Clonal populations. Medical search. Frequent questions

Different strains exist and the predominant strains are different in North America compared to Australia or Europe, but overall a highly clonal population structure exists for MRSA in contrast to MSSA, which is genetically extremely diverse. (vin.com)
MRSP strains also show a highly clonal population structure. (vin.com)
The pan-genome analysis revealed a highly clonal population of Staphylococcus isolates, particularly among S. aureus isolates. (bvsalud.org)

Knowledge about evolution of clonal hematopoiesis, which may drive malignant progression, is crucial for clinical decision-making. (hematologiegroningen.nl)
NEW YORK - A handful of germline gene variants contribute to the risk of developing aging-related clonal hematopoiesis, a new study has found. (genomeweb.com)
To find germline drivers of this condition, called clonal hematopoiesis of indeterminate potential (CHIP), a team led by Broad Institute researchers examined the genomes of thousands of individuals with and without CHIP. (genomeweb.com)
Overall, we observe that germline genetic variation shapes hematopoietic stem cell function, leading to CHIP through mechanisms that are specific to clonal hematopoiesis as well as shared mechanisms that lead to somatic mutations across tissues," co-senior authors Sekar Kathiresan and Pradeep Natarajan, both of the Broad, and their colleagues wrote in their paper. (genomeweb.com)

As people age, they can acquire somatic mutations that lead to clonal expansion within their population of regenerating hematopoietic stem cells, which in turn can lead to hematological cancer and coronary heart disease. (genomeweb.com)
These mutations and clonal T cells may potentially involve in the pathogenic baseline in these patients rendering exaggerated persistent thrombopoiesis oscillations of their intrinsic rhythm upon homeostatic perturbations. (stanford.edu)

A clonal colony or genet is a group of genetically identical individuals, such as plants, fungi, or bacteria, that have grown in a given location, all originating vegetatively, not sexually, from a single ancestor. (wikipedia.org)
Whereas their clonal populations are genetically identical, they contain phenotypically distinct individuals. (weizmann.ac.il)

McGranahan, N. & Swanton, C. Clonal heterogeneity and tumor evolution: past. (nature.com)

We also tested the alternative hypothesis that clonal diversity is maintained by the input of clones by mutation from sympatric sexuals. (ox.ac.uk)
The somatic mutation occurs initially in a single cell, which continues to grow and divide, producing a group of cells with the same mutation (a clonal population). (medlineplus.gov)

The Tabima lab uses a multidisciplinary approach of integrating tools and concepts from evolutionary theory, computational biology, genomics, genetics, and plant pathology/mycology in order to study these phenomena, as well as to create computational and molecular tools for the rapid identification of species, populations, genes of interest and molecular patterns of fungal evolution. (clarku.edu)
The effect of habitat choice on evolutionary rescue in subdivided populations. (mpg.de)
Evolutionary rescue in randomly mating, selfing, and clonal populations. (mpg.de)
Evolutionary rescue in structured populations. (mpg.de)

We investigated the landscape of clonal evolution by error-corrected sequencing on 7,045 sequential samples from 3,359 individuals in the prospective population-based Lifelines cohort, with a special focus on cytosis and cytopenia. (hematologiegroningen.nl)
Greaves, M. & Maley, C. C. Clonal evolution in cancer. (nature.com)
Burrell, R. A. & Swanton, C. Re-evaluating clonal dominance in cancer evolution. (nature.com)
In the first, the archetypal evolution experiment, populations derived from the same ancestor are serially propagated in a new environment. (frontiersin.org)
His lab is interested in identifying the patterns of genomic evolution of fungal species and populations, especially focused on the evolution, systematics, and genomics of secondary metabolism of the genus Basidiobolus . (clarku.edu)
author = {{Cronberg, Nils}}, issn = {{1615-6110}}, keywords = {{Bryophyta - Sphagnum rubellum - S. capillifolium - Isozymes - allozymes - genetic distance - genetic diversity - clonal diversity - breeding system - hybridization - gene flow - postglacial migration}}, language = {{eng}}, number = {{3-4}}, pages = {{139--158}}, publisher = {{Springer}}, series = {{Plant Systematics and Evolution}}, title = {{Population structure and interspecific differentiation of peat moss sister species Sphagnum capillifolium and S. rubellum in northern Europe. (lu.se)

Spatial transcriptomics of planktonic and sessile bacterial populations at single-cell resolution. (weizmann.ac.il)
George - You need to think of bacterial populations, of course, as clonal. (thenakedscientists.com)

Interspecific gene flow was indicated by the observation of occasional plants in sympatric populations with alleles otherwise unique to the other species. (lu.se)

We combined these data with a ddRAD-seq dataset to test the hypotheses that high elevation populations would exhibit ecological and genomic signatures of leading range edge populations. (nature.com)
van der Valk T, Díez-Del-Molino D, Marques-Bonet T, Guschanski K, Dalén L. Historical genomes reveal the genomic consequences of recent population decline. (upf.edu)

Background and objective: Clonal strains of Pseudomonas aeruginosa have been identified in large cystic fibrosis (CF) centres. (edu.au)
Methods: P. aeruginosa isolates from CF adults aged 15 years and over in Tasmania were genotyped using random amplified polymorphic DNA (RAPD)-PCR and clonal strains confirmed with pulsed field gel electrophoresis. (edu.au)
Conclusions: Clonal strains of P. aeruginosa may arise even in isolated CF populations. (edu.au)

2019 ). Leading edge populations are often those at higher elevation or latitude that have been established more recently, which is frequently accompanied by a reduction in genetic diversity and increased differentiation as a consequence of founder effects (Nei et al. (nature.com)
Population structure and interspecific differentiation of peat moss sister species Sphagnum capillifolium and S. rubellum in northern Europe. (lu.se)
capillifolium were dominated by few genotypes, and differentiation among populations was pronounced, indicating a low level of sexual recombination. (lu.se)

These data suggest a clonal population structure to B. thuringiensis with some consistency of Cry-plasmid composition within PFGE types. (hw.ac.uk)
In this study we used whole genome sequencing to characterize the clonal composition, virulence and resistance genetic determinants of 58 Staphylococcus/Mammaliicoccus spp. (bvsalud.org)

Exposure to a tumor promoter will evoke an altered response pattern wherein initiated cells, but not the normal population, are stimulated to grow. (bvsalud.org)

Here we measure clone dynamics in human cancers by using computational modeling of subclonal selection and theoretical population genetics applied to high-throughput sequencing data. (nature.com)
In this study, we analyzed the effect of topography, particularly slope, on the expansion rates and population dynamics of Echinospartum horridum at small spatial and temporal scales in the grassland communities of Ordesa-Monte Perdido National Park (OMPNP) (NE Spain). (bioone.org)
For scleractinian corals, spatial differences in temperature, light, water flow and water quality conditions can influence their distribution and population dynamics [ 2 - 5 ]. (plos.org)

2008 ), understanding the distribution of genetic diversity and the population connectivity across species ranges offers insight into the capacity for populations to endure climate change, especially at environmentally stochastic range edges (Razgour et al. (nature.com)
Clonal colonies are common in many plant species. (wikipedia.org)
This study reports the first evidence of population structure of fire corals in two common reef environments and illustrates the importance of water flow in driving population dynamic processes of these reef-building species. (plos.org)
capillifolium, versus 0.627 between populations of the two species. (lu.se)

Leading range edge populations, like those at upper elevation limits, are crucial for climate change responses but can exhibit low genetic diversity due to founder effects, isolation, or limited outbreeding. (nature.com)
Reduced diversity and high genetic load in leading edge populations can reduce overall population performance (Bontrager et al. (nature.com)
Parasites, sex, and clonal diversity in natural snail populations. (ox.ac.uk)
Although this mechanism might underlie the persistence of sexual reproduction, it might also maintain high clonal diversity. (ox.ac.uk)
Alternatively, clonal diversity might be maintained by multiple origins of parthenogens from conspecific sexuals, a feature in many animal groups. (ox.ac.uk)
We specifically examined the contribution of parasites to host clonal diversity and the frequency of sexually reproducing individuals in natural stream populations of Potamopyrgus antipodarum snails. (ox.ac.uk)
Clonal diversity and the frequency of sexual individuals were both positively related to infection frequency. (ox.ac.uk)
Our findings thus highlight the importance of parasites as drivers of clonal diversity, as well as sex. (ox.ac.uk)

Dubé CE, Mercière A, Vermeij MJA, Planes S (2017) Population structure of the hydrocoral Millepora platyphylla in habitats experiencing different flow regimes in Moorea, French Polynesia. (plos.org)
Risk of obstetric and perinatal complications in women presenting with breast cancer during pregnancy and the first year postpartum in Sweden 1973-2017: A population-based matched study. (cancercentrum.se)

The comparative genomics and complex population history of Papio baboons. (upf.edu)

With most woody plants, clonal colonies arise by wide-ranging roots that at intervals send up new shoots, termed suckers. (wikipedia.org)
Ferns and many herbaceous flowering plants often form clonal colonies via horizontal underground stems termed rhizomes, e.g. ostrich fern Matteuccia struthiopteris and goldenrod. (wikipedia.org)
It is however possible that undiscovered clonal colonies of trees rival or exceed its size and/or age. (wikipedia.org)
When woody plants form clonal colonies, they often remain connected through the root system, sharing roots, water and mineral nutrients. (wikipedia.org)
A few non-vining, woody plants that form clonal colonies are Bigelow oak (Quercus sinuata var. (wikipedia.org)
The size structure varied among reef habitats with higher proportions of larger colonies in calm nearshore reefs (fringing and patch reefs), while populations were dominated by smaller colonies in the exposed fore reefs. (plos.org)

Gaviria Rivera, AM & Priest, FG 2003, ' Pulsed field gel electrophoresis of chromosomal DNA reveals a clonal population structure to Bacillus thuringiensis that relates in general to crystal protein gene content ', FEMS Microbiology Letters , vol. 223, no. 1, pp. 61-66. (hw.ac.uk)
Clonal plasma cell proliferative diseases in which the Vl 6 gene is expressed are always associated with amyloid deposition. (medscape.com)

George - They're all identical in a population. (thenakedscientists.com)

Our lab applies single-cell and spatial transcriptomics approaches to globally study cell-cell variation across lifestyles, from free-living populations and biofilms assemblies to bacterial colonization of host tissues. (weizmann.ac.il)

Using the widespread herb, Argentina anserina , we measured ecological attributes (population density on the landscape, area of population occupancy, and plant and flower density) spanning a 1000 m elevation gradient, with high elevation populations at the range limit. (nature.com)
While the fire coral Millepora platyphylla is an important component of Indo-Pacific reefs, where it thrives in a wide range of environments, the ecological and biological processes driving its distribution and population structure are not well understood. (plos.org)

CONCLUSIONS: Our study provides clinically relevant information on the population profile, virulence and antibiotic resistance of Staphylococcus/Mammaliicoccus spp. (bvsalud.org)

So you can view that if one cell gets infected by a virus and give up it's life then, essentially, it's protecting the rest of the clones in that population. (thenakedscientists.com)
8/23 clones) at neuraminidase (NA) residue 292, as determined by clonal sequencing. (flutrackers.com)

Severe liver abscess infections caused by hypervirulent clonal-group CG23 Klebsiella pneumoniae have been increasingly reported since the mid-1980s. (pasteur.fr)

Our new study describes 15 stable wild populations in 9 European countries and provides evidence for incipient genetic separation of geographically separated populations. (nature.com)

DNA sequence analysis of T-cell receptors was used to further define clonal populations of HDI-responsive T cells. (cdc.gov)

Then generally, these infected cells burst open to release lots of new virus which then goes on to infect other bacteria in the population. (thenakedscientists.com)
The "Clonal Deletion theory," suggests that self-reactive lymphoid cells are eliminated during immunological development. (news-medical.net)
Proposed by Gustav Nossal, the "Clonal Anergy theory" suggests that reactive T- or B-cells become deactivated during development and fail to increase immune responses. (news-medical.net)
The "Clonal Ignorance theory" suggests that self-reactive T cells not present in the thymus move to the periphery where they fail to encounter target antigens . (news-medical.net)
The "Suppressor population or Regulatory T cell theory," holds that regulatory T-lymphocytes such as CD4+FoxP3+ cells prevent, down regulate or reduce aggressive immune responses to self tissues. (news-medical.net)

Nous suivons en parallèle la génétique des populations végétales: structure et diversité y compris à l'échelle du clone- individu, flux de gènes, tests de paternité. (uclouvain.be)

Studies have revealed a heterogeneous subclonal architecture to lung cancer, which contributes to the persistence of the disease by allowing the tumour to metastasise to distant sites, utilising the different phenotypic characteristics of the heterogeneous population. (dcu.ie)
Clonal expansion is not dependent on classical cancer risk factors (e.g., smoking). (hematologiegroningen.nl)
NCI supports a range of research, from understanding aging biology as a driver of cancer biology to eliminating population-level cancer disparities due to chronological, functional, or biological age. (cancer.gov)
This is achieved through mechanistic studies of functionally important epigenetic "driver" genes and molecular pathways altered by specific cancer risk agents and by the application of cutting-edge epigenomics in conjunction with unique biospecimens from population-based cohorts (Figure 1). (who.int)
The polymorphic genes have subtle effect on cancer risk at individual level but may have a large population impact because the relevant polymorphism may be highly prevalent in a population. (bvsalud.org)
Medical and surgical postoperative complications after breast conservation versus mastectomy in older women with breast cancer: Swedish population-based register study of 34 139 women. (cancercentrum.se)
Inflammatory Drugs and Risk of Breast Cancer: Evidence from a General Female Population and a Mammographic Screening Cohort in Sweden. (cancercentrum.se)
Schiza A, Fredriksson I, Sund M, Valachis A. De novo metastatic breast cancer in men vs women: a Swedish population-based cohort study. (cancercentrum.se)

These "low-risk" genes can also become important determinants to assess population risk 8 . (bvsalud.org)

Hovén E , Flynn KE, Weinfurt KP, Eriksson LE, Wttergren L. Psychometric evaluation of the Swedish version of the PROMIS Sexual Function and Satisfaction Measures in clinical and nonclinical young adult populations. (cancercentrum.se)

This outbreak of shigellosis highlights the threat of enteric diseases to vulnerable populations such as internally displaced persons in Papua New Guinea, as has been observed in other global settings. (who.int)

Phylogeographic analysis supported more recent colonization of high elevation populations which were also more genetically isolated, had more extreme heterozygote excess and had smaller effective population size than low. (nature.com)
Results support that colonization of high elevations was likely accompanied by increased asexuality, contributing to a decline in effective population size. (nature.com)

Modeling antimicrobial cycling and mixing: Differences arising from an individual-based versus a population-based perspective. (mpg.de)

With other vines, rooting of the stem where nodes come into contact with soil may establish a clonal colony, e.g. (wikipedia.org)
To establish a first size estimate for a marbled crayfish population, we used the mark-recapture approach. (nature.com)

It also facilitates cooperative interactions between different sub-populations via specialization in costly activities such as virulence factor production and through metabolite exchanges, forming an extended basis for sociality. (weizmann.ac.il)

As a consequence, the animals have formed numerous stable wild populations. (nature.com)
A good example for a stable wild population is provided by the type locality, Lake Reilingen, a small (9 ha) lake close to Heidelberg, Germany. (nature.com)
In addition, both patients had clonal T-cell populations that remained stable throughout platelet count cycles. (stanford.edu)

We measured vegetative clonal potential in the greenhouse for populations spanning the gradient. (nature.com)

Further, oxidant-induced toxicity in the normal population may facilitate the clonal expansion of the more resistant initiated cell during promotion 2,5,29 . (bvsalud.org)

They suggested that additional studies of diverse populations will likely uncover other important biological pathways. (genomeweb.com)

What's the benefit to the population as a whole of that bacterium surrendering itself? (thenakedscientists.com)

However, it is not always easy to recognize a clonal colony especially if it spreads underground and is also sexually reproducing. (wikipedia.org)

Hartl, D. L. & Clark, A. G. Principles of Population Genetics . (nature.com)

EGE also develops epigenomic methodologies, profiling strategies, and bioinformatics tools, applicable to population-based cohorts and molecular epidemiology studies coordinated by IARC researchers and external collaborators. (who.int)

We found that population density on the landscape declined towards the high elevation limit, as is expected towards range edges. (nature.com)
In the greenhouse, high elevation plants exhibited stronger clonal potential than low elevation plants, likely explaining increased plant density in the field. (nature.com)
Despite high plant density in leading edge populations, their small effective size, isolation and clonality could constrain adaptive potential. (nature.com)
The results suggested that the population consisted of 23,000 adult marbled crayfish, which represents a strikingly high number considering the small size of the habitat and the relatively adverse environment. (nature.com)
Clonal origin and development of high hyperdiploidy in childhood acute lymphoblastic leukaemia. (lu.se)

In addition to cases of monoclonal gammopathy in which the secreted clonal immunoglobulin remains in solution and those in which secreted clonal immunoglobulin forms amyloid deposits, a third group consists of cases in which the monoclonal proteins accumulate in various organs, but the deposits do not form fibrils. (medscape.com)

Overdiagnosis by "consensus-2" criteria has potential to be problematic, but underdiagnosis by "consensus-1" criteria seems the far larger problem given (1) increasing appreciation that MCAS is prevalent (up to 17% of the general population), and (2) most MCAS patients, regardless of illness duration prior to diagnosis, can eventually identify treatment yielding sustained improvement. (degruyter.com)

Finally, we discuss how certain hallmarks of ageing (epigenetic alterations, mitochondrial dysfunction, telomere attrition, cellular senescence, and altered intercellular communication) predispose the ageing population to severe COVID-19. (ersjournals.com)

Further theories currently being investigated include the "Clonal Ignorance theory," and the "Suppressor population or Regulatory T cell theory. (news-medical.net)

In plants, an individual in such a population is referred to as a ramet. (wikipedia.org)
capillifolium from a sample of 1313 plants representing 37 populations from Scandinavia, Great Britain and S Germany. (lu.se)

Kelly, Shane (2016) Proteomic characterisation of clonal populations from a humanlung carcinoma cell line. (dcu.ie)
Shootin-1 and Desmoglein-3 expression were affected by co-culture of the clonal subpopulations, highlighting the heterogeneous nature of the original DLKP cell line and the influences this has on protein expression. (dcu.ie)
This, in turn, creates a clonal population of a single abnormal cell. (medscape.com)
And that triggers the cell to then say well, I must wipe myself out because if I allow this virus to replicate in me I'm going to then infect the rest of my population. (thenakedscientists.com)
Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell (HSC) disease. (medscape.com)

AIM: The purpose of this study was to examine the prevalence of cigarette and water pipe tobacco use among pupils aged 13-17 years in the urban area of Sousse, Tunisia and to identify the factors which predict current cigarette and/or waterpipe smoking in this population. (who.int)

Anatomy3

Organisms2

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes21

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science4

Health Care3

Highly clonal population3

Hematopoiesis4

Mutations2

Genetically identical2

Heterogeneity1

Mutation2

Evolutionary4

Evolution6

Bacterial populations2

Sympatric1

Genomic2

Strains3

Differentiation3

Composition2

Tumor1

Dynamics3

Species4

Diversity8

20172

Genomics1

Colonies6

Gene2

Identical1

Spatial1

Ecological2

Conclusions1

Clones2

Infections1

Incipient1

Define1

CELLS5

Structure1

Cancer8

Determinants1

Clinical1

Diseases1

Colonization2

Versus1

Establish2

Virulence1

Stable3

Gradient1

Expansion1

Pathways1

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Sexually1

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High5

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