Clinical trials use fetal tissue. Medical search. Frequent questions

Implementation of Studer's cell replacement therapy clinical trial which utilizes dopamine neurons generated from human embryonic/pluripotent stem cells for Parkinson's disease would be the first of its kind. (wikipedia.org)
Overall, Studer's decades long investigation into neurological diseases such as Parkinson's disease and clinical applications of stem cells has helped advance the field of cell replacement therapy. (wikipedia.org)
There, he worked with Christian Spenger, culminating in the first clinical trial of fetal tissue transplantation for Parkinson's disease in Switzerland in 1995. (wikipedia.org)
Today, fetal tissue is still making an impact, with clinical trials underway using cells from fetal tissue to treat conditions including Parkinson's disease, ALS, and spinal cord injury," said Doug Melton, co-director of Harvard's Stem Cell Institute and president of the International Society for Stem Cell Research. (chicagotribune.com)
I'm part of one European study called TRANSEURO , which is now at the stage of transplanting fetal cells into patients with Parkinson's disease as part of a new clinical trial. (eurostemcell.org)
This involves research teams in the US, Europe and Japan working together to standardize research and clinical protocols for Parkinson's disease. (eurostemcell.org)
Since then, according to his resume , Dr. Svendsen has been involved in study after study, writing article after article regarding the use of pre-born baby brains and other fetal tissue to treat neurological diseases like Parkinson's and Lou Gehrig's disease. (californiafamily.org)
Between 1988 and 1994, roughly 140 Parkinson's disease patients received fetal tissue (up to six fetuses per patient), with varying results. (lozierinstitute.org)
[12] The results of these two large studies led to a moratorium on fetal tissue transplants for Parkinson's. (lozierinstitute.org)
Ten years after a fetal cell transplant, a Parkinson's patient's graft is still delivering dopamine to postsynaptic cells, according to a study appearing in the December issue of Nature Neuroscience. (alzforum.org)
Treating neurodegenerative diseases with cell transplantation has been within reach since the first pioneering clinical trials in which dopamine neuron progenitors from the fetal brain were transplanted to individuals with Parkinson's disease. (biologists.com)
Clinical studies of Parkinson's disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. (lu.se)

He is a developmental biologist and neuroscientist who is pioneering the generation of midbrain dopamine neurons for transplantation and clinical applications. (wikipedia.org)
He successfully demonstrated that upon transplantation, these newly developed dopaminergic neurons can improve clinical symptoms in Parkinsonian rat models. (wikipedia.org)
I'm coordinating the tissue team in Lund which is one of the two transplantation sites. (eurostemcell.org)
The work on fetal transplantation is interesting, is this a field that's just reappeared? (eurostemcell.org)
Report of the Human Fetal Tissue Transplantation Research Panel, December 1988 / consultants to the Advisory Committee to the Director, National Institutes of Health. (who.int)
The outcomes following transplantation of human fetal ventral mesencephalic tissue (hfVM) have been variable, with some patients coming off their anti-PD treatment for many years and others not responding and/or developing significant side effects, including graft-induced dyskinesia. (lu.se)
The TRANSEURO trial is currently ongoing as researchers have completed both recruitment into a large multicenter observational study of younger onset early-stage PD and transplantation of hfVM in 11 patients. (lu.se)
Xenotransplantation involves the transplantation of nonhuman tissues or organs into human recipients. (medscape.com)
The motivation for using animal sources for organ or tissue transplantation is driven by supply and demand. (medscape.com)

This also allows us the unique opportunity to directly compare our hESC-derived dopamine neurons with those sourced from human fetal tissue both in vitro and in vivo. (lu.se)

Embryo-Fetal Toxicity: Abiraterone acetate can cause fetal harm. (nih.gov)
Embryo-fetal toxicity. (empr.com)

The agency also noted that women of childbearing years should be advised that dabrafenib and trametinib carry the potential to cause fetal harm. (medscape.com)

One patient who received transplant of fetal brain tissue (from a total of 3 fetuses) died subsequently, and at autopsy was found to have various non-brain tissues ( e.g, skin-like tissue, hair, cartilage, and other tissue nodules) growing in his brain. (lozierinstitute.org)
Piccini and her colleagues took advantage of the built-in control provided by a patient who had received only a unilateral transplant of fetal cells, which was sufficient to bring about significant clinical improvement. (alzforum.org)

In this trial, patients received LYTGOBI orally once daily at a dose of 20mg until disease progression or unacceptable toxicity. (biospace.com)
Preliminary results from a clinical trial with the combination suggest that use of the 2 drugs together resulted in less toxicity, and specifically in fewer secondary skin cancers, than has been seen with vemurafenib used alone . (medscape.com)

Early polio research included the use of embryonic tissue . (salon.com)
there are reasons to have conversations about embryonic stem cell research and fetal tissue research. (salon.com)
Over 60 organizations, including the Association of American Universities, wrote to Senate leaders opposing prohibitions or restrictions that would further impede the use of federal funding for fetal tissue or embryonic stem cell research. (aau.edu)
A potentially pre-clinical aspect of this thesis is detailed in paper №4 where I describe a robust protocol for the generation of functional mesDA neurons from human embryonic stem cells that are functional in a rat model of PD. (lu.se)
Based on such scientific concepts, the extracts of embryonic tissues included in H-Ultracell have become richer. (dermalcosmetics.eu)

Now it is possible to generate authentic midbrain dopaminergic neurons from pluripotent stem cells and clinical trials using such cells are rapidly approaching. (biologists.com)

The clinical trial which already has begun recruiting patients, is expected to receive the FDA's study permission by the end of 2020, with an anticipated start date in 2021. (wikipedia.org)
Studies establishing effectiveness included patients with NYHA Functional Class II-IV symptoms and etiologies of idiopathic or heritable PAH (58%), PAH associated with congenital systemic-to-pulmonary shunts (23%), or PAH associated with connective tissue diseases (19%) [see Clinical Studies ]. (rxlist.com)
In patients with PAH requiring transition from epoprostenol, Remodulin is indicated to diminish the rate of clinical deterioration. (rxlist.com)
In affected patients, neuronal degeneration initiates in the striatum and progresses to the cerebral cortex, following a pattern that correlates to clinical progression of HD. (medscape.com)
The purpose of this Pediatric MATCH screening and multi-sub-study phase II trial studies how well treatment that is directed by genetic testing works in pediatric patients with solid tumors, non-Hodgkin lymphomas, or histiocytic disorders that have progressed following at least one line of standard systemic therapy and/or for which no standard treatment exists that has been shown to prolong survival. (mayoclinic.org)
It is clear that California taxpayers, through CIRM, are funding projects that rely on aborted fetal tissue for experiments, including experiments injecting human fetal cells into patients," Dr. Prentice said. (californiafamily.org)
Dr. Svendsen received his most recent grant of $6.2 million last Fall to fund a clinical trial where "they will implant middle-man "progenitor" cells made by maturing stem cells from fetal tissue," into the spinal cords of patients with hope the damaged neural cells will be repaired. (californiafamily.org)
A second large, controlled study published in 2003 showed similar results (funded by NIH), with over half of the patients developing potentially disabling tremors caused by the fetal brain tissue transplants. (lozierinstitute.org)
Long-term follow-up of a few of the patients in these large studies showed that even in fetal tissue that grew in patients' brains, the grafted tissue took on signs of the disease and were not effective. (lozierinstitute.org)
The approval of LYTGOBI is based on the results of the primary analysis of the FOENIX*-CCA2 trial, a global Phase 2 open-label trial evaluating 103 patients with unresectable, locally advanced or metastatic iCCA harboring FGFR2 gene rearrangements including fusions. (biospace.com)
Retinal Pigment Epithelial Detachment (RPED) , which may cause symptoms such as blurred vision, occurred in 9% of 318 patients who received LYTGOBI across clinical trials. (biospace.com)
This confirmation that brain grafts can innervate host tissue in an apparently normal fashion is especially timely, as an American double-blind, placebo-controlled trial of human fetal dopamine cell transplants has not turned up significant clinical benefit for any but the youngest patients (Freed CR et al. (alzforum.org)
METHODS: The authors performed a post hoc analysis of 189 patients treated with CDA from the 9 highest enrolling sites in a prospective multicenter randomized US FDA IDE clinical trial. (bvsalud.org)
In the pivotal clinical study , 29 of 30 evaluable patients (96.7%) achieved the primary endpoint of the absence of severe blood vessel blockage (known as vaso-occlusive crises, or VOCs) for at least 12 consecutive months. (acsh.org)
After her PhD studies she was employed at Skåne University Hospital in Lund, being responsible for tissue and cell preparation for the clinical trial TransEuro ( https://transeuro.org.uk/pages/partners.html ), in which patients with Parkinson´s disease was transplanted with dopaminergic neurons derived from human fetal tissue. (lu.se)
The public clinical trials database http://clinicaltrials.gov shows 123 clinical trials using MSCs for a very wide range of therapeutic applications (Figure 1 ), the majority of which are in Phase I (safety studies), Phase II (proof of concept for efficacy in human patients), or a mixture of PhaseI/II studies (Figure 2 ). (biomedcentral.com)
This new trial, TRANSEURO (NCT01898390), is an open-label study in which some individuals in a large observational cohort of patients with mild PD who were undergoing identical assessments were randomly selected to receive transplants of hfVM. (lu.se)
Currently, the standard of care for our patients is fetal surgery, which, while promising, still leaves more than half of children with spina bifida unable to walk independently," said Diana Farmer , professor and chair of surgery at UC Davis Health and principal investigator on the study. (ucdavis.edu)
Farmer, stem cell bioengineer Aijun Wang , and the clinical fetal treatment team led by Shinjiro Hirose , plan to treat six patients. (ucdavis.edu)
Our cellular therapy approach, in combination with surgery, should encourage tissue regeneration and help patients avoid impairments throughout their lives. (ucdavis.edu)
Our residents have access to and participate in the care and management of maternal-fetal medicine patients starting from pre-pregnancy, during the entire pregnancy, and after delivery. (nyu.edu)
In large clinical trials, abnormalities in routine liver tests were common in patients treated with pazopanib, with serum aminotransferase elevations occurring in up to half of patients and total serum bilirubin in approximately one-third. (nih.gov)
However, they reappear in patients that have had a heart attack, when they are involved in laying down scar tissue. (imperial.ac.uk)
We're hoping to set up a clinical trial to test whether these results translate to patients with heart failure. (imperial.ac.uk)
Patients are at the heart of the work we do, and we are committed to developing innovative solutions for people with urothelial cancer and challenging clinical needs," said Marjorie Green, M.D., Senior Vice President and Head of Late-Stage Development, Seagen. (businesswire.com)
In every fetal surgery, there are two patients: the baby and the mother, and caring for both the fetus and the mother is an important aspect of fetal procedures," said co-author Carol Benson, MD , staff radiologist at BWH and former co-director of BWH's High-Risk Obstetrical Ultrasound Service. (brighamandwomens.org)
While this is only our first treated patient and it is vital that we continue the trial to assess the safety and efficacy in other patients, this approach has the potential to mark a paradigm shift in managing vein of Galen malformation, where we repair the malformation prior to birth and head off the heart failure before it occurs rather than trying to reverse it after birth. (brighamandwomens.org)

The authors note that impaired energy generally precedes clinical diagnosis of HD, suggesting that the disruption of energy homeostasis is linked to the pathogenesis of HD. (medscape.com)
The Center for Fetal Research , the research extension of CHOP's Center for Fetal Diagnosis and Treatment , continues to seek to improve prenatal treatment of MMC through a less invasive approach that would allow for application earlier in gestation, with reduction in maternal and fetal risks, and the potential for reduced neurologic injury. (chop.edu)
Medical students, residents, and fellows train at clinical sites including NYU Langone's Fetal Diagnosis and Treatment Program , the only fetal surgery program on Long Island, and NYU Langone Hospital-Long Island's New Life Center , where more than 5,000 babies are born each year. (nyu.edu)
At the Fetal Diagnosis and Treatment Program, we develop new procedures, an advancement that has been published in obstetric journals. (nyu.edu)
1) Offer state-of-the-art clinical, histopathological and molecular diagnosis, with the set-up of Next Generation Sequencing. (neurogenycs.fr)
4) Improve the diagnosis and the understanding the neurodevelopmental diseases by fetopathological exam according to Haute Autorité de Santé recommendations (with the launching of a Fetal Pathology Unit in Strasbourg). (neurogenycs.fr)
5) Develop pluridisciplinary committees for improving fetal diagnosis. (neurogenycs.fr)
ER protein determinations were performed using two-thirds of all breast cancers are ER at the time of diagnosis, the standard methods in the routine clinical laboratory (9). (lu.se)

However, the success of fetal tissue transplants has been meager at best, and ethically-derived alternatives exist and are coming to dominate the field. (lozierinstitute.org)
The first recorded fetal tissue transplants were in 1921 in the UK, in a failed attempt to treat Addison's disease, [1] and in 1928 in Italy, in a failed attempt to treat cancer. (lozierinstitute.org)
That attempt also failed, as did subsequent similar fetal tissue transplants in 1959. (lozierinstitute.org)
Between 1970 and 1991 approximately 1,500 people received fetal pancreatic tissue transplants in attempts to treat diabetes, mostly in the former Soviet Union and the People's Republic of China. (lozierinstitute.org)
[8] Subsequent reports showed that severe problems developed from fetal tissue transplants. (lozierinstitute.org)
By the end of the twentieth century, many other transplants using different processes had been reported but there were challenges like the lack of appropriate donor tissue and use of immune-suppressive drugs to prevent rejection of the transplant. (livestemcells.asia)
While completion of TRANSEURO is not expected until 2021, we feel that sharing the rationale for the design of TRANSEURO, along with the lessons we have learned along the way, can help inform researchers and facilitate planning of transplants of dopamine-producing cells derived from human pluripotent stem cells for future clinical trials. (lu.se)

MSCs can be easily expanded in culture media containing fetal bovine serum (FBS) from selected lots. (biomedcentral.com)
Opinions differ as to whether those breast cancers supplemented by 10% fetal bovine serum, penicillin, and streptomycin. (lu.se)

The study, conducted in an animal model, was led by Diana Farmer, the fetal surgeon who helped pioneer in utero treatment for spina bifida -- a congenital birth defect that occurs when the spinal cord does not close properly, leading to lifelong cognitive, urological, musculoskeletal and motor disabilities. (sciencedaily.com)
The clinical trial, known formally as the " CuRe Trial: Cellular Therapy for In Utero Repair of Myelomeningocele," is funded by the state's stem cell agency, CIRM . (ucdavis.edu)
Fellows also gain hands-on experience in diagnostic invasive procedures as well as complex in utero fetal procedures. (nyu.edu)
As part of an ongoing clinical trial to treat vein of Galen malformation (VOGM) in utero, Boston Children's Hospital partnered with Brigham and Women's Hospital Fetal Therapy Program to perform the procedure in an obstetric operating room, with a maternal-fetal medicine specialist and fetal radiologist. (brighamandwomens.org)
A team that included clinicians from radiology, neurointerventional radiology, anesthesiology and maternal fetal care performed the in-utero embolization on a fetus with vein of Galen malformation (VOGM) at 34 weeks and 2 days gestational age. (brighamandwomens.org)

Microvascular decompression (MVD) surgery is the most effective and long-lasting treatment for HFS, but outcomes following this surgery may vary based on a variety of clinical and operative factors. (bvsalud.org)
CONCLUSION: Clinical outcomes following MVD for HFS have improved since 2005. (bvsalud.org)
Measuring the quality of asthma care has been challenging because of a lack of reliable data to assess clinical processes and track patient-specific outcomes. (cdc.gov)
Comprehensive reliability and validity testing of both clinical data and stratification across risk groups will be needed to determine whether a measure based on standardized assessments of asthma control indeed promote improved clinical outcomes. (cdc.gov)
While the MOMS trial has demonstrated conclusively that open fetal surgery for repair of myelomeningocele (MMC) improves outcomes - with reduction in hindbrain herniation and the need for shunting, and significant improvement in functional neurologic outcomes - open fetal surgery for MMC is not a cure. (chop.edu)

His expertise in cell engineering spans a wide range of cells/tissues within the nervous system geared toward disease modeling and exploring cell replacement therapy. (wikipedia.org)
Most notably, he has devised protocols for the transition (or "differentiation") of human pluripotent stem cells into neural and neural crest tissues and for the generation of functional dopaminergic neurons in large-scale quantities. (wikipedia.org)
cells that were extracted from fetal tissue, which was donated. (salon.com)
The chickenpox, rubella, hepatitis A, shingles and one rabies vaccine all derive from fetal embryo fibroblast cells cultivated in the 1960s -- and Catholic leadership has wrestled with the ethics of using those vaccines. (salon.com)
Adult tissue-derived mesenchymal stromal cells (MSCs) are showing promise in clinical trials for systemic lupus erythematosus (SLE). (nature.com)
However, the inability to manufacture large quantities of functional cells from a single donor as well as donor-dependent variability in quality limits their clinical utility. (nature.com)
[5] Conditions such as anemias and immunodeficiencies, for which fetal tissue attempts largely failed, are now treated routinely with adult stem cells, including umbilical cord blood stem cells, [6] even while the patient is still in the womb. (lozierinstitute.org)
Exa-cel, a new CRISPR-based treatment, modifies the genes of the patient's stem cells to induce them to produce fetal hemoglobin. (acsh.org)
The treatment involves gene editing of the patient's blood-forming stem cells to induce them to produce high levels of fetal hemoglobin (HbF, or hemoglobin F) in red blood cells. (acsh.org)
Adipose tissue (AT) represents a commonly used source of mesenchymal stem/stromal cells (MSCs) whose proregenerative potential has been widely investigated in multiple clinical trials worldwide. (mdpi.com)
Cells4Life has been authorised by the UK regulator, the Human Tissue Authority (HTA), to offer this service, giving parents access to a further two sources of perinatal stem cells at the birth of their new baby. (parentsguidecordblood.org)
By banking all four, cord blood, cord tissue, amniotic membrane and chorionic villi (placental cells), Cells4Life believes parents gain the potential to access the widest range of treatments possible, as various regenerative therapies begin to transition from clinical trials to the clinic. (parentsguidecordblood.org)
Studies suggest stem cells from different tissue sources such as cord blood, umbilical cord tissue and of course placenta will have different potential therapeutic applications. (parentsguidecordblood.org)
The emerging consensus amongst scientists is that MSCs from different sources are likely to vary in the types of therapies for which they are best suited: "MSC origins may have significant impact on the therapeutic potentials of such cells and should be taken into consideration in clinical applications" 1 . (parentsguidecordblood.org)
Theoretically, stem cells can be used to treat Type 1 diabetes by inducing them to be b-cells in the lab, and then introducing them to the body where they would repair the damaged tissue and help maintain enough b-cell mass. (livestemcells.asia)
We now think that when it's augmented with stem cells, fetal surgery could actually be a cure," said Wang. (sciencedaily.com)
Our laboratory has been testing and optimizing a variety of scaffolds, cells and growth factors to develop a tissue engineering construct that will ultimately be clinically applicable for prenatal closure of MMC. (chop.edu)
In recent years, clinical trials with stem cells have taken the emerging field in many new directions. (biomedcentral.com)
At the same time, the first three trials using cells derived from pluripotent cells have begun. (biomedcentral.com)
These early trials are showing roles for stem cells both in replacing damaged tissue as well as in providing extracellular factors that can promote endogenous cellular salvage and replenishment. (biomedcentral.com)
Placenta-derived stem cells are being considered for similar uses and are in Phase III clinical trial for critical limb ischemia by Israel's Pluristem Therapeutics. (biomedcentral.com)
A significant proportion of clinical studies that are underway involve bone marrow and cord blood stem cells for blood and immune disorders [ 3 ] and cancers. (biomedcentral.com)
The use of patient's own bone marrow aspirates, hematopoietic stem cells and MSCs, for heart muscle tissue repair can be puzzling because these cells do not normally contribute to the cardiac lineage types that are desired. (biomedcentral.com)
This led to a re-appraisal of the best way to do such trials, which resulted in a new European-Union-funded allograft trial with fetal dopamine cells across several centers in Europe. (lu.se)
A UC Davis Health team today announced the launch of the world's first, FDA-approved human clinical trial using stem cells before birth to treat the most serious form of spina bifida . (ucdavis.edu)
Stem cells are placed on the spinal cord using a special patch during fetal surgery (before birth) to repair the spina bifida defect. (ucdavis.edu)
During their procedure, the fetal surgeon will place a biological scaffold of special stem cells (in this case, placental mesenchymal stem cells) directly over the exposed spinal cord. (ucdavis.edu)
Farmer and Wang's team has generated the stem cells for the study from placental tissue. (ucdavis.edu)
These cells are found in the fetal heart but disappear shortly after birth. (imperial.ac.uk)
A micrograph of the human fetal heart, showing ordinary heart muscle cells in yellow and myofibroblasts in brown. (imperial.ac.uk)
The researchers grew myofibroblasts on top of heart muscle cells in the laboratory to create a model for studying the fetal heart. (imperial.ac.uk)
Exposing the cells to high level of bile acid, as found in the mother's and fetal blood in obstetric cholestasis, caused the cells to conduct electrical signals more slowly and increased the likelihood of arrhythmia. (imperial.ac.uk)
However, the quantity of MSCs is very low in bone marrow (about 0.001 to 0.01% of the mononuclear cells) and in vitro expansion is the prerequisite for their clinical application. (biomedcentral.com)
Tissues and Cells. (lu.se)
Some genes that influence fetal organ development or heart cells can increase your risk. (medlineplus.gov)

That's why at TRANSEURO we're working to address the previous issues that occurred in order to perform an improved clinical trial. (eurostemcell.org)
As a member of the European clinical trial TRANSEURO we also perform preclinical validation of human fetal dopamine neurons for clinical use. (lu.se)

Led by division chief Martin Chavez, MD , our faculty are leaders in the field and are board-certified in maternal-fetal medicine with expertise in diabetes care and education, obstetric ultrasound, and clinical informatics. (nyu.edu)
The researchers became interested in the role of myofibroblasts after observing that they appear in the heart tissue in the second and third trimesters of gestation, when sudden death of the infant is most common in pregnancies affected by obstetric cholestasis. (imperial.ac.uk)

Note that fetal tissue has been taken in a number of cases from fetuses at developmental ages where fetal surgery is now used to correct problems and save lives, and at stages where science now demonstrates that the unborn fetus can feel pain. (lozierinstitute.org)
Farmer and Wang are the first to combine fetal surgery with a placental stem cell treatment to reduce the effects of spina bifida, which in children can range from barely noticeable to severe. (sciencedaily.com)
For the current research, lambs with myelomeningocele received standard fetal surgery to return exposed tissue to the spinal canal. (sciencedaily.com)
Fetal surgery provided hope that most children with spina bifida would be able to live without shunts," Farmer said. (sciencedaily.com)
We anticipate being able to safely and successfully repair the birth defect that occurs when the protective tissue around a baby's developing spinal cord fails to fully close before birth," said Wang, an associate professor of surgery and biomedical engineering, and co-director of UC Davis' surgical bioengineering laboratory . (ucdavis.edu)
The 20-year history of fetal surgery at the Brigham underscores the commitment to continuous improvement and collaboration between Boston Children's Hospital and Brigham and Women's Hospital," said co-author Louise Wilkins-Haug, MD, Division Director of Maternal-Fetal Medicine at Brigham and Women's Hospital. (brighamandwomens.org)

Interestingly, its efficacy and short-term safety were not at issue because the FDA felt that they had been amply demonstrated during the clinical trials. (acsh.org)

Specialists in the Division of Maternal-Fetal Medicine care for people experiencing high-risk and complicated pregnancies. (nyu.edu)
These complications can be maternal, fetal, or both. (nyu.edu)
In line with our mission, our team provides comprehensive educational programs to ensure that the next generation of maternal-fetal medicine specialists are well prepared to become leaders and advance the field. (nyu.edu)
Trainees at NYU Grossman Long Island School of Medicine who are focusing on maternal-fetal medicine work closely with our renowned faculty and have access to state-of-the-art technologies. (nyu.edu)
Medical students in their clerkship year complete a six-week rotation in obstetrics and gynecology , led by maternal-fetal medicine clerkship director Nadia B. Kunzier, DO . (nyu.edu)
For physicians who seek additional subspecialty training, our Maternal-Fetal Medicine Fellowship provides training in clinical practice, research, and public health, and teaches fellows the skills they need to excel in the challenging environment of academic medicine. (nyu.edu)
Fellows learn to act as consultants to general obstetricians, as well as to participate in the regionalization of perinatal services, ensuring the full range of services is available to support maternal and fetal health. (nyu.edu)
At the end of training, our fellows are well prepared to obtain American Board of Obstetrics and Gynecology certification in maternal-fetal medicine. (nyu.edu)

We are currently focusing on improving the yield and transplantability of directly reprogrammed dopamine neurons, and also developing reprogramming methodology that are compatible with clinical use. (lu.se)
Here, I describe the developments towards using DA neurons derived from hESCs in clinical trials, and how new insights from developmental biology have guided several important steps in this process. (biologists.com)
In 2017 she was recruited back to the research group of Prof. Malin Parmar as a staff scientist, mainly focusing on the translational work required to introduce hESC derived dopaminergic neurons to the clinic, the STEM-PD trial. (lu.se)

The most common and disabling form of the disorder, called myelomeningocele, causes the spinal cord to emerge through the back, often pulling brain tissue into the spinal column and causing cerebrospinal fluid to fill the interior of the brain. (sciencedaily.com)
The surgeon will then close the opening in the baby's back to allow the tissue to regenerate and protect the infant's spinal cord. (ucdavis.edu)

Regenerative and reparative properties of somatic cell-based therapies hold tremendous promise for repairing injured tissue, preventing and reversing damage to organs, and restoring balance to compromised immune systems. (nih.gov)
Constriction around exposed organs at the abdominal wall opening late in fetal development may also contribute to organ injury. (medlineplus.gov)
Here is what H-Ultracell does - giving damaged organs and tissues a new cellular mold from which they will work and manufacture the corresponding organ. (dermalcosmetics.eu)

Since the early fetal-cell studies in the 1980s and 90s there hadn't been much advance, and also some dissapointments in the field. (eurostemcell.org)
Beginning in the mid 1980s, clinical trials and well-designed observational studies demonstrated that administering intravenous antibiotics during labor to women at risk for transmitting GBS to their newborns could prevent invasive disease in the first week of life (i.e., early-onset disease) ( 6--11 ). (cdc.gov)

[2] The first fetal tissue transplant in the U.S. was in 1939, using fetal pancreatic tissue in an attempt to treat diabetes. (lozierinstitute.org)
In the early 90's, Washington University Medical Center reported the success of the first transplant of the pancreatic islet tissue from a donor in a person ailing from Type 1 diabetes. (livestemcells.asia)

Watanabe M, Li H, Roybal J, Santore M, Radu A, Jo J, Kaneko M, Tabata Y, Flake A. A Tissue Engineering Approach for Prenatal Closure of Myelomeningocele: Comparison of Gelatin Sponge and Microsphere Scaffolds and Bioactive Protein Coatings . (chop.edu)

This means that for some therapies, MSCs originating from the chorion may be preferred, while in others, amnion, or cord tissue MSCs might be used instead. (parentsguidecordblood.org)
Since the first reported clinical trial in 1995, MSCs have been increasingly used for clinical research ranging from immunological intervention to tissue engineering and trauma repair[ 2 - 6 ]. (biomedcentral.com)

One of the most satisfying has been its journal's continuing involvement with clinical practice and its ethical problems-especially through our intermittent "at the coal face: medical ethics in practice" series. (bmj.com)
However, clinical practice and experiments have shown that ischemia, hypoxia, and inflammatory cell infiltration at the injured site will produce a large amount of ROS, forming an oxidative stress microenvironment. (researchsquare.com)
Our basic, translational, and clinical research programs provide faculty and trainees with opportunities to continually learn and apply new knowledge to their practice. (nyu.edu)

Clinical trials of pazopanib in malignant diseases in humans have shown activity against renal cell carcinoma and soft tissue sarcoma and promising effects in ovarian and thyroid cancer. (nih.gov)

The Health and Human Services Department said in a statement that government-funded research by universities that involves fetal tissue can continue for now, subject to additional scrutiny - although it also ended one major university project that used the tissue to test HIV treatments. (chicagotribune.com)
This work involves analysis of fetal brain anatomy, and identification of key genes and noncoding RNAs controlling the compartmentalisation of the brain. (lu.se)
We have chosen to concentrate on the emerging therapeutics that broadly involves a wide range of cell types in clinical trials registered on the National Institutes of Health's clinical trials web site. (biomedcentral.com)

Below is a list of the current clinical trials underway from the researchers at CSCI. (cam.ac.uk)
Clinical trials for numerous conditions such as arthritis, brain injury, cardiovascular conditions, diabetes and more are currently underway. (parentsguidecordblood.org)

But research using fetal tissue has led to lifesaving advances , including development of vaccines for rubella and rabies and drugs to treat HIV. (chicagotribune.com)
Scientists around the country denounced the decision, saying that fetal tissue was critically needed for research on HIV vaccines, treatments that harness the body's immune system to battle cancer, and other health threats, including some to fetuses themselves. (chicagotribune.com)
This is a very important interview between Robert F. Kennedy, Jr. and Dr. Theresa Deisher regarding the use of human fetal tissue to culture viruses for vaccines, because Dr. Deisher reveals that human DNA fragments are found in vaccines. (medicalkidnap.com)
Most of the COVID vaccines being developed are using human fetal tissue to culture the coronavirus. (medicalkidnap.com)
One of the more interesting questions Mr. Kennedy asked Dr. Deisher was why the manufacturers of vaccines switched from exclusively using animal tissue to culture viruses for vaccines, to start using aborted fetal tissue some years back. (medicalkidnap.com)
On June 15th, Robert F. Kennedy, Jr. interviewed the founder and president of Sound Choice Pharmaceutical Institute , Dr. Theresa Deisher, on the use of aborted fetal tissue in vaccines. (medicalkidnap.com)
Mr. Kennedy and Dr. Deisher covered a wide range of topics including which vaccines contain human fetal tissue, what the existing research tells us in terms of health risks, and what alternatives might be used in place of human DNA in vaccines. (medicalkidnap.com)
Myth: mRNA vaccines are made with fetal tissue. (vcuhealth.org)
Fetal tissue is in no way used to produce the vaccines. (vcuhealth.org)

A sample of placental tissue, which is normally discarded, would be collected by study staff after the procedure. (tuftsmedicalcenter.org)

LYTGOBI (pronounced "light-GOH-bee") delivered an objective response rate of 42% and median duration of response of 9.7 months in the primary analysis of the pivotal clinical trial. (biospace.com)

On October 31, the FDA's Cellular, Tissue, and Gene Therapies Advisory Committee discussed Exa-cel. (acsh.org)
We want to remain at the clinical forefront and our strong in-house R&D department will continue to spearhead the launch of processes that will help parents take advantage of new, exciting therapies that will begin to become available. (parentsguidecordblood.org)
Today, they are the subject of revolutionary clinical trials investigating therapies for premature babies, lung fibrosis and more. (parentsguidecordblood.org)
There has been a rapid surge in clinical trials involving stem cell therapies over the last two to three years and those trials are establishing the clinical pathways for an emergent new medicine. (biomedcentral.com)

Leveraging multidisciplinary collaborations between fetal therapists, tissue engineers, stem cell biologists and other experts, our team is working to develop creative solutions to the current challenges in prenatal surgical repair of MMC and to design clinical studies that compare the new technique to the established standard of open fetal surgical repair. (chop.edu)

A article from last fall, titled, "Ingenious CIRM-funded stem cell approach to treating ALS gets go-ahead to start clinical trial," highlights the work of Dr. Clive Svendsen, and his work to find a cure for Lou Gehrig's disease at the Cedars-Sinai Medical Center in Los Angeles. (californiafamily.org)
Through understanding functional recovery in terms of neuronal subtype and connectivity, the work presented in this thesis aims to bring the prospect of CRT closer to the clinic, I also describe the generation of a very promising alternative cell source that could rival fetal tissue. (lu.se)

4) increasing the accessibility to human fetal neuromuscular tissues by: targeting collection of diseased tissues for molecular investigations and establishing primary cultures/cell lines from normal brain at different developmental stages and from brains in specific pathological contexts. (neurogenycs.fr)

This opening varies in size and can usually be diagnosed early in fetal development, typically between the tenth and fourteenth weeks of pregnancy. (medlineplus.gov)
The clinical onset is typically within 4 to 12 weeks of starting pazopanib and the pattern of serum enzyme elevations is usually mixed. (nih.gov)
While much study has been devoted to genetic "triggers" of CNS neurodegeneration-notably mutant Htt in Huntington's disease (HD)-such inherited triggers are typically expressed from early fetal development and are fundamentally inaccessible to timely clinical intervention. (hdsa.org)

Dr. Deisher is an inventor on 23 issued U.S. patents, and her discoveries have led to clinical trials of FGF18 for osteoarthritis and cartilage repair, and for Factor XIII for surgical bleeding. (medicalkidnap.com)

They are ideal for repairing damaged tissues in something like spina bifida. (ucdavis.edu)

Below are current clinical trials. (mayoclinic.org)

CIRM's Sr. Director Public Communications & Patient Advocate Outreach, Kevin McCormack, downplayed the use of fetal tissue, but confirmed that fetal tissue research is included within the "Other" category. (californiafamily.org)
According to one review, "the clinical results and patient survival rates were largely dismal. (lozierinstitute.org)
A patient-reported measure of asthma control would incorporate key clinical indicators such as a validated age- and culturally appropriate test, and would reflect the combined outcome of medical management, self-management education, reduction of environmental exposures, and appropriate support services. (cdc.gov)
To reduce this burden and improve health equity, the NBCCEDP is expanding its scope to include population-based strategies to increase screening in health systems and communities through the implementation of patient and provider evidence-based interventions, connecting women in communities to clinical services, increasing opportunities to access screening, and enhancing the targeting of women in need of services. (cdc.gov)
Several of those are now considered applicable for patient treatments beyond the need for regulated clinical trials. (biomedcentral.com)

That breakthrough also had its roots at Johns Hopkins, specifically a 1995 study published in The New England Journal of Medicine with results so promising that the National Institutes of Health stopped early a clinical trial involving the use of the drug hydroxyurea to treat sickle cell anemia. (jhu.edu)

The rapid advance of stem cell clinical trials for a broad spectrum of conditions warrants an update of the review by Trounson (2009) [ 1 ]. (biomedcentral.com)

Clinical trials have demonstrated that CRT can provide long-lasting, significant clinical benefit. (lu.se)

abstract = "Clinical studies of Parkinson{\textquoteright}s disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. (lu.se)

This increase in pressure can prevent an infant's brain from draining adequately and lead to widespread brain injury or severe loss of tissue in the brain. (brighamandwomens.org)

In this project, involving engineers from LTH, we apply advanced microfluidic techniques to culture hESCs under the influence of chemical gradients to mimic the environment around the developing brain in the fetus, thereby generating neural tissue with anatomical characteristics resembling the developing human brain. (lu.se)

The NIH is funding a $20 million program to "develop, demonstrate, and validate experimental models that do not rely on human fetal tissue from elective abortions. (chicagotribune.com)
NIH "has directed funding toward the development of alternative research methods that do not rely on human fetal tissue from elective abortions and I remain supportive of that effort. (chicagotribune.com)

Anatomy24

Organisms7

Diseases28

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment86

Psychiatry and Psychology7

Phenomena and Processes30

Disciplines and Occupations11

Anthropology, Education, Sociology and Social Phenomena15

Technology, Industry, Agriculture2

Humanities11

Information Science9

Named Groups5

Health Care74

Geographicals3

Parkinson's12

Transplantation9

Sourced from human fetal tissue1

Embryo-Fetal Toxicity2

Cause fetal harm1

Transplant of fetal2

Toxicity2

Embryonic5

Midbrain1

Patients27

Diagnosis8

Transplants7

Bovine serum2

Utero5

Outcomes5

Cells35

TRANSEURO2

Obstetric2

Surgery6

Efficacy1

Maternal8

Neurons3

Spinal2

Organs3

1980s2

Pancreatic2

Myelomeningocele1

MSCs2

Practice3

Soft Tissue1

Involves3

Underway2

Vaccines9

Placental tissue1

Pivotal clinical1

Therapies4

Collaborations1

Work2

Brains1

Typically3

Cartilage1

Spina1

Current clinical trials1

Patient5

19951

Stem cell clinical1

Significant clinical benefit1

Abstract1

Severe1

Neural1

Rely2