To define the mechanistic basis of clonal hematopoiesis in SDS, we investigate somatic mutations acquired by patients with SDS followed longitudinally. (nature.com)
Here we report that multiple independent somatic hematopoietic clones arise early in life, most commonly harboring heterozygous mutations in EIF6 or TP53 . (nature.com)
All enrolled index case-patients and household con- of mutations, which results in clonal heterogeneity ( 4 ). (cdc.gov)
Instead, the mutations seem to have arisen through ordinary aging. (kateva.org)
This phenomenon is called clonal interference and causes competition among the mutations. (mercinewyork.com)
A surprise was the considerable variation in families, as to whether most mutations arose from the father or the mother. (uncommondescent.com)
Genetically identical2
A clonal colony or genet is a group of genetically identical individuals, such as plants, fungi, or bacteria, that have grown in a given location, all originating vegetatively, not sexually, from a single ancestor. (wikipedia.org)
Old Tjikko has had many trunks and after each one has died, a new genetically identical, or "clonal", stem has arisen from the root system. (thenakedscientists.com)
Proliferative3
LCH, once described as histiocytosis X, is a clonal proliferative disorder of Langerhans cells that stain immunohistochemically with S-100 and CD-1a and demonstrate cytoplasmic Birbeck granules under electron microscopy. (medscape.com)
9] The clonal, proliferative nature of LCH has long been debated as to whether it represents a reactive or neoplastic process. (medscape.com)
KNA+ cells had high clonal proliferative potential and specification into endothelial colony-forming cell (ECFCs) phenotype. (bu.edu)
Progenitor5
Neurons that arise in the adult nervous system originate from neural stem cells and neural progenitor cells. (elifesciences.org)
Consequently, neural stem and progenitor cells have usually been studied retrospectively, based on their ability to form colonies in laboratory cell cultures. (elifesciences.org)
Chronic myeloid leukemia (CML) is a clonal expansion of the progenitor hematopoietic stem cells arising from the existence of the fusion BCR-ABL oncogene, that represents 15%-20% of the newly diagnosed cases of leukemia patients [ 1 - 2 ]. (jcancer.org)
Clonal studies in the chronic myeloid disorders - Genetic and enzyme studies based upon X-chromosome inactivation patterns have revealed a multipotent progenitor cell origin for the neoplastic clone in both MDS [ 8 ] and MPN [ 9 ]. (medilib.ir)
The clonal process may develop at different progenitor cell levels in individual patients, and the clonal progenitor cell may or may not involve T and B lymphocytes [ 10 ]. (medilib.ir)
While the Aspen which grows from a small seedling into a large clonal colony through its many roots is known for the sound its many leaves make in the wind. (soaringheart.com)
The potential of Quaking Aspen roots to produce Ramets has resulted in the production of Pando Aspen , a unique clonal colony of genetically coded individuals that developed from one Quaking Aspen parent male. (biologyeye.com)
Populations1
To identify such genes, we have developed methodologies that allow for the selection of rare virus-sensitive clones arising after transfer of gene libraries into populations of virus-resistant parents. (biomedcentral.com)
Rhizomes1
Ferns and many herbaceous flowering plants often form clonal colonies via horizontal underground stems termed rhizomes, e.g. ostrich fern Matteuccia struthiopteris and goldenrod. (wikipedia.org)
Polyclonal1
Therefore, X-chromosome-based clonal assays might not be adequate in detecting a minor clonal population against a polyclonal background. (medilib.ir)
Isolates2
To assess the technique, we probed clonal isolates of 293-TREx cells that were targeted with three separate sgRNAs against the HuR gene. (biomedcentral.com)
We isolated and whole-genome sequenced up to five colonies of faecal E. coli from 66 asymptomatic children aged three-to-five years in rural Gambia (n = 88 isolates from 21 positive stools). (peerj.com)
Stem3
With other vines, rooting of the stem where nodes come into contact with soil may establish a clonal colony, e.g. (wikipedia.org)
These results demonstrate that the cells that form neurospheres in culture are not stem cells at all, and that real stem cells are not able to form colonies under existing culture conditions. (elifesciences.org)
They may contribute to a better understanding of MSC organisation in vitro , including features of clonal expansion, environmental adaptation and stem cell ageing. (biomedcentral.com)
Cells11
Previously, we found that in glucose-limited Saccharomyces cerevisiae colonies, metabolic constraints drive cells into groups exhibiting gluconeogenic or glycolytic states. (elifesciences.org)
Hence, different cells of the community exhibit metabolic interdependencies, presumably to balance out trade-offs arising from resource sharing. (elifesciences.org)
this has been exceptionally challenging to demonstrate within a clonal community of cells. (elifesciences.org)
As the colony matures, groups of cells exhibiting glycolytic metabolism emerge with spatial organization. (elifesciences.org)
rogue cells spread out across the esophagus, forming colonies of mutant cells, known as clones. (kateva.org)
When cells from the subventricular zone are cultured in a way that allows the cells to freely float around (rather than growing on a surface), a few percent form spherical colonies called neurospheres. (elifesciences.org)
term pre-GEPCOT cells (based on an acronym of the markers used to isolate the cells), were long-lived and quiescent, but they lacked the ability to form colonies in culture. (elifesciences.org)
TGCT or PVNS is a benign clonal neoplastic proliferation arising from the synovium characterized by a minor population of intratumoral cells that harbor a recurrent translocation. (nih.gov)
Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
Also in adults, the same discrimination finds its use in co-operation between individuals or cells (self-compatibility as in kin recognition, colony formation, nuclear fusion, dual recognition, transplantation). (tripod.com)
For example, variable expression of colony opacity (Opa) proteins changes the tropism of Neisseria for human epithelium, endothelium, and phagocytic cells [ 16 ]. (biomedcentral.com)
Neural1
PubMed] [Mix Ref]Coles-Takabe BL, Mind I, Purpura KA, Karpowicz P, Zandstra PW, Morshead CM, vehicle der Kooy M. Dont look: growing clonal versus nonclonal neural come cell colonies. (thetechnoant.info)
Spreads2
However, it is not always easy to recognize a clonal colony especially if it spreads underground and is also sexually reproducing. (wikipedia.org)
El Dorado mule ears is native to the Pine Hill area and spreads by underground root sprouts (clonal). (diki.pl)
Organs2
Non-woody plants with underground storage organs such as bulbs and corms can also form colonies, e.g. (wikipedia.org)
The other categories include woody plants, which may but need not possess organs of clonal growth and may be able or not of fragmentation and vegetative reproduction. (pladias.cz)
Shoots2
With most woody plants, clonal colonies arise by wide-ranging roots that at intervals send up new shoots, termed suckers. (wikipedia.org)
It grows as a sprawling shrub up to one metre (3 ft) high, often with basal shoots arising from an underground lignotuber. (diki.pl)
Sharing roots1
When woody plants form clonal colonies, they often remain connected through the root system, sharing roots, water and mineral nutrients. (wikipedia.org)
Species6
Clonal colonies are common in many plant species. (wikipedia.org)
A few plant species can form colonies via adventitious plantlets that form on leaves, e.g. (wikipedia.org)
A few plant species can form colonies via asexual seeds, termed apomixis, e.g. dandelion. (wikipedia.org)
A few species, notably Acer cappadocicum, frequently produce root sprouts , which can develop into clonal colonies. (diki.pl)
Hatchlings are then left alone in crèches, or groups, a characteristic common to bird species that breed in large colonies, while their parents forage for food. (animaldiversity.org)
Although clinical microbiology typically relies on single-colony picks (which has the potential to underestimate species diversity and transmission events), within-host diversity of E. coli in the gut is crucial to our understanding of inter-strain competition and co-operation and also for accurate diagnosis and epidemiological analyses. (peerj.com)
Cell2
We developed a procedure for rapid screening of clonal cell lines for the deletion of a protein of interest following CRISPR/Cas9 targeting in the absence of selective pressure based on dot immunoblots. (biomedcentral.com)
However, potentially erroneous characterization of cytotoxicity and cell proliferation can arise if verification of baseline interaction of test article with method employed is neglected. (cdc.gov)
Woody1
A few non-vining, woody plants that form clonal colonies are Bigelow oak (Quercus sinuata var. (wikipedia.org)
Possess1
Trees and shrubs with branches that may tend to bend and rest on the ground, or which possess the ability to form aerial roots can form colonies via layering, or aerial rooting, e. g. willow, blackberry, fig, and banyan. (wikipedia.org)
Chronic1
Treatment with granulocyte colony-stimulating factor is used to stimulate neutrophil production and prevent bacterial infections after cancer chemotherapy and with severe chronic neutropenia. (msdmanuals.com)
Form1
African penguins form colonies near a chain of islands between Hollamsbird Island, Namibia, and Bird Island in Algoa Bay, South Africa. (animaldiversity.org)
Mutation1
Depending on the desired mutation, several experimental options exist in the isolation of clonal lines, such as selection with introduced markers, or screening by PCR amplification of genomic DNA. (biomedcentral.com)
Constraints1
The biggest challenges from the algorithmic and theoretical points of view arise in script triggerbot valorant constraints where random and decision variables cannot be decoupled. (webnito.cz)
Common1
It propagates itself primarily through root sprouts , and extensive clonal colonies are common. (diki.pl)
Large1
African penguins live in large colonies on rocky coastlines of southwest Africa. (animaldiversity.org)
Time1
Old Tjikko only has one trunk at a time, but clonal tree colonies do exist elsewhere. (thenakedscientists.com)
Extensive1
2008,' Comparison of download the writers of many SNP classics in reminder technological value-based history', Data Mining and Analytics 2008: journals of the Seventh Australasian Data Mining Conference( AusDM 2008), Conferences in Research and Practice in IT( CRPIT), Vol. 87, Australian Data Mining Conference, Australian Computer Society, Adelaide, Australia, Coverage Data TB and expression order consider treated written to children in clonal images covering extensive licenses. (lightseed.com)
Long2
The hang doesn't arise as long as I don't let scaledPointSize exceed 30. (blogspot.com)
These clonal colonies are impossible to date with precision because the oldest decomposed long ago. (rvingwithrex.com)
Grow1
These colonies grow up to a meter a year to eventually cover whole mountains, reaching as much as 80,000 thousand of year they protect complex ecosystems and allow them to evolve. (soaringheart.com)
Results1
Within-host heterogeneity tive TB from whom sufficient mycobacterial DNA could be may arise through 2 mechanisms: 1) by reinfection or si- successfully obtained from the baseline sample to perform multaneous infection with multiple strains, which results MIRU-VNTR typing. (cdc.gov)
Production1
RÉSUMÉ L'émergence et la propagation rapide des souches de Klebsiella pneumoniae résistantes aux antibiotiques et porteuses du gène blaKPC codant la production de carbapénèmases ont compliqué la prise en charge des infections des patients. (who.int)
Blood1
It wasn't until later, during medieval times, that the myth of the man Siegfried arose, who became invulnerable after bathing in the blood of the dragon. (soaringheart.com)