Clonal immunoglobulin heavy chain gene gene rearrangement b lymphocyte heavy chain. Medical search. Frequent questions

The tissue tested positive for T-cell receptor gene rearrangement by polymerase chain reaction analysis. (biomedcentral.com)
In 1990, Burke et al ( 3 ), first reported the association between EBV and gastric carcinoma with characteristic lymphoepithelioma-like histology based on polymerase chain reaction (PCR) techniques. (spandidos-publications.com)
When lymphoid leukemia is suspected in cats, the diagnostic process often involves peripheral blood assessment, including complete blood count (CBC) with differential count, flow cytometry (FC) analysis, and polymerase chain reaction (PCR) for antigen receptor rearrangement (PARR). (e-jvc.org)
L&H cells from lymphocyte predominant HL cases and centroblasts from lymphadenites were micromanipulated and analysed for AID expression by quantitative real time polymerase chain reaction. (bmj.com)

Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
the gene expression profile during B lymphoid differentiation. (lu.se)
10. Fournillier A, Freida D, Defrance T, Merle P, Trépo C, Inchauspé G. Analysis of B-lymphocyte differentiation in patients infected with hepatitis C virus. (southernbiotech.com)
The basic and common immunologic defect in common variable immunodeficiency is a failure of B-lymphocyte differentiation into plasma cells that produce the various immunoglobulin (Ig) isotypes. (medscape.com)
Starting with the opening address on B lymphocyte differentiation and the tolerance problem, the remainder of the book presents the contributions made by researchers at the symposium. (elsevier.com)
The occurrence of switching without the accumulation of V gene mutations indicates that the processes of differentiation and diversification are not linked. (omicsdi.org)

11 To clarify this issue for lymphocyte predominant HL we quantitatively examined the expression of AID in the L&H cells of six patients with lymphocyte predominant HL at the transcription level, because suitable antibodies for immunohistochemistry are not yet available. (bmj.com)
Antibodies, also referred to as immunoglobulins, are proteins made by B-cells that play a crucial role in the immune response of our body. (e-adventure.net)
Such binding of antibodies to antigens initiates a chain of events that helps our immune system to destroy or remove the foreign pathogens from our body. (e-adventure.net)
Out of the two types of lymphocytes, B-cells are the ones responsible for producing antibodies. (e-adventure.net)
Antibodies are Y-shaped proteins that have a unique structure with two heavy chains and two light chains joined together by disulfide bonds. (e-adventure.net)
The production of antibodies by B-cells is a complex multistep process that involves extensive genetic rearrangement and recombination before the final product is produced. (e-adventure.net)
Antibodies are glycoproteins belonging to the immunoglobulin superfamily . (wikipedia.org)
Antibodies are heavy (~150 k Da ) proteins of about 10 nm in size, [7] arranged in three globular regions that roughly form a Y shape. (wikipedia.org)
Antibodies (also known as immunoglobulins [1] ) are proteins that are found in blood or other bodily fluids of vertebrates , and are used by the immune system to identify and neutralize foreign objects, such as bacteria and viruses . (wikidoc.org)
each antibody has two large heavy chains H and two small light chains L . Antibodies are produced by a kind of white blood cell called a B cell . (wikidoc.org)
There are several different types of antibody heavy chain, and several different kinds of antibodies, which are grouped into different isotypes based on which heavy chain they possess. (wikidoc.org)
The large and diverse population of antibodies is generated by random combinations of a set of gene segments that encode different antigen binding sites (or paratopes ), followed by random mutations in this area of the antibody gene, which create further diversity. (wikidoc.org)

To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
The three gene segments (variable, diversity, joining) which encode the variable domain (the VDJ region for the H chain, and the VJ region for the L chain) are capable of undergoing a process called recombination. (healthtipsdesk.com)
In all five CLLs, the pattern of C mu DNA probe hybridization to the digested genomic DNAs was consistent with deletion of the C mu exon from the rearranged Ig gene locus, suggesting that these CLL B cells had undergone DNA switch recombination. (omicsdi.org)

Acute lymphocytic leukemia (ALL) is a malignant clonal disorder of the bone marrow lymphopoietic precursor cells. (medscape.com)
Feline lymphocytic leukemia is a common neoplastic disorder characterized by the proliferation of neoplastic lymphocytes in bone marrow. (e-jvc.org)
B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
B lymphocytes, named after their site of origin in the bursa of Fabricius in birds or in the bone marrow in humans, form the basis for humoral immunity by their production of immunoglobulins. (medscape.com)
Therapies for these disorders (eg, intravenous immunoglobulin [IVIG], bone marrow transplantation, gene therapy) are very costly and require highly advanced facilities. (medscape.com)
The latter migrate back to the bone marrow and start producing immunoglobulins. (medscape.com)
We treat acute myocardial infarction by targeting exogenous bone marrow-derived stem cells (expressing CD45) or endogenous CD34-positive cells to injured cardiomyocytes (expressing myosin light chain. (regenerativemedicine.net)

1 Analysis of V gene rearrangements in single L&H cells revealed the presence of somatic mutations with intraclonal diversity in functional monoclonal V gene rearrangements, in line with a GC B cell origin. (bmj.com)
The immunoglobulin (Ig) variable region (V) genes expressed by IgM chronic lymphocytic leukemia (CLL) B cells display little or no somatic mutations. (omicsdi.org)
In all other class-switched CLLs, the Ig VH segment gene was mutated, but the point mutations were not associated with intraclonal diversification. (omicsdi.org)
These switched transcripts do not reveal evidence for the accumulation of significant numbers of new V(H) gene mutations. (omicsdi.org)
The genetic landscape of CLL has been recently enriched with mutations within a number of genes proposed as novel prognostic markers. (ndltd.org)
The aim of this thesis was to evaluate the prognostic relevance of recurrent gene mutations and to assess the clinicobiological associations and clinical impact of BcR IG stereotypy in CLL. (ndltd.org)
In a cohort of 3490 patients, NOTCH1, SF3B1 and TP53 mutations were enriched within clinically aggressive cases carrying unmutated IGHV genes (U-CLL), frequently co-occurring with trisomy 12, del(11q) and del(17p), respectively. (ndltd.org)
Mutations of the FOXP3 gene can prevent regulatory T cell development, causing the fatal autoimmune disease IPEX . (wikidoc.org)
To generate a large number of unselected mutations, we immunized B1-8 H chain transgenic mice with nitrophenyl to stimulate nitrophenyl-specific λ + germinal center B cells and sequenced the unexpressed κ L chains using next-generation methods. (aai.org)

In European registry data, serious infections were not related to presenting levels of serum immunoglobulin G (IgG). (medscape.com)

Burnet's clonal selection theory, formulated in 1957, states that every B-cell clone is characterized by an unique antigen specificity, i.e., it bears a specific antigen receptor. (healthtipsdesk.com)
The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. (elifesciences.org)

Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
Atypical lymphoid hyperplasia due to clonal expansion of B or T lymphocytes has been reported in as many as one third of patients with common variable immunodeficiency. (medscape.com)
immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
It is a clonal genetic heterogeneous disease generally thought to arise from the malignant transformation and expansion of a single lymphoid progenitor at various stages of development ( 3 - 5 ). (frontiersin.org)

The neoplastic cells are both small lymphocytes and larger, transformed lymphoblasts, and they invade the mantle zone of splenic follicles and erode the marginal zone, ultimately invading the red pulp of the spleen. (wikipedia.org)
The neoplastic cells circulating in the peripheral blood are termed villous lymphocytes due to their characteristic appearance. (wikipedia.org)
Reactive germinal centers in splenic white pulp are replaced by small neoplastic lymphocytes that efface the mantle zone and ultimately blend in with the marginal zone with occasional larger neoplastic cells that resemble blasts. (wikipedia.org)
The red pulp is always involved, with both nodules of larger neoplastic cells and sheets of the small neoplastic lymphocytes. (wikipedia.org)
The neoplastic cell is a hypoproliferative, immunologically incompetent small lymphocyte. (medscape.com)
In non-neoplastic mucosa, methylation of H. pylori infection associated genes was higher in patients with GC than those without. (hokudai.ac.jp)

The lymphocytic and histiocytic (L&H) cells of lymphocyte predominant Hodgkin lymphoma (HL) originate from germinal centre B cells and carry mutated V gene rearrangements, usually with intraclonal diversity. (bmj.com)
Intraclonal diversity in V gene rearrangements as a result of active somatic hypermutation is a typical feature of GC B cells. (bmj.com)
The diversity of T-cell receptors is also achieved by means of genetic rearrangement of V, D, and J segments. (healthtipsdesk.com)
V(D)J recombinations in lymphocytes are essential for immunological diversity. (vidjil.org)

The specificity of an antibody is determined by the amino acid sequence of the variable domains of the H and L chains, and this sequence is unique for each corresponding cell clone. (healthtipsdesk.com)
Out of all the types of leukocytes, lymphocytes are the key player responsible for antibody production. (e-adventure.net)
Upon BCR activation, the cell integrates various signaling pathways that lead to the expression of essential genes, including genes involved in antibody production. (e-adventure.net)
The tumour cells are malignant plasma cells of the same clonal origin, and secrete high amounts of monoclonal antibody, known as the M-component. (touchoncology.com)
An antibody ( Ab ), also known as an immunoglobulin ( Ig ), [1] is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and viruses . (wikipedia.org)
The terms antibody and immunoglobulin are often used interchangeably, [1] though the term 'antibody' is sometimes reserved for the secreted, soluble form, i.e. excluding B-cell receptors. (wikipedia.org)
Schematic structure of an antibody: two heavy chains (blue, yellow) and the two light chains (green, pink). (wikipedia.org)
[2] [5] Antibody genes also re-organize in a process called class switching that changes the base of the heavy chain to another, creating a different isotype of the antibody that retains the antigen specific variable region. (wikidoc.org)

Non-B, non-T cell lymphoproliferative diseases are characterized by the absence of B-cell or T-cell-specific antigens and instead express common lymphocyte antigens. (e-jvc.org)
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. (elifesciences.org)
T-cell receptors (TCR) and B-cell receptors (BCR) are hypervariable immunoglobulins that play a key role in recognizing antigens in the vertebrate immune system. (elifesciences.org)

Cytosine modifications directly affect the positioning of nucleosomes (the first level of chromatin organization into chromosome involving the DNA chain wound around a core of 8 histone proteins), and recruit chromatin-modifying complexes that modify histones. (i-sis.org.uk)
Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)

Patients who have common variable immunodeficiency and autoimmune conditions appear to have very low numbers of isotype-switched memory B cells in peripheral blood and are more likely to have a mutation in the gene that encodes TACI ( TNFRST13B ). (medscape.com)
7. Klein U, Rajewsky K, Küppers R. Human immunoglobulin (Ig)M + IgD + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. (southernbiotech.com)
To investigate the effects of age and gender on human lymphocyte populations, we studied lymphocyte subsets and their expression of activation markers in peripheral blood in healthy people above the age of 21, and analyzed this according to gender. (biomedcentral.com)

Membrane IgD and membrane IgM differ in capacity to transduce inhibitory signals within the same human B cell clonal populations. (southernbiotech.com)

The uniformity of the numbers of terminal repeats (TRs) among EBV positive carcinoma cells reflects the clonal origin of a tumor and suggests that EBV is a causative virus for gastric carcinoma ( 6 ). (spandidos-publications.com)
The leukogram also showed remarkable lymphocytic leukocytosis, with a lymphocyte count of 41,600 cells/μL (reference interval: 920-6,880 cells/μL), a total white blood cell counts of 45,570 cells/μL (reference interval: 2,870-17,020 cells/μL) and a neutrophil count of 140 cells/μL (reference interval: 2,300-10,290 cells/μL). (e-jvc.org)
The lymphocytic and histiocytic (L&H) cells of lymphocyte predominant HL express B cell markers and also the germinal centre (GC) marker BCL6, indicating that they are derived from GC B cells. (bmj.com)
CD5 is a potential selecting ligand for B-cell surface immunoglobulin: a possible role in maintenance and selective expansion of normal and malignant B cells. (southernbiotech.com)
We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Memory cells travel to the primary follicle, where, after exposure to dendritic cells, they differentiate into centroblasts (immunoglobulin class-switch). (medscape.com)
The immune system is comprised of various continuously circulating cells (T and B lymphocytes, and antigen-presenting cells present in various tissues). (healthtipsdesk.com)
Part VI examines immunoglobulin idiotypes while Part VII contains papers on the ontogeny of immunoglobulin-synthesizing cells. (elsevier.com)
These lymphocytes comprise two major types: T-cells and B-cells. (e-adventure.net)
These isotype-switched CLL B cells expressed surface HLA-DR, CD19, CD23, and CD5, and displayed no alterations of the bcl-1 and bcl-2 oncogenes and the p53 tumor-suppressor gene. (omicsdi.org)
The cDNA VH-D-JH gene sequence was joined with that of the C alpha gene in the B cells of the three IgA CLLs, and with that of the C gamma gene in the IgG CLL B cells. (omicsdi.org)
In the IgA/IgG-coexpressing CLL B cells, identical VH-D-JH cDNA sequences were spliced to either C alpha or C gamma genes. (omicsdi.org)
These findings suggest that IgA- and/or IgG-expressing CLLs represent, in their VH gene structure, transformants of B cells at different stages of ontogeny. (omicsdi.org)
They also suggest that Ag may play a role in the clonal selection of some of these isotype-switched leukemic cells, but bcl-1 and bcl-2 oncogene rearrangements and p53 tumor suppressor gene mutation are not associated with the pathogenesis of isotype-switched CLLs. (omicsdi.org)
To test the hypothesis that in vivo isotype class switching occurs in IgM+ B-type CLL cells, we analyzed the PBMC of 19 CLL patients for the presence of transcripts encoding the rearranged CLL V(H)DJ(H) associated with either gamma or alpha H chains. (omicsdi.org)
Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis. (omicsdi.org)
Most B cells in neonatal Alicia rabbits express V H n allotype immunoglobulin (Ig)M. Within weeks, the number of V H n B cells decreases, whereas V H a allotype B cells increase in number and become predominant. (silverchair.com)
Cells are slightly larger than lymphocytes . (wikidoc.org)
T cells belong to a group of white blood cells known as lymphocytes , and play a central role in cell-mediated immunity . (wikidoc.org)
They can be distinguished from other lymphocyte types, such as B cells and NK cells by the presence of a special receptor on their cell surface called the T cell receptor (TCR). (wikidoc.org)
Natural Killer T cells (NKT cells) are a special kind of lymphocyte that bridges the adaptive immune system with the innate immune system . (wikidoc.org)
A majority of T cells have a TCR composed of two glycoprotein chains called α- and β- TCR chains. (wikidoc.org)
However, in γδ T cells, the TCR is made up of one γ-chain and one δ-chain. (wikidoc.org)
This group of T cells is much less common (5% of total T cells) than the αβ T cells, but are found at their highest abundance in the gut mucosa , within a population of lymphocytes known as intraepithelial lymphocytes (IELs). (wikidoc.org)
Solitary or multiple benign cutaneous nodules comprised of immature and mature vascular structures intermingled with endothelial cells and a varied infiltrate of eosinophils, histiocytes, lymphocytes, and mast cells. (lookformedical.com)

High-throughput sequencing (HTS) of the immunoglobulin heavy chain ( IgH ) locus is a recent very efficient technique to monitor minimal residual disease of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). (frontiersin.org)
Initially identified as the fusion partner of the immunoglobulin heavy chain gene locus in the classic t(14;18) translocation of follicular lymphoma (FL), BCL2 overexpression was recognized to confer resistance to apoptosis [ 2 ]. (biomedcentral.com)

Immunoglobulin heavy chain rearrangement (IgH) by PCR analysis did not detect a clonal B-cell population, thereby confirming T-cell lymphoma. (biomedcentral.com)
It is unclear whether intraclonal V gene diversification by somatic hypermutation, which is strictly dependent on the enzyme activation induced cytidine deaminase (AID), is restricted to the early phase of lymphoma clone expansion and later silenced, or whether it remains active throughout malignant proliferation. (bmj.com)
Hodgkin lymphoma (HL) is subdivided into classic forms and lymphocyte predominant HL. (bmj.com)

In a series of 8593 CLL patients, stereotyped subsets showed marked differences in demographics, clinical presentation, cytogenetic aberrations and gene mutational spectrum. (ndltd.org)
We performed this study to see if there were differences between males and females in the frequency of the different lymphocyte subsets with age. (biomedcentral.com)
The cause of the change in percentage of lymphocyte subsets with age, and the different effects on males and females is not fully understood but warrants further study. (biomedcentral.com)

Chronic lymphocytic leukemia (CLL) represents a monoclonal expansion of lymphocytes. (medscape.com)

Chromosomal rearrangements may alter the structure or regulation of cellular oncogenes. (medscape.com)
Furthermore, post-transcriptional gene expression regulation by cellular and/or EBV-derived microRNAs has attracted considerable attention. (spandidos-publications.com)
Furthermore, we discuss recent findings on EBV associated gastric carcinogenesis by focusing on the roles of latent genes, epigenetic abnormalities, genomic alterations, and post-transcriptional regulation by cellular and viral microRNAs (miRNAs). (spandidos-publications.com)
9. Bräuninger A, Goossens T, Rajewsky K, Küppers R. Regulation of immunoglobulin light chain gene rearrangements during early B cell development in the human. (southernbiotech.com)

7 Several studies analysing AID expression and mutation patterns in V gene rearrangements in various B cell non-HLs showed that, although somatic hypermutation activity is strictly dependent on AID, the expression of this protein does not necessarily indicate ongoing somatic hypermutation. (bmj.com)
X-linked agammaglobulinemia (XLA), also known as Bruton agammaglobulinemia, results from a mutation of the BTK gene, which encodes the pre-B-cell receptor (Pre-BCR) and BCR. (medscape.com)

However, in most cases there are specific features that may aid in differentiating small reactive from non-reactive lymphocytes including the round shape of the nucleus, the absence of visible nucleoli and the presence of fine clumped chromatin. (cytojournal.com)
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)

Part I contains studies on immunoglobulin genes, messages, and molecules. (elsevier.com)
Part III examines membrane immunoglobulins while Part IV focuses on immunoglobulins as regulatory molecules. (elsevier.com)

The recirculating lymphocytes selectively infiltrate the lymph nodes, the spleen, and the liver. (medscape.com)

The AID transcription level was higher than background in three of the six lymphocyte predominant HL cases, although it was lower than that seen in centroblasts. (bmj.com)

Part II presents studies on cellular immunoglobulin production. (elsevier.com)

Previous studies have shown that some EBV latent genes have oncogenic properties. (spandidos-publications.com)

It also reveals the sequences of clonal rearrangements, therefore, the multiclonal structure, of BCP-ALL. (frontiersin.org)
chain repertoires, by establishing a near-complete list of unique receptor chain sequences, or 'clonotypes', present in a sample. (elifesciences.org)

A special characteristic of the immunoglobulin classes IgA and IgM is that these comprise a basic monomeric structure that can be doubled or quintupled. (healthtipsdesk.com)

The tissue was found to be positive for the T-cell receptor (TCR) by gamma gene rearrangement studies by PCR analysis (Figure 5 ). (biomedcentral.com)
Accordingly, once rearrangement of the Ig genes has taken place, the corresponding protein will be expressed as a surface receptor. (healthtipsdesk.com)
Mounting evidence also supports the pivotal role of the clonotypic B-cell receptor immunoglobulin (BcR IG) in the natural history of CLL. (ndltd.org)

The cause for this clonal expansion is poorly understood in most cases, but it appears to involve some rearrangement of the DNA. (medscape.com)

In 95% of cases, CLL is a predominantly malignant clonal disorder of B lymphocytes. (medscape.com)

Soon after fertilization, the vast majority of methylcytosine in sperm is converted by the Tet3 enzyme to hydroxymethylcytosine that gets lost by dilution during replication, effectively erasing cytosine methylation patterns except for a subset that is maintained, including those of some imprinted genes. (i-sis.org.uk)
We examined DNA methylation of well-validated H. pylori infection associated genes in GC and its adjacent mucosa and investigated its association with CIMP, various molecular subtypes and clinical features. (hokudai.ac.jp)
In primary GC tissues, higher methylation of H. pylori infection associated genes correlated with CIMP-positive and its related features, such as MLH1 methylated cases. (hokudai.ac.jp)
On the other hand, GC with lower methylation of these genes presented aggressive clinicopathological features including undifferentiated histopathology, advanced stage at diagnosis. (hokudai.ac.jp)

Earlier studies suggested a primary B-lymphocyte defect as a cause of common variable immunodeficiency in a small group of patients. (medscape.com)

These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
B-cell disorders are divided into defects of B-cell development/immunoglobulin production ( immunodeficiencies ) and excessive/uncontrolled proliferation ( lymphomas , leukemias ). (medscape.com)

Global CpG island hypermethylation, which induces epigenetic silencing of tumor suppressor genes, is also a unique feature of EBVaGC and is considered to be crucial for its carcinogenesis. (spandidos-publications.com)
That was the beginning of the epigenetic revolution [1] ( Epigenetic Inheritance - What Genes Remember , SiS 41). (i-sis.org.uk)

The deletion 7q21-32 is seen in 40% of SMZL patients, and translocations of the CDK6 gene located at 7q21 have also been reported. (wikipedia.org)
For patients with or without cancer (as defined in the policy), established standard-of-care MRD tests using single-gene PCR (i.e. (codemap.com)
Lymph node biopsies of six patients with lymphocyte predominant HL and three with non-specific lymphadenitis were analysed. (bmj.com)
We described the patterns of clonal complexity at diagnosis and investigated its association with patients' characteristics. (frontiersin.org)
Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. (cancer-genetics.org)

The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)

tures and gene expression patterns. (lu.se)
However, we observed species- and chain-specific targeting patterns, demonstrating the need for multiple SHM targeting models. (aai.org)

two identical heavy chains and two identical light chains connected by disulfide bonds . (wikipedia.org)

We identified five genes (IGF2, SLC16A2, SOX11, P2RX7, and MYOD1) as hypermethylated in H. pylori infected gastric mucosa. (hokudai.ac.jp)

Tumor-infiltrating lymphocytes are related to positive clinical prognoses in numerous cancer types. (cancer-genetics.org)

We studied 50 candidate loci in 24 gastric samples to identify H. pylori infection associated genes. (hokudai.ac.jp)

[ 4 . 5 ] Adding to the challenge, classic lymphoglandular bodies, representing remnants of lymphocyte cytoplasm, are typically inconspicuous or absent in effusion fluids, in contrast to FNA material from solid specimens. (cytojournal.com)

However, preliminary findings have shown that Ig V genes of IgA and IgG CLLs may be somatically mutated, suggesting that isotype-switched CLLs may represent a "subtype" of the disease. (omicsdi.org)

14)(q14-q15;q23-24), del(7)(q22q32), rearrangements involving 6p21, 10q, trisomy 12 , and deletions of 1p3q has been associated with the development of leiomyoma. (wikidoc.org)

However, genes expressed early in development may preferentially retain histones. (i-sis.org.uk)

Immunoglobulin gene rearrangement begins with heavy-chain gene rearrangement followed by light-chain gene rearrangement. (medscape.com)

Two indicators of clonal complexity were used, namely, the number of foster clones, described as clones with similar D-N 2 -J rearrangements but other V-rearrangement and N 1 -joining, and the maximum across all foster clones of the number of evolved clones from one foster clone. (frontiersin.org)

The BOB.1, OBF.1, OCA-B (now called BOB.1 / OBF.1) is a 35 kD protein encoded by a gene located on chromosome 11q23.1. (samatashkhis.com)
BOB.1 from "B cell binding Octamer protein 1 "is a specific coactivator of transcription factors Oct-1 and Oct-2 of B lymphocytes. (samatashkhis.com)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
What does this gene/protein do? (cancer-genetics.org)
What pathways are this gene/protein implicaed in? (cancer-genetics.org)

Anatomy33

Organisms11

Diseases26

Chemicals and Drugs89

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes82

Disciplines and Occupations1

Information Science4

Polymerase chain re4

Differentiation6

Antibodies12

Recombination3

Bone marrow7

Mutations9

Serum immunoglobulin1

Antigen receptor2

Lymphoid4

Neoplastic6

Diversity4

Antibody8

Antigens3

Proteins2

Peripheral3

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Variable1

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Trisomy 121

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Protein5