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  • Cohort
  • We constructed a cohort of 1,000 trial patients submitted to therapy with one of three different doses of a neutralizing antibody directed against tumor necrosis factor (anti-TNF) for 6, 24, or 48 hrs. (biomedsearch.com)
  • Control group is a group (or cohort) of individual patients that is used as a standard of comparison within a clinical trial. (wikipedia.org)
  • Behavioral
  • Behavioral trials evaluate or compare ways to promote behavioral changes designed to improve health. (nih.gov)
  • citation needed] Following his Bachelors and master's degrees in psychology at the University of Iceland in 1998 and 2003, Björnsson attended the University of Colorado at Boulder where he wrote a master´s thesis on depression amongst college students and received his PhD degree in 2009 based on his doctoral thesis, the topic of which was a randomized clinical trial employing cognitive behavioral group therapy. (wikipedia.org)
  • Endpoint
  • While not specifically related to clinical trials, the Council also recommended that FDA "make full use of accelerated approval for all drugs meeting the statutory standard of addressing an unmet need for a serious or lifethreatening disease, and demonstrating an impact on a clinical endpoint other than survival or irreversible morbidity, or on a surrogate endpoint, likely to predict clinical benefit. (wikipedia.org)
  • Interventions
  • Such biomarkers, implemented via a simple blood test , will identify subjects who are late asthmatic responders so that they can be pre-selected for clinical trials that examine how effective new pharmacological interventions are in attenuating inflammatory responses to allergen exposure," says Dr. Scott Tebbutt , Chief Scientific Officer of the PROOF Centre. (todaytopics.com)
  • However, the reality was that although NICE was principally aimed at aligning professional standards through clinical guidelines and audit, the acceptability of drugs, devices and technological interventions in defining those standards, could not be ignored and so the concept of a "fourth hurdle" for drugs accessing the NHS market was invoked. (wikipedia.org)
  • Supportive Care
  • Quality of life trials, or supportive care trials, explore and measure ways to improve the comfort and quality of life for people with conditions or illnesses. (nih.gov)
  • INVESTIGATOR
  • Ann Schreiber Mentored Investigator Award: This award was created in 2003, and funds clinical fellows or post-doctoral fellows working under the supervision of a mentor who is considered a leader in the field of ovarian cancer research. (wikipedia.org)
  • Symptoms
  • When the trial began, HT was already in common use for the treatment of menopausal symptoms. (nih.gov)
  • Treatment
  • Any of the treatment groups in a randomized trial. (lymphedemapeople.com)
  • 3. The initial time point in a clinical trial, just before a participant starts to receive the experimental treatment which is being tested. (lymphedemapeople.com)
  • Some examples are as follows: Patients who do not satisfy the inclusion and/or exclusion criteria are included in the trial, A patient is randomized to Treatment A, but is treated with Treatment B, Some patients drop out from the study, or Some patients are not compliant, that is, do not take their medication as instructed, and so on. (wikipedia.org)
  • An adaptive clinical trial is a clinical trial that evaluates a medical device or treatment by observing participant outcomes (and possibly other measures, such as side-effects) on a prescribed schedule, and modifying parameters of the trial protocol in accord with those observations. (wikipedia.org)
  • Includes topics such as coping, support, clinical trials and treatment options. (dmoztools.net)
  • This site offers education on oral health topics from A-Z. Includes condition overview, patient FAQS, treatment options and educational videos. (dmoztools.net)
  • optimal
  • It also attempted to offer flexibility to investigators to find the optimal clinical benefit without affecting the study's validity. (wikipedia.org)
  • NHLBI
  • The NHLBI is one of many types of organizations that support clinical trials. (nih.gov)
  • Search the NHLBI, use the drop down list to select: the entire site, the Health Topics section only, or the News and Resources section. (nih.gov)
  • patients
  • I did not see the trial criteria exclude patients who have acquired TKI resistance. (cancergrace.org)
  • Will these patients qualify for the trial? (cancergrace.org)
  • Using biological markers - genetic characteristics that are associated with some breast cancer patients - can increase the success rate of clinical trials for breast cancer drugs by almost 50 per cent, says new research from the University of Toronto Mississauga. (todaytopics.com)
  • To test this hypothesis, Parker and his team examined the clinical trial success rates for drugs tested on breast cancer patients who have a particular biomarker (HER2). (todaytopics.com)
  • When the team compared clinical trials that targeted patients with the HER2 biomarker to those that did not, they found the success rate of drug development increased from 15 per cent to 23 per cent. (todaytopics.com)
  • Children as well as adults, healthy volunteers and patients, and people of a diverse range of ethnic and racial backgrounds can and are encouraged to participate in clinical trials. (nih.gov)
  • In 40 comparative trials, other contrast media like metrizamide (Amipaque), ioxaglate (Hexabrix) and various monomeric ionic media were administered in 1292 patients included in this analysis. (mendeley.com)
  • For safety purposes, clinical trials start with small groups of patients to find out whether a new approach causes any harm. (nih.gov)
  • Under the Declaration of Helsinki, patients in clinical trials must participate entirely voluntarily and must have the right to leave the trial at any time. (wikipedia.org)
  • Drug
  • Modifications may include dosage, sample size, drug undergoing trial, patient selection criteria and "cocktail" mix. (wikipedia.org)
  • found
  • The trial found that one of the combinations worked much better than the other for moderate persistent asthma. (nih.gov)
  • placebo
  • Reviewing clinical trials involving phytosterol supplementation, the FDA concluded that when consumed in the range of 1 to 3 grams in enriched foods, phytosterols resulted in statistically significant (5-15%) reductions in blood LDL cholesterol levels relative to placebo. (wikipedia.org)
  • principles
  • The Belmont Report explains the unifying ethical principles that form the basis for the National Commission's topic-specific reports and the regulations that incorporate its recommendations. (wikipedia.org)
  • health
  • The subsequent larger trial should have the potential to make a significant impact on public health. (nih.gov)
  • Screening trials test new ways for detecting diseases or health conditions. (nih.gov)
  • Clinical trials produce the best data available for health care decisionmaking. (nih.gov)
  • Frank Dobson became Secretary of State and was supported by a team of Ministers keen on introducing clinical and health outcome measures to achieve improvements in the quality and delivery of care. (wikipedia.org)
  • Provides information for adults and children, including fact sheets, guidelines and recommendations on a variety of oral health topics. (dmoztools.net)
  • scientific
  • This page lists patient-reported quality of life surveys used in the field of medicine, pharmaceuticals, and other scientific trials. (wikipedia.org)
  • participation
  • The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial. (clinicaltrials.gov)
  • These interviews and discussions will address differences in HIV risk characteristics between groups of women and the legal, social, cultural, and delivery factors hindering women's participation in microbicide trials. (clinicaltrials.gov)