• Cloning of Animals On Sunday, February 23, 1997, Scottish researchers broke one of nature's greatest laws by cloning a lamb from a single cell of an adult ewe. (essaypride.com)
  • Dolly, the first mammal to be genetically cloned from adult cells, poses for the camera in 1997 at the Roslin Institute in Edinburgh, Scotland. (wunc.org)
  • In 1997 cloning became headline news when, following more than 250 failed attempts, Ian Wilmut (1944-) and his colleagues at the Roslin Institute in Edinburgh, Scotland, successfully cloned a sheep, which they named Dolly. (libraryindex.com)
  • A 1997 CNN/USA Today/Gallup Poll found that 87% of Americans polled believed human cloning would be a bad development for humanity, and 88% believed it would be morally wrong. (libraryindex.com)
  • In February 1997 Don Wolf (1939-) and his colleagues at the Oregon Regional Primate Center in Beaverton successfully cloned two rhesus monkeys using laboratory techniques that had previously produced frogs, cows, and mice. (libraryindex.com)
  • Expressed during embryogenesis to help blood cell development, ADAR1 subsequently turns off and is triggered by viral infections where it protects normal hematopoietic stem cells from attack. (labspaces.net)
  • 0.05) than in peripheral blood mononudear cells of nonallergic donors. (tudelft.nl)
  • In principle, scientists could produce a series of cell lines that would allow a close match for the majority of would-be cell recipients - just as transplant surgeons currently seek a close match for organ donors. (wunc.org)
  • There are ethical concerns surrounding nuclear transfer, particularly regarding recruitment and compensation for egg donors needed for stem cell research. (empr.com)
  • Acquired mutations in the mDNA contribute to differences between clones and their donors and are believed to influence the aging process. (libraryindex.com)
  • The claim went up in smoke in January of 2006 after a probe by the university concluded that Hwang had fabricated the evidence, which followed a similarly damning assessment of a landmark paper from the previous year in which the group falsely reported creating 11 cell lines genetically matched to their donors. (scientificamerican.com)
  • Finally it happens this small idea of science fiction becomes real with the first clone, Dolly the sheep, but now people are thinking that this might not be such a good idea. (essaypride.com)
  • Cloning has been all over the papers and the news lately, mostly caused by the death of possibly the world's most famous animal behind Lassie, Ian Wilmut's cloned sheep, Dolly. (essaypride.com)
  • The resulting egg was implanted in the womb of a third sheep, and the result was Dolly, the first clone of a mammal. (wunc.org)
  • Born several months later, Dolly was a true clone-genetically identical to the Finn Dorsett mammary cells and not to the blackface ewe, which served as her surrogate mother. (libraryindex.com)
  • An important distinction between the process that created Dolly and the one that produced the monkeys was that unspecialized embryonic cells were used to create the monkeys, whereas a specialized adult cell was used to create Dolly. (libraryindex.com)
  • These findings indicate that IP represents in its final stage in the aging C57BL mice an intrinsic cellular defect within the affected B cell clone, which is, however, different from that found in B cell malignancies. (tudelft.nl)
  • Spleen cells of BALB/c mice, immunized with fragments Y of normal human fibrinogen, were fused with P3 x 63 Ag 8653 myeloma cells. (tudelft.nl)
  • We have produced a panel of islet-specific T-cell clones from nonobese diabetic (NOD) mice. (pnas.org)
  • A series of genetic markers sprinkled throughout the cells' chromosomes show the same pattern found in parthenogenetic mice as opposed to cloned mice, according to a report published online today in the journal Cell Stem Cell . (scientificamerican.com)
  • Objective: In this study we therefore characterized peanut-specific T cells, cloned from a patient with severe peanut allergy. (tudelft.nl)
  • Methods: Peripheral blood mononudear cells from patients with peanut allergy and nonallergic individuals were stimulated with crude peanut extract (CPE) to compare the proliferative responses and to select a suitable patient for the cloning of CPE-specific T cells. (tudelft.nl)
  • The CPE-specific T-lymphocyte clones generated from the selected patient were all CD4+/CD8- T helper cells with a TH2 cytokine profile, secreting high amounts of IL-4 and IL-5, but little or no interferon-γ. (tudelft.nl)
  • The technique could potentially be used to take skin cells from a patient to create "personalised" stem cells. (www.nhs.uk)
  • Each of these treatments captures a patient's own tumor-fighting cells, grows them to high numbers in the lab, and infuses them back into the patient. (webmd.com)
  • He says since the reprogrammed cells use genetic material from the patient, there is no concern about transplant rejection. (abc.net.au)
  • Physicians could also extract DNA from the person who is going to receive the cellular transplant - creating a patient-specific treatment - though that would end up being far more expensive than drawing from a library of ready-made cells. (wunc.org)
  • For instance, because we transform a person's own cells, there are no issues of rejection when the stem cells are transplanted back into a patient. (salem-news.com)
  • These clones proliferate and make interleukin 2 in an antigen-specific manner in response to NOD antigen-presenting cells and islet cells. (pnas.org)
  • Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocompatibility complex of the NOD mouse. (pnas.org)
  • This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with affinity maturation. (wikipedia.org)
  • In 1880, a man named Walter Sutton made one of the most important discoveries towards cloning- he proved that chromosomes hold genetic information. (essaypride.com)
  • But in contrast, pairs of matching chromosomes in parthenogenetic cells tend to match one another in the middle and differ near the ends because of a genetic mixing process called recombination. (scientificamerican.com)
  • In their paper, Daley and colleagues report that the SNPs in the Korean cell line do indeed match toward the center of the chromosomes, similar to five parthenogenetic mouse cell lines that the team created for comparison. (scientificamerican.com)
  • The team pointed out years of research on monkey cells using the same technique have not successfully produced any monkey clones. (abc.net.au)
  • The result follows on the heels of an announcement last month by another California stem cell company, International Stem Cell Corporation (ISC) in Oceanside, that it had successfully achieved human parthenogenesis for the first time. (scientificamerican.com)
  • Whereas, the cells of clones dealt with here are specialized cells of a multicellular organism (usually vertebrates), and reside at quite distant places. (wikipedia.org)
  • The possibility that people might be cloned from the cells of a single adult human being had long been a subject primarily of fantasy and science fiction but became very definite at the end of the 20th century. (essaypride.com)
  • This was a laboratory study that aimed to produce embryonic stem cells from adult skin cells. (www.nhs.uk)
  • As I was heading into Parliament House this morning, I heard some coverage on ABC radio mentioning a briefing that was being held today with a leading researcher into adult stem cells. (andrewbartlett.com)
  • Dr. Arnold Kriegstein, director of the stem cell institute at the University of California, San Francisco, said he had been approached to be the San Francisco partner of the Korean foundation but had held back, in part because he wished to develop the university's own expertise. (nytimes.com)
  • Lanza's colleagues, including Young Gie Chung at the CHA Stem Cell Institute in Seoul, Korea (with labs in Los Angeles as well), now report success. (wunc.org)
  • Later, during a chance discussion with European colleagues, stem cell researcher George Daley of Children's Hospital Boston and the Harvard Stem Cell Institute learned that they had received samples of the cell line before the work was retracted. (scientificamerican.com)
  • When a chromosome from a sperm cell joins with that of an egg, these single nucleotide polymorphisms (SNPs or "snips") tend not to match each other. (scientificamerican.com)
  • This could lead to diabetic patients being able to produce their own cells that make insulin to replace their non-functioning cells. (empr.com)
  • The newly formed cell divided and was placed in the uterus of a blackface ewe to gestate. (libraryindex.com)
  • The resultant panel of CPE-reactive T-lymphocyte clones was serologically phenotyped by flow cytometty and analyzed for cytokine secretion by ELISA. (tudelft.nl)
  • The CD4+ phenotype and the TH2 cytokine profile of the CPE-specific T-lymphocyte clones suggest a functional role of allergen-specific TH2 cells in the pathophysiology of food allergy, similar to the function of inhalation allergen-specific TH2 cells. (tudelft.nl)
  • I am presently looking at cytokine mediated differential gene expression in T cells. (bio.net)
  • Introduction The idea of cloning has been around for a while, but the thought of it becoming a reality is surprisingly new. (essaypride.com)
  • A new study by Gerald de Haan, Leonid Bystrykh, and colleagues suggests that the skeletal distribution of transplanted hematopoietic stem cell (HSC) clones is surprisingly nonuniform. (rupress.org)
  • Their motive is it to obtain the power of speeding up the cloning process by hoping to improve their productivity. (brightkite.com)
  • The process has been difficult to do with human cells. (wunc.org)
  • What we show for the first time is that you can actually take skin cells, from a middle-aged 35-year-old male, but also from an elderly, 75-year-old male" and use the DNA from those cells in this cloning process, Lanza says. (wunc.org)
  • This process became the prototype for cloning. (libraryindex.com)
  • Despite the emergence of new therapies, such as tyrosine kinase inhibitors, CML and other leukemias remain problematic because some cancer stem cells avoid destruction and eventually regenerate themselves, a stem cell process known as self-renewal that can result in a return and spread (metastasis) of the disease. (labspaces.net)
  • Each of those two cells is able to divide indefinitely, "so from a small vial of those cells we could grow up as many cells as we would ever want," Lanza says. (wunc.org)
  • Most other cells cannot divide indefinitely as after a few cycles of cell division the cells stop expressing an enzyme telomerase. (wikipedia.org)
  • A technique appropriate to investigation of the developmental fates of distinct embryonic cell types is described and the fate of a particular type of chick myoblast (CMR-I) examined. (biologists.org)
  • While there is much work to be done in developing safe and effective stem cell treatments, we believe this is a significant step forward in developing the cells that could be used in regenerative medicine," Mitalipov says. (abc.net.au)
  • I think this is an extremely important-and solid-paper," says stem cell researcher Robert Lanza, vice president of research and scientific development at Applied Cell Technology, a regenerative medicine company headquartered in Alameda, Calif., who did not take part in the study. (scientificamerican.com)
  • And the other technique, which produces " induced pluripotent stem cells ," skips the step that requires a human egg cell, so some people find it less fraught, ethically. (wunc.org)
  • Furthermore, pancreatic sections from a disease transfer experiment with one of the clones showed a pronounced cellular infiltration and degranulation of islets in nondiabetic (CBA x NOD)F1 recipients. (pnas.org)
  • Clonal differences were observed with both young and old HSCs and were maintained when clones from particular bones were transplanted into secondary recipients. (rupress.org)