• BACKGROUND: Seasonal malaria chemoprevention (SMC) is a new strategy recommended by WHO in areas of highly seasonal transmission in March 2012. (rti.org)
  • We developed a pharmaco-epidemiological model, tailored to two settings of differing transmission intensity with already established insecticide-treated nets and seasonal malaria chemoprevention interventions. (imperial.ac.uk)
  • Dr Beshir also worked on molecular evaluation of the efficacy of ACTs as well as Seasonal Malaria Chemoprevention (SMC) therapies in West Africa. (lshtm.ac.uk)
  • Following successful clinical trials in 2012, the World Health Organization (WHO) recommends the use of seasonal malaria chemoprevention (SMC) in areas where there is a seasonal peak in malaria rates. (malariaconsortium.org)
  • For more information about seasonal malaria chemoprevention, including the progress achieved to date, the challenges facing further scale up and key messages for governments and development partners, please download our new SMC advocacy brief . (malariaconsortium.org)
  • Also, seasonal malaria chemoprevention applies SP in combination with amodiaquine ( 16 ). (cdc.gov)
  • Seasonal malaria chemoprevention (SMC) is effective to prevent malaria in children 3 to 59 months in the Sahel region. (who.int)
  • Mother's seasonal malaria chemoprevention related knowledge and attitudes and the coverage of the strategy among targeted children were assessed. (who.int)
  • Seasonal malaria chemoprevention (SMC) is a strategy medications to children aged 3 to 59 months during the which administers therapeutic doses of antimalarial period of high malaria transmission, to prevent them from *Corresponding author. (who.int)
  • Cleveland Clinic medical oncologist and principal investigator, G. Thomas Budd, MD, joins the Cancer Advances podcast to discuss the trial origins and what we are looking to accomplish. (clevelandclinic.org)
  • Now, Bailey is the lead investigator for the UW Chemoprevention Consortium, and also leads the team that oversees all chemoprevention clinical trials at UW Carbone. (uwhealth.org)
  • During that time, she was a Clinical Trials Coordinator and an Associate Investigator on two chemoprevention trials for women at increased risk of breast cancer. (cancer.gov)
  • We explore the pipeline of Akt inhibitors and their preclinical and clinical examination status, presenting the potential clinical application of these agents as a monotherapy or in combination with ionizing radiation, other targeted therapies, or chemotherapy. (spandidos-publications.com)
  • Part 1 of this two-part series will discuss prevention, screening, adjuvant treatment, neoadjuvant chemotherapy, and adjuvant chemotherapy trials for ovarian cancer. (cancernetwork.com)
  • METHODS: A non-randomized pragmatic trial with pre-post design was used, with one intervention district (Kita), where four rounds of SMC with sulfadoxine + amodiaquine (SP + AQ) took place in August-November 2014, and one comparison district (Bafoulabe). (rti.org)
  • Development of reliable intermediate biomarkers is valuable for clinical, chemoprevention intervention trials (Bayoumy et al . (scialert.net)
  • Dr Beshir previously worked on EDCTP-funded WANECAM project on Clinical trial of four Artemisinin Combination Therapies (ACT) in west Africa. (lshtm.ac.uk)
  • Chemoprevention is an appealing strategy with proven success in familial adenomatous polyposis (FAP) and breast cancer. (medscape.com)
  • Cleveland Clinic recently opened a clinical trial to determine the maximum tolerated dose of a vaccine in patients with non-metastatic triple-negative breast cancer (TNBC). (clevelandclinic.org)
  • He's here today to talk to us about a breast cancer vaccine trial. (clevelandclinic.org)
  • So I'm a Medical Oncologist at the Cleveland Clinic, with a particularly interest in breast cancer, sarcoma and clinical trials. (clevelandclinic.org)
  • Identify PCPs' awareness of breast cancer risk assessment and breast cancer chemoprevention knowledge, and identify perceived barriers and clinic solutions. (sutterhealth.org)
  • For instance, UW Carbone was a lead partner in a national, first-in-human clinical trial of a potential breast cancer prevention vaccine. (uwhealth.org)
  • At the time magnetic resonance imaging (MRI) was becoming widely used in breast cancer evaluation, investigators in CGB were eager to discover what role the technology might play in the clinical management of BRCA1/2 variant carriers enrolled in the Hereditary Breast and Ovarian Cancer Study. (cancer.gov)
  • Women with a family history of breast cancer are usually seen initially by the primary care team and referred to either a symptomatic breast clinic, to a familial breast cancer clinic, or directly to the clinical genetics service. (bmj.com)
  • The effectiveness of SMC has been demonstrated in frame, we proceeded as follows for the selection of compounds, clinical trials conducted in the Sahel region (Bojang et al. (who.int)
  • PRoBaND: Parkinson's Repository of Biosamples and Network Datasets: Prospective observational study of Parkinson's disease with repeat clinical assessment and biobanking of blood samples. (cddft.nhs.uk)
  • [ 12 ] Observational studies and clinical trials point to the substantial protective effects of aspirin on colorectal cancer and other digestive tract cancers, and modest risk reductions for breast and prostate cancers. (medscape.com)
  • CHEMOPREVENTION OF TOBACCO-RELATED CANCERS IN FORMER SMOKERS: CLINICAL STUDIES Release Date: March 28, 2002 RFA: CA-03-006 National Cancer Institute (NCI) ( http://www.nci.nih.gov/ ) LETTER OF INTENT RECEIPT DATE: June 21, 2002 APPLICATION RECEIPT DATE: July 26, 2002 This RFA is a reissue of RFA-CA-02-009 , which was published in the NIH Guide on 04/20/2001. (nih.gov)
  • This initiative will fund pilot clinical trials (phase I/II or phase II) evaluating the efficacy of chemopreventive agents in specified cohorts of former smokers with or without a prior history of a tobacco-related malignancy and translational studies performed on specimens (such as tissue, blood, urine, etc.) derived from these clinical trials. (nih.gov)
  • The purpose of this RFA is to stimulate phase I/II or phase II clinical trials that will identify agents suitable for definitive testing in the phase III trial context for tobacco-related cancers in cohorts of former smokers. (nih.gov)
  • The basic cancer-related chemical and biologic sciences, pathology, and epidemiology have contributed to (1) the understanding that antimutagenesis and antiproliferation are the important general mechanisms of chemoprevention and (2) the development of antimutagenic and antiproliferative agents as potential chemopreventive drugs. (medscape.com)
  • Jennifer Loud, R.N., C.R.N.P., D.N.P., adult nurse practitioner and assistant chief in the Clinical Genetics Branch (CGB), retired from the Division of Cancer Epidemiology and Genetics (DCEG) in late August 2020, after 27 years of service to the National Cancer Institute (NCI). (cancer.gov)
  • This study aims to provide oral mouth inspection and brush biopsy screening combined with comprehensive cancer screening for people with FA at regular intervals to determine if this practice improves early cancer diagnosis and overall clinical care. (fanconi.org)
  • Part 2, to be published in next month's issue of ONCOLOGY , will detail diagnosis and treatment trials for recurrent disease. (cancernetwork.com)
  • Culture-independent diagnostic tests (CIDTs) are increasingly used for clinical diagnosis of gastrointestinal diseases such as salmonellosis, Shiga toxin-producing E. coli disease, and shigellosis because of their speed, convenience, and generally high-performance characteristics. (cdc.gov)
  • Since phase III cancer prevention trials require large patient cohorts, major resources, and many years to give a definitive answer, it is imperative to prioritize promising agents before embarking on such trials. (nih.gov)
  • Phase II clinical cancer prevention trials depend on intermediate endpoints, whether they be histologic preinvasive lesions or molecular endpoints, to determine preliminary interventional agent efficacy. (nih.gov)
  • Collaborative molecular research projects will focus on the analysis of clinical biological materials collected from the study to develop an understanding of the natural history of squamous cell cancers in individuals with FA. (fanconi.org)
  • Dr. Galka's clinical interests include the management of hepato-pancreatico-biliary (pancreatic and hepatobiliary cancers) and gastrointestinal malignancies, melanoma and sarcoma. (rochester.edu)
  • HDAC inhibitors are the subject of strong research interest internationally, with over 97 clinical trials in numerous cancers currently recruiting worldwide. (nostomachforcancer.org)
  • Statin use has been linked with a risk reduction for cancers including hepatocellular carcinoma, breast, gastric, pancreatic, and biliary tract cancers, but data supporting the use of statins for chemoprevention against CRC is conflicting," Singh said during a virtual presentation at the annual meeting of the American College of Gastroenterology. (medscape.com)
  • Listed below are current clinical trials and research opportunities available. (fanconi.org)
  • This month's installment of Clinical Trials Referral Resource is devoted to current clinical trials of the Cancer Trials Support Unit, a National Cancer Institute pilot program. (cancernetwork.com)
  • [ 1 ] The success of several clinical trials in cancer prevention in high-risk populations suggests that chemoprevention is a rational and appealing strategy. (medscape.com)
  • RESEARCH OBJECTIVES Background An efficient way of identifying clinically useful chemopreventive agents is to perform short term pilot clinical studies examining the effect of interventional agents on molecular, imaging, and histologic endpoints in populations at high risk for developing invasive cancer. (nih.gov)
  • These studies serve to establish the safety and preliminary efficacy of the interventional strategies ("proof of principle") in high risk populations, including phenotypically normal cohorts as well as cohorts with dysplasia/intraepithelial neoplasia, and are crucial in determining which agents/strategies are safe and effective enough for further development in phase III clinical trials. (nih.gov)
  • Use of SP for prevention in many countries of sub-Saharan Africa, where clinical failure after SP treatment has been reported, underscores the need for effective surveillance of its protective efficacy and for monitoring of the development and spread of SP resistance in P. falciparum populations. (cdc.gov)
  • In this latest research funded by No Stomach For Cancer, we have extended that early work to a wider range of drugs in this class and validated their effect in an advanced pre-clinical model known as 'organoids. (nostomachforcancer.org)
  • We have now tested several HDAC inhibitors in this and other related models and identified two promising HDAC inhibitors for further development as HDGC chemoprevention drugs. (nostomachforcancer.org)
  • Cancer chemoprevention has earned serious consideration as a potential means of controlling cancer incidence, having become a top research priority of the National Cancer Institute (NCI). (medscape.com)
  • You'll work alongside many research, clinical and educational organisations. (ncl.ac.uk)
  • Cancer Advances, a Cleveland Clinic podcast for medical professionals, exploring the latest innovative research and clinical advances in the field of oncology. (clevelandclinic.org)
  • Nutritional photoprotection with flavanol-rich chocolate is a promising area for research, but double-blind clinical trials are required to confirm experimental findings. (biomedcentral.com)
  • At the time, Carbone oversaw the Eastern Cooperative Oncology Group (ECOG), a preeminent national cancer clinical trials group, and was able to continue that work from UW, creating new clinical research opportunities here in the Midwest. (uwhealth.org)
  • During this time, Carbone put an emphasis on translational research, or the idea of "translating" lab discoveries into clinical applications. (uwhealth.org)
  • With an increasing number of LFS study participants choosing this option in recent years, Dr. Loud saw an opportunity to marry her clinical and behavioral-psychosocial research interests by investigating the factors young women weigh when choosing mastectomy, as well as the effects of choosing not to have it. (cancer.gov)
  • In addition to being a member of professional organizations including the Society of Surgical Oncology, American Society of Clinical Oncology, American College of Surgeons, Association of Academic Surgeons and American Association of Cancer Research, Dr. Galka has developed clinical trials such as "A Pilot Study of Chemoprevention of Green Tea (Polyphenon E) in Women with Ductal Carcinoma in Situ (DCIS). (rochester.edu)
  • The UKCFSG meet twice a year to discuss new research proposals, to debate guidelines, to give feedback on research progress, and to present new data and updates on clinical management issues. (bmj.com)
  • The award is intended to extend funding for preclinical or clinical research directed towards improving human health. (aspet.org)
  • Community-wide annual administration (at 80% coverage) of TB31F over a three-year period was predicted to reduce clinical incidence by 54% (381 cases averted per 1000 people per year) in a high-transmission seasonal setting, and 74% (157 cases averted per 1000 people per year) in a low-transmission seasonal setting. (imperial.ac.uk)
  • Prior to her arrival in DCEG, Dr. Loud spent seven years as a Nurse Practitioner with the National Cancer Institute's Medical Oncology Branch, working with individuals enrolled in clinical trials of new cancer treatments. (cancer.gov)
  • Cancer genetics is a new and rapidly expanding speciality to which clinicians come with expertise in clinical and molecular genetics and in oncology. (bmj.com)
  • To examine the prostate cancer risk based on isoflavone intake and equol production, we carried out a phase II, randomized, double-blind, placebo-controlled trial of oral isoflavone (60 mg/day) for 12 months. (nih.gov)
  • We hope it will also enhance accrual to clinical trials by informing practicing oncologists of ongoing protocols. (cancernetwork.com)
  • So Dr. Tuohy has done a lot of preclinical work, developed this vaccine, and now it's ready to go into a clinical trial. (clevelandclinic.org)
  • Chemoprevention can be categorized as either primary chemoprevention or secondary chemoprevention. (medscape.com)
  • Primary chemoprevention is directed at patients with premalignant lesions (mucosal keratosis with atypia and erythroplakia). (medscape.com)
  • Secondary chemoprevention is targeted at patients with cancer who, in order to prevent recurrent disease or to prevent metachronous primary diseases, have undergone potentially curative therapy. (medscape.com)
  • Later, she became one of the main clinicians of the study, playing a primary role in seeing patients and families at the NIH Clinical Center, building relationships with them, sharing study updates, and following up on their concerns. (cancer.gov)
  • This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. (rochester.edu)
  • To view changes that have been made to the source record, or for additional information about this trial, click on the URL below to go to the source record in the primary register. (who.int)
  • Oral keratosis with atypia is an ideal model for the study of head and neck cancer development and chemoprevention because the lesions are readily accessible to visual examination, diagnostic sampling, and evaluation of response to treatment. (medscape.com)
  • If lung cancer is found, participation in one of the many clinical trials being done to improve treatment should be considered. (doereport.com)
  • Any of the treatment groups in a randomized trial. (ucsfhealth.org)
  • Clinical trials of ginseng as a treatment for Alzheimer's patients support its beneficial activity without side effects, demonstrating that ginseng might be a promising medicine for Alzheimer's disease. (novapublishers.com)
  • Secukinumab in patients with moderate to severe active, chronic plaque psoriasis who have failed on TNFα antagonists: a clinical trial evaluating treatment results. (cddft.nhs.uk)
  • Dr. Offit discussed international efforts to study these risk modifiers and plans for a clinical trial in BRCA2 mutation carriers to test how knowledge of modifying mutations will impact patient treatment decisions and outcomes. (bcrf.org)
  • The aims of this study were (1) to report the clinical and histological details of OEL on the jugal mucosa, and (2) to review the literature regarding OEL's demographic, clinical, and histological features, as well as its prognosis and treatment. (bvsalud.org)
  • Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials. (uc.edu)
  • Among the criteria for selection are that the trial is addressing an important question and is not expected to close in the immediate future (less than 1 year), and that initial staging or laboratory tests required for patient eligibility are widely practiced and available. (cancernetwork.com)
  • Therefore, the identification of molecular and imaging markers of risk and early neoplasia, and the testing of agents that can prevent the development of clinical cancer in this group are of high public health importance. (nih.gov)
  • Initial mammogram, breast MRI, or clinical breast examination prompts recommendation for biopsy by study investigators. (stanford.edu)
  • Registered with the UMIN Clinical Trials Registry (UMIN-CTR) for clinical trials in Japan (C000000446). (nih.gov)
  • and an international clinical trials registry. (cancernetwork.com)
  • Dr. Loud played a pivotal role in multiple clinical and epidemiologic studies aimed at improving understanding of clinical cancer genetics and the psychosocial impact of high genetic cancer risk on affected individuals. (cancer.gov)
  • To further explore the relationship between statin use and CRC in patients without IBD, the investigators analyzed data from 52 studies, including 8 randomized clinical trials, 17 cohort studies, and 27 case-control studies. (medscape.com)
  • Since these trials are intended to evaluate efficacy quickly, it is necessary to identify surrogates for cancer incidence/mortality to serve as trial endpoints. (nih.gov)
  • Cancer chemoprevention, as first defined in 1976 by Sporn, is the use of natural, synthetic, or biologic chemical agents to reverse, suppress, or prevent carcinogenic progression. (medscape.com)
  • Clinical patient data will be incorporated into a digital platform and analyzed to identify potential cancer-promoting risk factors in the FA population. (fanconi.org)
  • Since 1987, the National Cancer Institute…has tested more than 1,000 different potential agents for chemopreventive activity, of which only [a few dozen] were moved to clinical trials. (nutritionfacts.org)
  • Cancer chemoprevention is very attractive and has earned serious consideration as a potential means of controlling cancer incidence. (medscape.com)
  • Clinical Trials Referral Resource is designed to serve as a ready reference for oncologists to help identify clinical trials that might be suitable for their patients. (cancernetwork.com)
  • Currently in the United States less than 10% of eligible adult patients are entered into clinical trials. (cancernetwork.com)
  • We emphasize that this is an attempt to encourage referral of patients to these trials. (cancernetwork.com)
  • Clinical trials are taking place in most parts of the country for patients with all stages of non-small cell lung cancer. (doereport.com)
  • The process of getting patients onto a clinical trial, or the number of patients planned for a given trial. (ucsfhealth.org)
  • Receive email alerts when trials open to patients. (stanford.edu)
  • however, many patients present with metastatic disease with or without any clinical symptoms. (msdmanuals.com)
  • Prospective trials are needed to confirm the risk reduction of CRC in the IBD population, including whether the effects of statins differ between ulcerative colitis and Crohn's disease patients," Singh said. (medscape.com)
  • Who is responsible for publishing the results of old trials? (bmj.com)
  • The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)
  • Experimental hut trials (EHTs) are used to evaluate indoor vector control interventions against malaria vectors in a controlled setting. (imperial.ac.uk)
  • In this 2-group, parallel, double-blind, randomized controlled trial, 74 women aged 20-65 years and Fitzpatrick skin phototypes I or II were recruited from the general community in Quebec City, for randomization to either HFC (n = 33) or low-flavanol chocolate (LFC) (n = 41). (biomedcentral.com)