Loading...
  • sequences
  • Improvements to the in situ polymerase chain reaction (PCR), a process of in vitro enzymatic amplification of specific nucleic acid sequences within the cells where they originate, can be achieved by changing the way that the enzymatic reaction is started. (google.es)
  • We show that a clone containing Myf5 and 140 kb of upstream sequences is sufficient to recapitulate the known expression patterns of both genes. (biologists.org)
  • growth
  • one involved three rounds of adherence assays to bovine primary rectal epithelial cells while the other competed the clones over three rounds of growth in bovine rectal mucus. (frontiersin.org)
  • Viruses derived from the BAC clones were stable during in vitro passage, but showed differences in in vitro growth kinetics compared with the wild-type virus. (microbiologyresearch.org)
  • In spite of the difference in in vitro growth, viruses from both clones induced 100 % protection against infection by the virulent MDV strain RB-1B, indicating that the BAC-derived viruses could be used as vaccines with efficacies similar to that of the parental virus. (microbiologyresearch.org)
  • Researchers
  • It should be noted that no babies were born as a result of this research, and the researchers had no intention of producing a live cloned human being. (www.nhs.uk)
  • Researchers have been looking into ways of using a patient's own cells to create embryonic stem cells, as this would ensure that the genetic material in any cells used therapeutically would match the patient's DNA. (www.nhs.uk)
  • The researchers report that previous attempts to produce embryonic stem cells using this technique have failed, as the cells stopped dividing before they reached an advanced enough stage. (www.nhs.uk)
  • During their experiments, researchers identified two reasons for this inability to sufficiently grow the cells and developed techniques to overcome these limiting factors. (www.nhs.uk)
  • This study will no doubt be very exciting for researchers working with stem cells, but we're still a long way from the findings of this study being translated into new treatments for conditions such as Parkinson's disease or heart disease . (www.nhs.uk)
  • Researchers then optimised methods to prompt the egg cell to start and continue to divide using electricity and chemical compounds, including caffeine. (www.nhs.uk)
  • In the 18 years since researchers cloned a sheep, scientists have found another way to produce cloned human cell lines. (wunc.org)
  • An international team, headed by researchers at the University of California, San Diego School of Medicine, has identified a key enzyme in the reprogramming process that promotes malignant stem cell cloning and the growth of chronic myeloid leukemia (CML), a cancer of the blood and marrow that experts say is increasing in prevalence. (labspaces.net)
  • Harvard University researchers plan to ask women to donate their eggs for research as they race to grow embryonic stem cells matched to patients // which they say would hopefully find new treatments for many debilitating diseases such as diabates or neurodegenerative disease. (bio-medicine.org)
  • 6 January - A new way to destroy metastasizing cancer cells traveling through the bloodstream has been discovered by researchers at Cornell University. (wikipedia.org)
  • In this experiment, the researchers developed a protocol for using SCNT in human cells, which differs slightly from the one used in other organisms. (wikipedia.org)
  • donor's
  • SCNT involved taking the nucleus (the part of a cell containing most of the genetic information) from a person's skin cells, inserting its cells into a donor's unfertilised egg cell that had its nucleus removed. (www.nhs.uk)
  • antibodies
  • The process of immunological B-cell maturation involves transformation from an undifferentiated B cell to one that secretes antibodies with particular specificity. (wikipedia.org)
  • In lymphocytic neoplastic diseases such as multiple myeloma and lymphoma, but also other illnesses, there can be a massive expansion of a single B-cell clone, detectable by measuring the excessively-produced antibodies, measured in a serum protein electrophoresis test or peripheral blood flow cytometry. (wikipedia.org)
  • Such an expansion is said to be "monoclonal", and monoclonal antibodies produced by such a group of B cells can cause illnesses such as amyloidosis and lupus, or can be indicative of an underlying malignancy. (wikipedia.org)
  • Anatomy and Development: images, fate maps, and videos Community Link --- jobs, labs which study Xenopus Protocol List- identify clones, antibodies, procedures Stock Centre- The National Xenopus Resource (maintains frog stocks, offers advanced research training) The Nobel Prize for Medicine or Physiology was awarded to John B. Gurdon and Shinya Yamanaka on October 8, 2012. (wikipedia.org)
  • embryonic cell
  • A technique appropriate to investigation of the developmental fates of distinct embryonic cell types is described and the fate of a particular type of chick myoblast (CMR-I) examined. (biologists.org)
  • embryo
  • These are then fused with human cells - in this case skin cells - and the fused cell begins behaving in a similar way to an embryo by producing human stem cells. (www.nhs.uk)
  • This mouse egg (top) is being injected with genetic material from an adult cell to ultimately create an embryo - and, eventually, embryonic stem cells. (wunc.org)
  • They look like the cells in a human embryo - in fact, they're called embryonic stem cells. (wunc.org)
  • It was created using SCNT - a nucleus was taken from a man's leg cell and inserted into a cow's egg from which the nucleus had been removed, and the hybrid cell was cultured, and developed into an embryo. (wikipedia.org)
  • In this case, each embryo was created by taking a nucleus from a skin cell (donated by Wood and a colleague) and inserting it into a human egg from which the nucleus had been removed. (wikipedia.org)
  • OPS is the first purpose-developed tool for mammalian embryo and oocyte vitrification that has resulted in many breakthroughs in human and animal cryobiology including the first baby born after vitrification of human oocytes, and the first cloned mammal born after cryopreservation of the reconstructed embryo. (wikipedia.org)
  • Tong demonstrated that in hairy sea squirts, during the third division of cells in an embryo, cells divide unequally. (wikipedia.org)
  • Tong concluded that an organizing center existed in the fish embryo, similar to the Spemann-Mangold organizer in amphibians and to Henson's node in chicks, and that the organizing center and cells in the fish embryo worked together to control the development of the embryo. (wikipedia.org)
  • mammal
  • The resulting egg was implanted in the womb of a third sheep, and the result was Dolly, the first clone of a mammal. (wunc.org)
  • Hwang's
  • Jeffrey Janus, president and director of research for ISC, agrees that "Dr. Hwang's cells have characteristics found in parthenogenetic cells" but remains cautious, saying "it needs more study. (scientificamerican.com)
  • On November 2015, a Chinese biotech company Boyalife Group announced that it will partner with Hwang's laboratory, Sooam Biotech, to open the world's largest animal cloning factory in Tianjin as early as 2016. (wikipedia.org)
  • Hwang's next claim came only two months later in April 1999, when he announced the cloning of a Korean cow, Jin-i, also without providing any scientifically verifiable data. (wikipedia.org)
  • Until Hwang's claim, it was generally agreed that creating a human stem cell by cloning was next to impossible due to the complexity of primates. (wikipedia.org)
  • gene
  • I am presently looking at cytokine mediated differential gene expression in T cells. (bio.net)
  • CML is a cancer initiated by a mutant gene called BCR-ABL in blood forming stem cells that leads to an expansion of white blood cells and their precursors. (labspaces.net)
  • Genome browser BLAST Expression Search and Clone Search (search by gene symbol, gene name, or Affymetrix id) Gene nomenclature guidelines Literature search: Textpresso- uses an algorithm to match your search to specific criteria or section of a paper. (wikipedia.org)
  • T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene. (wikipedia.org)
  • Hwang
  • Hwang claimed to have created eleven different patent-specific stem cell lines. (wikipedia.org)
  • On May 12, 2006, Hwang was charged with embezzlement and bioethics law violations after it emerged much of his stem cell research had been faked. (wikipedia.org)
  • In February 2011, Hwang visited Libya as part of a $133 million project in the North African country to build a stem cell research center and transfer relevant technology. (wikipedia.org)
  • Hwang first caught media attention in South Korea when he announced he successfully created a cloned dairy cow, Yeongrong-i in February 1999. (wikipedia.org)
  • His alleged success was touted as the fifth instance in the world in cow cloning, with a notable caveat: Hwang failed to provide scientifically verifiable data for the research, giving only media sessions and photo-ops. (wikipedia.org)
  • During that period, Hwang claimed to have created a BSE-resistant cow (which has not been verified) and also stated his intention to clone a Siberian tiger. (wikipedia.org)
  • Hwang explained that his team used 242 eggs to create a single cell line. (wikipedia.org)
  • antigen-prese
  • Most of the clones respond to islet-cell antigen from different mouse strains but only in the presence of antigen-presenting cells bearing the class II major histocompatibility complex of the NOD mouse. (pnas.org)
  • This differentiation and activation of the B cell occurs most rapidly after exposure to antigen by antigen-presenting cells in the reticuloendothelial system, and under modulation by T cells, and is closely intertwined with affinity maturation. (wikipedia.org)
  • donors
  • In principle, scientists could produce a series of cell lines that would allow a close match for the majority of would-be cell recipients - just as transplant surgeons currently seek a close match for organ donors. (wunc.org)
  • There are ethical concerns surrounding nuclear transfer, particularly regarding recruitment and compensation for egg donors needed for stem cell research. (empr.com)
  • tissue
  • The resulting stem cells could then possibly be used to repair damaged tissue, or even treat genetic conditions. (www.nhs.uk)
  • The only region in which chick nuclei appeared at significantly greater frequency than in control tissue was the dorsal thigh muscle, the region into which the cloned chick cells were placed originally. (biologists.org)
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)
  • The term is generally used to refer to artificial human cloning, which is the reproduction of human cells and tissue. (wikipedia.org)
  • Working with Dr. Virginia Evans and a group of tissue-culture workers she became the first to successfully clone a mammalian cell in vitro. (wikipedia.org)
  • Prior to her discovery, tissue cultures had to be composed of multiple and various human body cells in order for them to survive and grow. (wikipedia.org)
  • Human embryonic kidney cells 293, also often referred to as HEK 293, HEK-293, 293 cells, or less precisely as HEK cells, are a specific cell line originally derived from human embryonic kidney cells grown in tissue culture. (wikipedia.org)
  • After presumably adapting to tissue culture, cells from this clone developed into the relatively stable HEK 293 line. (wikipedia.org)
  • A comprehensive study of the genomes and transcriptomes of HEK 293 and five derivative cell lines compared the HEK 293 transcriptome with that of human kidney, adrenal, pituitary and central nervous tissue. (wikipedia.org)
  • nucleus
  • The skin cell nucleus was then fused with the donor egg cell. (www.nhs.uk)
  • Eighteen years ago, scientists in Scotland took the nuclear DNA from the cell of an adult sheep and put it into another sheep's egg cell that had been emptied of its own nucleus. (wunc.org)
  • In 2011, scientists at the New York Stem Cell Foundation announced that they had succeeded in generating embryonic stem cell lines, but their process involved leaving the oocyte's nucleus in place, resulting in triploid cells, which would not be useful for cloning. (wikipedia.org)
  • Importance: Gurdon's experiments challenged the dogma of the time which suggested that the nucleus of a differentiated cell is committed to their fate (Example: a liver cell nucleus remains a liver cell nucleus and cannot return to an undifferentiated state). (wikipedia.org)
  • Experiment: Gurdon used a technique known as nuclear transfer to replace the killed-off nucleus of a frog (Xenopus) egg with a nucleus from a mature cell (intestinal epithelial). (wikipedia.org)
  • GCs affect cells by binding to the glucocorticoid receptor (GR). The activated GR complex, in turn, up-regulates the expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus (transrepression). (wikipedia.org)
  • viral
  • In order to propagate such viral vectors, a cell line that expresses the missing genes is required. (wikipedia.org)
  • Scientists
  • So ideally scientists would like to be able to extract DNA from the cells of older people - not just cells from infants - to create therapies for adult diseases. (wunc.org)
  • Although the possibility of cloning humans had been the subject of speculation for much of the 20th century, scientists and policy makers began to take the prospect seriously in the mid-1960s. (wikipedia.org)
  • Many nations outlawed it, while a few scientists promised to make a clone within the next few years. (wikipedia.org)
  • In 2013, a group of scientists led by Shoukhrat Mitalipov published the first report of embryonic stem cells created using SCNT. (wikipedia.org)
  • diabetic
  • This could lead to diabetic patients being able to produce their own cells that make insulin to replace their non-functioning cells. (empr.com)
  • patient
  • The technique could potentially be used to take skin cells from a patient to create "personalised" stem cells. (www.nhs.uk)
  • Each of these treatments captures a patient's own tumor-fighting cells, grows them to high numbers in the lab, and infuses them back into the patient. (webmd.com)
  • Physicians could also extract DNA from the person who is going to receive the cellular transplant - creating a patient-specific treatment - though that would end up being far more expensive than drawing from a library of ready-made cells. (wunc.org)
  • experiments
  • He was a professor of theriogenology and biotechnology at Seoul National University (dismissed on March 20, 2006) who became infamous for fabricating a series of experiments, which appeared in high-profile journals, in the field of stem cell research. (wikipedia.org)
  • Examples of such experiments include: Effects of a drug on sodium channels Inducible RNA interference system Isoform-selective protein kinase C agonist Interaction between two proteins Nuclear export signal in a protein A more specific use of HEK 293 cells is in the propagation of adenoviral vectors. (wikipedia.org)
  • successfully
  • The result follows on the heels of an announcement last month by another California stem cell company, International Stem Cell Corporation (ISC) in Oceanside, that it had successfully achieved human parthenogenesis for the first time. (scientificamerican.com)
  • In the 1940s she became the first person to successfully clone a mammalian cell in vitro, which allowed for more efficient means of creating pure strains of cells for study. (wikipedia.org)
  • reside
  • A somewhat similar concept is that of clonal colony (also called a genet), wherein the cells (usually unicellular) also share a common ancestry, but which also requires the products of clonal expansion to reside at "one place", or in close proximity. (wikipedia.org)
  • Whereas, the cells of clones dealt with here are specialized cells of a multicellular organism (usually vertebrates), and reside at quite distant places. (wikipedia.org)
  • Antibody
  • The B cells in the body have two important phenotypes (functional forms) -- the antibody secreting, terminally differentiated (that is, they cannot divide further) plasma cells, and the memory and the naive cells-both of which retain their proliferative potential. (wikipedia.org)
  • This diminishes both B cell clone expansion and antibody synthesis. (wikipedia.org)
  • experimental
  • March 5, 2012 -- One of 11 patients facing death from treatment-resistant, late-stage melanoma is cancer free 3.5 years after experimental treatment with clones of his own immune cells. (webmd.com)
  • Her experimental procedure required 929 iterations to find a combination of environmental and cell conditions that induced cloning. (wikipedia.org)
  • Viruses offer an efficient means of delivering genes into cells, which they evolved to do, and are thus of great use as experimental tools. (wikipedia.org)
  • endothelial
  • The discovery reveals the role of a growth factor and endothelial cells in thymus repair, and could have implications for chemotherapy and radiation patients' recovery following treatment. (the-scientist.com)
  • For many years it was assumed that HEK 293 cells were generated by transformation of either a fibroblastic, endothelial or epithelial cell, all of which are abundant in kidneys. (wikipedia.org)
  • Robert Lanza
  • Robert Lanza, chief scientific officer at Advanced Cell Technology , says that was an important step, but not ideal for medical purposes. (wunc.org)
  • I think this is an extremely important-and solid-paper," says stem cell researcher Robert Lanza, vice president of research and scientific development at Applied Cell Technology, a regenerative medicine company headquartered in Alameda, Calif., who did not take part in the study. (scientificamerican.com)
  • glucocorticoids
  • Glucocorticoids are distinguished from mineralocorticoids and sex steroids by their specific receptors, target cells, and effects. (wikipedia.org)
  • Glucocorticoids suppress the cell-mediated immunity. (wikipedia.org)
  • Glucocorticoids also suppress the humoral immunity, causing B cells to express smaller amounts of IL-2 and IL-2 receptors. (wikipedia.org)
  • human egg cell
  • And the other technique, which produces " induced pluripotent stem cells ," skips the step that requires a human egg cell, so some people find it less fraught, ethically. (wunc.org)
  • cancer
  • Successful treatment depended on isolating and cloning just the right kind of cancer -fighting immune cell. (webmd.com)
  • Despite the emergence of new therapies, such as tyrosine kinase inhibitors, CML and other leukemias remain problematic because some cancer stem cells avoid destruction and eventually regenerate themselves, a stem cell process known as self-renewal that can result in a return and spread (metastasis) of the disease. (labspaces.net)
  • People normally think about DNA instability in cancer, but in this case, it's how the RNA is edited by enzymes that really matters in terms of cancer stem cell generation and resistance to conventional therapy. (labspaces.net)
  • Despite tremendous advances in BCR-ABL tyrosine kinase inhibitor therapies, the majority of patients relapse if therapy is discontinued, in part as a result of dormant cancer stem cell resistance. (labspaces.net)
  • This work suggests a novel mechanism for overcoming cancer stem cell resistance to therapy that may prevent relapse and progression. (labspaces.net)
  • The expansion of a particular clone of immune B cells is usually interpreted by clinicians as evidence of unrestricted cell growth, the hallmark of cancer. (wikipedia.org)
  • It did not take her long to make an impact, as almost immediately after joining she made her largest discovery involving a method of cloning mammalian cancer cells in vitro. (wikipedia.org)
  • They also interfere with some of the abnormal mechanisms in cancer cells, so they are used in high doses to treat cancer. (wikipedia.org)
  • genetic material
  • SCNT involves taking donated egg cells from women and removing their genetic material. (www.nhs.uk)
  • The genetic material, in the form of deoxyribonucleic acid (DNA), continues to shorten with each cell division, and cells eventually stop dividing when they sense that their DNA is critically shortened. (wikipedia.org)
  • They repeated the process - this time starting with the genetic material extracted from the skin cells of a much older man. (wunc.org)
  • tend
  • When a chromosome from a sperm cell joins with that of an egg, these single nucleotide polymorphisms (SNPs or "snips") tend not to match each other. (scientificamerican.com)
  • But in contrast, pairs of matching chromosomes in parthenogenetic cells tend to match one another in the middle and differ near the ends because of a genetic mixing process called recombination. (scientificamerican.com)
  • humans
  • It also means that finally getting the sheep technology to work with cells from adult humans may not turn out to be a turning point for this technology, after all. (wunc.org)
  • process
  • The process has been difficult to do with human cells. (wunc.org)
  • What we show for the first time is that you can actually take skin cells, from a middle-aged 35-year-old male, but also from an elderly, 75-year-old male" and use the DNA from those cells in this cloning process, Lanza says. (wunc.org)
  • reveals
  • Analysis of the lipids from differentiating and nondifferentiating clones reveals the presence of sebaceous-type lipids in differentiating clones only. (aacrjournals.org)
  • artificial
  • Chemists have engineered a plastic artificial cell containing organelles capable of producing the various steps in a chemical reaction. (wikipedia.org)
  • Stem Cell Institute
  • Lanza's colleagues, including Young Gie Chung at the CHA Stem Cell Institute in Seoul, Korea (with labs in Los Angeles as well), now report success. (wunc.org)
  • Later, during a chance discussion with European colleagues, stem cell researcher George Daley of Children's Hospital Boston and the Harvard Stem Cell Institute learned that they had received samples of the cell line before the work was retracted. (scientificamerican.com)
  • Korean
  • In their paper, Daley and colleagues report that the SNPs in the Korean cell line do indeed match toward the center of the chromosomes, similar to five parthenogenetic mouse cell lines that the team created for comparison. (scientificamerican.com)
  • The Korea Times reported on June 10, 2007, that Seoul National University fired him, and the South Korean government canceled his financial support and barred him from engaging in stem cell research. (wikipedia.org)
  • cDNA
  • Multiple cloning sites are sometimes used to ensure that the fragments are inserted in all three possible reading frames so that the cDNA fragment is translated in the proper frame. (wikipedia.org)
  • protein
  • If a "phagemid" vector is used (a simplified display construct vector) phage particles will not be released from the E. coli cells until they are infected with helper phage, which enables packaging of the phage DNA and assembly of the mature virions with the relevant protein fragment as part of their outer coat on either the minor (pIII) or major (pVIII) coat protein. (wikipedia.org)
  • Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
  • Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. (wikipedia.org)
  • Caspase 3 is responsible for cellular differentiation, although it is unclear how this kind of protein can promote the cell apoptosis. (wikipedia.org)
  • proteins
  • Retention within the lumen of the ER correlates with an additional signal located at the C terminus, represented by the sequence Lys-Asp-Glu-Leu, known to be responsible for preventing secretion of proteins from the lumen of the ER in eukaryotic cells. (wikipedia.org)
  • Clathrin coated vesicles enable neurotransmitter receptors and other proteins to be endocytosed or taken up across neuronal membranes and across the membranes of other types of cells. (wikipedia.org)
  • Metabolism is usually divided into two categories: catabolism, the breaking down of organic matter for example, the breaking down of glucose to pyruvate, by cellular respiration, and anabolism, the building up of components of cells such as proteins and nucleic acids. (wikipedia.org)
  • Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)
  • Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
  • membranes
  • Jesse F. McClendon made substantial contributions in a variety of fields, including invertebrate zoology, nutrition, life processes of cell membranes, the importance of pH control, the role of iodine in human health, and specifically its relation to prevention of goiters. (wikipedia.org)
  • Their main structural uses are as part of biological membranes both internal and external, such as the cell membrane, or as a source of energy. (wikipedia.org)
  • proliferation
  • of TRPC decreased the cell routine S stage and cell migration, implicating an operating function for TRP-mediated Ca2+ entrance in cell proliferation and invasion. (cancercurehere.com)
  • Exogenous PUFA and a TRPC3 antagonist regularly attenuated breasts cancer tumor cell proliferation and migration, recommending a mechanism where PUFA restrains the breasts cancer partially via its inhibition of TRPC stations. (cancercurehere.com)
  • Ca2+ entrance via turned on TRPC was improved when PUFA had been absent, recommending a double-gating system for Danshensu TRPC which may be involved with MCF breasts cancer tumor cell proliferation and invasion. (cancercurehere.com)
  • nuclear
  • It has been associated with heterochromatin and PML-NBs (Promyelocytic Leukaemia nuclear bodies) and has been implicated in many nuclear processes including transcription and cell cycle regulation. (wikipedia.org)
  • When the cell is treated with TGF-β, HIPK2, a nuclear kinase, phosphorylates Daxx and the activated Daxx in turn activates the JNK pathway (see "The Daxx Pathway" figure). (wikipedia.org)
  • tissues
  • One more rising problem is that Kendall Reyes Chargers Jersey , in addition to im pting the advancent and survival of aberrant cells, CR and mTOR inhibition may well also impt the stem mobile partnt and enrich maintenance or fix of tissues. (xobor.com)
  • The expression of these Src family members are not the same throughout all tissues and cell types. (wikipedia.org)
  • As these molecules are vital for life, metabolic reactions either focus on making these molecules during the construction of cells and tissues, or by breaking them down and using them as a source of energy, by their digestion. (wikipedia.org)
  • serum
  • Components and strategies Cell lifestyle MCF-7 cells had been grown up in DMEM moderate filled with 10% fetal leg serum and 1% penicillin/streptomycin serum as defined (9). (cancercurehere.com)
  • The heterodimer also stimulated cAMP production and thymidine incorporation by cultured thyroid cells and increased serum thyroxine levels in TSH-suppressed rats in vivo. (jci.org)
  • HAP1 cells are grown in Iscove's Modified Dulbecco's Medium (IMDM) in the presence of 10% fetal calf serum and penicillin/ streptomycin. (horizondiscovery.com)
  • regulation
  • It is involved in the regulation of adenine nucleotide composition within a cell by catalyzing the reversible transfer of the terminal phosphate group between ATP and AMP. (mybiosource.com)
  • Enzymes also allow the regulation of metabolic pathways in response to changes in the cell's environment or to signals from other cells. (wikipedia.org)
  • Caspase
  • Per usual in non-apoptotic growing cells caspase activated dnase is held in check inactivated in the cytoplasm thanks to the association with its inhibitor, inhibitor of caspase-activated DNase (ICAD) also known as DNA fragmentation factor 45 kDa (DFF45). (wikipedia.org)
  • Caspase-3 is activated in the apoptotic cell. (wikipedia.org)
  • inhibition
  • Over-expression of PPARδ also sensitised THP-1 cells to phorbol ester and correspondingly, inhibition of PPARδ by anti-sense RNA completely abolished this response. (biomedcentral.com)
  • morphology
  • Specially M Wnt cells, cloned from a spontaneous mammary tumor from a MMTV Wnt 1 transgenic mouse, ow a senchy mal morphology, stably convey stem cell markers Manti Te'o Chargers Jersey , and swiftly create claudin reduced maArlen Booth s Cocaine Coma provides an important social mentary, exploring many societal problems while grounding itself in a story of an ordinary, middle class Chicago family to which anyone could relate. (xobor.com)
  • HAP1 cells are adherent with fibroblast-like morphology. (horizondiscovery.com)
  • inhibitory
  • Yilmaz and colleagues confird that CR, through its inhibitory consequences of mTOR signaling in Pah cells adja cent to intestinal stem cells, preserves and even enriches intestinal stem cells. (xobor.com)
  • Diabetes
  • A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. (wikipedia.org)
  • Genome
  • Further to this HAP1 wild-type cells have been extensively characterized by whole genome sequencing and transcriptome analysis . (horizondiscovery.com)
  • reactions
  • The word metabolism can also refer to the sum of all chemical reactions that occur in living organisms, including digestion and the transport of substances into and between different cells, in which case the set of reactions within the cells is called intermediary metabolism or intermediate metabolism. (wikipedia.org)
  • types
  • Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. (wikipedia.org)
  • cellular
  • Amino acids also contribute to cellular energy metabolism by providing a carbon source for entry into the citric acid cycle (tricarboxylic acid cycle), especially when a primary source of energy, such as glucose, is scarce, or when cells undergo metabolic stress. (wikipedia.org)
  • modification
  • Adjustments in the Ca2+ focus had been indicated as F/F, where F was the fluorescence strength when cells had been at rest, and F was the modification in fluorescence during excitement. (cancercurehere.com)