 days). (jabfm.org)
Clopidogrel is an effective inhibitor of platelet activation and aggregation due to its selective and irreversible blockade of the P2Y 12 receptor. (johnshopkins.edu)

Platelet aggregation inhibitors excl. (sukl.sk)

Consider use of another platelet P2Y 12 inhibitor in patients identified as CYP2C19 poor metabolizers. (medlibrary.org)

Available antiplatelet agents, such as cyclooxygenase-1 (COX-1) inhibitors (aspirin), ADP P2Y 12 receptor antagonists, and GP IIb/IIIa receptor inhibitors, are effective and save in the treatment and prevention of thrombotic events, these drugs interfere with the platelet activation process, including adhesion, release, and aggregation. (hindawi.com)

Clopidogrel is a prodrug. (medlibrary.org)
Clopidogrel is an inactive prodrug that requires enzymatic activation through the CYP enzymes like CYP2C19. (mapmygenome.in)

aspirin rectal increases effects of clopidogrel by pharmacodynamic synergism. (medscape.com)
cangrelor decreases effects of clopidogrel by receptor binding competition. (medscape.com)
note = "Funding Information: Dr. Gurbel has a research grant from Schering and Millenium in the last 2 years studying antiplatelet effects of clopidogrel and eptifibatide in elective stenting. (johnshopkins.edu)
Dr. Gurbel has a research grant from Astra Zeneca in the last 2 years studying antiplatelet effects of clopidogrel in relation to stent thrombosis. (johnshopkins.edu)

When possible, interrupt therapy with clopidogrel for five days prior to such surgery. (medlibrary.org)
Combination antiplatelet therapy with clopidogrel and aspirin is an important strategy for patients with acute coronary syndromes and those undergoing percutaneous interventions. (johnshopkins.edu)

Valvprin ® contains clopidogrel and aspirin, both of which are powerful platelet aggregation inhibitors. (pacificpharmaceuticals.com)

Both hemostasis and thrombosis depend on the coagulation cascade, vascular wall integrity, and platelet response. (medscape.com)

The expected antiplatelet effect of a 600 mg loading dose of clopidogrel was blocked when clopidogrel was administered during a cangrelor infusion. (medscape.com)
In patients who need an antiplatelet effect within hours, initiate clopidogrel tablets with a single 300 mg oral loading dose and then continue at 75 mg once daily. (medlibrary.org)
however, platelet transfusions within 4 hours of the loading dose or 2 hours of the maintenance dose may be less effective. (medlibrary.org)

METHODS: In a multicenter, double-blind, event-driven trial, we randomly assigned infants 92 days of age or younger with cyanotic congenital heart disease and a systemic-to-pulmonary-artery shunt to receive clopidogrel at a dose of 0.2 mg per kilogram of body weight per day (467 infants) or placebo (439 infants), in addition to conventional therapy (including aspirin in 87.9% of infants). (duke.edu)
RESULTS: We enrolled 320 patients (161 patients assigned to receive clopidogrel and 159 to receive aspirin plus esomeprazole). (hku.hk)

Primary outcomes will be the proportion of cyclooxygenase-2 inhibitors prescribed in the anti-inflammatory class, and the proportion of omeprazole in the proton pump inhibitors class at 18 months post-intervention. (biomedcentral.com)
BACKGROUND: Concurrent therapy with a proton-pump inhibitor is a standard treatment for patients receiving aspirin who are at risk for ulcer. (hku.hk)
nyto Prototype S is, the anti-ulcer drugs like omeprazole and also other proton pump inhibitors, diazepam, clopidogrel, and platelet aggregation inhibitors, w Whilst CYP2C8 metabolizes rosiglitazone and paclitaxel cancer. (dna-pkinhibitors.com)
Clopidogrel and proton pump inhibitor (PPI) interaction: separate intake and a non-omeprazole PPI the solution? (biomedcentral.com)
Therefore, co-therapy with a proton pump inhibitor (PPI) is recommended by most guidelines. (biomedcentral.com)

Use of drugs that induce the activity of CYP2C19 would be expected to result in increased drug levels of the active metabolite of clopidogrel and might potentiate the bleeding risk. (medlibrary.org)
The human CYP2C subfamily consists of Imatinib VEGFR-PDGFR inhibitor four members within the group like 10q24 chromosomal localization Cen CYP2C18 and CYP2C8, CYP2C19, CYP2C9, Tel, plus they represent about 20% on the cytochrome P450 enzymes while in the human liver. (dna-pkinhibitors.com)
However, there are warnings against combining PPIs with clopidogrel because of their interactions with cytochrome P450 isoenzyme 2C19 ( CYP2C19 ). (biomedcentral.com)
The effects of the combined or separate intake of 20 mg of omeprazole and 75 mg of clopidogrel on the clopidogrel-induced inhibition of platelet aggregation were measured in four healthy subjects whose CYP2C19 exon sequences were determined. (biomedcentral.com)
Clopidogrel is a pro-drug requiring a two-step oxidation by hepatic cytochromes, including CYP2C19, 3A/5, 1A2, 2B6 , and 2C9 , to generate its active thiol metabolite [ 5 ]. (biomedcentral.com)

According to phase III randomized trials, a cangrelor-clopidogrel combination is safe and has been found to be more effective than standard clopidogrel treatment at reducing ischemic events in the heart, without increasing major bleeding in the treatment of stenotic coronary arteries. (wikipedia.org)
Potential mechanisms for dyspnea following cangrelor treatment include: repeated binding and unbinding cycles, impaired platelet turnover, and lung sequestration or apoptosis of overloaded destructive platelets. (wikipedia.org)
The dyspnea risks following cangrelor treatment, suggest a common mechanism linking transfusion-related acute lung injury, dyspnea, and reversible platelet inhibition. (wikipedia.org)

They contain denser granules, secrete more serotonin and β -thromboglobulin, produce more thromboxane A2 and have more adhesion molecules (like P-selectin and platelet glycoprotein-GP-IIbIIIa), than smaller platelets. (hindawi.com)

We compared clopidogrel with aspirin plus esomeprazole for the prevention of recurrent bleeding from ulcers in high-risk patients. (hku.hk)
After the ulcers had healed, we randomly assigned patients who were negative for Helicobacter pylori to receive either 75 mg of clopidogrel daily plus esomeprazole placebo twice daily or 80 mg of aspirin daily plus 20 mg of esomeprazole twice daily for 12 months. (hku.hk)
Recurrent ulcer bleeding occurred in 13 patients receiving clopidogrel and 1 receiving aspirin plus esomeprazole. (hku.hk)
CONCLUSIONS: Among patients with a history of aspirin-induced ulcer bleeding whose ulcers had healed before they received the study treatment, aspirin plus esomeprazole was superior to clopidogrel in the prevention of recurrent ulcer bleeding. (hku.hk)

Clopidogrel is used to help prevent heart attacks, strokes, and other circulation problems for people who have atherosclerosis (narrowed blood vessels caused by 'hardening of the arteries') and have already experienced at least one atherothrombotic event such as heart attack or stroke, or have been diagnosed with peripheral arterial diseas e (problems with blood flow in the arteries). (pharmachoice.com)

The concurrent intake of omeprazole had no effect on clopidogrel-induced platelet inhibition in these subjects. (biomedcentral.com)
In the second heterozygous subject, omeprazole co-therapy reduced the clopidogrel anti-platelet effect when taken simultaneously or separately. (biomedcentral.com)
Rabeprazole did not affect the clopidogrel effect in a subject with a clear omeprazole-clopidogrel interaction. (biomedcentral.com)
In the last two years, pharmacological studies have reported an interaction between clopidogrel and omeprazole. (biomedcentral.com)
Data-bank analyses and retrospective cohort studies [ 10 - 13 ] have demonstrated an increased risk of adverse cardiac events in clopidogrel-treated patients who also take PPIs (mainly omeprazole). (biomedcentral.com)
Based in this uncertainty, both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMEA) have warned that omeprazole should not be combined with clopidogrel unless "absolutely necessary" (EMEA). (biomedcentral.com)

Normally, platelets help the blood to clot when needed, such as after an injury. (pharmachoice.com)

MPV is considered a marker of platelet function and activation: larger platelets are more reactive and aggregable. (hindawi.com)

Slides were prepared for histological analysis, which included Picrosirius red staining (collagen analysis), and immunohistochemistry (platelet endothelial cell adhesion molecule, alpha-smooth muscle actin, and transforming growth factor-beta). (bvsalud.org)
Additionally, the experimental group exhibited an increased number of blood vessels, total collagen (types I and III) and expression of platelet endothelial cell adhesion molecule, alpha-smooth muscle actin, and transforming growth factor-beta relative to the negative and positive control groups (p (bvsalud.org)

Inhibition of platelet aggregation by clopidogrel is achieved through an active metabolite. (medlibrary.org)

Prezcobix (darunavir and cobicistat) is a combination of a human immunodeficiency virus ( HIV -1) protease inhibitor and a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adult patients. (rxlist.com)

Cilostazol, a phosphodiesterase III inhibitor, has been shown to significantly improve high on-treatment platelet reactivity in patients receiving both aspirin and clopidogrel and has antiproliferative effects (inhibiting neointimal hyperplasia and smooth muscle proliferation), thus reducing the risk of restenosis after coronary stent implantation. (nih.gov)
Simultaneous inhibition of both of these pathways might produce significantly greater anti-platelet effects than inhibition of either alone. (ox.ac.uk)

clopidogrel will increase the level or effect of ombitasvir/paritaprevir/ritonavir & dasabuvir (DSC) by decreasing metabolism. (medscape.com)
The above findings have stimulated a close examination of clopidogrel metabolism. (johnshopkins.edu)

Discontinuation of clopidogrel increases the risk of cardiovascular events. (medlibrary.org)
Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)

Platelets from subjects with DM, particularly from those with type 2 diabetes, exhibit increased reactivity. (hindawi.com)
Factors that may contribute to this greater platelet reactivity are not completely elucidated and include metabolic abnormalities as hyperglycemia, hyperlipidemia, insulin resistance, and conditions as oxidative stress, inflammation, and endothelial dysfunction [ 3 ]. (hindawi.com)

We investigated whether the addition of clopidogrel to conventional therapy reduces mortality from any cause and morbidity related to the shunt. (duke.edu)
Clopidogrel reduces the chances of these events by preventing platelets from forming into clumps. (pharmachoice.com)
Abana also reduces platelet aggregation. (leehpl.com)

2023. https://emergency.unboundmedicine.com/emergency/view/Davis-Drug-Guide/51166/all/clopidogrel. (unboundmedicine.com)

The study tested whether clopidogrel will reduce the likelihood of recurrence of such events. (raiseacat.com)

Triple versus dual antiplatelet therapy in acute coronary syndromes: adding cilostazol to aspirin and clopidogrel? (nih.gov)

Most of the developments in pharmacotherapy have been in targeting platelet inhibition because platelet aggregation and the resultant formation of platelet-rich thrombi are the primary events in the pathogenesis of ACS. (jabfm.org)

CONCLUSIONS: Clopidogrel therapy in infants with cyanotic congenital heart disease palliated with a systemic-to-pulmonary-artery shunt, most of whom received concomitant aspirin therapy, did not reduce either mortality from any cause or shunt-related morbidity. (duke.edu)

Dual therapy with aspirin and clopidogrel increases the risk of gastrointestinal bleeding. (biomedcentral.com)

clopidogrel and apixaban both increase anticoagulation. (medscape.com)

These prevent platelets (blood cells) from sticking together and forming blood clots in arteries and veins. (pacificpharmaceuticals.com)

However, the simultaneous intake of rabeprazole did not reduce the clopidogrel effect. (biomedcentral.com)

Acquired platelet dysfunction, which is common, may result from aspirin , other nonsteroidal anti-inflammatory drugs (NSAIDs), or systemic disorders. (msdmanuals.com)
Drugs that affect platelet function. (msdmanuals.com)

Anatomy3

Organisms1

Diseases10

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes16

Information Science2

Health Care2

Ticlopidine6

P2Y1213

Adenosine diphosphate1

Myocardial Infarction9

Inhibits platelet3

Humans1

Prasugrel4

Ticagrelor3

Acute Coronary2

Bisulfate4

Plavix10

Inhibit3

Called platelets from clumping1

Effect on platelet1

Greater platelet inhibition1

Irreversible2

Excl1

Poor metabolizers1

Receptor antagonists1

Prodrug2

Effects of clopidogrel4

Therapy with clopidogrel2

Contains clopidogrel1

Thrombosis1

Loading dose3

Receive clopidogrel2

Proton5

CYP2C195

Cangrelor3

Glycoprotein1

Esomeprazole4

Stroke1

Omeprazole6

Clot1

Activation1

Adhesion2

Active metabolite1

Combination1

Significantly2

Metabolism2

Cardiovascular2

Reactivity2

Reduces3

20231

Recurrence1

Versus1

Resultant1

Conclusions1

Increases the risk1

Apixaban1

Blood clots1

Simultaneous1

Drugs2