2008 ) which causes reduction of heart rate and blood pressure beside its anxiolytic, analgesic, amnestic, and sedative properties without respiratory depression (Gupta et al. (springeropen.com)
Their reduced intrinsic efficacy relative to full agonists such as diazepam resulted in an improved preclinical pharmacological profile in that there was a large window between anxiolytic and sedative doses and their dependence and abuse liabilities were much lower. (hhs.gov)
The benzodiazepines (pronounced [ˌbɛnzoː.daɪˈæzəˌpiːn] , often abbreviated to "benzos" ) are a class of psychoactive drugs with varying hypnotic , sedative , anxiolytic , anticonvulsant , muscle relaxant and amnesic properties, which are mediated by slowing down the central nervous system . (wikidoc.org)
Analgesic1
Dexmedetomidine (DEX) is a highly selective α 2 -adrenergic agonist with a receptor affinity greater than clonidine, which acts through various mechanisms, such as increased hyperpolarization of action potential, causing hypnotic and analgesic effects [ 10 ]. (ekja.org)
Sequential use of midazolam and dexmedetomidine for long-term sedation may reduce weaning time in selected critically ill, mechanically ventilated patients: a randomized controlled study. (cienciaecuador.com.ec)
Prophylactic1
Prophylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis. (druglib.com)
Anticonvulsant1
citation needed] Melatonin has been found to be effective as a premedication in both adults and children due to its pharmacological properties of hypnotic, antinociceptive and anticonvulsant which produce effective anxiolysis and sedation. (wikipedia.org)
Hypnotics2
A Patient Group Dependent on Sedative-Hypnotics - Dependence Development, Medical Consultations and Choice of Drugs. (benzo.org.uk)
Coadministration with alcohol or sedative hypnotics are contraindicated because of additive CNS depression. (medscape.com)
Dependence2
Allgulander C, Borg S. Sedative-Hypnotic and Alcohol Dependence among Psychiatric In-Patients. (benzo.org.uk)
Allgulander C, Borg S, Vikander B. A 4-6 Year Follow-Up of 50 Patients with Primary Dependence on Sedative and Hypnotic Drugs. (benzo.org.uk)
Sedation2
Five minutes after premedication, subarachnoid block (SAB) was given with 3 ml of 0.5% hyperbaric bupivacaine following which sensory and motor blockade, hemodynamic changes, sedation, and complications of the surgery were recorded and this data was analyzed statistically using χ 2 test, corrected χ 2 test, Fisher´s exact test, and test of proportion (Z-test). (panafrican-med-journal.com)
Safety and Efficacy of Remimazolam Compared With Placebo and Midazolam for Moderate Sedation During Bronchoscopy. (cienciaecuador.com.ec)
Anesthesia1
Midazolam is effective in children in reducing anxiety associated with separation from parents and induction of anesthesia. (wikipedia.org)
Efficacy1
Thus, researchers have investigated the efficacy of various analgesics, including bupivacaine, levobupivacaine, clonidine and naloxone, on post-herniorrhaphy pain in children administered at different times through various routes [ 6 , 7 ] such as caudal analgesia, inguinal nerve block, or local infiltration combined with a general anesthetic [ 8 ]. (ekja.org)
Premedication is using medication before some other therapy (usually surgery or chemotherapy) to prepare for that forthcoming therapy. (wikipedia.org)
Patients5
In the adjunctive study, clonidine hydrochloride extended-release tablets were administered to patients who had been on a stable regimen of either methylphenidate or amphetamine (or their derivatives) and who had not achieved an optimal response. (druglib.com)
Clonidine hydrochloride extended-release tablets are indicated as an integral part of a total treatment program for ADHD that may include other measures (psychological, educational, and social) for patients with this syndrome. (druglib.com)
Clonidine hydrochloride extended-release tablets are not intended for use in patients who exhibit symptoms secondary to environmental factors and/or other primary psychiatric disorders, including psychosis. (druglib.com)
A randomized feasibility trial of clonidine to reduce perioperative cardiac risk in patients on chronic beta-blockade: the EPIC study. (druglib.com)
One hundred twenty-one patients having primary elective cardiopulmonary bypass graft (CABG) surgery were enrolled in a double-blind, randomized trial and anesthetized using a standardized sufentanil-midazolam regimen. (silverchair.com)
Dose1
It has a faster recovery time compared to midazolam and has a reduced incidence of post-operative excitement and results in a reduction in dose required of propofol and thiopental. (wikipedia.org)
Drugs1
Premedication before chemotherapy for cancer often consists of drug regimens (usually 2 or more drugs, e.g. dexamethasone, diphenhydramine and omeprazole) given to a patient minutes to hours before the chemotherapy to avert side effects or hypersensitivity reactions (i.e. allergic reactions). (wikipedia.org)
Medications1
Clonidine hydrochloride extended-release tablets are indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant medications. (druglib.com)
Clonidine hydrochloride extended-release tablets are a centrally acting alpha 2 -adrenergic agonist available as a 0.1 mg extended-release tablet for oral administration. (druglib.com)
One drawback of clonidine is that it can take up to 45 minutes to take full effect. (wikipedia.org)
Longer-term1
The effectiveness of clonidine hydrochloride extended-release tablets for longer-term use (more than 5 weeks) has not been systematically evaluated in controlled trials. (druglib.com)
Trial1
Clonidine Maintenance Prolongs Opioid Abstinence and Decouples Stress From Craving in Daily Life: A Randomized Controlled Trial With Ecological Momentary Assessment. (druglib.com)
Antiemetics1
Drugs of different classes like sedative- antianxiety drugs, opioids, anticholinergics, neuroleptics, H 2 blocker and antiemetics have been used for premedication. (ijpsr.com)
Respiratory2
The use of other sedatives that are not respiratory depressants are gaining favor. (medscape.com)
Obese patients are particularly sensitive to the sedative and respiratory depressive effects of long-acting opioids. (hkmj.org)
Anxiety3
Midazolam is effective in children in reducing anxiety associated with separation from parents and induction of anesthesia. (wikipedia.org)
Midazolam demonstrated the better sedative, amnesic and anti anxiety effects than diazepam. (ijpsr.com)
The effectiveness of anxiolytic premedication critically dependent on the anesthesist's ability to detect anxiety during the preoperative visit. (ijpsr.com)
Effects2
Premedication before chemotherapy for cancer often consists of drug regimens (usually 2 or more drugs, e.g. dexamethasone, diphenhydramine and omeprazole) given to a patient minutes to hours before the chemotherapy to avert side effects or hypersensitivity reactions (i.e. allergic reactions). (wikipedia.org)
The aim of this study was to investigate the effects of two imidazoline-derived intravenous anesthetics, etomidate and midazolam, on vascular adenosine triphosphate-sensitive potassium (KATP) channel activity. (silverchair.com)
One drawback of clonidine is that it can take up to 45 minutes to take full effect. (wikipedia.org)
Drug1
Immediately before taking to operation theatre i.e . 60 minutes after drug administration, 5 with diazepam and 13 with midazolam were highly sedated. (ijpsr.com)