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  • biology
  • The biology and replication of insect baculoviruses in cultured insect cells and in larvae, with a focus on the role of non-essential genes encoding proteins such as P10. (brookes.ac.uk)
  • Stuart Alan Newman (born April 4, 1945 in New York City) is a professor of cell biology and anatomy at New York Medical College in Valhalla, NY, United States. (wikipedia.org)
  • neuroD
  • In low-density cell culture, ngn1 overexpression increased neuroD expression and expanded the photoreceptor population but reduced the ganglion population. (arvojournals.org)
  • RPE was isolated, and the cells were dissociated, cultured, and guided to transdifferentiate by infection with retrovirus expressing neuroD (RCAS-neuroD), using RCAS-green fluorescence protein (GFP) as a control. (arvojournals.org)
  • In contrast, most cells from RCAS-neuroD-infected culture remained depigmented. (arvojournals.org)
  • cytoplasmic
  • Although many cytoplasmic binding partners for the cadherins have been identified, it will be essential to gain additional insight into how these molecules govern cadherin function to fully understand how cell-cell adhesions assemble during normal biological processes and how they become deregulated in diseased states. (biologists.org)
  • Taken together, these observations have led to the idea that many of the proteins recruited to the cadherin cytoplasmic domain regulate cadherin availability at the cell surface. (biologists.org)
  • dynamics
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)
  • human
  • Additionally, incorporating a truncated vesicular stomatitis virus G protein increased transduction efficacy and production of EGFP and BCL2 in human kidney (HK-2) and pancreatic islet β cells (EndoC βH3). (brookes.ac.uk)
  • Lastly, we have shown that our optimized BacMam vector can deliver and express egfp in intact pancreatic islet cells from human cadaveric donors. (brookes.ac.uk)
  • In 1997, in order to encourage public discussion of emerging technologies along these lines, he applied for a U.S. patent on a human-nonhuman chimera, a composite organism (like the "geep") arising from a mixture of embryonic cells of two or more species. (wikipedia.org)
  • control
  • The only region in which chick nuclei appeared at significantly greater frequency than in control tissue was the dorsal thigh muscle, the region into which the cloned chick cells were placed originally. (biologists.org)
  • type
  • i.e. one that repeatedly self-renews and generates a differentiated cell type by asymmetric division. (biologists.org)
  • However
  • However, this approach removes vinculin from both cell-matrix and cell-cell adhesions, making it impossible to distinguish its contribution at each site. (biologists.org)
  • role
  • To define the role of vinculin in cell-cell junctions, we established a powerful short hairpin-RNA-based knockdown/substitution model system that perturbs vinculin preferentially at sites of cell-cell adhesion. (biologists.org)
  • Nevertheless, some data on the role of vinculin at the latter site has emerged and provides evidence for the notion that vinculin modulates adhesion at sites of cell-cell contact. (biologists.org)
  • The authors investigated the role of proneural bHLH gene neurogenin1 ( ngn1 ) in photoreceptor genesis using the chick retina. (arvojournals.org)
  • system
  • When this system was applied to epithelial cells, cell morphology was altered, and cadherin-dependent adhesion was reduced. (biologists.org)
  • suggesting that in this system sister cells may become symmetrically fated neurons in vivo. (biologists.org)
  • function
  • Most of the attention on vinculin has focused on its presence in cell-matrix adhesions, leaving a gap in our knowledge of its function in cell-cell junctions. (biologists.org)
  • suggest
  • These findings suggest that an interaction between β-catenin and vinculin is crucial for stabilizing E-cadherin at the cell surface. (biologists.org)