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  • vitro
  • Moreover, hPSC-derived motor neurons were able to form neuromuscular junctions with human myotubes in vitro and induced acetylcholine receptor (AChR) clustering, as detected by Alexa 555-conjugated α-Bungarotoxin (α-BTX), suggesting that these hPSC-derived motor neurons formed functional contacts with skeletal muscles. (biomedcentral.com)
  • In particular, neural cells derived from disease-specific hiPSCs from patients with neurological disorders have been especially useful as in vitro disease models recapitulating in vivo pathogenesis, as cells in the nervous system cannot be usually obtained from patients themselves. (biomedcentral.com)
  • Unexpectedly, Sgcb -null cardiac progenitors spontaneously differentiated into skeletal muscle fibers both in vitro and when transplanted into regenerating muscles or infarcted hearts. (rupress.org)
  • Here, we report that Sgcb -null cardiac progenitors display an aberrant activation of skeletal muscle genes that are normally silenced in healthy cardiac progenitors and differentiate into skeletal muscle fibers both in vitro and in vivo. (rupress.org)
  • functional
  • Here we present a protocol for the generation of non-cellular killer artificial antigen presenting cells (KaAPC), which allows for the depletion of pathologic T cells while leaving the remaining immune system untouched and functional. (jove.com)
  • successfully
  • We and others have successfully generated and infused T-cells specific for Epstein Barr virus (EBV), cytomegalovirus (CMV) and Adenovirus (Adv) using monocytes and EBV-transformed lymphoblastoid cell (EBV-LCL) gene-modified with an adenovirus vector as antigen presenting cells (APCs). (jove.com)
  • among
  • To date, among the miRNAs known to regulate skeletal myogenesis, only miR669a and miR669q directly inhibit the MyoD 3′ untranslated region (UTR) and, consequently, skeletal myogenesis. (rupress.org)
  • mouse
  • At the same time, a technique for isolating primary germ cells from the rudiment of the mouse embryo gonad was developed. (iliveok.com)
  • null) mouse model, HLA-A2-restricted IGRP-specific CD8 T-cells induced a destructive insulitis. (jove.com)
  • immune
  • Therefore, new approaches need to be developed that target only the disease mediating cells and leave the remaining immune system intact. (jove.com)
  • several
  • I have several questions about cloning. (probe.org)
  • Chronic cardiac diseases are frequent findings in several forms of muscular dystrophy, including limb-girdle muscular dystrophies, caused by mutations in the sarcoglycan proteins that are involved in the maintenance of muscle integrity during contraction. (rupress.org)
  • blood
  • IGRP(265-273)-specific CD8 T-cells that were cloned from the peripheral blood of a recent onset T1D individual were shown to secrete IFN? (jove.com)
  • Potential
  • KaAPC is an alternative solution to cellular immunotherapy which has potential for treating autoimmune diseases and allograft rejections by regulating undesirable T cell responses in an antigen specific fashion. (jove.com)
  • loss
  • If we were to be able to clone cows it would mean that we would not have a loss of meat production. (probe.org)
  • It is believed that this is due to the frequent appearance of chromosomal abnormalities in the cultivation of teratocarcin cells: a loss of the Y chromosome, a variety of trisomy, deletions, or translocations. (iliveok.com)
  • factors
  • These features are key factors for successful stem cell transplantations that are used in cancer patients and in gene therapy protocols. (rupress.org)
  • primary
  • It should be noted that in the experiment the population of stem cells, which were formed from primary germ cells, have been studied since the 80s of the last century. (iliveok.com)
  • role
  • Despite increasing evidence that autoreactive CD8 T-cells are involved in both the initiation of type 1 diabetes (T1D) and the destruction of beta-cells, direct evidence for their destructive role in-vivo is lacking. (jove.com)
  • cause
  • Mutations in the Sgcb gene cause LMD2E (limb-girdle muscular dystrophy type 2E), often characterized by severe cardiomyopathy and mild muscle wasting. (rupress.org)
  • form
  • the two layers of cells, the ectoblast and entoblast, which form respectively the outer covering and inner wall of the gastrula. (thefreedictionary.com)
  • We do know that identical twins form when the early embryo-in the 2-8 cell stage-somehow divides completely in two. (probe.org)
  • So I assume a clone would have a soul since it is a form of technological twinning. (probe.org)