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  • Doses
  • The likelihood of such reactions to discontinuation of clonidine therapy appears to be greater after administration of higher doses or continuation of concomitant beta-blocker treatment and special caution is therefore advised in these situations. (nih.gov)
  • symptoms
  • Sudden cessation of clonidine treatment has, in some cases, resulted in symptoms such as nervousness, agitation, headache, and tremor accompanied or followed by a rapid rise in blood pressure and elevated catecholamine concentrations in the plasma. (nih.gov)
  • growth hormone
  • Clonidine acutely stimulates growth hormone release in both children and adults, but does not produce a chronic elevation of growth hormone with long-term use. (nih.gov)
  • Patients
  • Slowing of the pulse rate has been observed in most patients given clonidine, but the drug does not alter normal hemodynamic response to exercise. (nih.gov)
  • patients
  • Slowing of the pulse rate has been observed in most patients given clonidine, but the drug does not alter normal hemodynamic response to exercise. (nih.gov)
  • Patients will be randomized to either clonidine or placebo. (knowcancer.com)
  • Patients who derive a benefit from clonidine administration may continue for an additional 30 weeks of therapy. (knowcancer.com)
  • hours
  • The plasma level of clonidine peaks in approximately 3 to 5 hours and the plasma half-life ranges from 12 to 16 hours. (nih.gov)
  • Peak plasma clonidine levels are attained in approximately 1 to 3 hours. (nih.gov)