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  • intravenous
  • This is the first large multi-centre study of intravenous multipotent stem cells in the treatment of cerebral damage secondary to stroke. (springer.com)
  • Supplementation of cholesterol was provided by fetal intravenous and intraperitoneal transfusions of fresh frozen plasma during the third trimester. (medscape.com)
  • The first-of-its-kind study in heart attack patients will seek to demonstrate the safety, and roughly measure efficacy, of three intravenous doses of adult human stem cells versus placebo in lessening damage to heart muscle within ten days of first heart attack. (rxpgnews.com)
  • Alemtuzumab (Genzyme/Sanofi) - The two-year CARE-MS II phase III trial compared intravenous alemtuzumab against standard dosing of Rebif® (interferon beta-1a, EMD Serono Inc. and Pfizer) in 840 people with relapsing-remitting MS who had relapsed while on prior therapy. (mssociety.ca)
  • regeneration
  • The potential of stem-cell based technologies hold promise for the repair, restoration and regeneration of dysfunctional cells in the eye, yet significant challenges remain. (aao.org)
  • For many basic biomedical scientists, the capability offered by iPSCs technology is like a dream come true, says neuroscientist Arnold Kriegstein , MD, PhD, director of UCSF's Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research . (ucsf.edu)
  • In the process of regeneration, humans continually replace old blood and skin cells with new ones by re-starting some of the mechanisms (e.g. stem cell differentiation) that allowed those tissues to first develop in the fetus. (rxpgnews.com)
  • When humans receive an injury too serious to repair through regeneration, a process called fibrosis kicks in to patch the wound, but also leaves scar tissue that reduces the organ's performance. (rxpgnews.com)
  • The scientists said: "Because marrow stromal cells can be obtained repeatedly by bone marrow aspiration and expanded vastly in vitro before being implanted or used as autologous [same patient] implants, and because their use does not call for immunosuppression, the clinical use of marrow stromal cells for cellular cardiomyoplasty [heart tissue regeneration] appears to be most advantageous. (stemcellresearch.org)
  • currently underway
  • The story is still preliminary and unfolding (dozens of clinical trials using epigenetic drugs are currently underway), but Dr. Margaret Foti, chief executive officer of the American Association for Cancer Research, recently noted that epigenetics is already resulting in "significant improvements" in cancer diagnosis and therapy. (newsweek.com)
  • spinal
  • Stem cells injected into ALS patients' spinal cords have survived for years and have caused few side effects. (slate.com)
  • This limits the capacity of the brain and spinal cord to undergo repair and therefore results in more severe consequences from tissue damage. (springer.com)
  • These specialized cells differ from those found in the peripheral immune system (i.e. the immune system which operates in all parts of the body besides the brain and spinal cord). (stanford.edu)
  • I would expect these cells to be readily accepted by and integrated into a human nervous system, such as in an ALS or a spinal cord injury patient. (bio-medicine.org)
  • This study shows, at the ultra-structural level, that these cells make mature connections with host motor neurons in the spinal cord," said Dr. Vassilis E. Koliatsos, whose lab at Johns Hopkins conducted the study. (bio-medicine.org)
  • Clinical and animal studies have been conducted into the use of stem cells in cases of spinal cord injury . (wikipedia.org)
  • Clinical trials of these fetal tissue-derived cells are currently ongoing for amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease), spinal cord injury, stroke, and age-related macular degeneration. (isscr.org)
  • MSCs
  • Animal studies have shown that MSCs injected into heart muscle following a heart attack decreased the death of muscle cells and increased pumping strength. (rxpgnews.com)
  • For instance, research has shown that MSCs, like Blood Type O, are universally compatible, meaning they can be transplanted from person to person without fear of rejection by the recipient's immune system. (rxpgnews.com)
  • In addition to secreting factors that can stimulate tissue repair, MSCs can substantially alter their microenvironment, exerting effects that are both anti-nflammatory and anti-fibrotic. (reportsnreports.com)
  • MSCs appear to be an exceptionally promising tool for cell therapy, because of their unusual advantages, which include availability, expand ability, transplant ability, and ethical implications. (reportsnreports.com)
  • Additionally, MSCs well-suited for use in the exponential growth area of 3D printing, because of their capacity to form structural tissues. (reportsnreports.com)
  • To support this rapidly expanding marketplace, this 200+ page global strategic report presents trend rate data for MSC market, including rates of MSC patents, grants, scientific publications, and clinical trials, as well associal analytics that identify online behavior related to MSCs. (reportsnreports.com)
  • The report describes the current status of mesenchymal stem cell (MSC) research, ongoing clinical trials involving MSCs, late stage MSC clinical trials, and uses of MSCs in cell therapy. (reportsnreports.com)
  • differentiation
  • Stem cells are dividing cells that exhibit potency (ability to subdivide into multiple different cells types) and self-renewal (ability to undergo multiple cell cycles without differentiation). (springer.com)
  • We found a direct effect of AbPP on stem cell migration and differentiation. (alzforum.org)
  • George C.: Is there an effect of Ab on stem cell differentiation in culture? (alzforum.org)
  • Kiminobu Sugaya: We also found AbPP transfection to the cell causes glial differentiation rather than neural differentiation. (alzforum.org)
  • Kiminobu Sugaya: I think AbPP is the molecule to initiate migration or differentiation of stem cells. (alzforum.org)
  • sAPP treatment increases differentiation of stem cells in vitro. (alzforum.org)
  • Kiminobu Sugaya: Stem cell activity depressed in AbPP transgenic mice could be caused by the over differentiation to glial cells. (alzforum.org)
  • Actually, in AbPP transgenic mice, the stem cell population may be decreased by the glial differentiation, and this could happen in the AD brain, too. (alzforum.org)
  • Kiminobu Sugaya: AbPP overexpression just pushes glial differentiation of stem cells, which results in decreased stem cell population. (alzforum.org)
  • 2016
  • October 5, 2016 - Notice of Clarification of the Purpose and Research Objectives and Revised Research Strategy Instructions in PAR-16-115. (nih.gov)
  • Additional worldwide regulatory filings for this indication are underway, with a decision in the EU anticipated in 2016. (aktiespararna.se)
  • The budget item on March 20, 2012 , incorrectly stated that the stem cell agency's rent costs would rise to $1 million beginning in 2016. (blogspot.com)
  • Scientists
  • The Huntingtin gene makes a protein important for neurons, but scientists are still trying to understand what this protein does in cells and why too many 'CAG' repeats causes MSNs to die. (eurostemcell.org)
  • Using stem-like sphere-forming cells prepared from a mammary tumor and a lung adenocarcinoma cell line, scientists found that CD59 was upregulated to protect cancer stem cells (CSCs) from complement-dependent cytotoxicity. (cancerstemcellnews.com)
  • The scientists note that skeletal muscle stem cells are abundant and can be grafted successfully into the animal's own heart even after genetic manipulation in vitro. (stemcellresearch.org)
  • Columbia University scientists have implanted human bone-marrow-derived stem cells into rats with cardiac damage. (stemcellresearch.org)
  • Scientists at Duke University Medical Center have shown that adult stem cells from liver can transform into heart tissue when injected into mice. (stemcellresearch.org)
  • The International Society for Stem Cell Research (ISSCR) is the world's leading professional organization of stem cell scientists, representing more than 4,000 members in 45 U.S. states and 65 countries around the world. (isscr.org)
  • stem cell th
  • Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition. (wikipedia.org)
  • this is the only form of stem-cell therapy that is widely practiced. (wikipedia.org)
  • Another stem-cell therapy called Prochymal , was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)
  • Among several clinical trials reporting that adult stem cell therapy is safe and effective, actual evidence of benefit has been reported from only a few studies. (wikipedia.org)
  • Some preliminary clinical trials achieved only modest improvements in heart function following use of bone marrow stem cell therapy. (wikipedia.org)
  • 2 Trials of stem cell therapy have taken several approaches. (aao.org)
  • The Academy believes that, in the interests of public health and patient safety, the FDA should continue to investigate unlicensed clinics that offer unapproved stem-cell therapy and to take appropriate regulatory actions. (aao.org)
  • This study will seek to ensure that stem cell therapy is safe in treating heart failure, a major cause of death in heart attack survivors. (rxpgnews.com)
  • Following up with stem cell therapy and exome therapy immediately in the first 36 to 48 hours after stroke symptoms surface has proven to be crucial to long-term recovery and regaining mobility again. (euvolution.com)
  • Regenerative medicine now offers treatment for MS with stem cell therapy, which is an exciting and rapidly developing field of therapy. (euvolution.com)
  • adverse
  • Primary safety outcomes were dose-limiting toxic events at 7 days after infusion, allergic/adverse events secondary to cells, or worsening NIHSS of 4 points. (springer.com)
  • Questions remain about optimal delivery methods, host immune responses, in vivo monitoring, long-term adhesion, function and survival of cells, and adverse effects. (aao.org)
  • E3 tests of placental or feto-placental function are widely used in high-risk pregnancies to predict adverse fetal outcome [ 2 ]. (oatext.com)
  • genes
  • Research has identified several genes that can cause rare inherited forms of PD and other genes that influence age of onset and susceptibility to common PD. (nih.gov)
  • through epigenetic control, the fetal genes are permanently turned off at a certain stage of development, and the adult genes are permanently activated. (newsweek.com)
  • liver
  • E3 of fetal origin originates exclusively from the 16-hydroxylation of either dehydroepiandrosterone (DHEA) or DHEA sulfate (DHEAS) in the fetal liver, and is metabolized by steroid sulfatase in the placenta. (oatext.com)
  • DHEA/DHEAS is then converted to 16-OH DHEA/16-OH DHEAS in the fetal liver. (oatext.com)
  • rigorous
  • However, as with all research endeavours, enthusiasm should be tempered with robust biological rationale, rigorous ethical and methodological oversight, and clear and consistent trial methodology to show the evidence of benefit. (springer.com)
  • outcomes
  • MASTERS was a phase II randomised-controlled trial, with primary outcomes for safety and efficacy. (springer.com)
  • exploratory outcomes were MR volume change and levels of cytokines and regulatory T cells. (springer.com)
  • human
  • Neuralstem's Human Stem Cells Integrate into Nervous System of Rats with Animal Mo. (bio-medicine.org)
  • This tissue removed from his penis may be sold to companies and institutions seeking the rich human fibroblast cells and other cells it contains. (fourwinds10.com)
  • Certain microorganisms used by vaccine companies need living human cells to replicate. (fourwinds10.com)
  • Baby foreskins are used to research rubella, varicella and human papillomavirus (HPV) vaccines. (fourwinds10.com)
  • New drugs tested on human cells instead of animal models. (ucsf.edu)
  • A year later, they accomplished the feat with human cells. (ucsf.edu)
  • We've never had unrestricted access to living human brain cells. (ucsf.edu)
  • Now we can take skin cells and grow human cortex in a dish. (ucsf.edu)
  • A human embryo starts with one cell that divides to become many. (rxpgnews.com)
  • These proposals, if enacted, would obstruct critical biomedical research and inhibit efforts to improve human health. (isscr.org)
  • Fetal tissue is an essential "gold-standard" resource that enables laboratory-based research into how human tissues and organs develop. (isscr.org)
  • While other approaches, such as using animal models and cells from adults, can be helpful, for some congenital and developmental conditions it is necessary to study human fetal tissues. (isscr.org)
  • The Catholic church opposes hESC research because of its belief that it destroys human life. (blogspot.com)
  • Since the late 1980s, over 300-400 PD patients worldwide have received transplants of human fetal ventral mesencephalic (VM) tissue, rich in post-mitotic DA neurons. (hindawi.com)
  • The clinical relevance and biological significance of estriol (E3), one of the three major human estrogens, are presented in this review. (oatext.com)
  • normally
  • Tissue-specific stem cells normally only give rise to cells of the tissue in which they are found, for example, blood stem cells only produce blood cells. (springeropen.com)
  • Basic research on chemical signals in the brain, called neurotransmitters, led to recognition that the symptoms of PD reflect loss of nerve cells that normally release the neurotransmitter dopamine. (nih.gov)
  • Although the blood-brain barrier normally keeps these immune systems apart, Larimore's research interestingly showed that there was peripheral immune system activation in HD patients. (stanford.edu)
  • brain
  • an important overview and guidance for research using stem cells for immunomodulation and brain repair in multiple sclerosis. (springer.com)
  • Parkinson's disease (PD) is a neurodegenerative disorder, that is, a disease in which brain cells progressively die. (nih.gov)
  • Brain surgery that permanently destroyed regions of tissue involved in PD provided some benefit for people with the disease. (nih.gov)
  • DBS improves symptoms of PD by electrically stimulating brain cells in movement control areas of the brain through chronically implanted electrodes. (nih.gov)
  • Gene findings are yielding clues about what kills brain cells in inherited and non-inherited PD and suggesting new strategies, now at various stages of testing, to slow the course of disease. (nih.gov)
  • Ms. Larimore began her talk by explaining the immune system of the brain and the role of microglia cells. (stanford.edu)
  • This indicates that the neurological symptoms of HD are either paralleled in the peripheral immune system or communication between cells traverses the blood-brain barrier to connect the two immune systems. (stanford.edu)
  • Huntington's Disease (HD) mainly affects nerve cells in the brain called medium spiny neurons (MSNs). (eurostemcell.org)
  • Research has been conducted on the effects of stem cells on animal models of brain degeneration , such as in Parkinson's , Amyotrophic lateral sclerosis , and Alzheimer's disease . (wikipedia.org)
  • In healthy adult laboratory animals, progenitor cells migrate within the brain and function primarily to maintain neuron populations for olfaction (the sense of smell). (wikipedia.org)
  • Stroke and traumatic brain injury lead to cell death , characterized by a loss of neurons and oligodendrocytes within the brain. (wikipedia.org)
  • The stem cells will be implanted into 3 areas of the brain and drugs to avoid cell rejection will also be given to the childen. (bio-medicine.org)
  • NCL patients lack an enzyme responsible for breaking down complex fat and protein compounds in the brain," lead researcher Dr. Robert D. Steiner, vice chairman of pediatric research and head of the Division of Metabolism at Doernbecher Children's Hospital, said at a press briefing Friday. (bio-medicine.org)
  • Parkinsons is a neurodegenerative brain disorder caused by the gradual loss of dopamine-producing cells in the brain. (euvolution.com)
  • Is it a good tactic to make cholinergic cells in vitro then transplant them into the brain just throw these few ideas out to get us started. (alzforum.org)
  • This discovery makes it possible to explore new approaches to promote normal brain cell development in premature babies. (isscr.org)
  • Beyond the provision of symptomatic efficacy and safety data, it also remains to be identified whether the possibilities offered by stem cell and gene therapy technological advances might translate to meaningful neuroprotection and/or disease-modifying effects or alleviate the nonmotor aspects of PD and thus offer additional benefits beyond those achieved through conventional pharmacotherapy or deep brain stimulation (DBS). (hindawi.com)
  • neurons
  • The cells seem to protect diseased motor neurons, stimulating their survival. (slate.com)
  • George C.: It seems that a key question is whether the neuronal loss/damage is due to extracellular factors, which would be expected to damage the stem cell derived-neurons or whether intracellular metabolic effects are responsible for the dementia. (alzforum.org)
  • June Kinoshita: Just trying to make sure I understand: From what you are saying, AbPP overexpression doesn't decrease stem cell activity per se, but it pushes stem cells towards differentiating into glia rather than neurons. (alzforum.org)
  • scar tissue
  • Considering that significant changes in cardiac geometry and function are affected by relatively few engrafted cells 5,6 in the inhospitable environment of the myocardial scar tissue that do not transdifferentiate into cardiomyocytes, 7 paracrine effects induced by the implanted cells have been proposed as likely mechanisms for the prevention of cardiac failure. (ahajournals.org)
  • treatment
  • Stem cells hold terrific promise for the treatment-and, eventually, the defeat-of ALS. (slate.com)
  • Any treatment derived from fetal tissue is many years away at best, but the early research has been a success . (slate.com)
  • The experimental treatment slowed or reversed the progression of the disease in several patients in a small Phase I clinical trial. (slate.com)
  • The previous studies of stem cell treatment in stroke have been small, single-centre studies. (springer.com)
  • Note: This article includes references to Dimebon, which is no longer being considered as a potential treatment for HD after the HORIZON clinical trial showed that Dimebon was not better than a placebo . (stanford.edu)
  • a donor's healthy bone marrow reintroduces functional stem cells to replace the cells lost in the host's body during treatment. (wikipedia.org)
  • The FDA cautions that patients should check to be sure that any stem-cell treatment is approved by the FDA or is under a clinical investigation that has been approved by the FDA. (aao.org)
  • A phase I trial is conducted to determine the safety of a treatment, irrespective of its efficacy. (bio-medicine.org)
  • It is our hope that this trial will provide insight into a potential treatment option for this tragic disease," Steiner said. (bio-medicine.org)
  • [ 27 ] Potentially, cholesterol supplementation is a logical treatment because it may be expected to raise plasma and tissue cholesterol levels. (medscape.com)
  • The trial, to be conducted according to U.S. Food and Drug Administration guidelines, is designed to evaluate safety of treatment with stem cells obtained from healthy, unrelated, adult donors (not from a fetus, embryo or animal). (rxpgnews.com)
  • Have you or a member of your immediate family benefited from a clinical trial or treatment using adult or cord blood stem cells? (stemcellresearch.org)
  • For pharmaceutical companies, the report reveals how advances in MSC research can reveal potential new drug targets, improve methods of drug delivery, and provide personalized treatment strategies. (reportsnreports.com)
  • study
  • In this study, they reported that most TNF-expressing AML cells also express another pro-inflammatory cytokine, IL1β, which acts in a parallel manner. (cancerstemcellnews.com)
  • Children eligible for the study have clinical symptoms of one of two types of NCL -- infantile or late infantile NCL -- and loss-of-function mutations in either the CLN1 or CLN2 gene. (bio-medicine.org)
  • These funds are available only for study of stem cell lines derived from embryos that had been destroyed before the limit was set. (bio-medicine.org)
  • A retrospective study of simvastatin did not lead to clinical improvements in one series. (medscape.com)
  • The potential to re-build damaged heart muscle by implanting stem cells that then become new muscle cells is one of the most exciting in cardiology," said Craig R. Narins, M.D., assistant professor of Cardiology at the medical center and principal investigator for the current study. (rxpgnews.com)
  • We have not done any particular study with Ab , though I do not expect cell toxicity. (alzforum.org)
  • In another animal study, when compared to fetal heart cells, the adult stem cells were equally good at repairing heart damage. (stemcellresearch.org)
  • efficacy
  • This stem-cell product is not approved by the FDA, and the risks and efficacy are largely uncharacterized. (aao.org)
  • paracrine
  • Conclusions- Regardless of whether the cells were injected into the infarct or the noninfarcted myocardium early after an myocardial infarction or later, skeletal myoblasts improved cardiac function by preventing ventricular dilation and preserving matrix architecture in the remote region, likely mediated by paracrine effects. (ahajournals.org)
  • regenerative medicine
  • As part of the fast emerging science of regenerative medicine, labs worldwide are attempting to replace damaged tissue with new cells, much in the same way as salamanders re-grow limbs. (rxpgnews.com)
  • Regenerative medicine offers a non-surgical option that commonly uses the patients own stem cells, exosomes, and other sources of growth factors to regenerate healthy tissue to improve performance and sensation. (euvolution.com)
  • Regenerative medicine offers a non-surgical option that commonly uses the patients own stem cells, exosomes, and other sources of growth factors to reduce inflammation, promote natural healing and regenerate healthy tissue surrounding the joint for relief. (euvolution.com)
  • With more than 2.3 million page views and more than 4,666 items, this blog provides news and commentary on public policy, business and economic issues related to the $3 billion California stem cell agency, officially known as the California Institute for Regenerative Medicine(CIRM). (blogspot.com)
  • As the most common stem cell type being used in regenerative medicine, there is substantial potential for growth within the MSC market. (reportsnreports.com)
  • patients
  • Best management of these critically competing issues, to enable progress to be made as quickly as possible without exploitation of vulnerable patients, will be aided by a clear understanding of how the stem cell field has developed to where it is now. (springeropen.com)
  • The early promising results of clinical trials in patients with Smith-Lemli-Opitz syndrome, the known severity of the untreated condition, and the ability to confirm the diagnosis prenatally have drawn attention toward preconceptional and prenatal therapy. (medscape.com)
  • Forty-eight patients will participate in the trial, 22 of which have already been enrolled. (rxpgnews.com)
  • Trial entry must occur within 10 days of first heart attack, and patients will be followed for two years afterward. (rxpgnews.com)
  • Other approaches like harvesting stem cells from the patients' own tissue can be expensive, time-consuming and limited in the numbers of cells produced. (rxpgnews.com)
  • 1-4 However, improvements in ventricular function were less impressive in the clinical trials than in animal studies, perhaps due to advanced age and comorbidities in the patients. (ahajournals.org)
  • Further clinical trials are now underway in Europe and the U.S. for other patients with heart disease. (stemcellresearch.org)
  • In each case, the fetal tissue would be discarded if not donated by patients for medical research. (isscr.org)
  • The experience accumulated from open-label studies suggested significant clinical benefits across multiple parameters in patients receiving grafted cells accompanied by a general reduction in pharmacological requirements [ 9 - 11 ]. (hindawi.com)
  • vaccines
  • Foreskin cells can be used to turn a wild-type microorganism found in nature into a genetically modified microorganism for use in vaccines. (fourwinds10.com)
  • It is important to research how vaccines are made prior to receiving them, if you want to avoid unwanted contaminants in your body. (fourwinds10.com)
  • transplant
  • However, results also provided encouragement for better controlled methods of cell transplant therapy. (nih.gov)
  • endogenous
  • The central nervous system (CNS) undergoes little endogenous neural cell division beyond selected regions such as the hippocampus and striatum. (springer.com)
  • George C.: I believe Mark Mattson and coworkers have evidence in AbPP-transgenic mice that endogenous stem cell activity is depressed. (alzforum.org)
  • Yamanaka
  • For this research coup and his leading role pioneering stem cell work, Yamanaka - who holds academic appointments at Kyoto University and UC San Francisco - was the co-recipient of the 2012 Nobel Prize in Medicine or Physiology . (ucsf.edu)
  • migrate
  • The risk is that stem cells that are implanted in another environment and intended to perform a different function than their original function may multiply, may form tumors or incite inflammation and may migrate elsewhere other than the intended site. (aao.org)