Clinical trials radioimmunotherapy. Medical search. Frequent questions

In this article, we summarize the role of radioimmunotherapy in the treatment of leukemia. (medscape.com)
7. The role of radioimmunotherapy with yttrium-90 ibritumomab tiuxetan in the treatment of non-Hodgkin lymphoma. (nih.gov)

Clinical studies support using single-agent RIT in relapsed/refractory FL, in selected patients with new, untreated FL, and as consolidation after induction chemotherapy or chemoimmunotherapy. (nih.gov)
Patients must not have received systemic chemotherapy (corticosteroids not included) less than 3 weeks prior to enrollment in this trial. (mycancergenome.org)
METHODS: Patients who experienced progressive disease (PD) after a clinical benefit from chemotherapy plus a CPI were enrolled. (bvsalud.org)
CONCLUSIONS: Pembrolizumab plus next-line chemotherapy in patients with advanced NSCLC who experienced PD after a clinical benefit from a CPI was associated with statistically significant higher PFS in comparison with historical controls of single-agent chemotherapy alone. (bvsalud.org)
He graduated in medicine from the University of Oxford and trained in Clinical Oncology (Radiotherapy and Chemotherapy) in Cardiff, London and Leeds. (birc.uk)

Radioimmunotherapy (RIT) with (90)Y-ibritumomab tiuxetan or (131)I-tositumomab combines a radiation-emitting radionuclide with an antibody targeting CD20 to treat B-cell non-Hodgkin lymphoma. (nih.gov)
3. Radiation dosimetry results and safety correlations from 90Y-ibritumomab tiuxetan radioimmunotherapy for relapsed or refractory non-Hodgkin's lymphoma: combined data from 4 clinical trials. (nih.gov)
5. Radioimmunotherapy for non-Hodgkin's lymphoma with yttrium 90 ibritumomab tiuxetan. (nih.gov)
10. Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma. (nih.gov)
15. Radioimmunotherapy in non-Hodgkin's lymphoma: focus on 90Y-ibritumomab tiuxetan (Zevalin). (nih.gov)
17. Use of ibritumomab tiuxetan anti-CD20 radioimmunotherapy in a non-Hodgkin's lymphoma patient previously treated with a yttrium-90-labeled anti-CD22 monoclonal antibody. (nih.gov)
Data on 211 patients treated in four clinical trials were analysed to compare the efficacy and safety of 90 Y ibritumomab tiuxetan when it was used after the first relapse of NHL and when it was used after two or more prior therapies. (elsevierpure.com)
90 Y ibritumomab tiuxetan has substantial clinical benefits as a second-line therapy, especially in patients with follicular NHL. (elsevierpure.com)

But they do use immunotherapy for some types of cancer, and researchers are doing clinical trials to see whether it also works for other types. (medlineplus.gov)
Several types of immunotherapy are either approved for use by the Food and Drug Administration or are under study in clinical trials to determine their effectiveness in treating various types of cancer. (lls.org)
He and his collaborators will use what they learn to better inform their future early stage clinical trials of radio-immunotherapy starting with melanoma, head and neck cancers, and neuroblastoma. (nih.gov)
In 2007, Cheever established the Cancer Immunotherapy Trials Network , serving until recently as the network's director and principal investigator. (aacr.org)
The interdisciplinary component of the scientific programme includes sessions on a wide range of topics: Artificial Intelligence in radiation oncology: role and potential, Radio-immunotherapy, MR machines and treatment adaptation, Clinical trials for particle therapy, DNA damage response with radiotherapy, Radiotherapy biomarkers: a confluence of imaging, genetics and pathology as well as Predictive models of toxicity and big data and many other topics that trace the path to Precision Medicine. (youmed.it)

In a recent trial, BL22 resulted in an 81% response rate in patients with hairy cell leukemia refractory to cladribine. (medscape.com)
Nordic Nanovector ASA (OSE: NANO) reports an update on its LYMRIT 37-05 Phase 1 trial of Betalutin® in patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who are not eligible for autologous stem cell transplantation (SCT). (healthcap.eu)

Clinical trials have demonstrated that both rituximab, a chimeric anti- CD20 MAb, and Campath-1H, a humanized anti-CD52 MAb, have activity against chronic lymphocytic leukemia. (medscape.com)

11. Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody. (nih.gov)

He chairs the biomarker development group for FOCUS4 is Chief investigator for FOCUS4 D and leads on the radiotherapy quality assurance for the UK ARISTOTLE, COPERNICUS and TREC trials. (birc.uk)
Since returning to Scotland in 2016, Campbell has secured a CSO-funded Scottish Senior Clinical Fellowship to support his research into development of novel neoadjuvant strategies incorporating immune oncology-radiotherapy combinations in rectal cancer. (birc.uk)
They are also working on how radiotherapy treatment of tumours impacts on the immune system and anti-tumour immunity, in patients as well as pre-clinical model systems. (birc.uk)

In 1994, he cofounded Corixa Corp., a maker of therapeutic cancer vaccines that developed Bexxar, a radioimmunotherapy drug that secured approval from the U.S. Food and Drug Administration for the treatment of lymphoma. (aacr.org)

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2021 12 40 (4): 369-381. (cdc.gov)

The authors reviewed the published clinical trials of radioimmunotherapy in acute leukemia. (medscape.com)
Research interests include acute myeloid leukemia, radioimmunotherapy with alpha and beta particle-emitting radioisotopes, monoclonal antibody therapy for leukemia, the development of novel small molecule inhibitors for leukemia, and the molecular monitoring of minimal residual disease. (bioascend.com)
The Clinical both chronic and acute disease. (nih.gov)

Patients must not have received cranial or spinal irradiation less than 3 weeks prior to first dose of 131I-omburtamab in this trial. (mycancergenome.org)
14. Radioimmunotherapy for patients with relapsed B-cell non-Hodgkin lymphoma. (nih.gov)
This study assessed clinical effects of pazopanib therapy in RAIR-DTC patients with progressive disease, examining in parallel biomarker that might forecast/precede therapeutic response. (bvsalud.org)
Conclusions: This trial prospectively confirmed pazopanib to have clinical activity and manageable toxicities in patients with progressive RAIR-DTC. (bvsalud.org)
The ASCO Cancer Research Committee recently convened four disease-specific working groups-in pancreas, breast, lung, and colon cancers-to "consider the design of future clinical trials that would produce results that are clinically meaningful to patients. (ascopost.com)
The goals set forth in the perspective statement are meant to further the paradigm of designing and generating clinical trials that can demonstrate larger therapeutic gains in selected groups of patients with smaller trial populations ("smaller and smarter" trials). (ascopost.com)
In arriving at goals for clinical trials, both survival and quality of life were considered as important to outcomes that are clinically meaningful for patients. (ascopost.com)
Patients may have the option of participating in a radioimmunotherapy clinical trial that uses targeted radiation with the goal of striking tumor cells, while sparing healthy cells. (ymabs.com)
Severe infusion reactions occurred in 32-68% and serious infusion reactions occurred in 4-18% of patients in DANYELZA clinical studies. (ymabs.com)
Pain of any Grade occurred in 94-100% of patients in DANYELZA clinical studies. (ymabs.com)
As reflected in the partnership with Schlom, NCI scientists have been the main co-investigators in these projects and have served as the physicians to the patients enrolled in CC clinical trials in this 'brand new area of research' nuclear medicine in diagnosis and therapy. (nih.gov)
With Tom Waldmann , chief of the NCI Metabolism Branch , the NM team has performed preclinical evaluations and clinical analyses of pharmocokinetics and dosimetry of anti-Tac monoclonals (directed against the IL-2R a receptor) in patients with adult T-cell leukemia [Treatment of Tac-Expressing Cutaneous T-Cell Lymphoma and Adult T-Cell Leukemia with Yttrium-90 Radiolabeled Anti-Tac]. (nih.gov)
This open-label, dose-escalation safety trial is designed to assess the safety, tolerability, pharmacokinetic profile and preliminary anti-tumour activity of Betalutin® in up to 24 patients. (healthcap.eu)
Trial leader Damian Green, MD, of Fred Hutch reported initial results from these first patients today at the annual meeting of the American Society of Hematology, which ran through December 11 in San Diego. (cancerhealth.com)
He cautioned that researchers need to study trial participants for years to draw conclusions about how well the experimental therapy will help patients in the long run. (cancerhealth.com)
In fact, the cancers of two patients on the trial came back, one to six months after they had disappeared. (cancerhealth.com)
The approach being tested in the trial, which is designed to enroll a total of 25 participants, involves genetically engineering cancer-targeting machinery into patients' own immune cells. (cancerhealth.com)
On the trial, patients' T cells, a type of immune cell, are drawn from their bloodstreams at Seattle Cancer Care Alliance , Fred Hutch's clinical-care partner, and carried across the Hutch campus to a basement laboratory. (cancerhealth.com)
Compared to the one in Green's study, some have advanced further along in the clinical trials pipeline that can lead new treatment approaches to patients. (cancerhealth.com)
Interestingly, in phase I-II clinical trials , using a biotinylated anti-tenascin monoclonal antibody (1st step), avidin and streptavidin (2nd step) and an yttrium 90 labelled biotine (3rd step), the three-step therapy appears to be a promising strategy for the treatment of patients with recurrent high grade glioma, ie grade III/IV glioma and glioblastoma (Paganelli et al. (e-proteins.com)
Pretargeted adjuvant radioimmunotherapy with yttrium-90-biotin in malignant glioma patients: a pilot study. (e-proteins.com)
Therefore, based on these encouraging results, this randomized phase II multicenter trial compared the outcomes of BuME and BuCE as conditioning therapies for ASCT in patients with NHL. (e-crt.org)
A trial study conducted by the National Lung Screening Trial (NLST) showed that around 18% of lung cancers detected by low-dose CT screening were slow-growing tumors that would not have had any consequence on patients during their lifetime. (healthimaginghub.com)
Edward F. Patz Jr., MD, of Duke University Medical Center, and co-workers discovered that the trial revealed a mortality advantage to screening, but for every one lung cancer death prevented for every 320 patients with screening in the trial, 1.38 cases of overdiagnosis would be anticipated. (healthimaginghub.com)
In the 2008 WHO classification, grade 3b FL were separated and are universally treated as diffuse large reported the clinical outcomes in patients in which the ther- B-cell lymphoma (DLBCL) [2]. (health-articles.net)
With a legacy of putting patients first, Weill Cornell Medicine is committed to providing exemplary and individualized clinical care, making groundbreaking biomedical discoveries, and educating generations of exceptional doctors and scientists. (cornell.edu)
Radioimmunotherapies can be active, but owing to the potential for haematologic toxic effects, their use has been limited to patients with adequate marrow function and limited marrow involvement by tumour. (esmo.org)
Today we celebrate the patients and staff who have helped to make the Clinical Center a place of compas- sionate care and extraordinary scientific achievement. (nih.gov)
Throughout the years, dedicated scientists partnering with remarkable patients and devoted staff have created the perfect environment for long-term clinical research studies. (nih.gov)
Left) The Ambulatory Care Research Facility (ACRF), dedicated in 1981, All guests, patients, and staff are invited to attend a reception on the south greatly increased the Clinical Center's capacity for outpatient care. (nih.gov)
Center's innovative physical--and philosophical--structure permit- ment conducting clinical research (research on patients) was new ted a single scientist to work in both the lab and the clinic. (nih.gov)
TET-2 mutations predict poor outcomes and are associated with unfavorable clinical-biological features in PTCL, not otherwise specified and angioimmunoblastic T-cell lymphoma in Brazilian patients. (cdc.gov)

He was also a frequent contributor to AACR journals, including Cancer Research , Clinical Cancer Research , and Cancer Epidemiology, Biomarkers and Prevention . (aacr.org)
His research interests include clinical and translational cancer research and clinical trials. (birc.uk)
Following completion of his PhD at the Imperial Cancer Research Fund (now Cancer Research UK) in London, he was a post-doctoral research fellow at the Mayo Clinic, Minnesota, before returning to the UK, where in 2007 he became Professor of Clinical Oncology and Biotherapy at Leeds, before moving to London in 2016. (birc.uk)
Then they joined a clinical trial to be the first people ever to receive a new experimental, immune-harnessing therapy, whose design includes features based on pioneering research at Fred Hutchinson Cancer Research Center. (cancerhealth.com)
Clinical trials remain the cornerstone of cancer research, and are often the patient's best option. (lymphomainfo.net)

An ASCO perspective statement, reported in the Journal of Clinical Oncology by Lee M. Ellis, MD , of The University of Texas MD Anderson Cancer Center, Houston, and colleagues, offers their conclusions. (ascopost.com)
Dr Illidge completed his undergraduate degrees with a BSc in Biochemistry (London) and medicine (MB BS) at Guy's Hospital, Royal College of Physicians (1993) and trained in clinical oncology in Southampton gaining Fellow of Royal College of Radiologists in 1997. (birc.uk)

19. Radioimmunotherapy of B-cell non-Hodgkin's lymphoma: from clinical trials to clinical practice. (nih.gov)
His clinical practice and research is focused on lower gastrointestinal cancers. (birc.uk)
The current NCCN Guidelines, which reflect the most up-to-date, evidence-based data relating to the evaluation and management of bladder cancer, support the incorporation of some of these novel therapeutics into clinical practice. (jnccn.org)

Role of drug delivery in the management of cancers of the brain, the bladder, the breast, the ovaries and the prostate are used as examples to illustrate different approaches both experimental and clinical. (researchandmarkets.com)

Alternatively, in radioimmunotherapy a radioactive dose localizes a target cell line, delivering lethal chemical doses. (wikipedia.org)

The primary goal of the trial is to identify the maximally tolerated dose of Betalutin® which will then be further evaluated for safety and anti-tumour activity in an expansion cohort in order to select the recommended dose for phase 2. (healthcap.eu)

ASCO is most pleased that the legislation includes guaranteed insurance coverage for individuals participating in clinical trials. (lymphomainfo.net)

Continued approval for this indication may be contingent upon verification and description of clinical benefit in a confirmatory trial(s). (ymabs.com)
Continued approval for this indication may be contingent upon verification and description of clinical benefit in confirmatory trials. (nih.gov)

For several of them, this was the only trial in the world of this type of therapy for which they were eligible. (cancerhealth.com)
Between 2009 and 2017, results translated into a phase I-II trial for adults with severe SCD not eligible for other curative therapies and with severe organ damage. (nih.gov)

[ 10 ] Table 1 lists the labeled and unlabeled antibodies that have been used to treat leukemias in recent trials. (medscape.com)
However the dissimilarity between murine and human immune systems led to the clinical failure of these antibodies, except in some specific circumstances. (wikipedia.org)
9. The role of radiolabeled antibodies in the treatment of non-Hodgkin's lymphoma: the coming of age of radioimmunotherapy. (nih.gov)
And in his nearly two decades of research at NIH, where he came with his mentor in 1983 to establish a radioimmunodetection-radioimmunotherapy program in the Nuclear Medicine (NM) Department Carrasquillo has been instrumental in the development of more than 40 clinical research protocols involving antibodies and radioisotopes. (nih.gov)

The second presentation was by Dr. Courtney Fitzhugh, M.D , Lasker Clinical Research Scholar, Laboratory of Early Sickle Mortality Prevention on the NIH Experience in Nonmyeloablative Allogeneic Transplant for SCD. (nih.gov)
Journal of Laboratory and Clinical Medicine. (wustl.edu)

Radioimmunotherapy is a form of targeted radionuclide therapy that uses a monoclonal antibody to deliver localized radiation. (nih.gov)
12. Radioimmunotherapy for non-Hodgkin's lymphoma: a review for radiation oncologists. (nih.gov)

Examining RIT clinical effects and position within treatment algorithms is important to optimal patient benefit. (nih.gov)
To read more about this treatment, currently in clinical trials, please click here . (lls.org)
Treatment also had to be tailored to each individual patient, which was impracticable in routine clinical settings. (wikipedia.org)
A second treatment cycle of 131I-omburtamab is administered during week 5 (week 6 for Japan) if there is no objective disease progression week 5 after the first injection, and the participant is presenting without unexpected and clinical significant Grade 4 toxicity. (mycancergenome.org)
1. Development of radioimmunotherapy for the treatment of non-Hodgkin's lymphoma. (nih.gov)
13. Pretargeted radioimmunotherapy (PRIT) for treatment of non-Hodgkin's lymphoma (NHL). (nih.gov)
Discussion in the working groups was not limited to biomarker-driven trials, although it is acknowledged that the goals established in the treatment settings discussed, as well as in other treatment settings, will require enrichment strategies. (ascopost.com)

The network brings together leaders from 40 leading universities and cancer centers to coordinate and analyze clinical trials. (aacr.org)

During a trial, the NM team takes serial blood samples, urine specimens, and often bone marrow or tumor biopsies to evaluate the distribution of the monoclonal antibody in the body. (nih.gov)

He oversees collaborative translational research in numerous phase II/ III colorectal cancer trials. (birc.uk)

Damian Green, MD, presented the first results from his trial of genetically engineered immune cells for multiple myeloma. (cancerhealth.com)

4Lab-oratory of Clinical Epidemiology and Center of the Study of Myelofibrosis, the NIH Consensus Development Program [4]. (health-articles.net)
2018. A phase II study of radioimmunotherapy with intraventricular I-3F8 for medulloblastoma. . (cornell.edu)

He is author or coauthor of more than 80 articles and book chapters, has been the principal investigator on over 25 clinical trials, and regularly lectures at national and international meetings. (bioascend.com)

The Advisory Council (AC), com- posed of three members with expertise in clinical epidemiology, hema- 1Istituto di Ematologia ed Oncologia Medica ' Seragnoli,' Universita di Bolo- tology, and critical appraisal, oversaw the process. (health-articles.net)

Key secondary end points included the overall survival (OS), clinical benefit rate, and toxicity. (bvsalud.org)
The relationship of progression-free survival to overall survival in particular clinical contexts was extensively discussed within the working groups, with each deciding to use overall survival as the primary measure of clinically meaningful outcome. (ascopost.com)

The observations lay in the range of other clinical studies in this setting. (biomedcentral.com)

Non-growth-inhibitory doses of Cilengitide were shown to increase the efficacy of radioimmunotherapy in a breast cancer xenograft model [ 14 ]. (biomedcentral.com)

Clinical significance of MYD88 non-L265P mutations in diffuse large B-cell lymphoma. (cdc.gov)

The Influence of Interleukin-2 Gene Polymorphisms on the Risk and Clinical Outcome of Non-Hodgkin Lymphoma. (cdc.gov)

Each working group included clinical investigators, patient advocates, biostatisticians, U.S. Food and Drug Administration oncologists, and industry oncologists. (ascopost.com)

As the safety profile of Betalutin® will guide its potential for combination regimens as well as single agent consolidation therapy, we look forward to completing this part of the trial and proceeding with the expansion cohort. (healthcap.eu)

Carrasquillo s radioimmunotherapy brewery resides at the Building 21 Nuclear Pharmacy, where NM chemist Chang Paik performs the preliminary labeling and testing of research reagents destined for clinical trials. (nih.gov)
Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
Here, we review the principal tumours where research in this field has led to new knowledge and where radioimmunotherapy becomes a reality. (cun.es)
Grant Magnuson Clinical Center remains a national focal point for clinical research. (nih.gov)
That as much to strike a careful balance between basic and clinical research-- as anything permitted physician-scientists first to get an education prevailed, and the intramural program that centered on the patient and then to stay scientifically alive. (nih.gov)

Warren Grant Magnuson Clinical Center, NIH patient admission to the NIH Clinical Center. (nih.gov)

But it was from the ensuing collaborative clinical work between Schlom s and Carrasquillo s teams that there emerged in 1992 a new product to uncover metastatic colorectal and ovarian carcinoma (OncoScint, Cytogen Corp., Princeton, N.J. (nih.gov)

Evaluation of a new biotin-DOTA conjugate for pretargeted antibody-guided radioimmunotherapy (PAGRIT). (e-proteins.com)

Anatomy2

Organisms2

Diseases11

Chemicals and Drugs45

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes8

Disciplines and Occupations4

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science1

Health Care21

Role of radioimmunotherapy2

Chemotherapy5

Ibritumomab tiuxetan8

Immunotherapy5

Refractory2

Rituximab1

Zevalin1

Radiotherapy3

Bexxar1

American Society1

Acute3

Patients32

Cancer Research5

Oncology2

Practice3

Cancers1

Radioactive1

Dose1

ASCO1

Confirmatory2

Eligible2

Antibodies4

Laboratory2

Radiation2

Treatment7

Centers1

Monoclonal1

Translational research1

Results1

Study2

Principal investigator1

Epidemiology1

Overall survival2

Studies1

Breast1

Diffuse1

Outcome1

Investigators1

Safety1

Research5

Patient1

Collaborative1

Evaluation1