• We hypothesized that in children undergoing cardiac catheterization, general anesthesia with a combination of sevoflurane with xenon results in superior hemodynamic stability, compared to sevoflurane alone. (smarttots.org)
  • In this prospective, randomized, single-blinded, controlled clinical trial, children with a median age of 12 [IQR 3-36] months undergoing diagnostic/interventional cardiac catheterization were randomized to either general anesthesia with 50-65vol% xenon plus sevoflurane or sevoflurane alone. (smarttots.org)
  • Although it may be feasible to conduct annual whole-body MRI procedures on patients with RB1 germline mutations beginning at age 8-10 years (when general anesthesia would no longer be required), there is no consensus on the use of whole-body imaging as a surveillance tool. (aao.org)
  • Thus, an early performance of epidural analgesia turns out to be essential to control labor pain and to avoid a general anesthesia in such high-risk patients. (scielo.br)
  • Abstract Introduction Spinal anesthesia combined with sedation and general anesthesia combined with epidural are two techniques often used for patients undergoing abdominal hysterectomy. (scielo.br)
  • After applying the exclusion criteria, 80 patients underwent spinal anesthesia combined with sedation (Group 1) and 62 women underwent epidural anesthesia combined with general anesthesia (Group 2). (scielo.br)
  • General anesthesia for cesarean section: are we doing it well? (anesth-pain-med.org)
  • Korea has a higher rate of cesarean sections under general anesthesia than in other countries. (anesth-pain-med.org)
  • Neuraxial anesthesia is the gold standard for a cesarean section, but there are some cases in which general anesthesia is inevitable. (anesth-pain-med.org)
  • Therefore, obstetric anesthesiologists should be familiar in performing general anesthesia for cesarean section. (anesth-pain-med.org)
  • Rapid-sequence induction and intubation with cricoid pressure using thiopental-succinylcholine have been the standard for cesarean section under general anesthesia for a long time. (anesth-pain-med.org)
  • Pursuing the safety of obstetric patients and anesthesiologists at the same time, this review will help update the knowledge or training in performing general anesthesia for cesarean section. (anesth-pain-med.org)
  • Neuraxial anesthesia is currently recommended as the gold standard rather than general anesthesia for most patients undergoing cesarean section [ 3 , 4 ], since the mortality rate of cesarean section under general anesthesia is 16.7 times higher than that under regional anesthesia [ 5 ]. (anesth-pain-med.org)
  • There is no consensus on the ideal proportion of general anesthesia for cesarean sections, but approximately 5-6% are conducted under general anesthesia, which can be further reduced by obstetric anesthesiologist teams or obstetric specialized anesthesiologists [ 6 , 7 ]. (anesth-pain-med.org)
  • However, in patients with emergent conditions (e.g., placental abruption, cord prolapse, antenatal placental bleeding, and non-reassuring fetal tracing), the rate of general anesthesia has been reported to be up to 20% [ 8 ]. (anesth-pain-med.org)
  • Except for emergencies, induction of general anesthesia will continue in situations deemed "unavoidable and necessary," including patient refusals or contraindications to neuraxial anesthesia [ 9 ]. (anesth-pain-med.org)
  • As the overall safety of general anesthesia has significantly improved over the past two decades with newly developed drugs, devices, and monitors, general anesthesia no longer has an impact on anesthesia-related maternal mortality rates [ 10 , 11 ]. (anesth-pain-med.org)
  • In addition, general anesthesia is valuable in clinical obstetric conditions that require hemodynamic stability or rapid induction of anesthesia [ 12 ]. (anesth-pain-med.org)
  • General anesthesia for cesarean sections was not associated with overall neurodevelopmental delay at two years of age [ 13 ]. (anesth-pain-med.org)
  • The choice of general anesthesia varies across countries or hospitals. (anesth-pain-med.org)
  • In Korea, unlike previous data from the United Kingdom or the United States, the rate of general anesthesia use is steadily decreasing with time, but it is still over 20% [ 14 ]. (anesth-pain-med.org)
  • In some hospitals with a high volume of emergency cases or high-risk parturients, the rate of general anesthesia is close to 90% [ 15 ]. (anesth-pain-med.org)
  • Racial, ethnic, and socioeconomic disparities also contribute to the choice of general anesthesia [ 11 ]. (anesth-pain-med.org)
  • A retrospective audit conducted by a single British institution reported that the use of general anesthesia for cesarean section decreased from 76% in 1982 to 7.7% in 1998 and 4.9% in 2006 [ 16 , 17 ]. (anesth-pain-med.org)
  • General anesthesia is a loss of feeling and a complete loss of awareness that feels like a very deep sleep. (neuroblastoma-info.com)
  • Sub-umbilical surgery under caudal block in conjunction with sevoflurane sedation may be safe in terms of maintaining spontaneous breathing and avoiding complications associated with general anesthesia. (anesth-pain-med.org)
  • Most caudal blocks are performed as adjuvant procedures to general anesthesia with endotracheal intubation [ 1 ], but caudal block with sedation per se can be used as an alternative to general anesthesia [ 2 - 4 ]. (anesth-pain-med.org)
  • Moreover, compared to general anesthesia, it has a lower likelihood of precipitating postoperative respiratory events [ 5 ]. (anesth-pain-med.org)
  • The first report on paediatric spinal anesthesia was published by AUGUST BIER in 1899, when the technique was performed with cocaine in an 11 year old boy for ischium abscess drainage. (ispub.com)
  • The aim of this study was evaluate the relation of spinal microglia activity with pain related behaviors during Complete Freund's adjuvant (CFA)-induced inflammation. (ac.ir)
  • Intravenous versus intrathecal dexmedetomidine as an additive to hyperbaric bupivacaine in spinal anesthesia for hip arthroplasty. (ekja.org)
  • Maternal hypotension is the most common side effect of spinal anesthesia during cesarean delivery, accounting for 70-83% of all cases. (researchsquare.com)
  • Methods such as intrathecal adjuvant opioid use to reduce the total dose of anaesthetics delivered, 8 prophylactic use of vasopressors, 4,9 and the use of intravenous (IV) pre-load colloid liquid 10 have been proposed to reduce the incidence or extent of maternal hypotension after spinal anesthesia during cesarean delivery. (researchsquare.com)
  • it achieves sedation, analgesia, and sympathetic activation 12 with a relatively low risk of side effects to mothers or infants, 13 making it an optimum choice as an IV adjuvant for spinal anesthesia during cesarean delivery. (researchsquare.com)
  • We hypothesized that a single ultra-low IV bolus of S-ketamine may reduce the total need for spinal ropivacaine and thus reduce the incidence of post-spinal anesthesia hypotension during cesarean delivery. (researchsquare.com)
  • the incidence of post-spinal anesthesia hypotension was observed. (researchsquare.com)
  • The recovery of spinal anesthesia is assessed through a scale defined in 1979 by Bromage and is based exclusively on the return of motor function and does not take into account the recovery of ANS activity. (bvsalud.org)
  • The sample consisted of 60 ASA patients I to III, submitted to orthopedic surgery of lower limbs and lower abdomen under spinal anesthesia. (bvsalud.org)
  • The researchers conducted a randomized clinical trial protocol to assess autonomic function at motor recovery in patients receiving spinal anesthesia with isobaric bupivacaine alone or clonidine-associated isobaric bupivacaine. (bvsalud.org)
  • This study assesses the effect of intrathecal adjuvant bupivacaine plus sufentanil on intraoperative hemodynamic changes in elective coronary artery bypass surgery. (longdom.org)
  • Ropivacaine is a pures (-) enantiomer and is less cardiotoxic than equivalent concentrations of bupivacaine has recently introduced for its clinical use. (oaji.net)
  • Effect of oral low dose clonidine premedication on postoperative pain in patients undergoing abdominal hysterectomy: a randomized placebo controlled clinical trial. (druglib.com)
  • OBJECTIVE: To investigate the clinical efficacy of electrophysiological appropriateness technique (EAT) therapy based on the traditional Chinese medicine (TCM) meridian theory in managing postoperative pain after urethral reconstruction surgery. (bvsalud.org)
  • Radiation therapy is an essential component in Gynecology in the primary nonsurgical management and the adjuvant postoperative treatment of selected malignancies arising in the female reproductive tract. (medscape.com)
  • Images show initial anteroposterior (AP, left) and lateral (right) fields used for postoperative adjuvant pelvic external-beam radiotherapy in a patient with stage IC grade 2 adenocarcinoma of the endometrium who underwent hysterectomy. (medscape.com)
  • The depth of tumoral invasion and the histopathologic grade of the tumor influence the recommendations for adjuvant postoperative therapy. (medscape.com)
  • 2] Thus, there exists a great clinical need for effective and safe non-opioid analgesic alternatives for the management of acute postoperative pain. (asra.com)
  • 3] Indeed, local anesthetics have been the mainstay in regional anesthesia and provide superior control of postoperative pain. (asra.com)
  • Therefore, the enzyme has been used as a local adjuvant to increase the diffusion capacity of local anesthetics, increasing the analgesic efficacy, and the anesthetized area particularly in the first minutes following injection, resulting in diminished intra- and postoperative pain. (biomedcentral.com)
  • As a result, current practice and clinical quality improvement are increasingly focused on reducing more common postoperative outcomes, such as pain and nausea. (medscape.com)
  • A randomized feasibility trial of clonidine to reduce perioperative cardiac risk in patients on chronic beta-blockade: the EPIC study. (druglib.com)
  • Screening mammography in frail patients is questionable, and a clinical breast exam is likely to identify breast cancers that warrant intervention. (cancernetwork.com)
  • Intrathecal opioids have been used for many patients undergoing surgical operations to improve clinical outcomes. (longdom.org)
  • In a double-blind, randomized, placebo-controlled clinical trials, 80 patients scheduled for elective CABG were randomly assigned into 2 groups. (longdom.org)
  • It will be critical for more clinical trials in breast oncology to include elderly patients when appropriate in order to improve individualized treatment recommendations for this growing population. (medpagetoday.com)
  • For these reasons, standard breast cancer treatment that includes surgery and radiation should be considered in patients with a life expectancy of at least 2 years, Sarah L. Blair, MD , clinical professor in the Department of Surgery at the University of California San Diego, Moores Cancer Center, said at the Annual Conference of the National Comprehensive Cancer Network (NCCN). (medpagetoday.com)
  • Similarly, another study found that in older patients, tumors were more likely to be found by clinical breast examination and less often by radiologic procedures. (medpagetoday.com)
  • for example, a preliminary clinical trial reported that ketamine reduced the severity of symptoms in patients with PTSD. (nopainhanna.com)
  • This will potentially be of benefit in opening up appropriate clinical trial opportunities for this subset of patients in the future. (cancernetwork.com)
  • A few programs of particular impact are the distribution of low cost devices to improve the safety of care (including pulse oximeters for the routine monitoring of patients undergoing anesthesia and a new surgical headlight program) and Clean Cut, a surgical infection prevention and control program now being introduced in several countries. (stanford.edu)
  • Efficacy of Nanocurcumin as an Add-On Treatment for Patients Hospitalized with COVID-19: A Double-Blind, Randomized Clinical Trial. (medscape.com)
  • Anesthesia keeps patients from feeling pain during surgery and other procedures. (neuroblastoma-info.com)
  • 20 - 25 ] A major pooled analysis evaluating the impact of T and N stage and treatment on survival and relapse in patients with rectal cancer who are treated with adjuvant therapy confirmed these findings. (cancer.gov)
  • Thus, the authors retrospectively examined the link between propofol-based total intravenous anesthesia (TIVA) and recurrence or overall survival in patients undergoing modified radical mastectomy (MRM). (ekja.org)
  • Patients received either propofol-based TIVA (propofol group) or sevoflurane-based anesthesia (sevoflurane group). (ekja.org)
  • Despites the likelihood of dispersing cancer cells during surgery, however, only a small minority of patients develops clinical metastases, a phenomenon which may depend on the host defenses, including cell-mediated immunity and in particular, natural killer (NK) cell function. (ekja.org)
  • Anesthesia practice today has largely eliminated serious adverse events in healthy patients who are having routine surgery. (medscape.com)
  • In this clinical trial of 90 healthy patients (American Society of Anesthesiologists physical status score 1 or 2) undergoing inguinal hernia repair, appendectomy , varicocelec tomy, anal fistulotomy, breast lump resection, or a minor orthopedic surgical procedure, pain levels were assessed in the recovery room with a numerical rating scale from 0 (no pain) to 10 (worst imaginable pain). (medscape.com)
  • Neuropathic pain (NP) originates as a In non-oncological patients, chronic NP is The authors declare there are direct consequence of a lesion or disease common in clinical practice and consider- no conflict of interests. (bvsalud.org)
  • Braz J Anesthesiol, Ahead of Print, 2023 Posterior transversus abdominis plane block versus lateral quadratus lumborum block in children undergoing open orchiopexy: a randomized clinical trial Özgecan P. Zanbak Mutlu, Ayşe Ç. (bjan-sba.org)
  • this clinical situation requires adjuvant chemotherapy and radiation therapy. (aao.org)
  • Mismatch repair-deficient tumors do not respond well to chemotherapy applied in the neoadjuvant, adjuvant, or metastatic settings. (cancer.gov)
  • The SmartTots program is a multi-year collaborative effort designed to increase the safety of anesthetic and sedative drugs for the millions of children who undergo anesthesia and sedation each year. (smarttots.org)
  • Secondary outcomes included the incidences of hypotension related symptoms and managements, upper sensory level of anesthesia, level of sedation, neonatal outcomes, Edinburgh postnatal depression scale scores on admission and discharging of hospital and post-operative analgesic effect. (researchsquare.com)
  • Clonidine Maintenance Prolongs Opioid Abstinence and Decouples Stress From Craving in Daily Life: A Randomized Controlled Trial With Ecological Momentary Assessment. (druglib.com)
  • Thus, my inspiration for the work described here stems from both the clinical need for non-opioid alternatives and obligation to find longer lasting and safer local anesthetic agents. (asra.com)
  • After inclusion of 40 children, the trial was stopped as an a priori planned blinded interim analysis revealed that the overall rate of hemodynamic instability did not differ between groups [100% in both the xenon-sevoflurane and the sevoflurane group. (smarttots.org)
  • Larger and adequately powered clinical trials are warranted to investigate the impact of xenon on short- and long-term outcomes in pediatric anesthesia. (smarttots.org)
  • Hemodynamic and clinical outcomes including blood pressure values were measured during and after the operation. (longdom.org)
  • 1] The standard approach to pain management in clinical practice is multimodal analgesia. (asra.com)
  • An adjuvant therapy is the preemptive analgesia, which is a drug regimen prior to the nociceptive stimulus, aiming at preventing hyperalgesia and the subsequent pain amplification 1 . (bvsalud.org)
  • Pediatric pain management is challenging and one of the frontiers of modern anesthesia. (ispub.com)
  • We monitored EA episodes at 5 and 30 min in the post-anesthetic care unit (PACU) by using the fourpoint agitation scale and the Pediatric Anesthesia Emergence Delirium (PAED) scale. (anesth-pain-med.org)
  • Although adjuvant radiotherapy is commonly used to manage advanced or metastatic cervical and endometrial cancer, it is sometimes administered as adjuvant therapy for ovarian cancer. (medscape.com)
  • [8] Clonidine is now an acceptable adjuvant to local anaesthetic for epidural route nevertheless clinical trial provide evidence that less clonidine is needed intrathecaly than epidural to produce same analgesic effect with fewer side effects. (ispub.com)
  • The use of appropriate and effective anesthesia for cesarean section is important not only to reduce the incidence of maternal and fetal morbidities but also to reduce the incidence of intraoperative maternal awareness. (anesth-pain-med.org)
  • Can artificial intelligence be your angel to diagnose early gastric cancer in real clinical practice? (cdc.gov)
  • If the patient's life expectancy was more than 2 years and she had an acceptable risk for undergoing anesthesia, the patient was offered standard surgery. (medpagetoday.com)
  • The Efficacy and Safety of Teprotumumab in Thyroid Eye Disease: Evidence from Randomized Controlled Trials. (medscape.com)
  • The Clinical Efficacy of Autologous Platelet-Rich Plasma Interventional Circulatory Perfusion Combined with Radiofrequency Ablation and Thermocoagulation in the Treatment of Discogenic Low Back Pain. (medscape.com)
  • Consequently, apical membrane antigen 1 has been a target of vaccine development but vaccination with apical membrane antigen 1 alone in controlled human malaria infections failed to protect and showed limited efficacy in field trials. (nature.com)
  • There are few protocols for the use of 200 mg (200 mg/10 mL vial), diluted in 250 intravenous (IV) lidocaine as an adjuvant in ccs of 0.9 % saline solution to be given intra- the relief of neuropathic pain, such as the venously in one hour by continuous infusion pain guidelines of the Latin American Feder- pump by the attending physician. (bvsalud.org)
  • Recovery from anesthesia after administration of the high dose of MOR was considered undesirable and dangerous. (nih.gov)
  • The effectiveness of clonidine hydrochloride extended-release tablets for longer-term use (more than 5 weeks) has not been systematically evaluated in controlled trials. (druglib.com)
  • Prophylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis. (druglib.com)
  • The risk of breast cancer increases as women age, yet despite the higher prevalence of breast cancer in the older age group, older women are under-represented in clinical trials. (medpagetoday.com)
  • Current Research and Scholarly Interests Clinical trials in operative procedures such as Nipple-sparing mastectomy, arm lymphatic mapping, skin perfusion and Treatments for Breast Cancer, especially local recurrence. (stanford.edu)
  • Dr. Wapnir is institutional Principal Investigator and Chair for National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trials. (stanford.edu)
  • R, Flisberg P, Hedlund L, Östlund I, Bergkvist L. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. (cancercentrum.se)
  • Research at the Hugill Anesthesia Research Centre at The University of British Columbia (UBC) found that a quaternary derivative of lidocaine, QX-314, produces robust nociceptive, sensory, and motor blockade of long duration in animals in vivo . (asra.com)
  • One of the imperatives of clinical research going forward will be to demonstrate whether the ability of a compound to interact with a specific brain target is related to some measurable change in brain or behavioral activity that, in turn, can be associated with relief of symptoms. (nopainhanna.com)
  • Healthcare providers worry that anesthesia and other medications during and after surgery might increase this effect. (medlineplus.gov)
  • Clinical Effect of Uterosacral and Cardinal Ligament Fixation versus Sacrospinous Ligament Fixation of Vaginal Vault Prolapse: A Retrospective Analysis. (medscape.com)
  • Recently, with the introduction of new drugs (propofol, rocuronium, and sugammadex) and equipments (videolaryngoscopy and supraglottic airways), anesthesia methods have also gradually changed. (anesth-pain-med.org)
  • A recent study in Mali found no difference in time-to-infection in both children and adults, indicating no pre-erythrocytic immunity, but adults were significantly protected from clinical disease. (nature.com)
  • In a scientific research study or clinical trial, a flaw in the study design or the method of collecting or interpreting information. (neuroblastoma-info.com)
  • Biases can lead to incorrect conclusions about what the study or clinical trial showed. (neuroblastoma-info.com)
  • The COS-TCM-CPHD will improve the consistency of study reports and reduce publication bias, thereby improving the quality of TCM clinical trials and decision-making for evidence-based medicine. (hindawi.com)
  • This was a pilot study of a blinded, paired sample, randomized clinical trial. (bvsalud.org)
  • however, they also produce notable gastrointestinal and cardiovascular complications, which limit their clinical use. (asra.com)
  • In this article, clinical indications and common techniques for radiation therapy in the management of common gynecologic cancers are described. (medscape.com)
  • Intensive multi-modality therapy for extra-ocular retinoblastoma (RB): a Children's Oncology Group (COG) trial (ARET0321). (aao.org)
  • The oldest group is also less likely to have adjuvant therapy than women in their 60s and 70s. (medpagetoday.com)
  • If residual disease is found, adjuvant therapy with radioactive iodine (RAI) may be considered. (medscape.com)
  • Augmented Features Synergize Radiomics in Post-Operative Survival Prediction and Adjuvant Therapy Recommendation for Non-Small Cell Lung Cancer. (cdc.gov)
  • It is understood to be important to analyze these factors using methods already validated in the domain of chaos, complexity and fractality, more compatible with the complexity of the behavior of biological systems, in the characterization of the autonomic function during the subarachnoid anesthesia. (bvsalud.org)
  • Laboratory markers of oncotic pressure (albumin) and cardiac dysfunction (brain natriuretic peptide [BNP]) may be abnormal, but the clinical application remains unclear. (stanfordchildrens.org)
  • A randomised, double-blind clinical trial will be performed in a large hospital located in the southern region of Ceará, Brazil and at the HUJB in Cajazeiras, Paraíba. (bvsalud.org)
  • 4] Since the first public demonstration of local anesthesia with the aminodiester, cocaine, remarkable strides have been made in local anesthetic drug development. (asra.com)
  • In the opinion of the present authors, the most effective and simplest anesthesia currently available is eutectic mixture of local anesthetics (EMLA) or ELA-Max topical anesthetic cream. (medscape.com)
  • The development, clinical evaluation, regulatory approvals, and vaccination programs for messenger RNA (mRNA) and viral vector-based vaccines to SARS-CoV-2 have rapidly progressed during the past two years [1,2]. (medscimonit.com)
  • Hovén E , Flynn KE, Weinfurt KP, Eriksson LE, Wttergren L. Psychometric evaluation of the Swedish version of the PROMIS Sexual Function and Satisfaction Measures in clinical and nonclinical young adult populations. (cancercentrum.se)
  • Our results do not support routine clinical use of MOR administered IV at dosages of 0.25 or 2.0 mg/kg as an adjuvant to anesthesia in horses administered ISO. (nih.gov)